The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] See more...

Aliases for KRT37 Gene

Aliases for KRT37 Gene

  • Keratin 37 2 3 5
  • Keratin, Type I Cuticular Ha7 3 4
  • Keratin, Hair, Acidic, 7 2 3
  • Hair Keratin, Type I Ha7 3 4
  • Keratin 37, Type I 2 3
  • KRTHA7 3 4
  • K37 3 4
  • Keratin-37 4
  • KRT37 5
  • HHA7 4
  • HKA7 4
  • HA7 3

External Ids for KRT37 Gene

Previous HGNC Symbols for KRT37 Gene

  • KRTHA7

Previous GeneCards Identifiers for KRT37 Gene

  • GC17M036831
  • GC17M039581
  • GC17M035340

Summaries for KRT37 Gene

Entrez Gene Summary for KRT37 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT37 Gene

KRT37 (Keratin 37) is a Protein Coding gene. Diseases associated with KRT37 include Iron Overload In Africa. Among its related pathways are Relaxin signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT38.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT37 Gene

Genomics for KRT37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041424 Promoter 0.3 EPDnew 250.7 0.0 -20 0.1 HSALNG0116430 KRT37 KRT38 HSALNG0116429-001 LOC100505782
GH17J041649 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 11.4 -230.1 -230061 9.8 BRCA1 NFIC ZIC2 REST PLRG1 FOXA1 ZNF148 NONO HES1 MBD2 RETREG3 ENSG00000267758 HSD17B1-AS1 HSD17B1 DHX58 ENSG00000259623 KRT14 CNP PSMC3IP KRT37
GH17J041620 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 9.4 -199.6 -199613 6.5 IKZF1 ZNF600 ATF2 CEBPA BRCA1 NFIC ZIC2 REST CEBPB ZNF341 KRT17 KRT9 KRT15 KRT14 KRT19 KRT40 ENSG00000234477 KRT37 KRT16 KRT36
GH17J041505 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -82.1 -82091 3.4 ATF2 ZIC2 FEZF1 ZNF217 IRF2 FOXA2 CTBP1 ELF1 TEAD3 PRDM6 KRT13 lnc-KRT15-2 KRT9 KRT37 ENSG00000234477 KRT36 KRTAP3-1 JUP KRT19 HSALNG0116436
GH17J040908 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 9.7 +511.6 511610 8.7 ZNF654 JUND ATF2 CEBPA NFIC CHD4 BCL11A CEBPB CTCF REST KRT23 KRTAP3-2 MSL1 KRT20 KRT10-AS1 KRT37 KRT28 KRT40 LOC100505782 KRT31
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT37

Top Transcription factor binding sites by QIAGEN in the KRT37 gene promoter:
  • AP-4
  • Bach2
  • c-Myb
  • Evi-1
  • FOXF2
  • FOXO4
  • Pax-4a

Genomic Locations for KRT37 Gene

Latest Assembly
chr17:41,420,547-41,424,585
(GRCh38/hg38)
Size:
4,039 bases
Orientation:
Minus strand

Previous Assembly
chr17:39,576,799-39,580,837
(GRCh37/hg19 by Entrez Gene)
Size:
4,039 bases
Orientation:
Minus strand

chr17:39,577,005-39,580,775
(GRCh37/hg19 by Ensembl)
Size:
3,771 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr17(ALT_REF_LOCI_1):8,351-12,389 (+)

Genomic View for KRT37 Gene

Genes around KRT37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT37 Gene

Proteins for KRT37 Gene

  • Protein details for KRT37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76014-KRT37_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha7
    Protein Accession:
    O76014

    Protein attributes for KRT37 Gene

    Size:
    449 amino acids
    Molecular mass:
    49747 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT37 Gene

Post-translational modifications for KRT37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT37 Gene

Domains & Families for KRT37 Gene

Gene Families for KRT37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT37 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature

Suggested Antigen Peptide Sequences for KRT37 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-37 (KRT37_HUMAN)
  • HHa7 protein (Q6A165_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76014

UniProtKB/Swiss-Prot:

KRT37_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT37: view

Function for KRT37 Gene

Phenotypes From GWAS Catalog for KRT37 Gene

Gene Ontology (GO) - Molecular Function for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS,IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with KRT37: view
genes like me logo Genes that share phenotypes with KRT37: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT37

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT37 Gene

Localization for KRT37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT37 gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 4
plasma membrane 2
nucleus 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT37 Gene

Pathways & Interactions for KRT37 Gene

genes like me logo Genes that share pathways with KRT37: view

Pathways by source for KRT37 Gene

2 Reactome pathways for KRT37 Gene

Gene Ontology (GO) - Biological Process for KRT37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT37: view

No data available for SIGNOR curated interactions for KRT37 Gene

Drugs & Compounds for KRT37 Gene

No Compound Related Data Available

Transcripts for KRT37 Gene

mRNA/cDNA for KRT37 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT37

Alternative Splicing Database (ASD) splice patterns (SP) for KRT37 Gene

No ASD Table

Relevant External Links for KRT37 Gene

GeneLoc Exon Structure for
KRT37

Expression for KRT37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Colon (Gastrointestinal Tract)

mRNA differential expression in normal tissues according to GTEx for KRT37 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.7).

Protein differential expression in normal tissues from HIPED for KRT37 Gene

This gene is overexpressed in Skin (54.0) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT37 Gene



Protein tissue co-expression partners for KRT37 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT37

SOURCE GeneReport for Unigene cluster for KRT37 Gene:

Hs.673852

Evidence on tissue expression from TISSUES for KRT37 Gene

  • Blood(2.7)
  • Kidney(2.5)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with KRT37: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT37 Gene

Orthologs for KRT37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT37 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT37 30
  • 98 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 73 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 73 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
ManyToMany
-- 30
  • 69 (a)
ManyToMany
-- 30
  • 64 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 44 (a)
ManyToMany
-- 30
  • 39 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii wu:fb17f05 30
  • 38 (a)
ManyToMany
zgc:92061 30
  • 37 (a)
ManyToMany
krt17 30
  • 36 (a)
ManyToMany
cyt1 30
  • 36 (a)
ManyToMany
cyt1l 30
  • 36 (a)
ManyToMany
zgc:109868 30
  • 35 (a)
ManyToMany
zgc:153629 30
  • 35 (a)
ManyToMany
krt1-19d 30
  • 33 (a)
ManyToMany
zgc:136902 30
  • 33 (a)
ManyToMany
zgc:92035 30
  • 33 (a)
ManyToMany
krt15 30
  • 33 (a)
ManyToMany
si:dkeyp-113d7.4 30
  • 30 (a)
ManyToMany
BX469912.1 30
  • 19 (a)
ManyToMany
zgc:92533 30
  • 18 (a)
ManyToMany
Species where no ortholog for KRT37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for KRT37 Gene

ENSEMBL:
Gene Tree for KRT37 (if available)
TreeFam:
Gene Tree for KRT37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT37: view image
Alliance of Genome Resources:
Additional Orthologs for KRT37

Paralogs for KRT37 Gene

Pseudogenes.org Pseudogenes for KRT37 Gene

genes like me logo Genes that share paralogs with KRT37: view

Variants for KRT37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT37 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs16966811 -- p.Ala217Val
rs17737019 -- p.Pro434Ser
rs2071607 -- p.Ala306Asp
rs35371972 -- p.Ser421Phe
rs8071814 -- p.Thr422Met

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT37 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT37 Gene

Variant ID Type Subtype PubMed ID
esv2715932 CNV deletion 23290073
esv2758690 CNV gain+loss 17122850
nsv1071383 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789

Variation tolerance for KRT37 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.12; 99.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT37
Leiden Open Variation Database (LOVD)
KRT37

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT37 Gene

Disorders for KRT37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT37 Gene - From: COP

Disorder Aliases PubMed IDs
iron overload in africa
  • african iron overload
- elite association - COSMIC cancer census association via MalaCards
Search KRT37 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT37

genes like me logo Genes that share disorders with KRT37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT37 Gene

Publications for KRT37 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes. (PMID: 32487729) Rausell A … Abel L (Proceedings of the National Academy of Sciences of the United States of America 2020) 3
  5. The mutational constraint spectrum quantified from variation in 141,456 humans. (PMID: 32461654) Karczewski KJ … MacArthur DG (Nature 2020) 3

Products for KRT37 Gene

  • Boster Bio Antibodies for KRT37
  • Boster Bio ELISA Kits for KRT37

Sources for KRT37 Gene