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Aliases for KRT8 Gene

Aliases for KRT8 Gene

  • Keratin 8 2 3 5
  • Keratin, Type II Cytoskeletal 8 3 4
  • Type-II Keratin Kb8 3 4
  • Keratin 8, Type II 2 3
  • Cytokeratin-8 3 4
  • CK-8 3 4
  • CYK8 3 4
  • K8 3 4
  • Keratin-8 4
  • CARD2 3
  • K2C8 3
  • CK8 3
  • KO 3

External Ids for KRT8 Gene

Previous GeneCards Identifiers for KRT8 Gene

  • GC12P053389
  • GC12P053619
  • GC12M053007
  • GC12M051577
  • GC12M053290
  • GC12M050334

Summaries for KRT8 Gene

Entrez Gene Summary for KRT8 Gene

  • This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for KRT8 Gene

KRT8 (Keratin 8) is a Protein Coding gene. Diseases associated with KRT8 include Liver Cirrhosis and Hidrocystoma. Among its related pathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Gene Ontology (GO) annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT5.

UniProtKB/Swiss-Prot for KRT8 Gene

  • Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT8 Gene

Additional gene information for KRT8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT8 Gene

Genomics for KRT8 Gene

GeneHancer (GH) Regulatory Elements for KRT8 Gene

Promoters and enhancers for KRT8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J052923 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 609 +23.1 23107 6.2 ELF3 CC2D1A CTCF CBFA2T2 ZNF148 CEBPG AHR NCOA3 ZNF24 MAFK KRT8 KRT18 PFDN5 CSAD AAAS ZNF740 KRT84 LOC100652999 GC12M052900
GH12J052941 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +2.3 2343 11.7 MTA3 ZFX SP1 ZNF652 CC2D1A ELF3 ZNF148 POLR2A MLLT1 CEBPG KRT18 ZNF740 AAAS PCBP2 ENSG00000257808 SP1 TARBP2 LOC100652999 EIF4B ATG101
GH12J052894 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +47.0 47026 16.1 MTA3 ZNF652 ZFX CC2D1A SP1 ELF3 CTCF MNT CBFA2T2 ZNF148 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 LOC100652999 ENSG00000257808 ATF7 TARBP2
GH12J052869 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 7.3 +76.6 76629 7.1 MTA3 ZFX CC2D1A CTCF ZNF148 MLLT1 NCOA3 CDC5L MAFK TRIM24 AAAS ZNF740 KRT2 LOC100652999 PCBP2 ENSG00000257808 EIF4B SP1 ATF7 KRT84
GH12J052878 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 6.8 +70.6 70561 1.8 HDGF CC2D1A ZFX CTCF ZNF121 MYC ELF1 KLF14 EGR1 RAD21 KRT78 KRT8 PFDN5 RPL7P41
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT8 gene promoter:
  • AP-1
  • C/EBPalpha
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KRT8 Gene

Genomic Locations for KRT8 Gene
52,768 bases
Minus strand
52,768 bases
Minus strand

Genomic View for KRT8 Gene

Genes around KRT8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT8 Gene

Proteins for KRT8 Gene

  • Protein details for KRT8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type II cytoskeletal 8
    Protein Accession:
    Secondary Accessions:
    • A8K4H3
    • B0AZN5
    • F8VXB4
    • Q14099
    • Q14716
    • Q14717
    • Q53GJ0
    • Q6DHW5
    • Q6GMY0
    • Q6P4C7
    • Q96J60

    Protein attributes for KRT8 Gene

    483 amino acids
    Molecular mass:
    53704 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. Interacts with GPER1. Interacts with EPPK1 (By similarity).
    • (Microbial infection) Interacts with hepatitis C virus/HCV core protein.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Alternative splice isoforms for KRT8 Gene


neXtProt entry for KRT8 Gene

Post-translational modifications for KRT8 Gene

  • Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.
  • O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Ubiquitination at posLast=295295, isoforms=2325, posLast=130130, isoforms=2117, posLast=122122, posLast=207207, and isoforms=211
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • K2C8_HUMAN (313)

Antibody Products

No data available for DME Specific Peptides for KRT8 Gene

Domains & Families for KRT8 Gene

Gene Families for KRT8 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT8 Gene

