Aliases for KRT31 Gene
Aliases for KRT31 Gene
External Ids for KRT31 Gene
- HGNC: 6448
- Entrez Gene: 3881
- Ensembl: ENSG00000094796
- OMIM: 601077
- UniProtKB: Q15323
Previous HGNC Symbols for KRT31 Gene
- KRTHA1
Previous GeneCards Identifiers for KRT31 Gene
- GC17M036804
- GC17M039549
- GC17M035313
Summaries for KRT31 Gene
-
The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT31 Gene
KRT31 (Keratin 31) is a Protein Coding gene. Diseases associated with KRT31 include Skin Pilomatrix Carcinoma and Superficial Mycosis. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT33B.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT31 Gene
Genomics for KRT31 Gene
GeneHancer (GH) Regulatory Elements for KRT31 Gene
Promoters and enhancers for KRT31 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRT31 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRT31 gene promoter:
-
- Nkx2-5
- Tal-1
- E47
- c-Myb
- MRF-2
- FAC1
- Meis-1b
- Meis-1a
- Meis-1
- Bach2
Regulatory Element Products
Genomic Locations for KRT31 Gene
Genomic Locations for KRT31 Gene
- chr17:41,393,724-41,397,592
- (GRCh38/hg38)
- Size:
- 3,869 bases
- Orientation:
- Minus strand
- chr17:39,549,976-39,553,844
- (GRCh37/hg19)
- Size:
- 3,869 bases
- Orientation:
- Minus strand
Genomic View for KRT31 Gene
Genes around KRT31 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
- 17q21.2 by Ensembl
KRT31 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRT31 Gene
Proteins for KRT31 Gene
-
Protein details for KRT31 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15323-K1H1_HUMAN
- Recommended name:
- Keratin, type I cuticular Ha1
- Protein Accession:
- Q15323
- Q9UE12
Protein attributes for KRT31 Gene
- Size:
- 416 amino acids
- Molecular mass:
- 47237 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Protein Expression for KRT31 Gene
Post-translational modifications for KRT31 Gene
Other Protein References for KRT31 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for KRT31
-
Abcam antibodies for KRT31
- Invitrogen Antibodies for KRT31
- GeneTex KRT31 Antibody for KRT31
-
Boster Bio Antibodies for KRT31
Protein Products
-
OriGene Purified Proteins for KRT31
- Search Origene for MassSpec and Protein Over-expression Lysates for KRT31
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- Novus Biologicals proteins for KRT31
- Search GeneTex for Proteins for KRT31
Assay Products
No data available for DME Specific Peptides for KRT31 Gene
Domains & Families for KRT31 Gene
Gene Families for KRT31 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for KRT31 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRT31 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q15323- Family:
-
- Belongs to the intermediate filament family.
Function for KRT31 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005200 | structural constituent of cytoskeleton | TAS | 9405442 |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for KRT31 Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for KRT31
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- Applied Biological Materials CRISPR for KRT31
-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Clone Products
- Sino Biological Human cDNA Clone for KRT31
- VectorBuilder custom plasmid, inducible vectors for KRT31
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRT31
- genomics-online: cdna clones - Search results for available KRT31 gene related products
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- Applied Biological Materials Clones for KRT31
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRT31
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT31 Gene
Localization for KRT31 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| mitochondrion | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | HDA | 23580065 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | IEA,TAS | -- |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRT31 Gene
Pathways & Interactions for KRT31 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Circadian entrainment | ||
| 2 | Developmental Biology | ||
| 3 | Keratinization |
.33
|
|
Pathways by source for KRT31 Gene
2 Reactome pathways for KRT31 Gene
1 KEGG pathway for KRT31 Gene
Interacting Proteins for KRT31 Gene
Selected Interacting proteins:
Q15323-K1H1_HUMAN
ENSP00000251645
for KRT31 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for KRT31
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0008544 | epidermis development | TAS | 7578244 |
| GO:0031424 | keratinization | TAS | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for KRT31 Gene
Transcripts for KRT31 Gene
mRNA/cDNA for KRT31 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000251645 1596 bps (uc002hwn.4)
CRISPR Products
-
OriGene CRISPR knockouts for KRT31
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT31
- genomics-online: gRNA clones - Search results for available KRT31 gene related products
- Applied Biological Materials CRISPR for KRT31
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT31
- GenScript: Design CRISPR guide RNA sequences for KRT31
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRT31
- Browse OriGene Inhibitory RNA Products For KRT31
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT31
- genomics-online: shRNA clones - Search results for available KRT31 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRT31
- VectorBuilder custom plasmid, inducible vectors for KRT31
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KRT31
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRT31
- genomics-online: cdna clones - Search results for available KRT31 gene related products
- orf clones - Search results for available KRT31 gene related products
- Applied Biological Materials Clones for KRT31
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KRT31 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epidermis (Integumentary System)
- Basal Keratinocytes Embryonic Epidermis
-
Epithelial Cells
- Basal Keratinocytes Embryonic Epidermis
-
Hair
- Basal Keratinocytes Embryonic Epidermis
mRNA differential expression in normal tissues according to GTEx for KRT31 Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x37.5) and Skin - Sun Exposed (Lower leg) (x7.9).
