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Aliases for KRTAP16-1 Gene

Aliases for KRTAP16-1 Gene

  • Keratin Associated Protein 16-1 2 3 5
  • KAP16.1 3 4
  • Putative Keratin-Associated Protein 10-Like ENSP00000375147 3
  • Keratin-Associated Protein 16-1 3

External Ids for KRTAP16-1 Gene

Previous GeneCards Identifiers for KRTAP16-1 Gene

  • GC17U900020
  • GC17M039372
  • GC17M039837
  • GC17M036719
  • GC17M039463

Summaries for KRTAP16-1 Gene

GeneCards Summary for KRTAP16-1 Gene

KRTAP16-1 (Keratin Associated Protein 16-1) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is KRTAP29-1.

Additional gene information for KRTAP16-1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP16-1 Gene

Genomics for KRTAP16-1 Gene

GeneHancer (GH) Regulatory Elements for KRTAP16-1 Gene

Promoters and enhancers for KRTAP16-1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I041307 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 550.8 +0.5 473 2.5 ZNF449 POLR2A GLIS1 GABPB1 REST ZBTB40 GABPA KRTAP16-1 KRT38 KRT31 KRT36 TOP2A KRTAP29-1
GH17I041338 Enhancer 1 Ensembl ENCODE dbSUPER 10.6 -31.8 -31758 6 PKNOX1 YBX1 EBF1 RELA GATA3 NBN ZNF24 EZH2 KRT38 KRTAP16-1 KRTAP29-1 KRT31 LOC100505782 KRTAP17-1 KRTAP9-6 KRT37 ENSG00000234477 RNU2-32P
GH17I041336 Enhancer 0.3 ENCODE 10.4 -27.0 -26991 0.2 NRF1 ENSG00000108516 KRTAP29-1 KRTAP16-1 KRTAP17-1 KRTAP9-6 KRT31 KRT37 LOC100505782 ENSG00000234477 KRT32
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRTAP16-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRTAP16-1 Gene

Genomic Locations for KRTAP16-1 Gene
chr17:41,307,700-41,309,253
(GRCh38/hg38)
Size:
1,554 bases
Orientation:
Minus strand
chr17:39,463,952-39,465,505
(GRCh37/hg19)

Genomic View for KRTAP16-1 Gene

Genes around KRTAP16-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP16-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP16-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP16-1 Gene

Proteins for KRTAP16-1 Gene

  • Protein details for KRTAP16-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MUX0-KR161_HUMAN
    Recommended name:
    Keratin-associated protein 16-1
    Protein Accession:
    A8MUX0

    Protein attributes for KRTAP16-1 Gene

    Size:
    517 amino acids
    Molecular mass:
    53912 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRTAP16-1 Gene

Post-translational modifications for KRTAP16-1 Gene

No Post-translational modifications

Other Protein References for KRTAP16-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP16-1 Gene

Domains & Families for KRTAP16-1 Gene

Gene Families for KRTAP16-1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP16-1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A8MUX0

UniProtKB/Swiss-Prot:

KR161_HUMAN :
  • Belongs to the KRTAP type 16 family.
Family:
  • Belongs to the KRTAP type 16 family.
genes like me logo Genes that share domains with KRTAP16-1: view

No data available for Suggested Antigen Peptide Sequences for KRTAP16-1 Gene

Function for KRTAP16-1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP16-1 Gene

Localization for KRTAP16-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP16-1 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
mitochondrion 2
plasma membrane 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP16-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP16-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP16-1 Gene

Pathways & Interactions for KRTAP16-1 Gene

SuperPathways for KRTAP16-1 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP16-1: view

Pathways by source for KRTAP16-1 Gene

2 Reactome pathways for KRTAP16-1 Gene

Interacting Proteins for KRTAP16-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP16-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP16-1: view

No data available for SIGNOR curated interactions for KRTAP16-1 Gene

Drugs & Compounds for KRTAP16-1 Gene

No Compound Related Data Available

Transcripts for KRTAP16-1 Gene

mRNA/cDNA for KRTAP16-1 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP16-1 Gene

Keratin associated protein 16-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP16-1 Gene

No ASD Table

Relevant External Links for KRTAP16-1 Gene

GeneLoc Exon Structure for
KRTAP16-1
ECgene alternative splicing isoforms for
KRTAP16-1

Expression for KRTAP16-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP16-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP16-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x45.7) and Skin - Sun Exposed (Lower leg) (x5.7).

SOURCE GeneReport for Unigene cluster for KRTAP16-1 Gene:

Hs.721600
genes like me logo Genes that share expression patterns with KRTAP16-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP16-1 Gene

Orthologs for KRTAP16-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP16-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC468256 33
  • 99.03 (n)
KRTAP16-1 34
  • 37 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTAP16-1 33 34
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909661 33
  • 80.3 (n)
mouse
(Mus musculus)
Mammalia Gm11570 33
  • 80.11 (n)
Krtap16-1 16 34
  • 65 (a)
oppossum
(Monodelphis domestica)
Mammalia KRTAP16-1 34
  • 32 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRTAP16-1 34
  • 32 (a)
OneToOne
Species where no ortholog for KRTAP16-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP16-1 Gene

ENSEMBL:
Gene Tree for KRTAP16-1 (if available)
TreeFam:
Gene Tree for KRTAP16-1 (if available)

Paralogs for KRTAP16-1 Gene

(8) SIMAP similar genes for KRTAP16-1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KRTAP16-1 Gene

genes like me logo Genes that share paralogs with KRTAP16-1: view

Variants for KRTAP16-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP16-1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000290427 -- 41,307,544(-) C/G downstream_transcript_variant
rs1000584608 -- 41,309,283(-) A/G upstream_transcript_variant
rs1000718512 -- 41,309,420(-) A/G upstream_transcript_variant
rs1002255273 -- 41,310,575(-) T/C upstream_transcript_variant
rs1002389512 -- 41,311,010(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRTAP16-1 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv1055426 CNV gain 25217958
esv2758690 CNV gain+loss 17122850

Variation tolerance for KRTAP16-1 Gene

Gene Damage Index Score: 13.34; 95.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP16-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP16-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP16-1 Gene

Disorders for KRTAP16-1 Gene

Additional Disease Information for KRTAP16-1

No disorders were found for KRTAP16-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP16-1 Gene

Publications for KRTAP16-1 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  3. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58
  4. Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers MA … Schweizer J (The Journal of biological chemistry 2001) 3 58
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 3 58

Products for KRTAP16-1 Gene

Sources for KRTAP16-1 Gene

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