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Hair keratins and hair keratin-associated proteins (KAPs), such as KRTAP13-1, are the main structural proteins of hair fibers (Rogers et al., 2002 [PubMed 12359730]).[supplied by OMIM, Mar 2008]
KRTAP13-1 (Keratin Associated Protein 13-1) is a Protein Coding gene. Diseases associated with KRTAP13-1 include Miliaria Profunda and Miliaria Crystallina. Among its related pathways are Developmental Biology and Keratinization. An important paralog of this gene is KRTAP13-2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH21J030408 | Enhancer | 0.7 | ENCODE | 0.4 | +13.0 | 12987 | 0.2 | CREB1 CTCF FOXA1 POLR2A EZH2 RFX1 ZNF444 ZBTB17 PKNOX1 ZBTB11 | KRTAP13-4 KRTAP13-1 KRTAP13-3 LOC105372772 | |
GH21J030088 | Enhancer | 0.2 | FANTOM5 | 1.4 | -307.6 | -307589 | 0.4 | KRTAP23-1 KRTAP19-7 KRTAP27-1 KRTAP15-1 KRTAP13-3 KRTAP25-1 KRTAP19-4 KRTAP19-2 KRTAP19-6 KRTAP13-4 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005882 | intermediate filament | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology | ||
2 | Keratinization |
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0031424 | keratinization | TAS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KRTAP13-1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KRTAP13-2 30 |
|
||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | LOC100363184 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Krtap13-1 30 17 |
|
||
2310061N02Rik 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3646827 | CNV | gain | 21293372 |
nsv1057467 | CNV | gain | 25217958 |
nsv1060328 | CNV | loss | 25217958 |
nsv587354 | CNV | gain | 21841781 |
nsv587357 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
miliaria profunda |
|
|
miliaria crystallina |
|
|
miliaria rubra |
|
|
miliaria |
|
|