Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009] See more...

Aliases for KRT76 Gene

Aliases for KRT76 Gene

  • Keratin 76 2 3 5
  • KRT2B 2 3 4
  • KRT2P 2 3 4
  • Keratin, Type II Cytoskeletal 2 Oral 3 4
  • Keratin 76, Type II 2 3
  • Type-II Keratin Kb9 3 4
  • Cytokeratin-2P 3 4
  • HUMCYT2A 2 3
  • CK-2P 3 4
  • K2P 3 4
  • K76 3 4
  • Cytokeratin 2 3
  • Keratin 2p 3
  • Keratin-76 4
  • KRT76 5

External Ids for KRT76 Gene

Previous GeneCards Identifiers for KRT76 Gene

  • GC12M051450
  • GC12M053161
  • GC12M050205

Summaries for KRT76 Gene

Entrez Gene Summary for KRT76 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]

GeneCards Summary for KRT76 Gene

KRT76 (Keratin 76) is a Protein Coding gene. Diseases associated with KRT76 include Plantar Wart. Among its related pathways are Developmental Biology and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT3.

UniProtKB/Swiss-Prot Summary for KRT76 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT76 Gene

Genomics for KRT76 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT76 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J052777 Promoter 0.3 EPDnew 250.7 0.0 -20 0.1 KRT76 ENSG00000257404 KRT3
GH12J052609 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 10.1 +166.3 166344 17.2 ZIC2 USF2 RAD51 ATF4 TOE1 HDAC8 GLIS1 L3MBTL2 ZMYM3 ZFP3 KRT73-AS1 KRT72 KRT2 KRT1 KRT74 KRT71 KRT78 KRT4 KRT79 KRT76
GH12J052859 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -82.9 -82856 3.2 ZNF600 CEBPB ZNF217 CTBP1 CUX1 RFX5 SMARCE1 MAZ DPF2 RFX1 KRT79 KRT4 KRT76 KRT1 KRT2 KRT83 KRT71 KRT6A RARG KRT5
GH12J052579 Enhancer 1.1 FANTOM5 Ensembl ENCODE 9.5 +195.4 195443 4.6 ZNF654 ZIC2 CEBPB REST TRIM22 CTCF ZNF217 RXRA RAD21 SMC3 lnc-KRT72-1 KRT72 AAAS HNRNPA3P10 KRT1 ZNF740 KRT71 KRT78 KRT79 KRT2
GH12J052644 Enhancer 1 Ensembl ENCODE dbSUPER 10.3 +131.6 131644 8.2 ZNF600 ARNT ZNF318 SPI1 YBX1 CTCF MAFG ZEB2 ZBTB33 L3MBTL2 KRT72 KRT1 KRT77 KRT79 KRT76 KRT4 KRT78 KRT84 ENSG00000257700 KRT73
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT76 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT76

Top Transcription factor binding sites by QIAGEN in the KRT76 gene promoter:
  • AML1a
  • AREB6
  • COMP1
  • p300
  • p53
  • SREBP-1a
  • YY1

Genomic Locations for KRT76 Gene

Latest Assembly
chr12:52,768,155-52,777,345
(GRCh38/hg38)
Size:
9,191 bases
Orientation:
Minus strand

Previous Assembly
chr12:53,161,939-53,171,129
(GRCh37/hg19 by Entrez Gene)
Size:
9,191 bases
Orientation:
Minus strand

chr12:53,161,939-53,171,129
(GRCh37/hg19 by Ensembl)
Size:
9,191 bases
Orientation:
Minus strand

Genomic View for KRT76 Gene

Genes around KRT76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT76 Gene

Proteins for KRT76 Gene

  • Protein details for KRT76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01546-K22O_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 2 oral
    Protein Accession:
    Q01546
    Secondary Accessions:
    • B4DRR3
    • Q7Z795

    Protein attributes for KRT76 Gene

    Size:
    638 amino acids
    Molecular mass:
    65841 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    SequenceCaution:
    • Sequence=BAG61375.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT76 Gene

Post-translational modifications for KRT76 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT76 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for KRT76 Gene

Domains & Families for KRT76 Gene

Gene Families for KRT76 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT76 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature
  • Type II keratin signature
  • AMP-binding signature

Suggested Antigen Peptide Sequences for KRT76 Gene

GenScript: Design optimal peptide antigens:
  • Type-II keratin Kb9 (K22O_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q01546

UniProtKB/Swiss-Prot:

K22O_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT76: view

Function for KRT76 Gene

Molecular function for KRT76 Gene

UniProtKB/Swiss-Prot Function:
Probably contributes to terminal cornification.

