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Aliases for KRT34 Gene

Aliases for KRT34 Gene

  • Keratin 34 2 3 5
  • Keratin, Hair, Acidic, 4 2 3
  • Hair Keratin, Type I Ha4 3 4
  • Keratin 34, Type I 2 3
  • KRTHA4 3 4
  • HHa4 3 4
  • K34 3 4
  • Keratin, Type I Cuticular Ha4 3
  • Hard Keratin, Type I, 4 3
  • Hard Keratin Type I 4 2
  • Keratin-34 4
  • Ha-4 3
  • HKA4 4
  • HA4 3

External Ids for KRT34 Gene

Previous HGNC Symbols for KRT34 Gene

  • KRTHA4

Previous GeneCards Identifiers for KRT34 Gene

  • GC17M036788
  • GC17M039534
  • GC17M035298

Summaries for KRT34 Gene

Entrez Gene Summary for KRT34 Gene

  • The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT34 Gene

KRT34 (Keratin 34) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT33A.

Gene Wiki entry for KRT34 Gene

Additional gene information for KRT34 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT34 Gene

Genomics for KRT34 Gene

GeneHancer (GH) Regulatory Elements for KRT34 Gene

Promoters and enhancers for KRT34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I041401 Enhancer 1.1 Ensembl ENCODE 38.2 -19.9 -19856 3.4 PKNOX1 FOXA2 FEZF1 GLIS2 FOS JUNB REST TSHZ1 ZNF518A NFIL3 LOC100505782 KRT34 KRT38 ENSG00000267758 KRT36 KRT41P
GH17I041414 Enhancer 1.1 Ensembl ENCODE 38 -34.6 -34611 7 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 ZNF48 ETS1 ZNF143 FOS KRT34 KRT32 KRT38 KRT36 KRT31 KRT37 KRT41P LOC100505782
GH17I041377 Enhancer 0.8 Ensembl ENCODE 42.2 +3.8 3847 5.5 SREBF1 JUND JUN STAT3 CEBPB FOXP2 EP300 RFX5 KRT34 KRT38 KRT32 KRT36 KRT33B
GH17I041360 Enhancer 0.7 ENCODE dbSUPER 26.9 +23.0 23009 1.1 ZNF146 JUND ZNF580 FOS KRT34 KRT33A KRT33B
GH17I041333 Enhancer 0.5 ENCODE dbSUPER 37 +49.1 49146 1.8 EBF1 ENSG00000108516 KRT34 KRTAP29-1 KRT31 LOC100505782 KRT37 ENSG00000234477 KRT40 KRT33A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT34 gene promoter:

Genomic Locations for KRT34 Gene

Genomic Locations for KRT34 Gene
6,167 bases
Minus strand

Genomic View for KRT34 Gene

Genes around KRT34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT34 Gene

Proteins for KRT34 Gene

  • Protein details for KRT34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha4
    Protein Accession:
    Secondary Accessions:
    • Q8IUT8
    • Q8N4W2

    Protein attributes for KRT34 Gene

    436 amino acids
    Molecular mass:
    49424 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
    • Sequence=CAA76386.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KRT34 Gene

Post-translational modifications for KRT34 Gene

No Post-translational modifications

Other Protein References for KRT34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT34 Gene

Domains & Families for KRT34 Gene

Gene Families for KRT34 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT34: view

Function for KRT34 Gene

Phenotypes From GWAS Catalog for KRT34 Gene

Gene Ontology (GO) - Molecular Function for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT34: view

Phenotypes for KRT34 Gene

GenomeRNAi human phenotypes for KRT34:
genes like me logo Genes that share phenotypes with KRT34: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT34 Gene

Localization for KRT34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT34 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA,HDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with KRT34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT34 Gene

Pathways & Interactions for KRT34 Gene

SuperPathways for KRT34 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT34: view

Pathways by source for KRT34 Gene

2 Reactome pathways for KRT34 Gene

Interacting Proteins for KRT34 Gene

Gene Ontology (GO) - Biological Process for KRT34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 9756910
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT34: view

No data available for SIGNOR curated interactions for KRT34 Gene

Drugs & Compounds for KRT34 Gene

No Compound Related Data Available

Transcripts for KRT34 Gene

mRNA/cDNA for KRT34 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT34 Gene

Keratin 34:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT34 Gene

No ASD Table

Relevant External Links for KRT34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT34 Gene

mRNA differential expression in normal tissues according to GTEx for KRT34 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.7).

Protein differential expression in normal tissues from HIPED for KRT34 Gene

This gene is overexpressed in Hair follicle (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT34 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT34 Gene:


SOURCE GeneReport for Unigene cluster for KRT34 Gene:


mRNA Expression by UniProt/SwissProt for KRT34 Gene:

Tissue specificity: Expressed in the hair follicles.

Evidence on tissue expression from TISSUES for KRT34 Gene

  • Skin(4.6)
genes like me logo Genes that share expression patterns with KRT34: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT34 Gene

Orthologs for KRT34 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT34 33
  • 95.64 (n)
(Rattus norvegicus)
Mammalia Krt34 33
  • 87.66 (n)
(Mus musculus)
Mammalia Krt34 33 16 34
  • 87.59 (n)
Krt33a 34
  • 83 (a)
Krt33b 34
  • 82 (a)
Krt31 34
  • 80 (a)
(Bos Taurus)
Mammalia KRT34 33
  • 86.19 (n)
HKA1 34
  • 84 (a)
KRT33A 34
  • 83 (a)
-- 34
  • 82 (a)
KRT31 34
  • 80 (a)
(Canis familiaris)
Mammalia -- 34
  • 82 (a)
-- 34
  • 81 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
-- 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
-- 34
  • 74 (a)
-- 34
  • 74 (a)
Species where no ortholog for KRT34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT34 Gene

Gene Tree for KRT34 (if available)
Gene Tree for KRT34 (if available)

Paralogs for KRT34 Gene

genes like me logo Genes that share paralogs with KRT34: view

Variants for KRT34 Gene

Sequence variations from dbSNP and Humsavar for KRT34 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000333785 -- 41,385,418(-) T/C upstream_transcript_variant
rs1000339690 -- 41,384,268(-) T/C upstream_transcript_variant
rs1000543844 -- 41,378,326(-) T/C intron_variant
rs1001056170 -- 41,383,382(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001076589 -- 41,383,052(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT34 Gene

Variant ID Type Subtype PubMed ID
nsv978424 CNV duplication 23825009
nsv960602 CNV duplication 23825009
nsv960104 CNV duplication 23825009
nsv9554 CNV gain 18304495
nsv955398 CNV deletion 24416366
nsv817765 CNV gain 17921354
nsv817764 CNV gain 17921354
nsv575037 CNV gain 21841781
nsv525048 CNV gain 19592680
nsv514845 CNV gain 21397061
nsv513753 CNV insertion 21212237
nsv509656 CNV insertion 20534489
nsv499238 CNV gain 21111241
nsv483014 CNV loss 15286789
nsv442745 CNV gain 18776908
nsv2052 CNV insertion 18451855
nsv1151604 CNV duplication 26484159
nsv1146669 OTHER inversion 26484159
esv3640585 CNV gain 21293372
esv3573208 CNV gain 25503493
esv2761958 CNV gain 21179565
esv2760456 CNV gain+loss 21179565
esv2758690 CNV gain+loss 17122850
esv24006 CNV gain 19812545
dgv5598n54 CNV gain 21841781
dgv526n67 CNV gain 20364138
dgv1756e59 CNV duplication 20981092

Variation tolerance for KRT34 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.87; 79.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT34 Gene

Disorders for KRT34 Gene

Additional Disease Information for KRT34

No disorders were found for KRT34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT34 Gene

Publications for KRT34 Gene

  1. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 2 3 4 58
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  3. The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins. (PMID: 2431943) Heid HW … Franke WW (Differentiation; research in biological diversity 1986) 2 3 58
  4. Diagnostic Value of ERG in Prostate Needle Biopsies Containing Minute Cancer Foci. (PMID: 28384107) Bachurska SY … Belovezhdov VT (Folia medica 2017) 3 58
  5. Keratin 34betaE12/keratin7 expression is a prognostic factor of cancer-specific and overall survival in patients with early stage non-small cell lung cancer. (PMID: 26057535) Pøhl M … Hansen O (Acta oncologica (Stockholm, Sweden) 2016) 3 58

Products for KRT34 Gene

Sources for KRT34 Gene

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