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Aliases for KRTAP26-1 Gene

Aliases for KRTAP26-1 Gene

  • Keratin Associated Protein 26-1 2 3 5
  • KAP26.1 4

External Ids for KRTAP26-1 Gene

Previous GeneCards Identifiers for KRTAP26-1 Gene

  • GC21M030614
  • GC21M031691
  • GC21M017100

Summaries for KRTAP26-1 Gene

GeneCards Summary for KRTAP26-1 Gene

KRTAP26-1 (Keratin Associated Protein 26-1) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for KRTAP26-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP26-1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP26-1 Gene

Genomics for KRTAP26-1 Gene

GeneHancer (GH) Regulatory Elements for KRTAP26-1 Gene

Promoters and enhancers for KRTAP26-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I030320 Promoter 0.5 EPDnew 550.8 0.0 -19 0.1 KRTAP26-1 KRTAP27-1
GH21I030289 Promoter 0.6 EPDnew 0.3 +30.7 30722 0.1 PKNOX1 KRTAP25-1 KRTAP26-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRTAP26-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRTAP26-1 Gene

Genomic Locations for KRTAP26-1 Gene
chr21:30,319,124-30,320,316
(GRCh38/hg38)
Size:
1,193 bases
Orientation:
Minus strand
chr21:31,691,449-31,692,607
(GRCh37/hg19)

Genomic View for KRTAP26-1 Gene

Genes around KRTAP26-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP26-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP26-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP26-1 Gene

Proteins for KRTAP26-1 Gene

  • Protein details for KRTAP26-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEX3-KR261_HUMAN
    Recommended name:
    Keratin-associated protein 26-1
    Protein Accession:
    Q6PEX3
    Secondary Accessions:
    • B0RZD3

    Protein attributes for KRTAP26-1 Gene

    Size:
    210 amino acids
    Molecular mass:
    22554 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP26-1 Gene

Post-translational modifications for KRTAP26-1 Gene

No Post-translational modifications

Other Protein References for KRTAP26-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP26-1 Gene

Domains & Families for KRTAP26-1 Gene

Gene Families for KRTAP26-1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP26-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP26-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEX3

UniProtKB/Swiss-Prot:

KR261_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP26-1: view

Function for KRTAP26-1 Gene

Molecular function for KRTAP26-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Gene Ontology (GO) - Molecular Function for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with KRTAP26-1: view

Phenotypes for KRTAP26-1 Gene

genes like me logo Genes that share phenotypes with KRTAP26-1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP26-1 Gene

Localization for KRTAP26-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP26-1 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP26-1 Gene

Pathways & Interactions for KRTAP26-1 Gene

SuperPathways for KRTAP26-1 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP26-1: view

Pathways by source for KRTAP26-1 Gene

2 Reactome pathways for KRTAP26-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for SIGNOR curated interactions for KRTAP26-1 Gene

Drugs & Compounds for KRTAP26-1 Gene

No Compound Related Data Available

Transcripts for KRTAP26-1 Gene

mRNA/cDNA for KRTAP26-1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP26-1 Gene

Keratin associated protein 26-1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP26-1 Gene

No ASD Table

Relevant External Links for KRTAP26-1 Gene

GeneLoc Exon Structure for
KRTAP26-1
ECgene alternative splicing isoforms for
KRTAP26-1

Expression for KRTAP26-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP26-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP26-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.5) and Skin - Sun Exposed (Lower leg) (x8.2).

Protein differential expression in normal tissues from HIPED for KRTAP26-1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRTAP26-1 Gene



Protein tissue co-expression partners for KRTAP26-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP26-1 Gene:

Hs.28704

mRNA Expression by UniProt/SwissProt for KRTAP26-1 Gene:

Q6PEX3-KR261_HUMAN
Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).

Evidence on tissue expression from TISSUES for KRTAP26-1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with KRTAP26-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP26-1 Gene

Orthologs for KRTAP26-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP26-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP26-1 34
  • 100 (a)
OneToOne
LOC100613423 33
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia KRTAP26-1 33 34
  • 79.4 (n)
cow
(Bos Taurus)
Mammalia KRTAP26-1 33
  • 71.19 (n)
mouse
(Mus musculus)
Mammalia Krtap26-1 33 16 34
  • 69.68 (n)
rat
(Rattus norvegicus)
Mammalia Krtap26-1 33
  • 69.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRTAP26-1 34
  • 19 (a)
OneToOne
Species where no ortholog for KRTAP26-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP26-1 Gene

ENSEMBL:
Gene Tree for KRTAP26-1 (if available)
TreeFam:
Gene Tree for KRTAP26-1 (if available)

Paralogs for KRTAP26-1 Gene

No data available for Paralogs for KRTAP26-1 Gene

Variants for KRTAP26-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP26-1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000331720 -- 30,320,624(-) G/C upstream_transcript_variant
rs1001072724 -- 30,321,010(-) T/A upstream_transcript_variant
rs1001073324 -- 30,321,974(-) A/T upstream_transcript_variant
rs1001261960 -- 30,318,767(-) A/G downstream_transcript_variant
rs1002273912 -- 30,321,963(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRTAP26-1 Gene

Variant ID Type Subtype PubMed ID
nsv1057467 CNV gain 25217958
nsv1059954 CNV loss 25217958
nsv587354 CNV gain 21841781
nsv834076 CNV gain 17160897

Variation tolerance for KRTAP26-1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP26-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP26-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

Disorders for KRTAP26-1 Gene

Additional Disease Information for KRTAP26-1

No disorders were found for KRTAP26-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP26-1 Gene

Publications for KRTAP26-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B … Rezsohazy R (BMC developmental biology 2012) 3 58

Products for KRTAP26-1 Gene

Sources for KRTAP26-1 Gene

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