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KRTAP10-8 (Keratin Associated Protein 10-8) is a Protein Coding gene. Diseases associated with KRTAP10-8 include Trochlear Nerve Disease and Vulvitis. Among its related pathways are Developmental Biology and Keratinization. An important paralog of this gene is KRTAP10-1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH21J044876 | Enhancer | 1.4 | FANTOM5 ENCODE dbSUPER | 4.7 | +269.1 | 269121 | 7.2 | HNRNPL GATAD2A TFE3 LEF1 SOX13 IKZF1 NFKBIZ RCOR2 ZNF7 JUND | lnc-FAM207A-4 UBE2G2 PTTG1IP POFUT2 SUMO3 LINC01424 KRTAP10-6 KRTAP12-2 KRTAP10-11 KRTAP12-1 | |
GH21J044263 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE CraniofacialAtlas | 1.6 | -348.6 | -348578 | 1.4 | PRDM10 PRDM1 ZIC2 PATZ1 USF1 ZFHX2 NR2F1 ELF1 GLIS1 EGR2 | DNMT3L lnc-AIRE-5 ICOSLG AIRE TRAPPC10 ENSG00000184441 KRTAP12-2 KRTAP10-6 KRTAP12-4 KRTAP12-1 | |
GH21J044618 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | +5.9 | 5922 | 4.4 | CTCF ZIC2 CBX3 TRIM28 ZFHX2 POLR2A RAD21 CBX5 CBX1 BCL6 | KRTAP10-11 KRTAP12-3 KRTAP10-6 IMMTP1 KRTAP12-1 KRTAP10-2 KRTAP10-1 TSPEAR-AS1 KRTAP10-8 KRTAP10-9 | |
GH21J044600 | Enhancer | 0.4 | Ensembl | 0.4 | -10.9 | -10879 | 0.8 | ZIC2 KLF1 EGR2 CTCF | KRTAP10-7 KRTAP10-6 KRTAP10-8 KRTAP10-4 TSPEAR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25416956 |
GO:0042802 | identical protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005882 | intermediate filament | IEA | -- |
GO:0045095 | keratin filament | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Developmental Biology | ||
2 | Keratinization |
.33
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0031424 | keratinization | TAS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KRTAP10-8 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | LOC690425 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Gm19668 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs763238933 | A breast cancer sample | p.Ser159Phe | |||
VAR_036560 | A colorectal cancer sample | p.Ser64Asn | |||
rs411254 | - | p.His26Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2723675 | CNV | deletion | 23290073 |
esv2751931 | CNV | loss | 17911159 |
esv33817 | CNV | loss | 17666407 |
esv7169 | OTHER | inversion | 19470904 |
esv8518 | OTHER | inversion | 19470904 |
nsv1055163 | CNV | gain | 25217958 |
nsv587810 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
trochlear nerve disease |
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vulvitis |
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