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Aliases for KRT33B Gene

Aliases for KRT33B Gene

  • Keratin 33B 2 3 5
  • Hair Keratin, Type I Ha3-II 3 4
  • Keratin, Hair, Acidic, 3B 2 3
  • Keratin 33B, Type I 2 3
  • KRTHA3B 3 4
  • K33B 3 4
  • Keratin, Type I Cuticular Ha3-II 3
  • Hard Keratin, Type I, 3II 3
  • Hard Keratin Type I 3II 2
  • Type I Hair Keratin 3B 3
  • Keratin-33B 4
  • KRTHA3A 3
  • HHa3-II 3
  • HHA3-II 4
  • Ha-3II 3
  • HA3II 3
  • HKA3B 4

External Ids for KRT33B Gene

Previous HGNC Symbols for KRT33B Gene


Previous GeneCards Identifiers for KRT33B Gene

  • GC17M036774
  • GC17M039519
  • GC17M035284

Summaries for KRT33B Gene

Entrez Gene Summary for KRT33B Gene

  • This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

GeneCards Summary for KRT33B Gene

KRT33B (Keratin 33B) is a Protein Coding gene. Diseases associated with KRT33B include Type I. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT31.

Gene Wiki entry for KRT33B Gene

Additional gene information for KRT33B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT33B Gene

Genomics for KRT33B Gene

GeneHancer (GH) Regulatory Elements for KRT33B Gene

Promoters and enhancers for KRT33B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J041367 Enhancer 0.6 ENCODE dbSUPER 650.7 +2.0 1973 1.1 JUND ZBTB17 KRT33B KRT38 KRT36 KRT33A
GH17J041369 Promoter 0.5 EPDnew 650.7 0.0 -33 0.1 KRT33B KRT34
GH17J041377 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 0.4 -10.2 -10169 5.5 JUN CEBPB EP300 RFX5 SREBF1 JUND STAT3 FOXP2 MAFK KRT34 KRT38 KRT32 KRT36 KRT33B
GH17J041360 Enhancer 0.7 ENCODE dbSUPER 0.4 +9.0 8993 1.1 ZNF146 JUND ZNF580 FOS KRT34 KRT33A KRT33B
GH17J041352 Enhancer 0.7 FANTOM5 dbSUPER 0.4 +16.6 16641 0.3 ZNF629 TSHZ1 REST KRTAP2-1 KRTAP9-1 KRTAP2-2 KRTAP9-2 KRTAP9-9 KRT37 KRT40 KRTAP2-4 KRT35 KRT38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT33B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT33B gene promoter:
  • Spz1
  • Msx-1
  • Nkx2-5
  • Ik-2
  • E47
  • Tal-1
  • AP-2gamma
  • Nkx5-1
  • ATF6

Genomic Locations for KRT33B Gene

Genomic Locations for KRT33B Gene
6,307 bases
Minus strand
6,307 bases
Minus strand

Genomic View for KRT33B Gene

Genes around KRT33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT33B Gene

Proteins for KRT33B Gene

  • Protein details for KRT33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cuticular Ha3-II
    Protein Accession:
    Secondary Accessions:
    • O76010

    Protein attributes for KRT33B Gene

    404 amino acids
    Molecular mass:
    46214 Da
    Quaternary structure:
    No Data Available
    • There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

neXtProt entry for KRT33B Gene

Post-translational modifications for KRT33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT33B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT33B Gene

Domains & Families for KRT33B Gene

Gene Families for KRT33B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT33B Gene

Suggested Antigen Peptide Sequences for KRT33B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT33B: view

Function for KRT33B Gene

Gene Ontology (GO) - Molecular Function for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with KRT33B: view
genes like me logo Genes that share phenotypes with KRT33B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT33B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT33B Gene

Localization for KRT33B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT33B gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 23580065
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT33B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT33B Gene

Pathways & Interactions for KRT33B Gene

genes like me logo Genes that share pathways with KRT33B: view

Pathways by source for KRT33B Gene

2 Reactome pathways for KRT33B Gene
1 KEGG pathway for KRT33B Gene

Gene Ontology (GO) - Biological Process for KRT33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IDA 21916889
GO:0031424 keratinization TAS --
GO:0042633 hair cycle IDA 21916889
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT33B: view

No data available for SIGNOR curated interactions for KRT33B Gene

Drugs & Compounds for KRT33B Gene

No Compound Related Data Available

Transcripts for KRT33B Gene

mRNA/cDNA for KRT33B Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT33B Gene

Keratin 33B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT33B

Alternative Splicing Database (ASD) splice patterns (SP) for KRT33B Gene

No ASD Table

Relevant External Links for KRT33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT33B Gene

mRNA differential expression in normal tissues according to GTEx for KRT33B Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x46.3) and Skin - Sun Exposed (Lower leg) (x5.8).

