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The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
KRT32 (Keratin 32) is a Protein Coding gene. Among its related pathways are Relaxin signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT35.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005198 | structural molecule activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0005882 | intermediate filament | IEA | -- |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Relaxin signaling pathway | ||
2 | Staphylococcus aureus infection | ||
3 | Developmental Biology | ||
4 | Keratinization |
.33
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008544 | epidermis development | TAS | 7556444 |
GO:0031424 | keratinization | TAS | -- |
GO:0070268 | cornification | TAS | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | KRT32 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | KRT32 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Krt32 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | KRT32 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Krt32 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | KRT32 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1111168 | - | p.Glu151Asp | |||
rs16966929 | - | p.Thr339Met | |||
rs2071560 | - | p.Ile171Thr | |||
rs2071561 | - | p.Ser222Tyr | |||
rs2071563 | - | p.Thr395Met |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758690 | CNV | gain+loss | 17122850 |
nsv1146669 | OTHER | inversion | 26484159 |
nsv483014 | CNV | loss | 15286789 |
nsv510711 | CNV | deletion | 20534489 |
No disorders were found for KRT32 Gene.