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Aliases for KRT35 Gene

Aliases for KRT35 Gene

  • Keratin 35 2 3 5
  • Keratin, Hair, Acidic, 5 2 3
  • Hair Keratin, Type I Ha5 3 4
  • Keratin 35, Type I 2 3
  • KRTHA5 3 4
  • HHa5 3 4
  • K35 3 4
  • HHa5 Hair Keratin Type I Intermediate Filament 3
  • Keratin, Type I Cuticular Ha5 3
  • Hard Keratin, Type I, 5 3
  • Hard Keratin Type I 5 2
  • Keratin-35 4
  • Ha-5 3
  • HKA5 4
  • HA5 3

External Ids for KRT35 Gene

Previous HGNC Symbols for KRT35 Gene

  • KRTHA5

Previous GeneCards Identifiers for KRT35 Gene

  • GC17M036887
  • GC17M039632
  • GC17M035396

Summaries for KRT35 Gene

Entrez Gene Summary for KRT35 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT35 Gene

KRT35 (Keratin 35) is a Protein Coding gene. Diseases associated with KRT35 include Skin Pilomatrix Carcinoma. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT36.

Additional gene information for KRT35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT35 Gene

Genomics for KRT35 Gene

GeneHancer (GH) Regulatory Elements for KRT35 Gene

Promoters and enhancers for KRT35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I041481 Promoter 0.5 EPDnew 550.8 +1.7 1655 0.1 KRT35 KRT32
GH17I041534 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.5 -54.5 -54500 5.4 PKNOX1 CLOCK FOXA2 NFIB NEUROD1 SIN3A NFXL1 BMI1 ZBTB7B ZNF121 ENSG00000267758 SMARCE1 KRT36 STAT5A KRT35 GHDC NAGLU KRT31 LOC100505782 KRT19
GH17I041352 Enhancer 0.7 FANTOM5 dbSUPER 1.6 +129.6 129584 0.3 ZNF629 TSHZ1 REST KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35 KRT38
GH17I041486 Enhancer 0.6 ENCODE 0.8 -4.3 -4251 0.1 CTCF RB1 L3MBTL2 MAX ARID4B SIN3A REST RAD21 IKZF1 ZNF143 KRT35 KRT36
GH17I041557 Enhancer 0.2 FANTOM5 2 -74.6 -74601 0.4 GC17M041544 KRTAP9-2 KRTAP9-1 KRTAP9-9 KRT16 KRT37 KRTAP2-4 KRT38 KRT35 KRT9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT35 gene promoter:

Genomic Locations for KRT35 Gene

Genomic Locations for KRT35 Gene
6,055 bases
Minus strand

Genomic View for KRT35 Gene

Genes around KRT35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT35 Gene

Proteins for KRT35 Gene

  • Protein details for KRT35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha5
    Protein Accession:
    Secondary Accessions:
    • O76012
    • Q92651

    Protein attributes for KRT35 Gene

    455 amino acids
    Molecular mass:
    50361 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    • Sequence=CAA62286.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA76387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for KRT35 Gene

Post-translational modifications for KRT35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT35 Gene

Domains & Families for KRT35 Gene

Gene Families for KRT35 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT35: view

Function for KRT35 Gene

Gene Ontology (GO) - Molecular Function for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT35: view
genes like me logo Genes that share phenotypes with KRT35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT35 Gene

Localization for KRT35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT35 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA,IDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with KRT35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT35 Gene

Pathways & Interactions for KRT35 Gene

SuperPathways for KRT35 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT35: view

Pathways by source for KRT35 Gene

2 Reactome pathways for KRT35 Gene

Interacting Proteins for KRT35 Gene

Gene Ontology (GO) - Biological Process for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 8823373
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT35: view

No data available for SIGNOR curated interactions for KRT35 Gene

Drugs & Compounds for KRT35 Gene

(1) Additional Compounds for KRT35 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT35: view

Transcripts for KRT35 Gene

mRNA/cDNA for KRT35 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT35 Gene

Keratin 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT35 Gene

No ASD Table

Relevant External Links for KRT35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT35 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x40.7) and Skin - Sun Exposed (Lower leg) (x9.1).

Protein differential expression in normal tissues from HIPED for KRT35 Gene

This gene is overexpressed in Hair follicle (54.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT35 Gene

Protein tissue co-expression partners for KRT35 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT35 Gene:


SOURCE GeneReport for Unigene cluster for KRT35 Gene:


mRNA Expression by UniProt/SwissProt for KRT35 Gene:

Tissue specificity: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.

Evidence on tissue expression from TISSUES for KRT35 Gene

  • Skin(4.2)
  • Blood(2.4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with KRT35: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT35 Gene

Orthologs for KRT35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT35 33 34
  • 98.9 (n)
(Canis familiaris)
Mammalia KRT35 33 34
  • 89.52 (n)
(Bos Taurus)
Mammalia KRT35 33 34
  • 88.57 (n)
(Mus musculus)
Mammalia Krt35 33 16 34
  • 87.62 (n)
(Rattus norvegicus)
Mammalia Krt35 33
  • 86.67 (n)
(Monodelphis domestica)
Mammalia KRT35 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491736 33
  • 61.23 (n)
Species where no ortholog for KRT35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT35 Gene

Gene Tree for KRT35 (if available)
Gene Tree for KRT35 (if available)

Paralogs for KRT35 Gene

Variants for KRT35 Gene

Sequence variations from dbSNP and Humsavar for KRT35 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000349646 -- 41,483,834(-) C/T upstream_transcript_variant
rs1001062970 -- 41,477,063(-) C/T coding_sequence_variant, missense_variant
rs1001644174 -- 41,479,236(-) G/T intron_variant
rs1002246038 -- 41,483,740(-) C/T upstream_transcript_variant
rs1002460826 -- 41,482,352(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT35 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv3582667 CNV loss 25503493
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489
nsv526466 CNV gain 19592680

Variation tolerance for KRT35 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT35 Gene

Disorders for KRT35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
skin pilomatrix carcinoma
  • malignant pilomatricoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT35

genes like me logo Genes that share disorders with KRT35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT35 Gene

Publications for KRT35 Gene

  1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers MA … Schweizer J (The Journal of investigative dermatology 1996) 2 3 4 22 58
  2. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. (PMID: 18021261) Gilon M … Gat U (Differentiation; research in biological diversity 2008) 3 22 58
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  4. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L … Schweizer J (The Journal of biological chemistry 1999) 3 22 58
  5. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 3 4 58

Products for KRT35 Gene

Sources for KRT35 Gene

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