This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in... See more...

Aliases for KRT27 Gene

Aliases for KRT27 Gene

  • Keratin 27 2 3 5
  • Type I Inner Root Sheath-Specific Keratin-K25irs3 3 4
  • Keratin, Type I Cytoskeletal 27 3 4
  • Keratin 27, Type I 2 3
  • Cytokeratin-27 3 4
  • Keratin-25C 3 4
  • KRT25C 3 4
  • CK-27 3 4
  • K25C 3 4
  • K27 3 4
  • Type I Inner Root Sheath Specific Keratin 25 Irs3 3
  • Keratin 25C 2
  • Keratin-27 4
  • K25IRS3 3
  • KRT27 5

External Ids for KRT27 Gene

Previous HGNC Symbols for KRT27 Gene

  • KRT25C

Previous GeneCards Identifiers for KRT27 Gene

  • GC17M036187
  • GC17M038933
  • GC17M034728

Summaries for KRT27 Gene

Entrez Gene Summary for KRT27 Gene

  • This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

GeneCards Summary for KRT27 Gene

KRT27 (Keratin 27) is a Protein Coding gene. Diseases associated with KRT27 include Plantar Wart and Woolly Hair, Autosomal Dominant. Among its related pathways are Relaxin signaling pathway and Developmental Biology. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT25.

UniProtKB/Swiss-Prot Summary for KRT27 Gene

  • Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT27 Gene

Genomics for KRT27 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT27 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040803 Enhancer 1 Ensembl ENCODE 10.8 -21.4 -21394 0.9 MYC ZNF600 ZNF654 SSRP1 ZBTB10 MXD4 CTCF REST DEK TRIM22 HSALNG0116396 lnc-TMEM99-6 KRT10-AS1 KRT27 KRT26 KRT222 SMARCE1 ENSG00000264488 KRT28 LOC105371776
GH17J040827 Enhancer 1 ENCODE 10.5 -46.0 -46031 2.9 MYC IKZF1 NCOR1 ZNF600 ZNF580 ZNF592 ATF2 ZNF10 ZSCAN16 NFIC P3H4 KRT27 KRT23 MED24 piR-37265 KRT10 KRT10-AS1 KRT12
GH17J040707 Enhancer 0.8 Ensembl ENCODE 10.2 +74.4 74350 2 CEBPA CEBPB MAX EP300 PRDM1 RARA TBP GABPA ZNF146 JUND KRT24 KRT27 KRT222 SMARCE1 KRT37 lnc-KRT24-2 KRT25
GH17J040825 Enhancer 0.6 ENCODE 10.5 -43.6 -43617 0.9 IKZF1 ZNF592 NFIC CEBPB EP300 ZNF664 TRIM28 ZNF366 ZSCAN4 GATAD2A KRT10-AS1 KRT27 KRT23 MED24 KRT10 piR-37265 KRT12
GH17J040846 Enhancer 0.5 FANTOM5 10 -64.4 -64413 0.1 CEBPB MAX RFX5 STAT3 SCRT1 POLR2A SCRT2 ZSCAN5C LOC105371777 KRT10-AS1 KRT10 KRT28 KRT27 KRT26 ENSG00000234477 KRT222 SMARCE1 KRTAP2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT27 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT27

Top Transcription factor binding sites by QIAGEN in the KRT27 gene promoter:
  • AP-2gamma
  • COMP1
  • HNF-1
  • HNF-1A
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for KRT27 Gene

Latest Assembly
chr17:40,776,808-40,782,550
(GRCh38/hg38)
Size:
5,743 bases
Orientation:
Minus strand

Previous Assembly
chr17:38,933,060-38,938,802
(GRCh37/hg19 by Entrez Gene)
Size:
5,743 bases
Orientation:
Minus strand

chr17:38,933,060-38,938,786
(GRCh37/hg19 by Ensembl)
Size:
5,727 bases
Orientation:
Minus strand

Genomic View for KRT27 Gene

Genes around KRT27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT27 Gene

Proteins for KRT27 Gene

  • Protein details for KRT27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Y8-K1C27_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 27
    Protein Accession:
    Q7Z3Y8

    Protein attributes for KRT27 Gene

    Size:
    459 amino acids
    Molecular mass:
    49822 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with KRT6A to form filaments (By similarity).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT27 Gene

Post-translational modifications for KRT27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRT27 Gene

Domains & Families for KRT27 Gene

Gene Families for KRT27 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT27 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature

Suggested Antigen Peptide Sequences for KRT27 Gene

GenScript: Design optimal peptide antigens:
  • Type I inner root sheath-specific keratin-K25irs3 (K1C27_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z3Y8

UniProtKB/Swiss-Prot:

K1C27_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT27: view

Function for KRT27 Gene

Molecular function for KRT27 Gene

UniProtKB/Swiss-Prot Function:
Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs).

Phenotypes From GWAS Catalog for KRT27 Gene

Gene Ontology (GO) - Molecular Function for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with KRT27: view
genes like me logo Genes that share phenotypes with KRT27: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT27

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT27 Gene

Localization for KRT27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT27 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT27 gene
Compartment Confidence
extracellular 4
cytosol 4
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with KRT27: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KRT27 Gene

Pathways & Interactions for KRT27 Gene

genes like me logo Genes that share pathways with KRT27: view

Pathways by source for KRT27 Gene

2 Reactome pathways for KRT27 Gene

Gene Ontology (GO) - Biological Process for KRT27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0031069 hair follicle morphogenesis IEA --
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT27: view

No data available for SIGNOR curated interactions for KRT27 Gene

Drugs & Compounds for KRT27 Gene

No Compound Related Data Available

Transcripts for KRT27 Gene

mRNA/cDNA for KRT27 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT27

Alternative Splicing Database (ASD) splice patterns (SP) for KRT27 Gene

No ASD Table

Relevant External Links for KRT27 Gene

GeneLoc Exon Structure for
KRT27

Expression for KRT27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT27 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x41.7) and Skin - Sun Exposed (Lower leg) (x8.6).

Protein differential expression in normal tissues from HIPED for KRT27 Gene

This gene is overexpressed in Hair follicle (25.9), Skin (18.0), Urine (8.3), Brain (6.7), and Bone marrow mesenchymal stem cell (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT27 Gene



Protein tissue co-expression partners for KRT27 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT27

SOURCE GeneReport for Unigene cluster for KRT27 Gene:

Hs.59363

mRNA Expression by UniProt/SwissProt for KRT27 Gene:

Q7Z3Y8-K1C27_HUMAN
Tissue specificity: Strongly expressed in skin and scalp. In the hair follicle, expressed in Henle layer, Huxley layer and in the inner root sheath cuticle of the hair follicle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).

Evidence on tissue expression from TISSUES for KRT27 Gene

  • Intestine(2.1)
  • Adrenal gland(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with KRT27: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT27 Gene

Orthologs for KRT27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT27 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT27 29 30
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRT27 29 30
  • 90.34 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRT27 29 30
  • 87.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 87 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Krt27 29
  • 83.89 (n)
Mouse
(Mus musculus)
Mammalia Krt27 29 16 30
  • 83.41 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 58 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia krt16 29
  • 61.98 (n)
Species where no ortholog for KRT27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT27 Gene

ENSEMBL:
Gene Tree for KRT27 (if available)
TreeFam:
Gene Tree for KRT27 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT27: view image
Alliance of Genome Resources:
Additional Orthologs for KRT27

Paralogs for KRT27 Gene

genes like me logo Genes that share paralogs with KRT27: view

Variants for KRT27 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT27 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs12453124 -- p.Glu144Lys
rs17558532 -- p.Ala284Thr
rs17558560 -- p.Gly193Ser
rs2469826 -- p.Ser52Thr
rs981684 -- p.Ile305Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KRT27 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KRT27 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT27 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.01; 99.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT27
Leiden Open Variation Database (LOVD)
KRT27

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT27 Gene

Disorders for KRT27 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KRT27 Gene - From: COP

Disorder Aliases PubMed IDs
plantar wart
  • verruca plantaris
woolly hair, autosomal dominant
  • adwh
ectodermal dysplasia 4, hair/nail type
  • ectd4
tick infestation
  • tick infestations
- elite association - COSMIC cancer census association via MalaCards
Search KRT27 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT27

genes like me logo Genes that share disorders with KRT27: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT27 Gene

Publications for KRT27 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3
  2. The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain. (PMID: 15617563) Rogers MA … Schweizer J (Differentiation; research in biological diversity 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. E3 Ligase Trim21 Ubiquitylates and Stabilizes Keratin 17 to Induce STAT3 Activation in Psoriasis. (PMID: 29859926) Yang L … Wang G (The Journal of investigative dermatology 2018) 3
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3

Products for KRT27 Gene

Sources for KRT27 Gene