Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009] See more...

Aliases for KRT73 Gene

Aliases for KRT73 Gene

  • Keratin 73 2 3 5
  • Type II Inner Root Sheath-Specific Keratin-K6irs3 3 4
  • Keratin, Type II Cytoskeletal 73 3 4
  • Type-II Keratin Kb36 3 4
  • Keratin 73, Type II 2 3
  • Cytokeratin-73 3 4
  • KRT6IRS3 3 4
  • K6IRS3 3 4
  • CK-73 3 4
  • K73 3 4
  • Keratin 6 Irs3 3
  • Keratin-73 4
  • IRT6IRS3 3
  • KB36 4

External Ids for KRT73 Gene

Previous GeneCards Identifiers for KRT73 Gene

  • GC12M051288
  • GC12M053001
  • GC12M050045

Summaries for KRT73 Gene

Entrez Gene Summary for KRT73 Gene

  • Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

GeneCards Summary for KRT73 Gene

KRT73 (Keratin 73) is a Protein Coding gene. Among its related pathways are Developmental Biology and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT71.

UniProtKB/Swiss-Prot Summary for KRT73 Gene

  • Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Additional gene information for KRT73 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT73 Gene

Genomics for KRT73 Gene

GeneHancer (GH) Regulatory Elements for KRT73 Gene

Promoters and enhancers for KRT73 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J052629 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 758.3 -11.6 -11585 6.2 HLF MAX NFIB MAFK PKNOX1 ZNF316 MAFG ZNF707 NFIC NFIL3 KRT73 LOC105369772 KRT72 ENSG00000257605 HNRNPA3P10 KRT1 ATG101 KRT71 ENSG00000257475 KRT128P
GH12J052620 Enhancer 0.2 Ensembl 760.9 -1.2 -1185 1.8 KRT73 LOC105369772
GH12J052579 Enhancer 1.1 FANTOM5 Ensembl ENCODE 6.9 +38.2 38214 4.6 PPP1R10 CTCF CC2D1A RAD21 SP1 SP7 PRDM1 ZIC2 ARID2 RXRA lnc-KRT72-1 KRT72 AAAS HNRNPA3P10 KRT1 ZNF740 KRT71 KRT78 KRT79 KRT2
GH12J052644 Enhancer 1 Ensembl ENCODE dbSUPER 7.4 -25.6 -25585 8.2 ZBTB6 L3MBTL2 ZNF639 MNT EGR1 MTA3 CTBP1 ZNF766 MAFG E2F5 KRT72 KRT1 KRT77 KRT79 KRT76 KRT4 KRT78 KRT84 ENSG00000257700 KRT73
GH12J052609 Enhancer 1 Ensembl ENCODE dbSUPER 6.8 +9.1 9115 17.2 USF2 L3MBTL2 CBFA2T2 BACH1 ZIC2 SCRT2 MGA NFYB ESRRA E2F5 KRT72 KRT2 KRT1 KRT74 KRT71 KRT78 KRT4 KRT79 KRT76 KRT84
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT73 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • E47
  • IRF-7A
  • NF-1
  • PPAR-alpha
  • STAT5A
  • Tal-1beta

Genomic Locations for KRT73 Gene

Genomic Locations for KRT73 Gene
chr12:52,602,883-52,620,116
(GRCh38/hg38)
Size:
17,234 bases
Orientation:
Minus strand
chr12:53,001,354-53,012,343
(GRCh37/hg19)
Size:
10,990 bases
Orientation:
Minus strand

Genomic View for KRT73 Gene

Genes around KRT73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT73 Gene

Proteins for KRT73 Gene

  • Protein details for KRT73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y46-K2C73_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 73
    Protein Accession:
    Q86Y46
    Secondary Accessions:
    • Q32MB2

    Protein attributes for KRT73 Gene

    Size:
    540 amino acids
    Molecular mass:
    58923 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Alternative splice isoforms for KRT73 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT73 Gene

Post-translational modifications for KRT73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT73 Gene

Domains & Families for KRT73 Gene

Gene Families for KRT73 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT73 Gene

GenScript: Design optimal peptide antigens:
  • Type-II keratin Kb36 (K2C73_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86Y46

UniProtKB/Swiss-Prot:

K2C73_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT73: view

Function for KRT73 Gene

Molecular function for KRT73 Gene

UniProtKB/Swiss-Prot Function:
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).

Gene Ontology (GO) - Molecular Function for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRT73: view
genes like me logo Genes that share phenotypes with KRT73: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT73 Gene

Localization for KRT73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT73 gene
Compartment Confidence
cytosol 4
mitochondrion 3
cytoskeleton 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with KRT73: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT73 Gene

Pathways & Interactions for KRT73 Gene

PathCards logo

SuperPathways for KRT73 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT73: view

Pathways by source for KRT73 Gene

2 Reactome pathways for KRT73 Gene

Gene Ontology (GO) - Biological Process for KRT73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT73: view

No data available for SIGNOR curated interactions for KRT73 Gene

Drugs & Compounds for KRT73 Gene

No Compound Related Data Available

Transcripts for KRT73 Gene

mRNA/cDNA for KRT73 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT73 Gene

No ASD Table

Relevant External Links for KRT73 Gene

GeneLoc Exon Structure for
KRT73
ECgene alternative splicing isoforms for
KRT73

Expression for KRT73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT73 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT73 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x23.0), Skin - Not Sun Exposed (Suprapubic) (x21.8), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for KRT73 Gene

This gene is overexpressed in Saliva (60.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT73 Gene



Protein tissue co-expression partners for KRT73 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT73 Gene:

KRT73

SOURCE GeneReport for Unigene cluster for KRT73 Gene:

Hs.55410

mRNA Expression by UniProt/SwissProt for KRT73 Gene:

Q86Y46-K2C73_HUMAN
Tissue specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS cuticle, but not in Henle or Huxley layers of the IRS. In the IRS cuticle, it is expressed between the lowermost bulb region of the cuticle and the region where Henle cells undergo abrupt terminal differentiation. Detected up to the uppermost cortex region where cuticle cells terminally differentiate (at protein level).

Evidence on tissue expression from TISSUES for KRT73 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KRT73: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT73 Gene

Orthologs for KRT73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT73 33 32
  • 98.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KRT73 32
  • 89.07 (n)
cow
(Bos Taurus)
Mammalia KRT73 33 32
  • 88.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krt73 32
  • 84.6 (n)
mouse
(Mus musculus)
Mammalia Krt73 17 33 32
  • 84.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 80 (a)
ManyToMany
-- 33
  • 76 (a)
ManyToMany
-- 33
  • 71 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 48 (a)
ManyToMany
Species where no ortholog for KRT73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT73 Gene

ENSEMBL:
Gene Tree for KRT73 (if available)
TreeFam:
Gene Tree for KRT73 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT73: view image

Paralogs for KRT73 Gene

(43) SIMAP similar genes for KRT73 Gene using alignment to 2 proteins:

  • K2C73_HUMAN
  • H0YIC5_HUMAN
genes like me logo Genes that share paralogs with KRT73: view

Variants for KRT73 Gene

Sequence variations from dbSNP and Humsavar for KRT73 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1210935768 A colorectal cancer sample 52,616,193(-) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs142246988 A colorectal cancer sample 52,614,655(-) G/A/C coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000072587 -- 52,620,816(-) T/C upstream_transcript_variant
rs1000655764 -- 52,605,854(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000875914 -- 52,610,198(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT73 Gene

Variant ID Type Subtype PubMed ID
esv1004870 CNV deletion 20482838
esv3629522 CNV loss 21293372
nsv428281 CNV gain 18775914
nsv522631 CNV loss 19592680
nsv832415 CNV loss 17160897
nsv975493 CNV duplication 23825009

Variation tolerance for KRT73 Gene

Residual Variation Intolerance Score: 92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.11; 75.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT73

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT73 Gene

Disorders for KRT73 Gene

Additional Disease Information for KRT73

No disorders were found for KRT73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT73 Gene

Publications for KRT73 Gene

  1. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. (PMID: 12648212) Langbein L … Schweizer J (The Journal of investigative dermatology 2003) 2 3 4 23 56
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 56
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 56
  4. CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality. (PMID: 28977666) Hoffmeister H … Längst G (Nucleic acids research 2017) 3 56
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 56

Products for KRT73 Gene

Sources for KRT73 Gene