Aliases for KRT32 Gene
Aliases for KRT32 Gene
External Ids for KRT32 Gene
- HGNC: 6449
- Entrez Gene: 3882
- Ensembl: ENSG00000108759
- OMIM: 602760
- UniProtKB: Q14532
Previous HGNC Symbols for KRT32 Gene
- KRTHA2
Previous GeneCards Identifiers for KRT32 Gene
- GC17M036870
- GC17M039615
- GC17M035379
Summaries for KRT32 Gene
-
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT32 Gene
KRT32 (Keratin 32) is a Protein Coding gene. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT35.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT32 Gene
Genomics for KRT32 Gene
GeneHancer (GH) Regulatory Elements for KRT32 Gene
Promoters and enhancers for KRT32 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRT32 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRT32 gene promoter:
-
- CHOP-10
- CUTL1
- ARP-1
- Nkx2-5
- C/EBPalpha
- Tal-1beta
- E47
Regulatory Element Products
Genomic Locations for KRT32 Gene
Genomic Locations for KRT32 Gene
- chr17:41,459,513-41,469,252
- (GRCh38/hg38)
- Size:
- 9,740 bases
- Orientation:
- Minus strand
- chr17:39,615,765-39,623,681
- (GRCh37/hg19)
- Size:
- 7,917 bases
- Orientation:
- Minus strand
Genomic View for KRT32 Gene
Genes around KRT32 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
- 17q21.2 by Ensembl
KRT32 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRT32 Gene
Proteins for KRT32 Gene
-
Protein details for KRT32 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14532-K1H2_HUMAN
- Recommended name:
- Keratin, type I cuticular Ha2
- Protein Accession:
- Q14532
Protein attributes for KRT32 Gene
- Size:
- 448 amino acids
- Molecular mass:
- 50343 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
- SequenceCaution:
-
- Sequence=CAA57179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for KRT32 Gene
Post-translational modifications for KRT32 Gene
Other Protein References for KRT32 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KRT32
- Novus Biologicals Antibodies for KRT32
- Invitrogen Antibodies for KRT32 (AFLGC-KRT32)
- Search GeneTex for Antibodies for KRT32
-
Boster Bio Antibodies for KRT32
Protein Products
-
OriGene Purified Proteins for KRT32
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- Search GeneTex for Proteins for KRT32
-
Abcam proteins for KRT32
Assay Products
No data available for DME Specific Peptides for KRT32 Gene
Domains & Families for KRT32 Gene
Gene Families for KRT32 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for KRT32 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRT32 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14532- Family:
-
- Belongs to the intermediate filament family.
Function for KRT32 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
Phenotypes for KRT32 Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for KRT32
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- Overview of 71 available KRT32 gene related products
- Applied Biological Materials CRISPR for KRT32
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT32
- GenScript: Design CRISPR guide RNA sequences for KRT32
miRNA for KRT32 Gene
- miRTarBase miRNAs that target KRT32
-
- hsa-mir-335-5p (MIRT019160)
- hsa-mir-26b-5p (MIRT030276)
- hsa-mir-4753-3p (MIRT650704)
- hsa-mir-6867-3p (MIRT650705)
- hsa-mir-7111-3p (MIRT650706)
- hsa-mir-130b-5p (MIRT650707)
- hsa-mir-4685-3p (MIRT650708)
- hsa-mir-4287 (MIRT650709)
- hsa-mir-7113-3p (MIRT650710)
- hsa-mir-4469 (MIRT650711)
- hsa-mir-6769b-3p (MIRT650712)
- hsa-mir-4723-3p (MIRT650713)
- hsa-mir-5193 (MIRT650714)
- hsa-mir-3183 (MIRT650715)
- hsa-mir-1470 (MIRT650716)
- hsa-mir-4667-3p (MIRT650717)
- hsa-mir-944 (MIRT650718)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRT32
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- genomics-online: shRNA clones - Search results for 71 available KRT32 gene related products
- Overview of 71 available KRT32 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRT32
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- Applied Biological Materials Clones for KRT32
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRT32
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT32 Gene
Localization for KRT32 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| cytoskeleton | 3 |
| mitochondrion | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT32 Gene
Pathways & Interactions for KRT32 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Circadian entrainment | ||
| 2 | Developmental Biology | ||
| 3 | Keratinization |
.33
|
|
Pathways by source for KRT32 Gene
2 Reactome pathways for KRT32 Gene
1 KEGG pathway for KRT32 Gene
Interacting Proteins for KRT32 Gene
GPS-Prot Interaction Network for KRT32
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | TAS | 7556444 |
| GO:0031424 | keratinization | TAS | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for KRT32 Gene
Transcripts for KRT32 Gene
mRNA/cDNA for KRT32 Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (18) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000225899 1750 bps (uc002hwr.4)
CRISPR Products
-
OriGene CRISPR knockouts for KRT32
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT32
- genomics-online: gRNA clones - Search results for 71 available KRT32 gene related products
- Overview of 71 available KRT32 gene related products
- Applied Biological Materials CRISPR for KRT32
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT32
- GenScript: Design CRISPR guide RNA sequences for KRT32
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRT32
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- Overview of 71 available KRT32 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRT32
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- Applied Biological Materials Clones for KRT32
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KRT32 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
-
Epithelial Cells
- Fetal Hair Shaft Cuticle Cells Hair Shaft
- Fetal Medulla Cells Hair Shaft
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for KRT32 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x34.1), Skin - Sun Exposed (Lower leg) (x8.0), and Esophagus - Mucosa (x5.1).
This gene is overexpressed in Cervix (21.9), Skin (15.9), Saliva (11.1), and Bone marrow mesenchymal stem cell (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT32 Gene
NURSA nuclear receptor signaling pathways regulating expression of KRT32 Gene:
KRT32SOURCE GeneReport for Unigene cluster for KRT32 Gene:
Hs.41752mRNA Expression by UniProt/SwissProt for KRT32 Gene:
Q14532-K1H2_HUMAN
Tissue specificity:
Restricted to the hair cuticle.
Evidence on tissue expression from TISSUES for KRT32 Gene
- Skin(4)
- Gall bladder(2)
Primer Products
-
OriGene qPCR primer pairs for KRT32
- genomics-online: primer clones - Search results for 71 available KRT32 gene related products
- Overview of 71 available KRT32 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT32 Gene
Orthologs for KRT32 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KRT32 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KRT32 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Krt32 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | KRT32 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Krt32 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | KRT32 34 |
|
OneToOne |
- Species where no ortholog for KRT32 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KRT32 Gene
- ENSEMBL:
- Gene Tree for KRT32 (if available)
- TreeFam:
- Gene Tree for KRT32 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRT32: view image
Paralogs for KRT32 Gene
Paralogs for KRT32 Gene
(33) SIMAP similar genes for KRT32 Gene using alignment to 1 proteins:
- K1H2_HUMAN
Variants for KRT32 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000275820 | -- | 41,461,852(-) | G/T | genic_downstream_transcript_variant, intron_variant | |
| rs1000686036 | -- | 41,467,973(-) | T/C | genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000709323 | -- | 41,462,235(-) | T/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000762442 | -- | 41,468,204(-) | C/A | genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1000904388 | -- | 41,463,459(-) | C/T | genic_downstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758690 | CNV | gain+loss | 17122850 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv483014 | CNV | loss | 15286789 |
| nsv510711 | CNV | deletion | 20534489 |
Residual Variation Intolerance Score:
98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
24.40;
99.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRT32 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- KRT32
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT32 Gene
Disorders for KRT32 Gene
Additional Disease Information for KRT32
No disorders were found for KRT32 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT32 Gene
Publications for KRT32 Gene
- Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5. (PMID: 8823373) Rogers MA … Schweizer J (The Journal of investigative dermatology 1996) 2 3 4 22 58
- Sequence data and chromosomal localization of human type I and type II hair keratin genes. (PMID: 7556444) Rogers MA … Schweizer J (Experimental cell research 1995) 2 3 4 58
- New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L … Schweizer J (The Journal of biological chemistry 1999) 3 22 58
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
Products for KRT32 Gene
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- Overview of 71 available KRT32 gene related products
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Sources for KRT32 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt