This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in... See more...

Aliases for KRT28 Gene

Aliases for KRT28 Gene

  • Keratin 28 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs4 3 4
  • Keratin, Type I Cytoskeletal 28 3 4
  • Keratin 28, Type I 2 3
  • Cytokeratin-28 3 4
  • Keratin-25D 3 4
  • KRT25D 3 4
  • CK-28 3 4
  • K25D 3 4
  • K28 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs4 3
  • Keratin 25D 2
  • Keratin-28 4
  • K25IRS4 3
  • KRT28 5

External Ids for KRT28 Gene

Previous HGNC Symbols for KRT28 Gene

  • KRT25D

Previous GeneCards Identifiers for KRT28 Gene

  • GC17M036202
  • GC17M038948
  • GC17M034742

Summaries for KRT28 Gene

Entrez Gene Summary for KRT28 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT28 Gene

KRT28 (Keratin 28) is a Protein Coding gene. Diseases associated with KRT28 include Skin Pilomatrix Carcinoma and Loose Anagen Hair Syndrome. Among its related pathways are Relaxin signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT27.

UniProtKB/Swiss-Prot Summary for KRT28 Gene

  • Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT28 Gene

Genomics for KRT28 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040799 Promoter 0.3 EPDnew 250.7 +0.3 300 0.1 ENSG00000264488 KRT28 LOC105371776 KRT17 KRT27
GH17J040800 Promoter 0.3 EPDnew 250.7 0.0 -13 0.1 ENSG00000264488 KRT28 LOC105371776 KRT17 KRT10
GH17J040908 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 9.7 -113.0 -113016 8.7 ZNF654 JUND ATF2 CEBPA NFIC CHD4 BCL11A CEBPB CTCF REST KRT23 KRTAP3-2 MSL1 KRT20 KRT10-AS1 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17J040595 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.5 +202.0 202032 4.3 BCLAF1 SP1 ZNF207 ATF3 YY1 BCL11A REST ZNF592 SIN3A TRIM22 ENSG00000279775 lnc-SMARCE1-2 SMARCE1 CCR7 SNORD124 KRT222 KRT28 RARA WIPF2 KRTAP3-2
GH17J040857 Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 10.6 -57.5 -57528 1.4 ZNF654 ZNF580 ZNF592 NFIC REST TRIM22 ZNF639 CTCF NBN RAD21 KRT10-AS1 KRT20 KRT28 KRTAP1-5 KRT37 KRTAP1-4 KRT31 LOC100505782 MED24 ENSG00000265359
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT28 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT28

Top Transcription factor binding sites by QIAGEN in the KRT28 gene promoter:
  • C/EBPbeta
  • HNF-1
  • HNF-1A
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for KRT28 Gene

Latest Assembly
chr17:40,792,196-40,799,959
(GRCh38/hg38)
Size:
7,764 bases
Orientation:
Minus strand

Previous Assembly
chr17:38,948,448-38,956,211
(GRCh37/hg19 by Entrez Gene)
Size:
7,764 bases
Orientation:
Minus strand

chr17:38,948,455-38,956,211
(GRCh37/hg19 by Ensembl)
Size:
7,757 bases
Orientation:
Minus strand

Genomic View for KRT28 Gene

Genes around KRT28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT28 Gene

Proteins for KRT28 Gene

  • Protein details for KRT28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Y7-K1C28_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 28
    Protein Accession:
    Q7Z3Y7
    Secondary Accessions:
    • Q6ZP84

    Protein attributes for KRT28 Gene

    Size:
    464 amino acids
    Molecular mass:
    50567 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    SequenceCaution:
    • Sequence=BAC85240.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT28 Gene

Post-translational modifications for KRT28 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT28 Gene

Domains & Families for KRT28 Gene

Gene Families for KRT28 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT28 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature

Suggested Antigen Peptide Sequences for KRT28 Gene

GenScript: Design optimal peptide antigens:
  • Type I inner root sheath-specific keratin-K25irs4 (K1C28_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z3Y7

UniProtKB/Swiss-Prot:

K1C28_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT28: view

Function for KRT28 Gene

Molecular function for KRT28 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).

Phenotypes From GWAS Catalog for KRT28 Gene

Gene Ontology (GO) - Molecular Function for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with KRT28: view
genes like me logo Genes that share phenotypes with KRT28: view

miRNA for KRT28 Gene

miRTarBase miRNAs that target KRT28

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT28

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT28 Gene

Localization for KRT28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT28 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT28 gene
Compartment Confidence
extracellular 4
cytosol 4
cytoskeleton 3
mitochondrion 1
nucleus 1
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT28: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KRT28 Gene

Pathways & Interactions for KRT28 Gene

genes like me logo Genes that share pathways with KRT28: view

Pathways by source for KRT28 Gene

2 Reactome pathways for KRT28 Gene

Gene Ontology (GO) - Biological Process for KRT28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT28: view

No data available for SIGNOR curated interactions for KRT28 Gene

Drugs & Compounds for KRT28 Gene

No Compound Related Data Available

Transcripts for KRT28 Gene

mRNA/cDNA for KRT28 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT28

Alternative Splicing Database (ASD) splice patterns (SP) for KRT28 Gene

No ASD Table

Relevant External Links for KRT28 Gene

GeneLoc Exon Structure for
KRT28

Expression for KRT28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT28 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x40.3) and Skin - Sun Exposed (Lower leg) (x9.3).

Protein differential expression in normal tissues from HIPED for KRT28 Gene

This gene is overexpressed in Skin (26.0), Heart (17.7), and Brain (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT28 Gene



Protein tissue co-expression partners for KRT28 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT28

SOURCE GeneReport for Unigene cluster for KRT28 Gene:

Hs.59736

mRNA Expression by UniProt/SwissProt for KRT28 Gene:

Q7Z3Y7-K1C28_HUMAN
Tissue specificity: Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).

Evidence on tissue expression from TISSUES for KRT28 Gene

  • Heart(2.2)
  • Intestine(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with KRT28: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT28 Gene

Orthologs for KRT28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRT28 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT28 29 30
  • 99.28 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRT28 29 30
  • 88.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRT28 29
  • 88.43 (n)
Rat
(Rattus norvegicus)
Mammalia Krt28 29
  • 82.94 (n)
Mouse
(Mus musculus)
Mammalia Krt28 29 16 30
  • 82.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KRT28 30
  • 79 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KRT28 30
  • 77 (a)
OneToOne
Species where no ortholog for KRT28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT28 Gene

ENSEMBL:
Gene Tree for KRT28 (if available)
TreeFam:
Gene Tree for KRT28 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT28: view image
Alliance of Genome Resources:
Additional Orthologs for KRT28

Paralogs for KRT28 Gene

(32) SIMAP similar genes for KRT28 Gene using alignment to 1 proteins:

  • K1C28_HUMAN
genes like me logo Genes that share paralogs with KRT28: view

Variants for KRT28 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT28 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17558995 -- p.Ala286Thr
rs4624233 -- p.Ala62Val
rs7209228 -- p.Gly52Asp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT28 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT28 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT28 Gene

Residual Variation Intolerance Score: 84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.68; 82.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT28
Leiden Open Variation Database (LOVD)
KRT28

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT28 Gene

Disorders for KRT28 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KRT28 Gene - From: COP

Disorder Aliases PubMed IDs
skin pilomatrix carcinoma
  • malignant pilomatricoma
loose anagen hair syndrome
  • loose anagen syndrome
white sponge nevus 1
  • wsn1
steatocystoma multiplex
  • sebaceous cysts, multiple
- elite association - COSMIC cancer census association via MalaCards
Search KRT28 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT28

genes like me logo Genes that share disorders with KRT28: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT28 Gene

Publications for KRT28 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3

Products for KRT28 Gene

Sources for KRT28 Gene