The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is at... See more...

Aliases for KRT6A Gene

Aliases for KRT6A Gene

  • Keratin 6A 2 3 5
  • Keratin, Type II Cytoskeletal 6A 3 4
  • Keratin 6A, Type II 2 3
  • Type-II Keratin Kb6 3 4
  • KRT6D 3 4
  • CK6C 2 3
  • CK6D 2 3
  • K6A 3 4
  • K6C 2 3
  • K6D 2 3
  • Keratin, Epidermal Type II, K6A 3
  • Keratin 6A, , Type II 3
  • Allergen Hom S 5 4
  • Cytokeratin 6A 3
  • Cytokeratin 6C 3
  • Cytokeratin 6D 3
  • Cytokeratin-6A 4
  • Cytokeratin-6D 4
  • Keratin 6C 2
  • Keratin 6D 2
  • Keratin-6A 4
  • CK-6C 3
  • CK-6E 3
  • KRT6C 3
  • KRT6A 5
  • CK-6A 4
  • CK-6D 4
  • CK6A 3
  • PC3 3

External Ids for KRT6A Gene

Previous HGNC Symbols for KRT6A Gene

  • KRT6C
  • KRT6D

Previous GeneCards Identifiers for KRT6A Gene

  • GC12M053016
  • GC12M052871
  • GC12M052598
  • GC12M051168
  • GC12M051170
  • GC12M051173
  • GC12M051176
  • GC12M052880
  • GC12M049927

Summaries for KRT6A Gene

Entrez Gene Summary for KRT6A Gene

  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]

GeneCards Summary for KRT6A Gene

KRT6A (Keratin 6A) is a Protein Coding gene. Diseases associated with KRT6A include Pachyonychia Congenita 3 and Pachyonychia Congenita 1. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT6B.

UniProtKB/Swiss-Prot Summary for KRT6A Gene

  • Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.

Gene Wiki entry for KRT6A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT6A Gene

Genomics for KRT6A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT6A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J052491 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 263.4 -1.3 -1300 6.4 ZIC2 CEBPB SIN3A STAT3 EBF1 JUND CTCF GLIS1 SP1 ATF7 KRT6A KRT6B JA662198 KRT6C KRT5 KRT71 KRT82 KRT84 KRT87P KRT86
GH12J052515 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.5 -28.1 -28109 12.1 ZIC2 DEK MAX CTBP1 MAFF SMC3 ZNF316 JUND FOSL2 MAFK KRT5 HSALNG0091189 HSALNG0091190 lnc-KRT6A-1 KRT6A KRT6C KRT71 KRT74 KRT84 KRT2
GH12J052143 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 5.1 +342.7 342654 14.9 ZNF654 ZNF600 JUND BRCA1 POLR2A ZIC2 ZNF217 CTCF CEBPB REST HSALNG0091158-001 LINC00592 HNRNPA3P10 KRT5 ENSG00000257989 KRT7 KRT6A OR7E47P IGFBP6 KRT6C
GH12J052513 Enhancer 0.7 ENCODE dbSUPER 10.7 -20.7 -20709 1.2 ZNF316 NFE2 MAFG ATF4 CEBPB ATF3 EMSY CEBPG KRT6A KRT71 KRT6C KRT5 NR4A1AS lnc-KRT6A-1 HSALNG0091188 HSALNG0091189 HSALNG0091187
GH12J052435 Enhancer 0.8 Ensembl ENCODE dbSUPER 4.6 +56.7 56738 2.1 NFIC NR2F6 NR2C1 NFIB NR2F1 KRT6C KRT6A KRT75 HSALNG0091184-001 KRT6B lnc-KRT6B-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT6A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT6A

Top Transcription factor binding sites by QIAGEN in the KRT6A gene promoter:
  • AML1a
  • AP-1
  • AP-4
  • AREB6
  • FOXO4
  • GATA-2
  • HNF-4alpha1
  • Pax-5
  • STAT5A

Genomic Locations for KRT6A Gene

Latest Assembly
chr12:52,487,176-52,493,257
(GRCh38/hg38)
Size:
6,082 bases
Orientation:
Minus strand

Previous Assembly
chr12:52,880,960-52,887,041
(GRCh37/hg19 by Entrez Gene)
Size:
6,082 bases
Orientation:
Minus strand

chr12:52,880,958-52,887,041
(GRCh37/hg19 by Ensembl)
Size:
6,084 bases
Orientation:
Minus strand

Genomic View for KRT6A Gene

Genes around KRT6A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT6A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT6A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT6A Gene

Proteins for KRT6A Gene

  • Protein details for KRT6A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02538-K2C6A_HUMAN
    Recommended name:
    Keratin, type II cytoskeletal 6A
    Protein Accession:
    P02538
    Secondary Accessions:
    • A4QPC1
    • P48667
    • Q08AR4
    • Q6NT67
    • Q96CL4

    Protein attributes for KRT6A Gene

    Size:
    564 amino acids
    Molecular mass:
    60045 Da
    Quaternary structure:
    • Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17 (By similarity). Interacts with TCHP (PubMed:15731013).
    Miscellaneous:
    • There are at least six isoforms of human type II keratin-6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
    • There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

    Three dimensional structures from OCA and Proteopedia for KRT6A Gene

neXtProt entry for KRT6A Gene

Post-translational modifications for KRT6A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT6A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for KRT6A Gene

Domains & Families for KRT6A Gene

Gene Families for KRT6A Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT6A Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type II keratin signature

Suggested Antigen Peptide Sequences for KRT6A Gene

GenScript: Design optimal peptide antigens:
  • Type-II keratin Kb6 (K2C6A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P02538

UniProtKB/Swiss-Prot:

K2C6A_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT6A: view

Function for KRT6A Gene

Molecular function for KRT6A Gene

UniProtKB/Swiss-Prot Function:
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair.
GENATLAS Biochemistry:
keratin 6A,type II,upper outer hair root sheat,nail bed,palm and sole skin,suprabasal orogenital mucosal keratinocytes,dimerizing with KRT16

Phenotypes From GWAS Catalog for KRT6A Gene

Gene Ontology (GO) - Molecular Function for KRT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 7543104
GO:0005515 protein binding IPI 15731013
genes like me logo Genes that share ontologies with KRT6A: view
genes like me logo Genes that share phenotypes with KRT6A: view

Human Phenotype Ontology for KRT6A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for KRT6A Gene

miRTarBase miRNAs that target KRT6A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT6A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT6A Gene

Localization for KRT6A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT6A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 3
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0016020 membrane HDA 19946888
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRT6A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT6A Gene

Pathways & Interactions for KRT6A Gene

PathCards logo

SuperPathways for KRT6A Gene

genes like me logo Genes that share pathways with KRT6A: view

Pathways by source for KRT6A Gene

1 BioSystems pathway for KRT6A Gene
2 Reactome pathways for KRT6A Gene
1 GeneGo (Thomson Reuters) pathway for KRT6A Gene
  • Cytoskeleton remodeling Keratin filaments
1 Cell Signaling Technology pathway for KRT6A Gene

Gene Ontology (GO) - Biological Process for KRT6A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001899 negative regulation of cytolysis by symbiont of host cells IDA 23006328
GO:0002009 morphogenesis of an epithelium ISS --
GO:0007010 cytoskeleton organization IEA --
GO:0008284 positive regulation of cell proliferation NAS 7543104
GO:0030154 cell differentiation NAS 7543104
genes like me logo Genes that share ontologies with KRT6A: view

No data available for SIGNOR curated interactions for KRT6A Gene

Drugs & Compounds for KRT6A Gene

(4) Drugs for KRT6A Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma Target 1706
zinc acetate Approved, Investigational Pharma Target 0
TD101 Pharma 0
genes like me logo Genes that share compounds with KRT6A: view

Transcripts for KRT6A Gene

mRNA/cDNA for KRT6A Gene

1 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT6A

Alternative Splicing Database (ASD) splice patterns (SP) for KRT6A Gene

No ASD Table

Relevant External Links for KRT6A Gene

GeneLoc Exon Structure for
KRT6A

Expression for KRT6A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT6A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT6A Gene

This gene is overexpressed in Esophagus - Mucosa (x24.1), Vagina (x14.0), and Cervix - Ectocervix (x8.1).

Protein differential expression in normal tissues from HIPED for KRT6A Gene

This gene is overexpressed in Saliva (26.9) and Urinary Bladder (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT6A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT6A

SOURCE GeneReport for Unigene cluster for KRT6A Gene:

Hs.700779

mRNA Expression by UniProt/SwissProt for KRT6A Gene:

P02538-K2C6A_HUMAN
Tissue specificity: Expressed in the corneal epithelium (at protein level).

Evidence on tissue expression from TISSUES for KRT6A Gene

  • Skin(4.9)
  • Nervous system(4.9)
  • Pancreas(4.6)
  • Liver(4.4)
  • Lung(3.6)
  • Thyroid gland(2.4)
  • Blood(2.3)
  • Eye(2.2)
  • Intestine(2.2)
  • Heart(2.1)
  • Kidney(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT6A Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • scalp
  • skull
  • tongue
  • tooth
  • vocal cord
Limb:
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
General:
  • hair
  • skin
  • sweat gland
genes like me logo Genes that share expression patterns with KRT6A: view

No data available for Protein tissue co-expression partners for KRT6A Gene

Orthologs for KRT6A Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT6A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT6A 29 30
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 89 (a)
OneToMany
KRT6B 29
  • 86.29 (n)
Mouse
(Mus musculus)
Mammalia Krt6a 30
  • 88 (a)
ManyToMany
Krt6b 30
  • 86 (a)
ManyToMany
Gm5414 30
  • 70 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia KRT6B 30
  • 87 (a)
ManyToMany
-- 30
  • 87 (a)
ManyToMany
-- 30
  • 87 (a)
ManyToMany
KRT6C 29
  • 85.77 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 74 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves KRT6A 30
  • 73 (a)
ManyToMany
KRT3 29
  • 71.91 (n)
KRT75 30
  • 67 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 68 (a)
OneToMany
Species where no ortholog for KRT6A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT6A Gene

ENSEMBL:
Gene Tree for KRT6A (if available)
TreeFam:
Gene Tree for KRT6A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT6A: view image
Alliance of Genome Resources:
Additional Orthologs for KRT6A

Paralogs for KRT6A Gene

genes like me logo Genes that share paralogs with KRT6A: view

Variants for KRT6A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT6A Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
1012820 Likely Benign: not provided 52,488,079(-) T/C
NM_005554.4(KRT6A):c.1449A>G (p.Gln483=)
SYNONYMOUS
1031548 Pathogenic: Pachyonychia congenita 3 52,487,721(-) T/C
NM_005554.4(KRT6A):c.1694A>G (p.Ter565=)
SYNONYMOUS
1031549 Pathogenic: Pachyonychia congenita 3 52,490,716(-) CT/C
NM_005554.4(KRT6A):c.929del (p.Gln310fs)
FRAMESHIFT
930292 Uncertain Significance: Pachyonychia congenita 3 52,490,078(-) A/G
NM_005554.4(KRT6A):c.1078-10T>C
INTRON
950541 Uncertain Significance: not provided 52,490,678(-) T/A
NM_005554.4(KRT6A):c.968A>T (p.Asp323Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT6A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT6A Gene

Variant ID Type Subtype PubMed ID
dgv1505n100 CNV loss 25217958
dgv95n21 CNV loss 19592680
esv2660079 CNV deletion 23128226
esv2745892 CNV deletion 23290073
esv3581627 CNV gain 25503493
nsv1035936 CNV gain 25217958
nsv832410 CNV gain 17160897
nsv832411 CNV loss 17160897
nsv832412 CNV loss 17160897
nsv832413 CNV loss 17160897
nsv973066 CNV duplication 23825009

Variation tolerance for KRT6A Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.98; 89.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT6A Gene

Human Gene Mutation Database (HGMD)
KRT6A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT6A
Leiden Open Variation Database (LOVD)
KRT6A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT6A Gene

Disorders for KRT6A Gene

MalaCards: The human disease database

(22) MalaCards diseases for KRT6A Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
pachyonychia congenita 3
  • pc3
pachyonychia congenita 1
  • pc1
median rhomboid glossitis
  • persistent tuberculum impar
fissured tongue
  • congenital fissure of tongue
glossitis
- elite association - COSMIC cancer census association via MalaCards
Search KRT6A in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

K2C6A_HUMAN
  • Pachyonychia congenita 3 (PC3) [MIM:615726]: An autosomal dominant genodermatosis characterized by hypertrophic nail dystrophy, painful and highly debilitating plantar keratoderma, oral leukokeratosis, and a variety of epidermal cysts. {ECO:0000269 PubMed:10232400, ECO:0000269 PubMed:11886499, ECO:0000269 PubMed:15387942, ECO:0000269 PubMed:15840119, ECO:0000269 PubMed:16250206, ECO:0000269 PubMed:17309457, ECO:0000269 PubMed:17719747, ECO:0000269 PubMed:18489596, ECO:0000269 PubMed:19416275, ECO:0000269 PubMed:21326300, ECO:0000269 PubMed:22668561, ECO:0000269 PubMed:7545493}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for KRT6A

genes like me logo Genes that share disorders with KRT6A: view

No data available for Genatlas for KRT6A Gene

Publications for KRT6A Gene

  1. Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. (PMID: 11886499) Terrinoni A … McLean WH (The Journal of investigative dermatology 2001) 3 4 22 72
  2. Novel and recurrent keratin 6A (KRT6A) mutations in Chinese patients with pachyonychia congenita type 1. (PMID: 19416275) Lv YM … Zhang XJ (The British journal of dermatology 2009) 3 4 22
  3. A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita. (PMID: 17719747) Liao H … Smith FJ (Journal of dermatological science 2007) 3 4 22
  4. Mutation of a type II keratin gene (K6a) in pachyonychia congenita. (PMID: 7545493) Bowden PE … Turner RJ (Nature genetics 1995) 3 4 22
  5. Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. (PMID: 1713141) Rosenberg M … Shows TB (Cytogenetics and cell genetics 1991) 2 3 22

Products for KRT6A Gene

Sources for KRT6A Gene