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Aliases for KRT28 Gene

Aliases for KRT28 Gene

  • Keratin 28 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs4 3 4
  • Keratin 28, Type I 2 3
  • Cytokeratin-28 3 4
  • Keratin-25D 3 4
  • KRT25D 3 4
  • CK-28 3 4
  • K25D 3 4
  • K28 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs4 3
  • Keratin, Type I Cytoskeletal 28 3
  • Keratin 25D 2
  • Keratin-28 4
  • K25IRS4 3

External Ids for KRT28 Gene

Previous HGNC Symbols for KRT28 Gene

  • KRT25D

Previous GeneCards Identifiers for KRT28 Gene

  • GC17M036202
  • GC17M038948
  • GC17M034742

Summaries for KRT28 Gene

Entrez Gene Summary for KRT28 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT28 Gene

KRT28 (Keratin 28) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT27.

UniProtKB/Swiss-Prot for KRT28 Gene

  • Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).

Additional gene information for KRT28 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT28 Gene

Genomics for KRT28 Gene

GeneHancer (GH) Regulatory Elements for KRT28 Gene

Promoters and enhancers for KRT28 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040799 Promoter 0.5 EPDnew 550.8 0.0 -13 0.1 KRT28 LOC105371776 KRT17 GC17M040770
GH17I040800 Promoter 0.5 EPDnew 550.8 +0.3 300 0.1 KRT28 LOC105371776 KRT17 GC17M040770 GC17P040784
GH17I040908 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -113.0 -113016 8.7 FOXA2 MLX ARID4B SIN3A IRF4 ZNF48 ETS1 ZNF213 ARID2 ZNF143 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17I040595 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +202.0 202032 4.3 HDGF PKNOX1 FOXA2 SMAD1 MLX YBX1 IRF4 YY1 ZNF207 ZNF143 ENSG00000279775 SMARCE1 CCR7 SNORD124 KRT222 KRT28 RARA WIPF2 KRTAP3-2 CASC3
GH17I040900 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.9 -102.8 -102839 5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 KRT23 SNORD124 KRT12 TMEM99 KRT28 KRTAP3-2 KRT40 KRT37 KRT38 KRT26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT28 gene promoter:

Genomic Locations for KRT28 Gene

Genomic Locations for KRT28 Gene
7,764 bases
Minus strand

Genomic View for KRT28 Gene

Genes around KRT28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT28 Gene

Proteins for KRT28 Gene

  • Protein details for KRT28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 28
    Protein Accession:
    Secondary Accessions:
    • Q6ZP84

    Protein attributes for KRT28 Gene

    464 amino acids
    Molecular mass:
    50567 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).
    • Sequence=BAC85240.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for KRT28 Gene

Post-translational modifications for KRT28 Gene

No Post-translational modifications

Other Protein References for KRT28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT28 Gene

Domains & Families for KRT28 Gene

Gene Families for KRT28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT28 Gene

Suggested Antigen Peptide Sequences for KRT28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT28: view

Function for KRT28 Gene

Molecular function for KRT28 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).

Phenotypes From GWAS Catalog for KRT28 Gene

Gene Ontology (GO) - Molecular Function for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT28: view
genes like me logo Genes that share phenotypes with KRT28: view

Animal Model Products

CRISPR Products

miRNA for KRT28 Gene

miRTarBase miRNAs that target KRT28

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT28 Gene

Localization for KRT28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT28 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT28 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA,IDA 23533145
genes like me logo Genes that share ontologies with KRT28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KRT28 Gene

Pathways & Interactions for KRT28 Gene

SuperPathways for KRT28 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRT28: view

Pathways by source for KRT28 Gene

2 Reactome pathways for KRT28 Gene

Gene Ontology (GO) - Biological Process for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT28: view

No data available for SIGNOR curated interactions for KRT28 Gene

Drugs & Compounds for KRT28 Gene

No Compound Related Data Available

Transcripts for KRT28 Gene

mRNA/cDNA for KRT28 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(78) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT28 Gene

Keratin 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT28 Gene

No ASD Table

Relevant External Links for KRT28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT28 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x40.3) and Skin - Sun Exposed (Lower leg) (x9.3).

Protein differential expression in normal tissues from HIPED for KRT28 Gene

This gene is overexpressed in Skin (26.0), Heart (17.7), and Brain (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRT28 Gene

Protein tissue co-expression partners for KRT28 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KRT28 Gene:


SOURCE GeneReport for Unigene cluster for KRT28 Gene:


mRNA Expression by UniProt/SwissProt for KRT28 Gene:

Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).

Evidence on tissue expression from TISSUES for KRT28 Gene

  • Heart(2.2)
  • Intestine(2.1)
  • Adrenal gland(2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with KRT28: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT28 Gene

Orthologs for KRT28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT28 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT28 33 34
  • 99.28 (n)
(Bos Taurus)
Mammalia KRT28 33 34
  • 88.58 (n)
(Canis familiaris)
Mammalia KRT28 33
  • 88.43 (n)
(Rattus norvegicus)
Mammalia Krt28 33
  • 82.94 (n)
(Mus musculus)
Mammalia Krt28 33 16 34
  • 82.47 (n)
(Ornithorhynchus anatinus)
Mammalia KRT28 34
  • 79 (a)
(Monodelphis domestica)
Mammalia KRT28 34
  • 77 (a)
Species where no ortholog for KRT28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRT28 Gene

Gene Tree for KRT28 (if available)
Gene Tree for KRT28 (if available)

Paralogs for KRT28 Gene

Paralogs for KRT28 Gene

genes like me logo Genes that share paralogs with KRT28: view

Variants for KRT28 Gene

Sequence variations from dbSNP and Humsavar for KRT28 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000240254 -- 40,793,632(-) T/G intron_variant
rs1000977923 -- 40,800,140(-) A/G upstream_transcript_variant
rs1001062447 -- 40,800,071(-) A/C upstream_transcript_variant
rs1001160426 -- 40,795,269(-) T/C intron_variant
rs1001450563 -- 40,801,707(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT28 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT28 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT28 Gene

Disorders for KRT28 Gene

Additional Disease Information for KRT28

No disorders were found for KRT28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT28 Gene

Publications for KRT28 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 58
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 4 58
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  4. The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PMID: 21800051) Fang Y … Shen X (Molecular and cellular biochemistry 2012) 3 58
  5. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. (PMID: 16874310) Langbein L … Schweizer J (The Journal of investigative dermatology 2006) 4 58

Products for KRT28 Gene

Sources for KRT28 Gene

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