Aliases for KRTAP26-1 Gene

Aliases for KRTAP26-1 Gene

  • Keratin Associated Protein 26-1 2 3 5
  • Keratin-Associated Protein 26-1 3 4
  • KRTAP26-1 5
  • KAP26.1 4

External Ids for KRTAP26-1 Gene

Previous GeneCards Identifiers for KRTAP26-1 Gene

  • GC21M030614
  • GC21M031691
  • GC21M017100

Summaries for KRTAP26-1 Gene

GeneCards Summary for KRTAP26-1 Gene

KRTAP26-1 (Keratin Associated Protein 26-1) is a Protein Coding gene. Diseases associated with KRTAP26-1 include Human Monocytic Ehrlichiosis and Human Granulocytic Anaplasmosis. Among its related pathways are Developmental Biology and Keratinization. An important paralog of this gene is KRTAP11-1.

UniProtKB/Swiss-Prot Summary for KRTAP26-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP26-1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRTAP26-1 Gene

Genomics for KRTAP26-1 Gene

Genomic Locations for KRTAP26-1 Gene

Genomic Locations for KRTAP26-1 Gene
chr21:30,319,124-30,320,315
(GRCh38/hg38)
Size:
1,192 bases
Orientation:
Minus strand
chr21:31,691,449-31,692,607
(GRCh37/hg19)
Size:
1,159 bases
Orientation:
Minus strand

Genomic View for KRTAP26-1 Gene

Genes around KRTAP26-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP26-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP26-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP26-1 Gene

No data available for GeneHancer (GH) Regulatory Elements for KRTAP26-1 Gene

Proteins for KRTAP26-1 Gene

  • Protein details for KRTAP26-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEX3-KR261_HUMAN
    Recommended name:
    Keratin-associated protein 26-1
    Protein Accession:
    Q6PEX3
    Secondary Accessions:
    • B0RZD3

    Protein attributes for KRTAP26-1 Gene

    Size:
    210 amino acids
    Molecular mass:
    22554 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP26-1 Gene

Post-translational modifications for KRTAP26-1 Gene

No Post-translational modifications

Other Protein References for KRTAP26-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP26-1 Gene

Domains & Families for KRTAP26-1 Gene

Gene Families for KRTAP26-1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP26-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP26-1 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-associated protein 26-1 (KR261_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6PEX3

UniProtKB/Swiss-Prot:

KR261_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP26-1: view

Function for KRTAP26-1 Gene

Molecular function for KRTAP26-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Gene Ontology (GO) - Molecular Function for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with KRTAP26-1: view
genes like me logo Genes that share phenotypes with KRTAP26-1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KRTAP26-1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP26-1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP26-1 Gene

Localization for KRTAP26-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP26-1 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP26-1 Gene

Pathways & Interactions for KRTAP26-1 Gene

PathCards logo

SuperPathways for KRTAP26-1 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP26-1: view

Pathways by source for KRTAP26-1 Gene

2 Reactome pathways for KRTAP26-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for SIGNOR curated interactions for KRTAP26-1 Gene

Drugs & Compounds for KRTAP26-1 Gene

No Compound Related Data Available

Transcripts for KRTAP26-1 Gene

mRNA/cDNA for KRTAP26-1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP26-1

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP26-1 Gene

No ASD Table

Relevant External Links for KRTAP26-1 Gene

GeneLoc Exon Structure for
KRTAP26-1

Expression for KRTAP26-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRTAP26-1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP26-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.5) and Skin - Sun Exposed (Lower leg) (x8.2).

Protein differential expression in normal tissues from HIPED for KRTAP26-1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTAP26-1 Gene



Protein tissue co-expression partners for KRTAP26-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRTAP26-1

SOURCE GeneReport for Unigene cluster for KRTAP26-1 Gene:

Hs.28704

mRNA Expression by UniProt/SwissProt for KRTAP26-1 Gene:

Q6PEX3-KR261_HUMAN
Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).

Evidence on tissue expression from TISSUES for KRTAP26-1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with KRTAP26-1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP26-1 Gene

Orthologs for KRTAP26-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP26-1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRTAP26-1 31
  • 100 (a)
OneToOne
LOC100613423 30
  • 99.68 (n)
Dog
(Canis familiaris)
Mammalia KRTAP26-1 30 31
  • 79.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRTAP26-1 30
  • 71.19 (n)
Mouse
(Mus musculus)
Mammalia Krtap26-1 30 17 31
  • 69.68 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krtap26-1 30
  • 69.24 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KRTAP26-1 31
  • 19 (a)
OneToOne
Species where no ortholog for KRTAP26-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRTAP26-1 Gene

ENSEMBL:
Gene Tree for KRTAP26-1 (if available)
TreeFam:
Gene Tree for KRTAP26-1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRTAP26-1: view image

Paralogs for KRTAP26-1 Gene

genes like me logo Genes that share paralogs with KRTAP26-1: view

Variants for KRTAP26-1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRTAP26-1 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs12483584 - p.Pro188Thr
rs3804007 - p.Ser26Tyr

Additional dbSNP identifiers (rs#s) for KRTAP26-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRTAP26-1 Gene

Variant ID Type Subtype PubMed ID
nsv1057467 CNV gain 25217958
nsv1059954 CNV loss 25217958
nsv587354 CNV gain 21841781
nsv834076 CNV gain 17160897

Variation tolerance for KRTAP26-1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP26-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP26-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

Disorders for KRTAP26-1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KRTAP26-1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
human monocytic ehrlichiosis
  • ehrlichiosis chafeensis
human granulocytic anaplasmosis
  • hge
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with KRTAP26-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRTAP26-1 Gene

Publications for KRTAP26-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3

Products for KRTAP26-1 Gene

Sources for KRTAP26-1 Gene