The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008] See more...

Aliases for KRT34 Gene

Aliases for KRT34 Gene

  • Keratin 34 2 3 5
  • Keratin, Type I Cuticular Ha4 3 4
  • Hair Keratin, Type I Ha4 3 4
  • Keratin, Hair, Acidic, 4 2 3
  • Keratin 34, Type I 2 3
  • KRTHA4 3 4
  • K34 3 4
  • Hard Keratin, Type I, 4 3
  • Hard Keratin Type I 4 2
  • Keratin-34 4
  • Ha-4 3
  • HHa4 3
  • HHA4 4
  • HKA4 4
  • HA4 3

External Ids for KRT34 Gene

Previous HGNC Symbols for KRT34 Gene

  • KRTHA4

Previous GeneCards Identifiers for KRT34 Gene

  • GC17M036788
  • GC17M039534
  • GC17M035298

Summaries for KRT34 Gene

Entrez Gene Summary for KRT34 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT34 Gene

KRT34 (Keratin 34) is a Protein Coding gene. Diseases associated with KRT34 include Sarcomatoid Squamous Cell Skin Carcinoma. Among its related pathways are Keratinization and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT33A.

Gene Wiki entry for KRT34 Gene

Additional gene information for KRT34 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT34 Gene

Genomics for KRT34 Gene

GeneHancer (GH) Regulatory Elements for KRT34 Gene

Promoters and enhancers for KRT34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041377 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 542.1 +3.5 3514 6.2 EP300 CEBPB JUN JUND RFX5 STAT3 FOXP2 BHLHE40 ZBTB40 SREBF1 KRT34 KRT38 KRT32 KRT36 KRT33B
GH17J041392 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 534.8 -10.4 -10357 2.9 EP300 FOSL2 JUND FOS REST KRT34 KRT38 KRT32 KRT31 HSALNG0116428
GH17J041401 Enhancer 1.1 Ensembl ENCODE 38.2 -20.3 -20262 4.2 NCOR1 JUND FOS ZNF639 TCF7 TRIM28 RFX1 EP300 TEAD1 TBX3 ENSG00000234859 LOC100505782 KRT34 KRT38 ENSG00000267758 KRT36 KRT31 KRT41P
GH17J041414 Enhancer 1.1 Ensembl ENCODE 38 -34.6 -34611 7 ZNF217 CTCF NCOR1 TCF7 SKI TEAD1 ZBTB26 GATAD2B CTBP1 NR2F2 KRT34 KRT32 KRT38 KRT36 KRT31 KRT37 KRT41P ENSG00000234859
GH17J041333 Enhancer 1 Ensembl ENCODE dbSUPER 37 +44.9 44928 10.2 NRF1 RELA MAFF ARNT MEF2B NBN SPI1 GATA3 YBX1 EBF1 KRT34 KRT38 KRT32 KRTAP16-1 KRTAP29-1 KRT31 ENSG00000234859 KRTAP17-1 KRTAP9-6 KRT37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT34 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT34

Top Transcription factor binding sites by QIAGEN in the KRT34 gene promoter:
  • CREB
  • E47
  • FAC1
  • Ik-2
  • LyF-1
  • Msx-1
  • Nkx2-5
  • Spz1
  • Tal-1

Genomic Locations for KRT34 Gene

Genomic Locations for KRT34 Gene
chr17:41,377,650-41,383,816
(GRCh38/hg38)
Size:
6,167 bases
Orientation:
Minus strand
chr17:39,533,902-39,538,655
(GRCh37/hg19)
Size:
4,754 bases
Orientation:
Minus strand

Genomic View for KRT34 Gene

Genes around KRT34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT34 Gene

Proteins for KRT34 Gene

  • Protein details for KRT34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76011-KRT34_HUMAN
    Recommended name:
    Keratin, type I cuticular Ha4
    Protein Accession:
    O76011
    Secondary Accessions:
    • Q8IUT8
    • Q8N4W2

    Protein attributes for KRT34 Gene

    Size:
    436 amino acids
    Molecular mass:
    49424 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    SequenceCaution:
    • Sequence=CAA76386.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KRT34 Gene

Post-translational modifications for KRT34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT34 Gene

Domains & Families for KRT34 Gene

Gene Families for KRT34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT34 Gene

Blocks:
  • Intermediate filament protein
  • Type I keratin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRT34 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-34 (KRT34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O76011

UniProtKB/Swiss-Prot:

KRT34_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT34: view

Function for KRT34 Gene

Phenotypes From GWAS Catalog for KRT34 Gene

Gene Ontology (GO) - Molecular Function for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT34: view
genes like me logo Genes that share phenotypes with KRT34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT34 Gene

Localization for KRT34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT34 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 2
plasma membrane 1
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT34 Gene

Pathways & Interactions for KRT34 Gene

genes like me logo Genes that share pathways with KRT34: view

Pathways by source for KRT34 Gene

2 Reactome pathways for KRT34 Gene

Gene Ontology (GO) - Biological Process for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9756910
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT34: view

No data available for SIGNOR curated interactions for KRT34 Gene

Drugs & Compounds for KRT34 Gene

No Compound Related Data Available

Transcripts for KRT34 Gene

mRNA/cDNA for KRT34 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT34

Alternative Splicing Database (ASD) splice patterns (SP) for KRT34 Gene

No ASD Table

Relevant External Links for KRT34 Gene

GeneLoc Exon Structure for
KRT34

Expression for KRT34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT34 Gene

mRNA differential expression in normal tissues according to GTEx for KRT34 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.7).

Protein differential expression in normal tissues from HIPED for KRT34 Gene

This gene is overexpressed in Hair follicle (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT34 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT34

SOURCE GeneReport for Unigene cluster for KRT34 Gene:

Hs.296942

mRNA Expression by UniProt/SwissProt for KRT34 Gene:

O76011-KRT34_HUMAN
Tissue specificity: Expressed in the hair follicles.

Evidence on tissue expression from TISSUES for KRT34 Gene

  • Skin(4.6)
genes like me logo Genes that share expression patterns with KRT34: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT34 Gene

Orthologs for KRT34 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT34 30
  • 95.64 (n)
rat
(Rattus norvegicus)
Mammalia Krt34 30
  • 87.66 (n)
mouse
(Mus musculus)
Mammalia Krt34 17 31 30
  • 87.59 (n)
Krt33a 31
  • 83 (a)
ManyToMany
Krt33b 31
  • 82 (a)
ManyToMany
Krt31 31
  • 80 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia KRT34 30
  • 86.19 (n)
HKA1 31
  • 84 (a)
ManyToMany
KRT33A 31
  • 83 (a)
ManyToMany
-- 31
  • 82 (a)
ManyToMany
KRT31 31
  • 80 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 82 (a)
ManyToMany
-- 31
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
ManyToMany
-- 31
  • 77 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 76 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
-- 31
  • 74 (a)
ManyToMany
Species where no ortholog for KRT34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT34 Gene

ENSEMBL:
Gene Tree for KRT34 (if available)
TreeFam:
Gene Tree for KRT34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT34: view image

Paralogs for KRT34 Gene

(33) SIMAP similar genes for KRT34 Gene using alignment to 2 proteins:

  • KRT34_HUMAN
  • L0R6J1_HUMAN
genes like me logo Genes that share paralogs with KRT34: view

Variants for KRT34 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT34 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs2071599 - p.His348Arg
rs2239710 - p.Ile280Thr

Additional dbSNP identifiers (rs#s) for KRT34 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT34 Gene

Variant ID Type Subtype PubMed ID
dgv1756e59 CNV duplication 20981092
dgv526n67 CNV gain 20364138
dgv5598n54 CNV gain 21841781
esv24006 CNV gain 19812545
esv2758690 CNV gain+loss 17122850
esv2760456 CNV gain+loss 21179565
esv2761958 CNV gain 21179565
esv3573208 CNV gain 25503493
esv3640585 CNV gain 21293372
nsv1146669 OTHER inversion 26484159
nsv1151604 CNV duplication 26484159
nsv2052 CNV insertion 18451855
nsv442745 CNV gain 18776908
nsv483014 CNV loss 15286789
nsv499238 CNV gain 21111241
nsv509656 CNV insertion 20534489
nsv513753 CNV insertion 21212237
nsv514845 CNV gain 21397061
nsv525048 CNV gain 19592680
nsv575037 CNV gain 21841781
nsv817764 CNV gain 17921354
nsv817765 CNV gain 17921354
nsv955398 CNV deletion 24416366
nsv9554 CNV gain 18304495
nsv960104 CNV duplication 23825009
nsv960602 CNV duplication 23825009
nsv978424 CNV duplication 23825009

Variation tolerance for KRT34 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.87; 79.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT34 Gene

Disorders for KRT34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT34 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sarcomatoid squamous cell skin carcinoma
  • spindle cell squamous cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT34 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT34

genes like me logo Genes that share disorders with KRT34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT34 Gene

Publications for KRT34 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 54
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 54
  3. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid HW … Franke WW (Differentiation; research in biological diversity 1986) 2 3 54
  4. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3 54
  5. Diagnostic Value of ERG in Prostate Needle Biopsies Containing Minute Cancer Foci. (PMID: 28384107) Bachurska SY … Belovezhdov VT (Folia medica 2017) 3 54

Products for KRT34 Gene

Sources for KRT34 Gene