Aliases for KRTAP21-3 Gene

Aliases for KRTAP21-3 Gene

  • Keratin Associated Protein 21-3 2 3 5
  • Keratin-Associated Protein 21-3 3 4
  • KRTAP21-3 5
  • KAP21.3 4

External Ids for KRTAP21-3 Gene

Previous GeneCards Identifiers for KRTAP21-3 Gene

  • GC00U925162
  • GC21M032091
  • GC21M017499

Summaries for KRTAP21-3 Gene

GeneCards Summary for KRTAP21-3 Gene

KRTAP21-3 (Keratin Associated Protein 21-3) is a Protein Coding gene. Among its related pathways are Developmental Biology and Keratinization.

UniProtKB/Swiss-Prot Summary for KRTAP21-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP21-3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRTAP21-3 Gene

Genomics for KRTAP21-3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRTAP21-3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J030716 Enhancer 0.9 Ensembl ENCODE 600.7 +0.5 479 2.7 BACH1 TCF12 IKZF2 TRIM22 PKNOX1 DPF2 RELB JUND RUNX3 BCL11A KRTAP21-3 KRTAP20-4 LOC105372773 HSALNG0132601 FJ601684-286 KRTAP20-3
GH21J030995 Enhancer 0.4 FANTOM5 Ensembl 2.8 -276.8 -276849 0.4 KRTAP21-3 LOC105372776 lnc-KRTAP19-8-2 lnc-KRTAP20-3-1 KRTAP19-8 KRTAP11-1
GH21J030893 Enhancer 0.2 FANTOM5 2.6 -174.9 -174876 0.1 KRTAP21-3 KRTAP19-4 KRTAP6-3 KRTAP13-4 KRTAP15-1 HSALNG0132608 KRTAP11-1 KRTAP19-8
GH21J030709 Enhancer 0.2 ENCODE 0.4 +8.0 7992 1.8 KRTAP21-3 LOC105372773 HSALNG0132601 FJ601684-286 KRTAP20-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRTAP21-3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRTAP21-3

Genomic Locations for KRTAP21-3 Gene

Genomic Locations for KRTAP21-3 Gene
chr21:30,718,525-30,718,777
(GRCh38/hg38)
Size:
253 bases
Orientation:
Minus strand
chr21:32,090,843-32,091,095
(GRCh37/hg19)
Size:
253 bases
Orientation:
Minus strand

Genomic View for KRTAP21-3 Gene

Genes around KRTAP21-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP21-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP21-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP21-3 Gene

Proteins for KRTAP21-3 Gene

  • Protein details for KRTAP21-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LHN1-KR213_HUMAN
    Recommended name:
    Keratin-associated protein 21-3
    Protein Accession:
    Q3LHN1

    Protein attributes for KRTAP21-3 Gene

    Size:
    58 amino acids
    Molecular mass:
    6456 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP21-3 Gene

Post-translational modifications for KRTAP21-3 Gene

No Post-translational modifications

Other Protein References for KRTAP21-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP21-3 Gene

Domains & Families for KRTAP21-3 Gene

Gene Families for KRTAP21-3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP21-3 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP21-3 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-associated protein 21-3 (KR213_HUMAN)
genes like me logo Genes that share domains with KRTAP21-3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KRTAP21-3 Gene

Function for KRTAP21-3 Gene

Molecular function for KRTAP21-3 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes From GWAS Catalog for KRTAP21-3 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP21-3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP21-3 Gene

Localization for KRTAP21-3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP21-3 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2

Gene Ontology (GO) - Cellular Components for KRTAP21-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP21-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP21-3 Gene

Pathways & Interactions for KRTAP21-3 Gene

PathCards logo

SuperPathways for KRTAP21-3 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP21-3: view

Pathways by source for KRTAP21-3 Gene

2 Reactome pathways for KRTAP21-3 Gene

Interacting Proteins for KRTAP21-3 Gene

Gene Ontology (GO) - Biological Process for KRTAP21-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP21-3: view

No data available for SIGNOR curated interactions for KRTAP21-3 Gene

Drugs & Compounds for KRTAP21-3 Gene

No Compound Related Data Available

Transcripts for KRTAP21-3 Gene

mRNA/cDNA for KRTAP21-3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP21-3

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP21-3 Gene

No ASD Table

Relevant External Links for KRTAP21-3 Gene

GeneLoc Exon Structure for
KRTAP21-3

Expression for KRTAP21-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRTAP21-3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRTAP21-3

SOURCE GeneReport for Unigene cluster for KRTAP21-3 Gene:

Hs.580877
genes like me logo Genes that share expression patterns with KRTAP21-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP21-3 Gene

Orthologs for KRTAP21-3 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for KRTAP21-3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614985 30
  • 98.85 (n)
KRTAP21-3 31
  • 98 (a)
OneToOne
Species where no ortholog for KRTAP21-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRTAP21-3 Gene

ENSEMBL:
Gene Tree for KRTAP21-3 (if available)
TreeFam:
Gene Tree for KRTAP21-3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRTAP21-3: view image

Paralogs for KRTAP21-3 Gene

No data available for Paralogs for KRTAP21-3 Gene

Variants for KRTAP21-3 Gene

Additional dbSNP identifiers (rs#s) for KRTAP21-3 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRTAP21-3 Gene

Variant ID Type Subtype PubMed ID
dgv4424n100 CNV gain 25217958
esv2762106 CNV gain 21179565
nsv1057467 CNV gain 25217958
nsv459237 CNV gain 19166990
nsv587359 CNV gain 21841781

Variation tolerance for KRTAP21-3 Gene

Gene Damage Index Score: 5.47; 71.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP21-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP21-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRTAP21-3 Gene

Disorders for KRTAP21-3 Gene

No disorders were found for KRTAP21-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP21-3 Gene

Publications for KRTAP21-3 Gene

No publications were found for KRTAP21-3 Gene.

Products for KRTAP21-3 Gene

Sources for KRTAP21-3 Gene