Protein differential expression in normal tissues from HIPED for KRT33B Gene

This gene is overexpressed in Hair follicle (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT33B Gene

Protein tissue co-expression partners for KRT33B Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT33B Gene:


SOURCE GeneReport for Unigene cluster for KRT33B Gene:


Evidence on tissue expression from TISSUES for KRT33B Gene

  • Skin(4.3)
  • Kidney(4.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT33B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT33B Gene

Orthologs for KRT33B Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT33B 34
  • 99 (a)
(Mus musculus)
Mammalia Krt33a 34
  • 88 (a)
Krt33b 34
  • 87 (a)
Krt34 34
  • 86 (a)
Krt31 34
  • 85 (a)
(Canis familiaris)
Mammalia -- 34
  • 88 (a)
-- 34
  • 87 (a)
(Bos Taurus)
Mammalia -- 34
  • 87 (a)
KRT33A 34
  • 86 (a)
HKA1 34
  • 85 (a)
KRT31 34
  • 83 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 83 (a)
-- 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
-- 34
  • 79 (a)
-- 34
  • 79 (a)
Species where no ortholog for KRT33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT33B Gene

Gene Tree for KRT33B (if available)
Gene Tree for KRT33B (if available)
Evolutionary constrained regions (ECRs) for KRT33B: view image

Paralogs for KRT33B Gene

Paralogs for KRT33B Gene

(37) SIMAP similar genes for KRT33B Gene using alignment to 1 proteins:

  • KT33B_HUMAN Pseudogenes for KRT33B Gene

genes like me logo Genes that share paralogs with KRT33B: view

Variants for KRT33B Gene

Sequence variations from dbSNP and Humsavar for KRT33B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1001513582 -- 41,364,885(-) C/T coding_sequence_variant, missense_variant
rs1001533348 -- 41,370,098(-) C/T upstream_transcript_variant
rs1001534485 -- 41,371,770(-) A/G upstream_transcript_variant
rs1001546133 -- 41,365,070(-) C/T intron_variant
rs1001847099 -- 41,366,085(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT33B Gene

Variant ID Type Subtype PubMed ID
dgv23n64 CNV loss 17921354
dgv3171n100 CNV loss 25217958
dgv3172n100 CNV loss 25217958
dgv3173n100 CNV loss 25217958
esv2422104 CNV deletion 20811451
esv25327 CNV loss 19812545
esv2671270 CNV deletion 23128226
esv2758690 CNV gain+loss 17122850
esv2760456 CNV gain+loss 21179565
esv2762377 CNV loss 21179565
esv3640584 CNV loss 21293372
nsv1146669 OTHER inversion 26484159
nsv1160486 CNV duplication 26073780
nsv2051 CNV deletion 18451855
nsv438274 CNV loss 16468122
nsv442744 CNV loss 18776908
nsv457741 CNV loss 19166990
nsv483014 CNV loss 15286789
nsv509656 CNV insertion 20534489
nsv514844 CNV loss 21397061
nsv516965 CNV loss 19592680
nsv518572 CNV loss 19592680
nsv526464 CNV gain 19592680
nsv575036 CNV loss 21841781
nsv9553 CNV loss 18304495
nsv960103 CNV duplication 23825009
nsv960488 CNV duplication 23825009
nsv960601 CNV deletion 23825009

Variation tolerance for KRT33B Gene

Residual Variation Intolerance Score: 96.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT33B Gene

Disorders for KRT33B Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT33B Gene - From: GeneCards

Disorder Aliases PubMed IDs
type i
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KRT33B

genes like me logo Genes that share disorders with KRT33B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT33B Gene

Publications for KRT33B Gene

  1. A novel human type I hair keratin gene: evidence for two keratin hHa3 isoforms. (PMID: 7565656) Rogers MA … Winter H (Molecular biology reports 1994) 2 3 4 58
  2. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 3 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for KRT33B Gene

Sources for KRT33B Gene

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