Aliases for KRT7 Gene
External Ids for KRT7 Gene
Previous GeneCards Identifiers for KRT7 Gene
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT7 Gene
KRT7 (Keratin 7) is a Protein Coding gene. Diseases associated with KRT7 include Pseudomyxoma Peritonei and Signet Ring Cell Adenocarcinoma. Among its related pathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT5.
UniProtKB/Swiss-Prot Summary for KRT7 Gene
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).