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Aliases for KRT37 Gene

Aliases for KRT37 Gene

  • Keratin 37 2 3 5
  • Hair Keratin, Type I Ha7 3 4
  • Keratin, Hair, Acidic, 7 2 3
  • Keratin 37, Type I 2 3
  • KRTHA7 3 4
  • K37 3 4
  • Keratin, Type I Cuticular Ha7 3
  • Keratin-37 4
  • HHA7 4
  • HKA7 4
  • HA7 3

External Ids for KRT37 Gene

Previous HGNC Symbols for KRT37 Gene

  • KRTHA7

Previous GeneCards Identifiers for KRT37 Gene

  • GC17M036831
  • GC17M039581
  • GC17M035340

Summaries for KRT37 Gene

Entrez Gene Summary for KRT37 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT37 Gene

KRT37 (Keratin 37) is a Protein Coding gene. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT38.

Additional gene information for KRT37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT37 Gene

Genomics for KRT37 Gene

GeneHancer (GH) Regulatory Elements for KRT37 Gene

Promoters and enhancers for KRT37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041424 Promoter 0.5 EPDnew 650.7 0.0 -35 0.1 KRT37 KRT38 LOC100505782
GH17J041649 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -230.1 -230076 9.8 HDGF ARNT ZNF133 NEUROD1 YBX1 BRCA1 TCF12 GLIS2 ZNF143 ZNF207 ENSG00000267758 JUP HSD17B1 DHX58 GHDC ENSG00000259623 KRT14 CNP PSMC3IP RETREG3
GH17J040908 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +511.6 511595 8.7 FOXA2 MLX ARID4B SIN3A IRF4 ZNF213 ZNF143 FOS DEK SP5 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17J041620 Promoter/Enhancer 1.6 EPDnew FANTOM5 ENCODE 9.4 -199.6 -199628 6.5 PKNOX1 NFIB KLF17 BRCA1 ZNF335 GLIS2 ZNF366 RCOR1 KLF7 EGR2 KRT17 GC17M041622 GC17M041625 KRT9 KRT15 KRT14 KRT19 KRT40 ENSG00000234477 KRT37
GH17J040900 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.7 +521.8 521772 5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 KRT23 SNORD124 KRT12 TMEM99 KRT28 KRTAP3-2 KRT40 KRT37 KRT38 KRT26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT37 gene promoter:
  • AP-4
  • FOXF2
  • Bach2
  • Pax-4a
  • Evi-1
  • c-Myb
  • FOXO4

Genomic Locations for KRT37 Gene

Genomic Locations for KRT37 Gene
chr17:41,420,557-41,424,570
(GRCh38/hg38)
Size:
4,014 bases
Orientation:
Minus strand
chr17:39,576,809-39,580,822
(GRCh37/hg19)
Size:
4,014 bases
Orientation:
Minus strand

Genomic View for KRT37 Gene

Genes around KRT37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT37 Gene

Proteins for KRT37 Gene

  • Protein details for KRT37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76014-KRT37_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha7
    Protein Accession:
    O76014

    Protein attributes for KRT37 Gene

    Size:
    449 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT37 Gene

Post-translational modifications for KRT37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT37 Gene

Domains & Families for KRT37 Gene

Gene Families for KRT37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT37 Gene

Suggested Antigen Peptide Sequences for KRT37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76014

UniProtKB/Swiss-Prot:

KRT37_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT37: view

Function for KRT37 Gene

Phenotypes From GWAS Catalog for KRT37 Gene

Gene Ontology (GO) - Molecular Function for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT37: view
genes like me logo Genes that share phenotypes with KRT37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT37 Gene

Localization for KRT37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT37 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT37 Gene

Pathways & Interactions for KRT37 Gene

genes like me logo Genes that share pathways with KRT37: view

Pathways by source for KRT37 Gene

2 Reactome pathways for KRT37 Gene
1 KEGG pathway for KRT37 Gene

Interacting Proteins for KRT37 Gene

Gene Ontology (GO) - Biological Process for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT37: view

No data available for SIGNOR curated interactions for KRT37 Gene

Drugs & Compounds for KRT37 Gene

No Compound Related Data Available

Transcripts for KRT37 Gene

mRNA/cDNA for KRT37 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT37 Gene

Keratin 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT37

Alternative Splicing Database (ASD) splice patterns (SP) for KRT37 Gene

No ASD Table

Relevant External Links for KRT37 Gene

GeneLoc Exon Structure for
KRT37
ECgene alternative splicing isoforms for
KRT37

Expression for KRT37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT37 Gene

mRNA differential expression in normal tissues according to GTEx for KRT37 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.7).

Protein differential expression in normal tissues from HIPED for KRT37 Gene

This gene is overexpressed in Skin (54.0) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT37 Gene



Protein tissue co-expression partners for KRT37 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT37 Gene:

KRT37

SOURCE GeneReport for Unigene cluster for KRT37 Gene:

Hs.673852

Evidence on tissue expression from TISSUES for KRT37 Gene

  • Blood(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT37: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT37 Gene

Orthologs for KRT37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT37 34
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
ManyToMany
-- 34
  • 69 (a)
ManyToMany
-- 34
  • 64 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii wu:fb17f05 34
  • 38 (a)
ManyToMany
zgc:92061 34
  • 37 (a)
ManyToMany
krt17 34
  • 36 (a)
ManyToMany
cyt1 34
  • 36 (a)
ManyToMany
cyt1l 34
  • 36 (a)
ManyToMany
zgc:109868 34
  • 35 (a)
ManyToMany
zgc:153629 34
  • 35 (a)
ManyToMany
krt1-19d 34
  • 33 (a)
ManyToMany
zgc:136902 34
  • 33 (a)
ManyToMany
zgc:92035 34
  • 33 (a)
ManyToMany
krt15 34
  • 33 (a)
ManyToMany
si:dkeyp-113d7.4 34
  • 30 (a)
ManyToMany
BX469912.1 34
  • 19 (a)
ManyToMany
zgc:92533 34
  • 18 (a)
ManyToMany
Species where no ortholog for KRT37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT37 Gene

ENSEMBL:
Gene Tree for KRT37 (if available)
TreeFam:
Gene Tree for KRT37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT37: view image

Paralogs for KRT37 Gene

Pseudogenes.org Pseudogenes for KRT37 Gene

genes like me logo Genes that share paralogs with KRT37: view

Variants for KRT37 Gene

Sequence variations from dbSNP and Humsavar for KRT37 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000243811 -- 41,423,586(-) T/G intron_variant
rs1001060879 -- 41,422,593(-) G/C intron_variant
rs1001318303 -- 41,424,602(-) CCAACC/CC upstream_transcript_variant
rs1002839701 -- 41,424,854(-) C/T upstream_transcript_variant
rs1003201509 -- 41,426,113(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT37 Gene

Variant ID Type Subtype PubMed ID
esv2715932 CNV deletion 23290073
esv2758690 CNV gain+loss 17122850
nsv1071383 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789

Variation tolerance for KRT37 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.12; 99.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT37

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT37 Gene

Disorders for KRT37 Gene

Additional Disease Information for KRT37

No disorders were found for KRT37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT37 Gene

Publications for KRT37 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 58
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  4. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M … Superti-Furga G (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 58
  5. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 58

Products for KRT37 Gene

Sources for KRT37 Gene

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