The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the inter... See more...

Aliases for KRT7 Gene

Aliases for KRT7 Gene

  • Keratin 7 2 3 5
  • Keratin, Type II Cytoskeletal 7 2 3 4
  • Sarcolectin 2 3 4
  • SCL 2 3 4
  • K7 2 3 4
  • Keratin, 55K Type II Cytoskeletal 2 3
  • Type-II Keratin Kb7 3 4
  • Keratin 7, Type II 2 3
  • Cytokeratin 7 2 3
  • K2C7 2 3
  • CK-7 3 4
  • CK7 2 3
  • Keratin, Simple Epithelial Type I, K7 3
  • Type II Mesothelial Keratin K7 3
  • Cytokeratin-7 4
  • Keratin-7 4
  • KRT7 5

External Ids for KRT7 Gene

Previous GeneCards Identifiers for KRT7 Gene

  • GC12M052275
  • GC12P052657
  • GC12P052343
  • GC12P050913
  • GC12P049659
  • GC12P052626

Summaries for KRT7 Gene

Entrez Gene Summary for KRT7 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT7 Gene

KRT7 (Keratin 7) is a Protein Coding gene. Diseases associated with KRT7 include Pseudomyxoma Peritonei and Signet Ring Cell Adenocarcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT5.

UniProtKB/Swiss-Prot Summary for KRT7 Gene

  • Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Gene Wiki entry for KRT7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT7 Gene

Genomics for KRT7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT7

Top Transcription factor binding sites by QIAGEN in the KRT7 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KRT7 Gene

Genomic Locations for KRT7 Gene
chr12:52,232,520-52,252,667
(GRCh38/hg38)
Size:
20,148 bases
Orientation:
Plus strand
chr12:52,626,304-52,645,970
(GRCh37/hg19)
Size:
19,667 bases
Orientation:
Plus strand

Genomic View for KRT7 Gene

Genes around KRT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT7 Gene

Proteins for KRT7 Gene

  • Protein details for KRT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08729-K2C7_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 7
    Protein Accession:
    P08729
    Secondary Accessions:
    • Q92676
    • Q9BUD8
    • Q9Y3R7

    Protein attributes for KRT7 Gene

    Size:
    469 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10. Interacts with GPER1.
    • (Microbial infection) Interacts with human papillomavirus 16/HPV16 protein E7.
    SequenceCaution:
    • Sequence=CAA26956.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Three dimensional structures from OCA and Proteopedia for KRT7 Gene

neXtProt entry for KRT7 Gene

Post-translational modifications for KRT7 Gene

  • Arg-20 is dimethylated, probably to asymmetric dimethylarginine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT7 Gene

Antibody Products

No data available for DME Specific Peptides for KRT7 Gene

Domains & Families for KRT7 Gene

Gene Families for KRT7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT7 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature
  • Type II keratin signature
ProtoNet:

Suggested Antigen Peptide Sequences for KRT7 Gene

GenScript: Design optimal peptide antigens:
  • Type-II keratin Kb7 (K2C7_HUMAN)
  • KRT7 protein (Q3B834_HUMAN)
  • KRT7 protein (Q3KNV1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08729

UniProtKB/Swiss-Prot:

K2C7_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT7: view

Function for KRT7 Gene

Molecular function for KRT7 Gene

UniProtKB/Swiss-Prot Function:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
UniProtKB/Swiss-Prot Induction:
Up-regulated by retinoic acid.
GENATLAS Biochemistry:
keratin 7,type II,simple epithelial

Phenotypes From GWAS Catalog for KRT7 Gene

Gene Ontology (GO) - Molecular Function for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11169732
genes like me logo Genes that share ontologies with KRT7: view
genes like me logo Genes that share phenotypes with KRT7: view

Animal Models for KRT7 Gene

MGI Knock Outs for KRT7:
  • Krt7 Krt7<tm1Whim>
  • Krt7 Krt7<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KRT7 Gene

Localization for KRT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT7 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IEA,IDA 2459129
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA,NAS 2415537
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT7: view

Pathways & Interactions for KRT7 Gene

PathCards logo

SuperPathways for KRT7 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
2 Developmental Biology
3 Keratinization
4 Cytoskeleton remodeling Neurofilaments
.32
genes like me logo Genes that share pathways with KRT7: view

Pathways by source for KRT7 Gene

2 Reactome pathways for KRT7 Gene
1 GeneGo (Thomson Reuters) pathway for KRT7 Gene
  • Cytoskeleton remodeling Keratin filaments
1 Cell Signaling Technology pathway for KRT7 Gene

SIGNOR curated interactions for KRT7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KRT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT7: view

Drugs & Compounds for KRT7 Gene

(14) Drugs for KRT7 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Primaquine Approved Pharma Target, other/unknown 99
Verpasep caltespen Investigational Pharma Target 0

(20) Additional Compounds for KRT7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT7: view

Transcripts for KRT7 Gene

mRNA/cDNA for KRT7 Gene

1 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT7

Alternative Splicing Database (ASD) splice patterns (SP) for KRT7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - - - -
SP2: - -
SP3: - - - - - -
SP4:
SP5:
SP6: -
SP7:

Relevant External Links for KRT7 Gene

GeneLoc Exon Structure for
KRT7

Expression for KRT7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.2), Lung (x6.8), and Thyroid (x6.1).

Protein differential expression in normal tissues from HIPED for KRT7 Gene

This gene is overexpressed in Salivary gland (24.3), Placenta (8.3), and Islet of Langerhans (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT7

SOURCE GeneReport for Unigene cluster for KRT7 Gene:

Hs.411501

mRNA Expression by UniProt/SwissProt for KRT7 Gene:

P08729-K2C7_HUMAN
Tissue specificity: Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.

Evidence on tissue expression from TISSUES for KRT7 Gene

  • Pancreas(4.9)
  • Lung(4.9)
  • Liver(4.7)
  • Thyroid gland(4.6)
  • Kidney(4.6)
  • Skin(4.6)
  • Stomach(3.6)
  • Intestine(3.5)
  • Gall bladder(3.3)
  • Heart(3)
  • Blood(3)
  • Lymph node(2.9)
  • Adrenal gland(2.8)
  • Nervous system(2.7)
  • Muscle(2.7)
  • Eye(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with KRT7: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT7 Gene

Orthologs for KRT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT7 30 31
  • 99.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRT7 30 31
  • 88.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRT7 30
  • 86.06 (n)
Mouse
(Mus musculus)
Mammalia Krt7 30 17 31
  • 84.46 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krt7 30
  • 83.81 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KRT7 31
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KRT7 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KRT7 30 31
  • 74.39 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KRT7 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia krt5.7 30
  • 67.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397878 30
Zebrafish
(Danio rerio)
Actinopterygii krt4 31
  • 55 (a)
ManyToMany
si:dkey-222f2.1 31
  • 53 (a)
ManyToMany
krt8 31
  • 50 (a)
ManyToMany
krt5 31
  • 49 (a)
ManyToMany
zgc:158846 31
  • 49 (a)
ManyToMany
Species where no ortholog for KRT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KRT7 Gene

ENSEMBL:
Gene Tree for KRT7 (if available)
TreeFam:
Gene Tree for KRT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT7: view image

Paralogs for KRT7 Gene

genes like me logo Genes that share paralogs with KRT7: view

Variants for KRT7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT7 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
710358 Likely Benign: not provided 52,248,642(+) C/T MISSENSE_VARIANT
714178 Benign: not provided 52,241,562(+) G/A MISSENSE_VARIANT
745178 Likely Benign: not provided 52,233,560(+) C/T SYNONYMOUS_VARIANT
768543 Benign: not provided 52,248,646(+) C/T SYNONYMOUS_VARIANT
769820 Benign: not provided 52,233,347(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KRT7 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT7 Gene

Variant ID Type Subtype PubMed ID
dgv1501n100 CNV gain 25217958
esv2759899 CNV gain 17122850
nsv975489 CNV duplication 23825009

Variation tolerance for KRT7 Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.20; 61.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT7 Gene

Human Gene Mutation Database (HGMD)
KRT7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT7 Gene

Disorders for KRT7 Gene

MalaCards: The human disease database

(405) MalaCards diseases for KRT7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pseudomyxoma peritonei
  • mucinous ascites
signet ring cell adenocarcinoma
  • signet ring carcinoma
bile duct adenoma
  • cholangioadenoma
cystadenoma
  • cystoma
mucinous cystadenocarcinoma
  • pseudomucinous cystadenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with KRT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT7 Gene

Publications for KRT7 Gene

  1. Sarcolectin (SCL): structure and expression of the recombinant molecule. (PMID: 10492017) Kaba A … Chany C (Biochimie 1999) 3 4 23
  2. G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. (PMID: 21149639) Sandén C … Leeb-Lundberg LM (Molecular pharmacology 2011) 3 4
  3. Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. (PMID: 20398190) Nagashio R … Okayasu I (Pathology international 2010) 3 23
  4. CDX2, cytokeratins 7 and 20 immunoreactivity in rectal adenocarcinoma. (PMID: 19098678) Saad RS … Rowsell C (Applied immunohistochemistry & molecular morphology : AIMM 2009) 3 23
  5. Keratin 7 expression as an early marker of reflux-related columnar mucosa without intestinal metaplasia in the esophagus. (PMID: 19396034) Cabibi D … Aragona F (Medical science monitor : international medical journal of experimental and clinical research 2009) 3 23

Products for KRT7 Gene

Sources for KRT7 Gene