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Aliases for KRTAP20-3 Gene
Aliases for KRTAP20-3 Gene
External Ids for KRTAP20-3 Gene
- HGNC: 34001
- Entrez Gene: 337985
- Ensembl: ENSG00000206104
- UniProtKB: Q3LI60
Previous HGNC Symbols for KRTAP20-3 Gene
- KRTAP19P4
Previous GeneCards Identifiers for KRTAP20-3 Gene
- GC21P030938
- GC21P032015
- GC21P017423
Summaries for KRTAP20-3 Gene
GeneCards Summary for KRTAP20-3 Gene
KRTAP20-3 (Keratin Associated Protein 20-3) is a Protein Coding gene. Diseases associated with KRTAP20-3 include Three M Syndrome 1.
UniProtKB/Swiss-Prot Summary for KRTAP20-3 Gene
-
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Additional gene information for KRTAP20-3 Gene
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRTAP20-3 Gene
Genomics for KRTAP20-3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KRTAP20-3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH21J030716 | Enhancer | 0.9 | Ensembl ENCODE | 0.2 | +75.4 | 75434 | 2.7 | BACH1 TCF12 IKZF2 TRIM22 PKNOX1 DPF2 RELB JUND RUNX3 BCL11A | KRTAP21-3 KRTAP20-4 LOC105372773 HSALNG0132601 FJ601684-286 KRTAP20-3 | |
| GH21J030709 | Enhancer | 0.2 | ENCODE | 0.2 | +67.9 | 67921 | 1.8 | KRTAP21-3 LOC105372773 HSALNG0132601 FJ601684-286 KRTAP20-3 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRTAP20-3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRTAP20-3
- Top Transcription factor binding sites by QIAGEN in the KRTAP20-3 gene promoter:
-
- Evi-1
- GATA-1
- Nkx2-2
- Pbx1a
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- RFX1
Genomic Locations for KRTAP20-3 Gene
Genomic Locations for KRTAP20-3 Gene
- chr21:30,642,864-30,643,136
- (GRCh38/hg38)
- Size:
- 273 bases
- Orientation:
- Plus strand
- chr21:32,015,183-32,015,455
- (GRCh37/hg19)
- Size:
- 273 bases
- Orientation:
- Plus strand
Genomic View for KRTAP20-3 Gene
Genes around KRTAP20-3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by HGNC
- 21q22.11 by Entrez Gene
- 21q22.11 by Ensembl
KRTAP20-3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRTAP20-3 Gene
Proteins for KRTAP20-3 Gene
-
Protein details for KRTAP20-3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3LI60-KR203_HUMAN
- Recommended name:
- Keratin-associated protein 20-3
- Protein Accession:
- Q3LI60
Protein attributes for KRTAP20-3 Gene
- Size:
- 44 amino acids
- Molecular mass:
- 4909 Da
- Quaternary structure:
-
- Interacts with hair keratins.
Post-translational modifications for KRTAP20-3 Gene
Other Protein References for KRTAP20-3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KRTAP20-3
- Invitrogen Antibodies for KRTAP20-3 (AFLGC-KRTAP20-3)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP20-3
- Origene Custom Protein Services for KRTAP20-3
- Novus Biologicals proteins for KRTAP20-3
No data available for DME Specific Peptides for KRTAP20-3 Gene
Domains & Families for KRTAP20-3 Gene
Gene Families for KRTAP20-3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KRTAP20-3 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for KRTAP20-3 Gene
- GenScript: Design optimal peptide antigens:
-
- Keratin-associated protein 20-3 (KR203_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q3LI60- Family:
-
- Belongs to the KRTAP type 20 family.
Function for KRTAP20-3 Gene
Molecular function for KRTAP20-3 Gene
- UniProtKB/Swiss-Prot Function:
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Phenotypes From GWAS Catalog for KRTAP20-3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP20-3 - Select products 50% OFF >
- * KRTAP20-3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KRTAP20-3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP20-3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRTAP20-3
- Browse OriGene Inhibitory RNA Products For KRTAP20-3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-3
Clone Products
- Applied Biological Materials (abm): Clones for KRTAP20-3 - Select products 50% OFF >
- * KRTAP20-3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for KRTAP20-3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KRTAP20-3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-3
Cell Line Products
-
Horizon Cell Lines for KRTAP20-3
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP20-3 Gene
Localization for KRTAP20-3 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| cytoskeleton | 3 |
| cytosol | 1 |
| nucleus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005882 | intermediate filament | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP20-3 Gene
Transcripts for KRTAP20-3 Gene
mRNA/cDNA for KRTAP20-3 Gene
- 1 REFSEQ mRNAs :
- 1 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000382826 273 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP20-3 - Select products 50% OFF >
- * KRTAP20-3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KRTAP20-3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-3
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP20-3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRTAP20-3
- Browse OriGene Inhibitory RNA Products For KRTAP20-3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-3
Clone Products
- Applied Biological Materials (abm): Clones for KRTAP20-3 - Select products 50% OFF >
- * KRTAP20-3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene ORF clones in human for KRTAP20-3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KRTAP20-3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-3
Relevant External Links for KRTAP20-3 Gene
- GeneLoc Exon Structure for
- KRTAP20-3
Expression for KRTAP20-3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRTAP20-3
SOURCE GeneReport for Unigene cluster for KRTAP20-3 Gene:
Hs.580878Evidence on tissue expression from TISSUES for KRTAP20-3 Gene
- Skin(4)
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP20-3 Gene
Orthologs for KRTAP20-3 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KRTAP20-3 31 |
|
OneToOne |
- Species where no ortholog for KRTAP20-3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for KRTAP20-3 Gene
- ENSEMBL:
- Gene Tree for KRTAP20-3 (if available)
- TreeFam:
- Gene Tree for KRTAP20-3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRTAP20-3: view image
Paralogs for KRTAP20-3 Gene
No data available for Paralogs for KRTAP20-3 Gene
Variants for KRTAP20-3 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1057467 | CNV | gain | 25217958 |
Gene Damage Index Score:
0.03;
0.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRTAP20-3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRTAP20-3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRTAP20-3 Gene
Disorders for KRTAP20-3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| three m syndrome 1 |
|
|
Search KRTAP20-3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KRTAP20-3
No data available for UniProtKB/Swiss-Prot and Genatlas for KRTAP20-3 Gene
Publications for KRTAP20-3 Gene
- Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers MA … Schweizer J (The Journal of biological chemistry 2002) 3
- The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3
Products for KRTAP20-3 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KRTAP20-3
- Origene Custom Protein Services for KRTAP20-3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRTAP20-3
- Browse OriGene Inhibitory RNA Products For KRTAP20-3
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for KRTAP20-3
- OriGene ORF clones in human for KRTAP20-3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Sino Biological Human cDNA Clone for KRTAP20-3
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KRTAP20-3
- Novus Biologicals proteins for KRTAP20-3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for KRTAP20-3 (AFLGC-KRTAP20-3)
- VectorBuilder Custom and pre-made DNA vectors for KRTAP20-3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KRTAP20-3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KRTAP20-3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KRTAP20-3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KRTAP20-3
- antibodies-online: Search results for available KRTAP20-3 related products ranked by validation data
- antibodies-online: Search results for available KRTAP20-3 related products ranked by validation data
- antibodies-online: Search results for available KRTAP20-3 related products ranked by validation data
- Horizon Cell Lines for KRTAP20-3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KRTAP20-3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-3
Sources for KRTAP20-3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB