The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] See more...

Aliases for KRT35 Gene

Aliases for KRT35 Gene

  • Keratin 35 2 3 5
  • Keratin, Type I Cuticular Ha5 3 4
  • Hair Keratin, Type I Ha5 3 4
  • Keratin, Hair, Acidic, 5 2 3
  • Keratin 35, Type I 2 3
  • KRTHA5 3 4
  • K35 3 4
  • HHa5 Hair Keratin Type I Intermediate Filament 3
  • Hard Keratin, Type I, 5 3
  • Hard Keratin Type I 5 2
  • Keratin-35 4
  • Ha-5 3
  • HHa5 3
  • HHA5 4
  • HKA5 4
  • HA5 3

External Ids for KRT35 Gene

Previous HGNC Symbols for KRT35 Gene

  • KRTHA5

Previous GeneCards Identifiers for KRT35 Gene

  • GC17M036887
  • GC17M039632
  • GC17M035396

Summaries for KRT35 Gene

Entrez Gene Summary for KRT35 Gene

  • The protein encoded by this gene is a member of the keratin gene family. This type I hair keratin is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT35 Gene

KRT35 (Keratin 35) is a Protein Coding gene. Diseases associated with KRT35 include Skin Pilomatrix Carcinoma and Diffuse Alopecia Areata. Among its related pathways are Keratinization and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT36.

Additional gene information for KRT35 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT35 Gene

Genomics for KRT35 Gene

GeneHancer (GH) Regulatory Elements for KRT35 Gene

Promoters and enhancers for KRT35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041484 Enhancer 0.5 Ensembl 500.7 -1.8 -1757 0.2 TAL1 NR2F1 HDAC2 NR2F6 ARID1B HMBOX1 CBFA2T3 NR2F2 KRT35 KRT36
GH17J041481 Promoter 0.3 EPDnew 500.7 +1.7 1655 0.1 KRT35 RF00994-402
GH17J041534 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 -55.4 -55440 7.2 ZNF217 ZSCAN5C TEAD4 ZFX ZIC2 REST CLOCK CUX1 GATAD2B CTBP1 piR-48749-013 KRT36 KRT35 ENSG00000234859 KRT31 KRT19 KRTAP2-1 KRTAP2-2 KRTAP9-1 KRTAP9-2
GH17J041352 Enhancer 0.7 FANTOM5 dbSUPER 1.6 +129.6 129584 0.3 MIER1 REST EHMT2 FOS ZNF629 TSHZ1 KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35 KRT38
GH17J041486 Enhancer 0.8 Ensembl ENCODE 0.7 -4.2 -4191 0.7 CTCF REST MYC SMC3 RAD21 MAX TCF12 EHMT2 SMAD4 SIN3A KRT38 KRT35 KRT36
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT35 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT35

Top Transcription factor binding sites by QIAGEN in the KRT35 gene promoter:
  • ARP-1
  • C/EBPalpha
  • CHOP-10
  • E47
  • Nkx2-5
  • p53
  • Pax-6

Genomic Locations for KRT35 Gene

Genomic Locations for KRT35 Gene
chr17:41,476,689-41,482,743
(GRCh38/hg38)
Size:
6,055 bases
Orientation:
Minus strand
chr17:39,632,941-39,637,392
(GRCh37/hg19)
Size:
4,452 bases
Orientation:
Minus strand

Genomic View for KRT35 Gene

Genes around KRT35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT35 Gene

Proteins for KRT35 Gene

  • Protein details for KRT35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92764-KRT35_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha5
    Protein Accession:
    Q92764
    Secondary Accessions:
    • O76012
    • Q92651

    Protein attributes for KRT35 Gene

    Size:
    455 amino acids
    Molecular mass:
    50361 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    SequenceCaution:
    • Sequence=CAA62286.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA76387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for KRT35 Gene

Post-translational modifications for KRT35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT35 Gene

Domains & Families for KRT35 Gene

Gene Families for KRT35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT35 Gene

Blocks:
  • Intermediate filament protein
  • Type I keratin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRT35 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-35 (KRT35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92764

UniProtKB/Swiss-Prot:

KRT35_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT35: view

Function for KRT35 Gene

Gene Ontology (GO) - Molecular Function for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT35: view
genes like me logo Genes that share phenotypes with KRT35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT35

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT35 Gene

Localization for KRT35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT35 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
plasma membrane 2
mitochondrion 2
nucleus 2
golgi apparatus 2
extracellular 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT35: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT35 Gene

Pathways & Interactions for KRT35 Gene

genes like me logo Genes that share pathways with KRT35: view

Pathways by source for KRT35 Gene

2 Reactome pathways for KRT35 Gene

Gene Ontology (GO) - Biological Process for KRT35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 8823373
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT35: view

No data available for SIGNOR curated interactions for KRT35 Gene

Drugs & Compounds for KRT35 Gene

(1) Additional Compounds for KRT35 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT35: view

Transcripts for KRT35 Gene

mRNA/cDNA for KRT35 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT35

Alternative Splicing Database (ASD) splice patterns (SP) for KRT35 Gene

No ASD Table

Relevant External Links for KRT35 Gene

GeneLoc Exon Structure for
KRT35

Expression for KRT35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT35 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x40.7) and Skin - Sun Exposed (Lower leg) (x9.1).

Protein differential expression in normal tissues from HIPED for KRT35 Gene

This gene is overexpressed in Hair follicle (54.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT35 Gene



Protein tissue co-expression partners for KRT35 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT35

SOURCE GeneReport for Unigene cluster for KRT35 Gene:

Hs.73082

mRNA Expression by UniProt/SwissProt for KRT35 Gene:

Q92764-KRT35_HUMAN
Tissue specificity: Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.

Evidence on tissue expression from TISSUES for KRT35 Gene

  • Skin(4.2)
  • Blood(2.4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with KRT35: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT35 Gene

Orthologs for KRT35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT35 31 30
  • 98.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KRT35 31 30
  • 89.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KRT35 31 30
  • 88.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Krt35 17 31 30
  • 87.62 (n)
rat
(Rattus norvegicus)
Mammalia Krt35 30
  • 86.67 (n)
oppossum
(Monodelphis domestica)
Mammalia KRT35 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491736 30
  • 61.23 (n)
Species where no ortholog for KRT35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT35 Gene

ENSEMBL:
Gene Tree for KRT35 (if available)
TreeFam:
Gene Tree for KRT35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT35: view image

Paralogs for KRT35 Gene

genes like me logo Genes that share paralogs with KRT35: view

Variants for KRT35 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT35 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs12451652 - p.Cys441Tyr
rs2071601 - p.Pro443Ala
rs743686 - p.Ser36Pro

Additional dbSNP identifiers (rs#s) for KRT35 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT35 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv3582667 CNV loss 25503493
nsv1146669 OTHER inversion 26484159
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489
nsv526466 CNV gain 19592680

Variation tolerance for KRT35 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT35

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT35 Gene

Disorders for KRT35 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KRT35 Gene - From: DISEASES

Disorder Aliases PubMed IDs
skin pilomatrix carcinoma
  • malignant pilomatricoma
diffuse alopecia areata
  • diffuse alopecia
hair follicle neoplasm
  • hair matrix neoplasm
pilomatrixoma
  • pilomatricoma; ptr
- elite association - COSMIC cancer census association via MalaCards
Search KRT35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT35

genes like me logo Genes that share disorders with KRT35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT35 Gene

Publications for KRT35 Gene

  1. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers MA … Schweizer J (The Journal of investigative dermatology 1996) 2 3 4 23 54
  2. Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA. (PMID: 18021261) Gilon M … Gat U (Differentiation; research in biological diversity 2008) 3 23 54
  3. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 54
  4. The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L … Schweizer J (The Journal of biological chemistry 1999) 3 23 54
  5. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 3 4 54

Products for KRT35 Gene

Sources for KRT35 Gene