GenScript: Design optimal peptide antigens:
  • Type-II keratin Kb8 (K2C8_HUMAN)
  • KRT8 protein (Q969I0_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT8: view

Function for KRT8 Gene

Molecular function for KRT8 Gene

UniProtKB/Swiss-Prot Function:
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
GENATLAS Biochemistry:
keratin 8,type II,early embryonic,dimerizing with KRT18

Phenotypes From GWAS Catalog for KRT8 Gene

Gene Ontology (GO) - Molecular Function for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10852826
GO:0044877 protein-containing complex binding IEA --
GO:0097110 scaffold protein binding IPI 10852826
genes like me logo Genes that share ontologies with KRT8: view
genes like me logo Genes that share phenotypes with KRT8: view

Animal Models for KRT8 Gene

MGI Knock Outs for KRT8:
  • Krt8 Krt8<tm1Rgo>
  • Krt8 Krt8<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT8

Clone Products

  • Addgene plasmids for KRT8
  • Applied Biological Materials (abm): Clones for KRT8 - Now 50% OFF >
  • * KRT8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KRT8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KRT8 Gene

Localization for KRT8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT8 Gene

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT8 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
plasma membrane 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA,IEA 21630459
GO:0005654 nucleoplasm IEA --
GO:0005737 cytoplasm IDA,IEA 15846844
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IDA,IEA 10852826
genes like me logo Genes that share ontologies with KRT8: view

Pathways & Interactions for KRT8 Gene

genes like me logo Genes that share pathways with KRT8: view

Pathways by source for KRT8 Gene

1 GeneGo (Thomson Reuters) pathway for KRT8 Gene
1 Cell Signaling Technology pathway for KRT8 Gene

SIGNOR curated interactions for KRT8 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for KRT8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0031424 keratinization TAS --
GO:0033209 tumor necrosis factor-mediated signaling pathway IEA --
GO:0045214 sarcomere organization IEA --
GO:0051599 response to hydrostatic pressure IEA --
genes like me logo Genes that share ontologies with KRT8: view

Drugs & Compounds for KRT8 Gene

(33) Drugs for KRT8 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 226
Tenecteplase Approved Pharma Target 46
Lanoteplase Investigational Pharma Target 0

(24) Additional Compounds for KRT8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT8: view

Transcripts for KRT8 Gene

Unigene Clusters for KRT8 Gene

Keratin 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT8

Clone Products

  • Addgene plasmids for KRT8
  • Applied Biological Materials (abm): Clones for KRT8 - Now 50% OFF >
  • * KRT8 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * KRT8 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for KRT8 Gene

No ASD Table

Relevant External Links for KRT8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT8 Gene

mRNA differential expression in normal tissues according to GTEx for KRT8 Gene

This gene is overexpressed in Colon - Transverse (x11.7), Small Intestine - Terminal Ileum (x4.9), and Pancreas (x4.9).

Protein differential expression in normal tissues from HIPED for KRT8 Gene

This gene is overexpressed in Liver, secretome (14.1), Stomach (6.8), Salivary gland (6.7), and Islet of Langerhans (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT8 Gene

Protein tissue co-expression partners for KRT8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT8 Gene:


SOURCE GeneReport for Unigene cluster for KRT8 Gene:


mRNA Expression by UniProt/SwissProt for KRT8 Gene:

Tissue specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.

Evidence on tissue expression from TISSUES for KRT8 Gene

  • Intestine(5)
  • Liver(4.9)
  • Lung(4.9)
  • Pancreas(4.9)
  • Kidney(4.7)
  • Stomach(4.7)
  • Eye(3.2)
  • Muscle(2.7)
  • Gall bladder(2.5)
  • Thyroid gland(2.4)
  • Skin(2.3)
  • Heart(2.2)
  • Blood(2.1)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT8 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • head
  • mouth
  • salivary gland
  • breast
  • esophagus
  • heart
  • lung
  • kidney
  • liver
  • spleen
  • stomach
  • testicle
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • blood
  • blood vessel
  • coagulation system
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with KRT8: view