This gene is overexpressed in Hair follicle (67.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT31 Gene
NURSA nuclear receptor signaling pathways regulating expression of KRT31 Gene:
KRT31SOURCE GeneReport for Unigene cluster for KRT31 Gene:
Hs.41696mRNA Expression by UniProt/SwissProt for KRT31 Gene:
Q15323-K1H1_HUMAN
Tissue specificity:
Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.
Evidence on tissue expression from TISSUES for KRT31 Gene
- Skin(4.5)
Primer Products
-
OriGene qPCR primer pairs for KRT31
- genomics-online: primer clones - Search results for available KRT31 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT31 Gene
Orthologs for KRT31 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KRT31 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KRT31 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| mouse (Mus musculus) |
Mammalia | Krt33a 34 |
|
ManyToMany | |
| Krt33b 16 34 |
|
||||
| Krt34 34 |
|
ManyToMany | |||
| Krt31 34 33 |
|
ManyToMany | |||
| cow (Bos Taurus) |
Mammalia | KRT31 34 33 |
|
ManyToMany | |
| KRT33A 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| HKA1 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Krt31 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for KRT31 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KRT31 Gene
- ENSEMBL:
- Gene Tree for KRT31 (if available)
- TreeFam:
- Gene Tree for KRT31 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRT31: view image
Paralogs for KRT31 Gene
Paralogs for KRT31 Gene
(38) SIMAP similar genes for KRT31 Gene using alignment to 1 proteins:
- K1H1_HUMAN
Variants for KRT31 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000113340 | -- | 41,397,315(-) | A/T | coding_sequence_variant, synonymous_variant | |
| rs1001526131 | -- | 41,397,739(-) | C/T | upstream_transcript_variant | |
| rs1001777836 | -- | 41,398,587(-) | G/A | upstream_transcript_variant | |
| rs1001923688 | -- | 41,396,203(-) | G/C | intron_variant | |
| rs1002597644 | -- | 41,398,624(-) | A/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758690 | CNV | gain+loss | 17122850 |
| esv3640586 | CNV | loss | 21293372 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv2052 | CNV | insertion | 18451855 |
| nsv483014 | CNV | loss | 15286789 |
| nsv962322 | CNV | duplication | 23825009 |
| nsv962323 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.66;
65.84% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRT31 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT31 Gene
Disorders for KRT31 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin pilomatrix carcinoma |
|
|
| superficial mycosis |
|
|
| nodular basal cell carcinoma |
|
|
| pityriasis versicolor |
|
|
Search KRT31 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KRT31
No data available for UniProtKB/Swiss-Prot and Genatlas for KRT31 Gene
Publications for KRT31 Gene
- A cDNA encoding the human type I hair keratin hHal. (PMID: 7578244) Fink P … Schweizer J (Biochimica et biophysica acta 1995) 2 3 4 58
- New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. (PMID: 10391933) Langbein L … Schweizer J (The Journal of biological chemistry 1999) 3 22 58
- Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle. (PMID: 9457912) Bowden PE … Hodgins MB (The Journal of investigative dermatology 1998) 3 4 58
- Characterization of a 190-kilobase pair domain of human type I hair keratin genes. (PMID: 9756910) Rogers MA … Schweizer J (The Journal of biological chemistry 1998) 3 4 58
Products for KRT31 Gene
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- VectorBuilder custom plasmid, inducible vectors for KRT31
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available KRT31 related products ranked by validation data
- antibodies-online: Search results for available KRT31 related products ranked by validation data
- antibodies-online: Search results for available KRT31 related products ranked by validation data
- GeneTex KRT31 Antibody for KRT31
- Search GeneTex for Proteins for KRT31
- Horizon Cell Lines for KRT31
- genomics-online: cdna clones - Search results for available KRT31 gene related products
- orf clones - Search results for available KRT31 gene related products
- genomics-online: gRNA clones - Search results for available KRT31 gene related products
- genomics-online: primer clones - Search results for available KRT31 gene related products
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Sources for KRT31 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
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- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt