Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT79 Gene

Aliases for KRT79 Gene

  • Keratin 79 2 3 5
  • Type-II Keratin Kb38 3 4
  • Keratin 79, Type II 2 3
  • Cytokeratin-79 3 4
  • CK-79 3 4
  • KRT6L 3 4
  • K6L 3 4
  • K79 3 4
  • Keratin, Type II Cytoskeletal 79 3
  • Keratin 6-Like 2
  • Keratin-6-Like 4
  • Keratin 6L 3
  • Keratin-6L 4
  • Keratin-79 4
  • KB38 4

External Ids for KRT79 Gene

Previous GeneCards Identifiers for KRT79 Gene

  • GC12M051502
  • GC12M053215
  • GC12M050259

Summaries for KRT79 Gene

Entrez Gene Summary for KRT79 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in skeletal muscle, skin and scalp. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT79 Gene

KRT79 (Keratin 79) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and signal transducer activity. An important paralog of this gene is KRT1.

Gene Wiki entry for KRT79 Gene

Additional gene information for KRT79 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT79 Gene

Genomics for KRT79 Gene

GeneHancer (GH) Regulatory Elements for KRT79 Gene

Promoters and enhancers for KRT79 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I052835 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 550.8 -2.0 -1961 0.8 HDAC1 LEF1 ETV1 JUN MAX ZIC2 FOSL1 TCF12 ZFHX2 BRD9 KRT79 ENSG00000257389 PFDN5
GH12I052834 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 0.0 -36 0.1 KRT79 ENSG00000257389
GH12I052832 Enhancer 0.3 dbSUPER 550.8 +1.6 1612 0.8 SCRT2 KRT79 KRT4
GH12I052894 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -68.6 -68633 16.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GC12M052900 ZNF740 AAAS PCBP2 SP1 MAP3K12 ATF7 LOC100652999 EIF4B ENSG00000257808
GH12I052869 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -39.0 -39030 7.1 HDGF PKNOX1 SMAD1 NEUROD1 SIN3A ZBTB7B POLR2B ZNF766 CBX5 ZNF207 KRT2 PCBP2 EIF4B AAAS SP1 ZNF740 ATF7 KRT84 LOC100652999 PFDN5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT79 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT79 gene promoter:

Genomic Locations for KRT79 Gene

Genomic Locations for KRT79 Gene
chr12:52,821,410-52,834,295
(GRCh38/hg38)
Size:
12,886 bases
Orientation:
Minus strand
chr12:53,215,194-53,228,079
(GRCh37/hg19)

Genomic View for KRT79 Gene

Genes around KRT79 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT79 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT79 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT79 Gene

Proteins for KRT79 Gene

  • Protein details for KRT79 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5XKE5-K2C79_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 79
    Protein Accession:
    Q5XKE5
    Secondary Accessions:
    • Q6P465
    • Q7Z793

    Protein attributes for KRT79 Gene

    Size:
    535 amino acids
    Molecular mass:
    57836 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

neXtProt entry for KRT79 Gene

Post-translational modifications for KRT79 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT79 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT79 Gene

Domains & Families for KRT79 Gene

Gene Families for KRT79 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT79 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5XKE5

UniProtKB/Swiss-Prot:

K2C79_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT79: view

Function for KRT79 Gene

Gene Ontology (GO) - Molecular Function for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with KRT79: view
genes like me logo Genes that share phenotypes with KRT79: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT79 Gene

Localization for KRT79 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT79 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome HDA,IDA 19199708
genes like me logo Genes that share ontologies with KRT79: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT79 Gene

Pathways & Interactions for KRT79 Gene

SuperPathways for KRT79 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT79: view

Pathways by source for KRT79 Gene

2 Reactome pathways for KRT79 Gene

Gene Ontology (GO) - Biological Process for KRT79 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT79: view

No data available for SIGNOR curated interactions for KRT79 Gene

Drugs & Compounds for KRT79 Gene

No Compound Related Data Available

Transcripts for KRT79 Gene

mRNA/cDNA for KRT79 Gene

Unigene Clusters for KRT79 Gene

Keratin 79:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT79 Gene

No ASD Table

Relevant External Links for KRT79 Gene

GeneLoc Exon Structure for
KRT79
ECgene alternative splicing isoforms for
KRT79

Expression for KRT79 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT79 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT79 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x34.7) and Skin - Sun Exposed (Lower leg) (x15.1).

Protein differential expression in normal tissues from HIPED for KRT79 Gene

This gene is overexpressed in Saliva (54.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT79 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT79 Gene:

KRT79

SOURCE GeneReport for Unigene cluster for KRT79 Gene:

Hs.711471

mRNA Expression by UniProt/SwissProt for KRT79 Gene:

Q5XKE5-K2C79_HUMAN
Tissue specificity: Expressed in skeletal muscle, skin and scalp, but not in any other tissues or organs examined.

Evidence on tissue expression from TISSUES for KRT79 Gene

  • Skin(4.6)
genes like me logo Genes that share expression patterns with KRT79: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT79 Gene

Orthologs for KRT79 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT79 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT79 33 34
  • 98.82 (n)
dog
(Canis familiaris)
Mammalia KRT79 33 34
  • 88.47 (n)
cow
(Bos Taurus)
Mammalia KRT79 33 34
  • 87.35 (n)
mouse
(Mus musculus)
Mammalia Krt79 33 16 34
  • 82.61 (n)
rat
(Rattus norvegicus)
Mammalia Krt79 33
  • 82.35 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRT5 34
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia krt1 33
  • 61.95 (n)
Species where no ortholog for KRT79 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT79 Gene

ENSEMBL:
Gene Tree for KRT79 (if available)
TreeFam:
Gene Tree for KRT79 (if available)

Paralogs for KRT79 Gene

Pseudogenes.org Pseudogenes for KRT79 Gene

genes like me logo Genes that share paralogs with KRT79: view

Variants for KRT79 Gene

Sequence variations from dbSNP and Humsavar for KRT79 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000099622 -- 52,825,840(-) C/A/T intron_variant
rs1000245535 -- 52,830,835(-) G/A/T intron_variant
rs1000255684 -- 52,833,934(-) A/C coding_sequence_variant, missense_variant
rs1000467090 -- 52,828,722(-) C/T intron_variant
rs1000573135 -- 52,829,737(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT79 Gene

Variant ID Type Subtype PubMed ID
esv3307974 CNV mobile element insertion 20981092
esv3432030 CNV insertion 20981092
esv3629524 CNV gain 21293372
nsv1048816 CNV gain 25217958
nsv470293 CNV loss 18288195
nsv832416 CNV loss 17160897

Variation tolerance for KRT79 Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.10; 80.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT79 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT79

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT79 Gene

Disorders for KRT79 Gene

Additional Disease Information for KRT79

No disorders were found for KRT79 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT79 Gene

Publications for KRT79 Gene

  1. Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. (PMID: 11683385) Hesse M … Weber K (Journal of cell science 2001) 2 3 4 58
  2. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers MA … Schweizer J (The Journal of investigative dermatology 2005) 3 4 58
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon KS … Liu Q (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 58
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R … Pardo OE (Nucleic acids research 2014) 3 58

Products for KRT79 Gene

Sources for KRT79 Gene

Content
Loading form....