Aliases for KRT5 Gene
External Ids for KRT5 Gene
Previous HGNC Symbols for KRT5 Gene
Previous GeneCards Identifiers for KRT5 Gene
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT5 Gene
KRT5 (Keratin 5) is a Protein Coding gene. Diseases associated with KRT5 include Epidermolysis Bullosa Simplex With Mottled Pigmentation and Epidermolysis Bullosa Simplex, Generalized. Among its related pathways are Glucocorticoid receptor regulatory network and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT6A.