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Aliases for KRTAP20-2 Gene
Aliases for KRTAP20-2 Gene
External Ids for KRTAP20-2 Gene
- HGNC: 18944
- Entrez Gene: 337976
- Ensembl: ENSG00000184032
- UniProtKB: Q3LI61
Previous GeneCards Identifiers for KRTAP20-2 Gene
- GC00U906263
- GC21U900111
- GC21P030929
- GC21P030930
- GC21P032007
- GC21P017416
Summaries for KRTAP20-2 Gene
GeneCards Summary for KRTAP20-2 Gene
KRTAP20-2 (Keratin Associated Protein 20-2) is a Protein Coding gene. Among its related pathways are Developmental Biology and Keratinization.
UniProtKB/Swiss-Prot Summary for KRTAP20-2 Gene
-
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Additional gene information for KRTAP20-2 Gene
- HGNC(18944)
- Entrez Gene(337976)
- Ensembl(ENSG00000184032)
- UniProtKB(Q3LI61)
- Open Targets Platform(ENSG00000184032)
- Search for KRTAP20-2 at DataMed
- Search for KRTAP20-2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRTAP20-2 Gene
Genomics for KRTAP20-2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRTAP20-2
- Top Transcription factor binding sites by QIAGEN in the KRTAP20-2 gene promoter:
-
- Evi-1
- GATA-1
- Nkx2-2
- Pbx1a
- POU2F1
- POU2F1a
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- RFX1
Genomic Locations for KRTAP20-2 Gene
Genomic Locations for KRTAP20-2 Gene
- chr21:30,635,206-30,635,619
- (GRCh38/hg38)
- Size:
- 414 bases
- Orientation:
- Plus strand
- chr21:32,007,555-32,007,938
- (GRCh37/hg19)
- Size:
- 384 bases
- Orientation:
- Plus strand
Genomic View for KRTAP20-2 Gene
Genes around KRTAP20-2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by HGNC
- 21q22.11 by Entrez Gene
- 21q22.11 by Ensembl
KRTAP20-2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRTAP20-2 Gene
Proteins for KRTAP20-2 Gene
-
Protein details for KRTAP20-2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q3LI61-KR202_HUMAN
- Recommended name:
- Keratin-associated protein 20-2
- Protein Accession:
- Q3LI61
Protein attributes for KRTAP20-2 Gene
- Size:
- 65 amino acids
- Molecular mass:
- 6961 Da
- Quaternary structure:
-
- Interacts with hair keratins.
Protein Expression for KRTAP20-2 Gene
Post-translational modifications for KRTAP20-2 Gene
Other Protein References for KRTAP20-2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
Protein Products
-
OriGene Purified Proteins for KRTAP20-2
- Search Origene for MassSpec and Protein Over-expression Lysates for KRTAP20-2
- Origene Custom Protein Services for KRTAP20-2
No data available for DME Specific Peptides for KRTAP20-2 Gene
Domains & Families for KRTAP20-2 Gene
Gene Families for KRTAP20-2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KRTAP20-2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRTAP20-2 Gene
- GenScript: Design optimal peptide antigens:
-
- Keratin-associated protein 20-2 (KR202_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q3LI61- Family:
-
- Belongs to the KRTAP type 20 family.
Function for KRTAP20-2 Gene
Molecular function for KRTAP20-2 Gene
- UniProtKB/Swiss-Prot Function:
- In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Phenotypes for KRTAP20-2 Gene
- GenomeRNAi human phenotypes for KRTAP20-2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP20-2 - Select products 50% OFF >
- * KRTAP20-2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KRTAP20-2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP20-2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for KRTAP20-2
- Browse OriGene Inhibitory RNA Products For KRTAP20-2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-2
Clone Products
- Applied Biological Materials (abm): Clones for KRTAP20-2 - Select products 50% OFF >
- * KRTAP20-2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KRTAP20-2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-2
Cell Line Products
-
Horizon Cell Lines for KRTAP20-2
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP20-2 Gene
Localization for KRTAP20-2 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| extracellular | 3 |
| cytoskeleton | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP20-2 Gene
Pathways & Interactions for KRTAP20-2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
| 2 | Keratinization |
.33
|
|
Pathways by source for KRTAP20-2 Gene
2 Reactome pathways for KRTAP20-2 Gene
Interacting Proteins for KRTAP20-2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0031424 | keratinization | TAS | -- |
No data available for SIGNOR curated interactions for KRTAP20-2 Gene
Transcripts for KRTAP20-2 Gene
mRNA/cDNA for KRTAP20-2 Gene
- 1 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000330798 414 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KRTAP20-2 - Select products 50% OFF >
- * KRTAP20-2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KRTAP20-2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-2
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRTAP20-2
miRNA Products
Inhibitory RNA Products
- Origene shrna and sirna products in human, mouse, rat for KRTAP20-2
- Browse OriGene Inhibitory RNA Products For KRTAP20-2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-2
Clone Products
- Applied Biological Materials (abm): Clones for KRTAP20-2 - Select products 50% OFF >
- * KRTAP20-2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for KRTAP20-2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-2
Relevant External Links for KRTAP20-2 Gene
- GeneLoc Exon Structure for
- KRTAP20-2
Expression for KRTAP20-2 Gene
mRNA differential expression in normal tissues according to GTEx for KRTAP20-2 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x42.0) and Skin - Sun Exposed (Lower leg) (x8.5).
This gene is overexpressed in Hair follicle (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTAP20-2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRTAP20-2
SOURCE GeneReport for Unigene cluster for KRTAP20-2 Gene:
Hs.553698Evidence on tissue expression from TISSUES for KRTAP20-2 Gene
- Skin(4)
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP20-2 Gene
Orthologs for KRTAP20-2 Gene
Evolution for KRTAP20-2 Gene
- ENSEMBL:
- Gene Tree for KRTAP20-2 (if available)
- TreeFam:
- Gene Tree for KRTAP20-2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRTAP20-2: view image
No data available for Orthologs for KRTAP20-2 Gene
Paralogs for KRTAP20-2 Gene
No data available for Paralogs for KRTAP20-2 Gene
Variants for KRTAP20-2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1057467 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.48;
10.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRTAP20-2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRTAP20-2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP20-2 Gene
Disorders for KRTAP20-2 Gene
Additional Disease Information for KRTAP20-2
No disorders were found for KRTAP20-2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP20-2 Gene
Publications for KRTAP20-2 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers MA … Schweizer J (The Journal of biological chemistry 2002) 2 3
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
Products for KRTAP20-2 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for KRTAP20-2
- Search Origene for MassSpec and Protein Over-expression Lysates for KRTAP20-2
- Origene Custom Protein Services for KRTAP20-2
- Origene shrna and sirna products in human, mouse, rat for KRTAP20-2
- Browse OriGene Inhibitory RNA Products For KRTAP20-2
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for KRTAP20-2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KRTAP20-2
- Sino Biological Human cDNA Clone for KRTAP20-2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- VectorBuilder Custom and pre-made DNA vectors for KRTAP20-2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KRTAP20-2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KRTAP20-2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KRTAP20-2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KRTAP20-2
- antibodies-online: Search results for available KRTAP20-2 related products ranked by validation data
- antibodies-online: Search results for available KRTAP20-2 related products ranked by validation data
- antibodies-online: Search results for available KRTAP20-2 related products ranked by validation data
- Horizon Cell Lines for KRTAP20-2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRTAP20-2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRTAP20-2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KRTAP20-2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRTAP20-2
Sources for KRTAP20-2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB