Aliases for KRTAP21-1 Gene
Aliases for KRTAP21-1 Gene
External Ids for KRTAP21-1 Gene
- HGNC: 18945
- Entrez Gene: 337977
- Ensembl: ENSG00000187005
- UniProtKB: Q3LI58
Previous GeneCards Identifiers for KRTAP21-1 Gene
- GC00U906264
- GC21U900112
- GC21M031047
- GC21M031049
- GC21M032127
- GC21M017536
Summaries for KRTAP21-1 Gene
GeneCards Summary for KRTAP21-1 Gene
KRTAP21-1 (Keratin Associated Protein 21-1) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.
UniProtKB/Swiss-Prot for KRTAP21-1 Gene
-
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Additional gene information for KRTAP21-1 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP21-1 Gene
Genomics for KRTAP21-1 Gene
GeneHancer (GH) Regulatory Elements for KRTAP21-1 Gene
Promoters and enhancers for KRTAP21-1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21I030747 | Promoter | 0.5 | EPDnew | 0.4 | +8.1 | 8149 | 0.1 | KRTAP21-2 KRTAP21-1 GC21M030725 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around KRTAP21-1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRTAP21-1 gene promoter:
Regulatory Element Products
Genomic Locations for KRTAP21-1 Gene
Genomic Locations for KRTAP21-1 Gene
- chr21:30,754,830-30,755,428
- (GRCh38/hg38)
- Size:
- 599 bases
- Orientation:
- Minus strand
- chr21:32,127,439-32,127,746
- (GRCh37/hg19)
Genomic View for KRTAP21-1 Gene
Genes around KRTAP21-1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by Ensembl
- 21q22.11 by Entrez Gene
- 21q22.11 by HGNC
KRTAP21-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRTAP21-1 Gene
Proteins for KRTAP21-1 Gene
-
Protein details for KRTAP21-1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3LI58-KR211_HUMAN
- Recommended name:
- Keratin-associated protein 21-1
- Protein Accession:
- Q3LI58
Protein attributes for KRTAP21-1 Gene
- Size:
- 79 amino acids
- Molecular mass:
- 7937 Da
- Quaternary structure:
-
- Interacts with hair keratins.
Post-translational modifications for KRTAP21-1 Gene
No Post-translational modifications
Other Protein References for KRTAP21-1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP21-1
- Origene Custom Protein Services for KRTAP21-1
- antibodies-online: Search results for 2 available KRTAP21-1 Proteins ranked by validation data
- Compare Top KRTAP21-1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for KRTAP21-1
Assay Products
No data available for DME Specific Peptides for KRTAP21-1 Gene
Domains & Families for KRTAP21-1 Gene
Gene Families for KRTAP21-1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KRTAP21-1 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for KRTAP21-1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KRTAP21-1 Gene
Function for KRTAP21-1 Gene
Molecular function for KRTAP21-1 Gene
- UniProtKB/Swiss-Prot Function:
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Phenotypes for KRTAP21-1 Gene
- GenomeRNAi human phenotypes for KRTAP21-1:
Animal Model Products
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-
-
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CRISPR Products
- Browse CRISPR knockouts for KRTAP21-1
- genomics-online: gRNA clones - Search results for available KRTAP21-1 gene related products
- Applied Biological Materials CRISPR for KRTAP21-1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP21-1
- GenScript: Design CRISPR guide RNA sequences for KRTAP21-1
miRNA Products
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Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available KRTAP21-1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP21-1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for KRTAP21-1
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available KRTAP21-1 gene related products
- orf clones - Search results for available KRTAP21-1 gene related products
- Applied Biological Materials Clones for KRTAP21-1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRTAP21-1
-
ViGene Biosciences adenoviral particle packaged cDNA for KRTAP21-1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP21-1 gene
- Search ViGene Biosciences for KRTAP21-1
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP21-1 Gene
Localization for KRTAP21-1 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| cytoskeleton | 3 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP21-1 Gene
Pathways & Interactions for KRTAP21-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRTAP21-1 Gene
2 Reactome pathways for KRTAP21-1 Gene
