Aliases for KRTAP10-5 Gene
External Ids for KRTAP10-5 Gene
Previous HGNC Symbols for KRTAP10-5 Gene
Previous GeneCards Identifiers for KRTAP10-5 Gene
This is an intronless gene located in a cluster of related genes on the q arm of chromosome 21. The proteins encoded by these genes form disulfide bonds with cysteine residues in hair keratins, thereby contributing to the structure and stability of hair fibers. [provided by RefSeq, Apr 2014]
GeneCards Summary for KRTAP10-5 Gene
KRTAP10-5 (Keratin Associated Protein 10-5) is a Protein Coding gene. Diseases associated with KRTAP10-5 include Three M Syndrome 1. Among its related pathways are Developmental Biology and Keratinization. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is KRTAP10-1.
UniProtKB/Swiss-Prot Summary for KRTAP10-5 Gene
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.