Orthologs for KRT8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT8 35
  • 96 (a)
LOC464613 34
  • 92.32 (n)
(Bos Taurus)
Mammalia KRT8 35 34
  • 88.89 (n)
-- 35
  • 87 (a)
(Canis familiaris)
Mammalia KRT8 34
  • 88.38 (n)
-- 35
  • 86 (a)
-- 35
  • 77 (a)
-- 35
  • 72 (a)
-- 35
  • 72 (a)
(Mus musculus)
Mammalia Krt8 17 35 34
  • 85.02 (n)
(Rattus norvegicus)
Mammalia Krt8 34
  • 84.61 (n)
(Ornithorhynchus anatinus)
Mammalia KRT8 35
  • 69 (a)
(Gallus gallus)
Aves KRT8 35
  • 76 (a)
(Anolis carolinensis)
Reptilia KRT8 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt8 34
  • 69.72 (n)
Str.8042 34
African clawed frog
(Xenopus laevis)
Amphibia krt8-prov 34
(Danio rerio)
Actinopterygii krt5 34
  • 71.51 (n)
krt8 35
  • 61 (a)
zgc:158846 35
  • 58 (a)
krt4 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.40 34
Species where no ortholog for KRT8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT8 Gene

Gene Tree for KRT8 (if available)
Gene Tree for KRT8 (if available)
Evolutionary constrained regions (ECRs) for KRT8: view image

Paralogs for KRT8 Gene

(52) SIMAP similar genes for KRT8 Gene using alignment to 8 proteins:

  • K2C8_HUMAN
  • F8VP67_HUMAN
  • F8W1U3_HUMAN
  • Q969I0_HUMAN
genes like me logo Genes that share paralogs with KRT8: view

Variants for KRT8 Gene

Sequence variations from dbSNP and Humsavar for KRT8 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs11554495 pathogenic, risk-factor, not-provided, Cirrhosis, cryptogenic, Cirrhosis, noncryptogenic, susceptibility to, not provided, Cirrhosis (CIRRH) [MIM:215600] 52,904,798(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs200221269 not-provided, Hepatitis c virus, susceptibility to 52,949,307(-) G/C genic_upstream_transcript_variant, intron_variant
rs201507031 not-provided, uncertain-significance, not provided, not specified 52,897,488(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs386834221 not-provided, Hepatitis c virus, susceptibility to 52,898,848(-) C/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs386834222 not-provided, Hepatitis c virus, susceptibility to 52,897,468(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT8 Gene

Variant ID Type Subtype PubMed ID
esv3581638 CNV gain 25503493
esv3629533 CNV loss 21293372
nsv53037 CNV deletion 16902084
nsv558965 CNV loss 21841781
nsv819337 CNV loss 19587683
nsv832416 CNV loss 17160897
nsv952181 CNV deletion 24416366
nsv983328 CNV duplication 23825009

Variation tolerance for KRT8 Gene

Residual Variation Intolerance Score: 86.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT8 Gene

Disorders for KRT8 Gene

MalaCards: The human disease database

(76) MalaCards diseases for KRT8 Gene - From: HGMD, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
liver cirrhosis
  • cirrhosis
  • apocrine cystadenoma
cryptogenic cirrhosis
  • cirrhosis, cryptogenic
breast osteosarcoma
  • osteogenic sarcoma of breast
idiopathic corneal edema
- elite association - COSMIC cancer census association via MalaCards
Search KRT8 in MalaCards View complete list of genes associated with diseases


  • Cirrhosis (CIRRH) [MIM:215600]: A liver disease characterized by severe panlobular liver-cell swelling with Mallory body formation, prominent pericellular fibrosis, and marked deposits of copper. Clinical features include abdomen swelling, jaundice and pulmonary hypertension. {ECO:0000269 PubMed:12724528}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for KRT8

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KRT8: view

No data available for Genatlas for KRT8 Gene

Publications for KRT8 Gene

  1. Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs. (PMID: 1705144) Waseem A … Lane EB (The New biologist 1990) 2 3 4 23 58
  2. Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease. (PMID: 17509943) Tao GZ … Duerr RH (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007) 3 23 45 58
  3. Keratins as susceptibility genes for end-stage liver disease. (PMID: 16143128) Ku NO … Omary MB (Gastroenterology 2005) 3 23 45 58
  4. Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies. (PMID: 12724528) Ku NO … Omary MB (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23 58
  5. Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation. (PMID: 11788583) Ku NO … Omary MB (The Journal of biological chemistry 2002) 3 4 23 58

Products for KRT8 Gene