Phenotypes From GWAS Catalog for KRT76 Gene

Gene Ontology (GO) - Molecular Function for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with KRT76: view
genes like me logo Genes that share phenotypes with KRT76: view

Animal Models for KRT76 Gene

MGI Knock Outs for KRT76:
  • Krt76 Krt76<tm1a(KOMP)Wtsi>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT76

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KRT76 Gene

Localization for KRT76 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT76 gene
Compartment Confidence
cytoskeleton 5
extracellular 4
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament NAS 1282112
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT76 Gene

Pathways & Interactions for KRT76 Gene

PathCards logo

SuperPathways for KRT76 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT76: view

Pathways by source for KRT76 Gene

2 Reactome pathways for KRT76 Gene

Gene Ontology (GO) - Biological Process for KRT76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization NAS 1282112
GO:0008544 epidermis development IEA --
GO:0031424 keratinization TAS --
GO:0043473 pigmentation IEA --
GO:0048733 sebaceous gland development IEA --
genes like me logo Genes that share ontologies with KRT76: view

No data available for SIGNOR curated interactions for KRT76 Gene

Drugs & Compounds for KRT76 Gene

No Compound Related Data Available

Transcripts for KRT76 Gene

mRNA/cDNA for KRT76 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT76

Alternative Splicing Database (ASD) splice patterns (SP) for KRT76 Gene

No ASD Table

Relevant External Links for KRT76 Gene

GeneLoc Exon Structure for
KRT76

Expression for KRT76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT76 Gene

mRNA differential expression in normal tissues according to GTEx for KRT76 Gene

This gene is overexpressed in Minor Salivary Gland (x32.4), Skin - Not Sun Exposed (Suprapubic) (x4.9), and Esophagus - Mucosa (x4.0).

Protein differential expression in normal tissues from HIPED for KRT76 Gene

This gene is overexpressed in Saliva (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT76 Gene



Protein tissue co-expression partners for KRT76 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT76

SOURCE GeneReport for Unigene cluster for KRT76 Gene:

Hs.654392

Evidence on tissue expression from TISSUES for KRT76 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with KRT76: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT76 Gene

Orthologs for KRT76 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT76 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT76 29 30
  • 99.17 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Krt76 29 16 30
  • 88.08 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krt76 29
  • 86.96 (n)
Cow
(Bos Taurus)
Mammalia LOC100336907 29
  • 85.17 (n)
-- 30
  • 71 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia LOC100683401 29
  • 84.94 (n)
KRT76 30
  • 83 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 72 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 71 (a)
OneToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 64 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 56 (a)
OneToMany
Species where no ortholog for KRT76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT76 Gene

ENSEMBL:
Gene Tree for KRT76 (if available)
TreeFam:
Gene Tree for KRT76 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT76: view image
Alliance of Genome Resources:
Additional Orthologs for KRT76

Paralogs for KRT76 Gene

Pseudogenes.org Pseudogenes for KRT76 Gene

genes like me logo Genes that share paralogs with KRT76: view

Variants for KRT76 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT76 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
VAR_036368 A breast cancer sample p.Leu168Val
rs11170271 -- p.Ala283Thr
rs2280480 -- p.Thr629Met
rs6580904 -- p.Ala359Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT76 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT76 Gene

Variant ID Type Subtype PubMed ID
esv3306574 CNV mobile element insertion 20981092
esv3424879 CNV insertion 20981092
esv3629524 CNV gain 21293372
nsv528616 CNV loss 19592680
nsv558964 CNV loss 21841781
nsv976622 CNV duplication 23825009

Variation tolerance for KRT76 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.51; 96.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT76
Leiden Open Variation Database (LOVD)
KRT76

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT76 Gene

Disorders for KRT76 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT76 Gene - From: COP

Disorder Aliases PubMed IDs
plantar wart
  • verruca plantaris
- elite association - COSMIC cancer census association via MalaCards
Search KRT76 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT76

genes like me logo Genes that share disorders with KRT76: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT76 Gene

Publications for KRT76 Gene

  1. Suprabasal marker proteins distinguishing keratinizing squamous epithelia: cytokeratin 2 polypeptides of oral masticatory epithelium and epidermis are different. (PMID: 1282112) Collin C … Franke WW (Differentiation; research in biological diversity 1992) 2 3 4 22
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3
  3. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. (PMID: 15737194) Rogers MA … Schweizer J (The Journal of investigative dermatology 2005) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. (PMID: 31501420) Liu Y … Sun F (Cell death & disease 2019) 3

Products for KRT76 Gene

Sources for KRT76 Gene