Interacting Proteins for KRTAP21-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031424 | keratinization | TAS | -- |
No data available for SIGNOR curated interactions for KRTAP21-1 Gene
Transcripts for KRTAP21-1 Gene
mRNA/cDNA for KRTAP21-1 Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for KRTAP21-1
- genomics-online: gRNA clones - Search results for available KRTAP21-1 gene related products
- Applied Biological Materials CRISPR for KRTAP21-1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP21-1
- GenScript: Design CRISPR guide RNA sequences for KRTAP21-1
miRNA Products
- Search ViGene Biosciences for KRTAP21-1
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available KRTAP21-1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for KRTAP21-1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for KRTAP21-1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRTAP21-1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available KRTAP21-1 gene related products
- orf clones - Search results for available KRTAP21-1 gene related products
- Applied Biological Materials Clones for KRTAP21-1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KRTAP21-1 Gene
SOURCE GeneReport for Unigene cluster for KRTAP21-1 Gene:
Hs.539723Evidence on tissue expression from TISSUES for KRTAP21-1 Gene
- Skin(4)
Primer Products
- genomics-online: primer clones - Search results for available KRTAP21-1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP21-1 Gene
Orthologs for KRTAP21-1 Gene
No data available for Orthologs for KRTAP21-1 Gene
Paralogs for KRTAP21-1 Gene
(3) SIMAP similar genes for KRTAP21-1 Gene using alignment to 2 proteins:
No data available for Paralogs for KRTAP21-1 Gene
Variants for KRTAP21-1 Gene
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs757919425 | A breast cancer sample | 30,755,336(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000342267 | -- | 30,754,777(-) | A/G | downstream_transcript_variant | |
| rs1003829725 | -- | 30,755,714(-) | A/C/G | upstream_transcript_variant | |
| rs1003873403 | -- | 30,755,661(-) | G/A | upstream_transcript_variant | |
| rs1005494223 | -- | 30,756,778(-) | A/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4424n100 | CNV | gain | 25217958 |
| esv2762106 | CNV | gain | 21179565 |
| nsv1057467 | CNV | gain | 25217958 |
| nsv459237 | CNV | gain | 19166990 |
| nsv587359 | CNV | gain | 21841781 |
| nsv962670 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.07;
21.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRTAP21-1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRTAP21-1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP21-1 Gene
Disorders for KRTAP21-1 Gene
Additional Disease Information for KRTAP21-1
No disorders were found for KRTAP21-1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP21-1 Gene
Publications for KRTAP21-1 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers MA … Schweizer J (The Journal of biological chemistry 2002) 2 3 58
- The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for KRTAP21-1 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for KRTAP21-1
- VectorBuilder custom plasmid, inducible vectors for KRTAP21-1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRTAP21-1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available KRTAP21-1 related products ranked by validation data
- antibodies-online: Search results for available KRTAP21-1 related products ranked by validation data
- antibodies-online: Search results for 2 available KRTAP21-1 Proteins ranked by validation data
- Compare Top KRTAP21-1 Proteins
- Quality Products:
- Search GeneTex for Antibodies for KRTAP21-1
- Search GeneTex for Proteins for KRTAP21-1
- ViGene Biosciences adenoviral particle packaged cDNA for KRTAP21-1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for KRTAP21-1 gene
- Search ViGene Biosciences for KRTAP21-1
- Horizon Cell Lines for KRTAP21-1
- genomics-online: cdna clones - Search results for available KRTAP21-1 gene related products
- orf clones - Search results for available KRTAP21-1 gene related products
- genomics-online: gRNA clones - Search results for available KRTAP21-1 gene related products
- genomics-online: primer clones - Search results for available KRTAP21-1 gene related products
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Sources for KRTAP21-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (128) ViGene Biosciences
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems