The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] See more...

Aliases for KRT36 Gene

Aliases for KRT36 Gene

  • Keratin 36 2 3 5
  • Keratin, Type I Cuticular Ha6 3 4
  • Keratin, Hair, Acidic, 6 2 3
  • Hair Keratin, Type I Ha6 3 4
  • Keratin 36, Type I 2 3
  • KRTHA6 3 4
  • K36 3 4
  • Keratin-36 4
  • KRT36 5
  • HHa6 3
  • HHA6 4
  • HKA6 4
  • HA6 3

External Ids for KRT36 Gene

Previous HGNC Symbols for KRT36 Gene

  • KRTHA6

Previous GeneCards Identifiers for KRT36 Gene

  • GC17M036896
  • GC17M039642
  • GC17M035406

Summaries for KRT36 Gene

Entrez Gene Summary for KRT36 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT36 Gene

KRT36 (Keratin 36) is a Protein Coding gene. Among its related pathways are Relaxin signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT35.

Gene Wiki entry for KRT36 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT36 Gene

Genomics for KRT36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT36

Top Transcription factor binding sites by QIAGEN in the KRT36 gene promoter:
  • ARP-1
  • ATF6
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-5
  • p53
  • Pax-6

Genomic Locations for KRT36 Gene

Latest Assembly
chr17:41,486,136-41,492,546
(GRCh38/hg38)
Size:
6,411 bases
Orientation:
Minus strand

Previous Assembly
chr17:39,642,388-39,646,162
(GRCh37/hg19 by Entrez Gene)
Size:
3,775 bases
Orientation:
Minus strand

chr17:39,642,388-39,648,798
(GRCh37/hg19 by Ensembl)
Size:
6,411 bases
Orientation:
Minus strand

Genomic View for KRT36 Gene

Genes around KRT36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT36 Gene

Proteins for KRT36 Gene

  • Protein details for KRT36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76013-KRT36_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha6
    Protein Accession:
    O76013
    Secondary Accessions:
    • Q86XG4

    Protein attributes for KRT36 Gene

    Size:
    467 amino acids
    Molecular mass:
    52247 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Alternative splice isoforms for KRT36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT36 Gene

Post-translational modifications for KRT36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT36 Gene

Domains & Families for KRT36 Gene

Gene Families for KRT36 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT36 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature

Suggested Antigen Peptide Sequences for KRT36 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-36 (KRT36_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76013

UniProtKB/Swiss-Prot:

KRT36_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT36: view

Function for KRT36 Gene

Phenotypes From GWAS Catalog for KRT36 Gene

Gene Ontology (GO) - Molecular Function for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI --
GO:0030280 structural constituent of epidermis NAS 9756910
genes like me logo Genes that share ontologies with KRT36: view
genes like me logo Genes that share phenotypes with KRT36: view

Animal Models for KRT36 Gene

MGI Knock Outs for KRT36:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT36

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for KRT36 Gene

Localization for KRT36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT36 gene
Compartment Confidence
cytosol 5
extracellular 4
cytoskeleton 3
mitochondrion 2
nucleus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045111 intermediate filament cytoskeleton IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT36: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT36 Gene

Pathways & Interactions for KRT36 Gene

genes like me logo Genes that share pathways with KRT36: view

Pathways by source for KRT36 Gene

2 Reactome pathways for KRT36 Gene

Gene Ontology (GO) - Biological Process for KRT36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0045616 regulation of keratinocyte differentiation IEA --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT36: view

No data available for SIGNOR curated interactions for KRT36 Gene

Drugs & Compounds for KRT36 Gene

No Compound Related Data Available

Transcripts for KRT36 Gene

mRNA/cDNA for KRT36 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT36

Alternative Splicing Database (ASD) splice patterns (SP) for KRT36 Gene

No ASD Table

Relevant External Links for KRT36 Gene

GeneLoc Exon Structure for
KRT36

Expression for KRT36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT36 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x21.5), Skin - Sun Exposed (Lower leg) (x6.3), and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for KRT36 Gene

This gene is overexpressed in Skin (14.2), Bone marrow mesenchymal stem cell (12.4), Plasma (8.4), and Saliva (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT36 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT36

SOURCE GeneReport for Unigene cluster for KRT36 Gene:

Hs.248189

mRNA Expression by UniProt/SwissProt for KRT36 Gene:

O76013-KRT36_HUMAN
Tissue specificity: Expressed in the hair follicles.

Evidence on tissue expression from TISSUES for KRT36 Gene

  • Blood(2.3)
genes like me logo Genes that share expression patterns with KRT36: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT36 Gene

Orthologs for KRT36 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT36 29 30
  • 98.72 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRT36 29 30
  • 88.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRT36 29 30
  • 87.67 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Krt36 29 16 30
  • 85.8 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krt36 29
  • 85.07 (n)
Oppossum
(Monodelphis domestica)
Mammalia KRT36 30
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 78 (a)
OneToMany
-- 30
  • 70 (a)
OneToMany
Species where no ortholog for KRT36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT36 Gene

ENSEMBL:
Gene Tree for KRT36 (if available)
TreeFam:
Gene Tree for KRT36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT36: view image
Alliance of Genome Resources:
Additional Orthologs for KRT36

Paralogs for KRT36 Gene

(35) SIMAP similar genes for KRT36 Gene using alignment to 1 proteins:

  • KRT36_HUMAN
genes like me logo Genes that share paralogs with KRT36: view

Variants for KRT36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT36 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs8069943 Benign: not provided 41,489,488(-) T/Cp.Gln126Arg
NM_003771.4(KRT36):c.377A>G (p.Gln126Arg)
MISSENSE
rs8082683 Benign: not provided 41,489,509(-) G/Ap.Ala119Val
NM_003771.4(KRT36):c.356C>T (p.Ala119Val)
MISSENSE
rs11657323 -- p.Asn357Thr
rs2301354 -- p.Thr315Met
rs9675246 -- p.Arg179Gln

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT36 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv3640588 CNV gain 21293372
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489
nsv524606 CNV loss 19592680
nsv526466 CNV gain 19592680
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495

Variation tolerance for KRT36 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.74; 98.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT36
Leiden Open Variation Database (LOVD)
KRT36

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT36 Gene

Disorders for KRT36 Gene

Additional Disease Information for KRT36

No disorders were found for KRT36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT36 Gene

Publications for KRT36 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3
  5. Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma. (PMID: 28038473) Boldrup L … Nylander K (Oncotarget 2017) 3

Products for KRT36 Gene

Sources for KRT36 Gene