Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRT23 Gene

Aliases for KRT23 Gene

  • Keratin 23 2 3 5
  • Keratin 23 (Histone Deacetylase Inducible) 2 3
  • Keratin 23, Type I 2 3
  • CK-23 3 4
  • K23 3 4
  • Hyperacetylation-Inducible Type I Keratin 3
  • Histone Deacetylase Inducible Keratin 23 3
  • Type I Intermediate Filament Cytokeratin 3
  • Keratin, Type I Cytoskeletal 23 3
  • Cytokeratin 23 3
  • Cytokeratin-23 4
  • Keratin-23 4
  • HAIK1 3
  • CK23 3

External Ids for KRT23 Gene

Previous GeneCards Identifiers for KRT23 Gene

  • GC17M041254
  • GC17M038987
  • GC17M039452
  • GC17M036332
  • GC17M039078
  • GC17M034873

Summaries for KRT23 Gene

Entrez Gene Summary for KRT23 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for KRT23 Gene

KRT23 (Keratin 23) is a Protein Coding gene. Among its related pathways are Keratinization and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is KRT9.

Gene Wiki entry for KRT23 Gene

Additional gene information for KRT23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT23 Gene

Genomics for KRT23 Gene

GeneHancer (GH) Regulatory Elements for KRT23 Gene

Promoters and enhancers for KRT23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040935 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 682.6 +0.2 157 3.6 SOX13 FOXA2 SAP130 ARID4B CEBPG ZNF48 GATA3 POLR2A SOX5 RFX1 KRT23 TMEM99 KRT39 KRTAP3-2 KRTAP2-1 GC17M040929 ENSG00000234477
GH17J040908 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 18.9 +24.7 24668 8.7 FOXA2 MLX ARID4B SIN3A IRF4 ZNF213 ZNF143 FOS DEK SP5 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17J040948 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -17.1 -17070 11.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 DMAP1 SLC30A9 FOS SP5 KRTAP3-2 KRT23 KRTAP2-1 KRT39 KRT40 KRTAP2-2 ENSG00000234477 KRTAP3-3 KRTAP1-5 KRTAP3-1
GH17J040900 Enhancer 1.4 Ensembl ENCODE dbSUPER 14.5 +34.8 34845 5 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS SP5 KRT23 SNORD124 KRT12 TMEM99 KRT28 KRTAP3-2 KRT40 KRT37 KRT38 KRT26
GH17J040932 Enhancer 0.4 ENCODE 30.7 +4.8 4829 0.2 SOX13 PRPF4 KRT23 GC17M040929 ENSG00000234477
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT23 gene promoter:
  • POU2F1a
  • POU2F1
  • YY1
  • C/EBPalpha
  • Evi-1
  • Hlf
  • C/EBPbeta
  • SRF
  • SRF (504 AA)
  • NF-AT1

Genomic Locations for KRT23 Gene

Genomic Locations for KRT23 Gene
14,948 bases
Minus strand
14,939 bases
Minus strand

Genomic View for KRT23 Gene

Genes around KRT23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT23 Gene

Proteins for KRT23 Gene

  • Protein details for KRT23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin, type I cytoskeletal 23
    Protein Accession:
    Secondary Accessions:
    • A8K084
    • B7Z7J2
    • I3L3Q6
    • Q9NUR6

    Protein attributes for KRT23 Gene

    422 amino acids
    Molecular mass:
    48131 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins.
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Alternative splice isoforms for KRT23 Gene


neXtProt entry for KRT23 Gene

Post-translational modifications for KRT23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRT23 Gene

Domains & Families for KRT23 Gene

Gene Families for KRT23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT23: view

Function for KRT23 Gene

Gene Ontology (GO) - Molecular Function for KRT23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT23: view
genes like me logo Genes that share phenotypes with KRT23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRT23 Gene

Localization for KRT23 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT23 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT23 Gene

Pathways & Interactions for KRT23 Gene

genes like me logo Genes that share pathways with KRT23: view

Pathways by source for KRT23 Gene

2 Reactome pathways for KRT23 Gene
1 KEGG pathway for KRT23 Gene

Interacting Proteins for KRT23 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9C075-K1C23_HUMAN ENSP00000209718 for KRT23 Gene via IID STRING

Gene Ontology (GO) - Biological Process for KRT23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT23: view

No data available for SIGNOR curated interactions for KRT23 Gene

Drugs & Compounds for KRT23 Gene

No Compound Related Data Available

Transcripts for KRT23 Gene

Unigene Clusters for KRT23 Gene

Keratin 23 (histone deacetylase inducible):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT23

Alternative Splicing Database (ASD) splice patterns (SP) for KRT23 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP2: - -

Relevant External Links for KRT23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT23 Gene

This gene is overexpressed in Minor Salivary Gland (x14.5), Skin - Sun Exposed (Lower leg) (x11.2), Skin - Not Sun Exposed (Suprapubic) (x9.1), and Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for KRT23 Gene

This gene is overexpressed in Salivary gland (48.0) and Cervix (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT23 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT23 Gene:


SOURCE GeneReport for Unigene cluster for KRT23 Gene:

genes like me logo Genes that share expression patterns with KRT23: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT23 Gene

Orthologs for KRT23 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KRT23 34 33
  • 99.51 (n)
(Bos Taurus)
Mammalia KRT23 34 33
  • 85.54 (n)
(Canis familiaris)
Mammalia KRT23 34 33
  • 84.76 (n)
(Mus musculus)
Mammalia Krt23 16 34 33
  • 82.66 (n)
(Rattus norvegicus)
Mammalia Krt23 33
  • 82.66 (n)
(Monodelphis domestica)
Mammalia KRT23 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia KRT23 34
  • 64 (a)
(Gallus gallus)
Aves KRT23 33
  • 60.51 (n)
(Anolis carolinensis)
Reptilia KRT23 34
  • 44 (a)
(Danio rerio)
Actinopterygii KRT23 34
  • 35 (a)
Species where no ortholog for KRT23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT23 Gene

Gene Tree for KRT23 (if available)
Gene Tree for KRT23 (if available)
Evolutionary constrained regions (ECRs) for KRT23: view image

Paralogs for KRT23 Gene

Paralogs for KRT23 Gene

(39) SIMAP similar genes for KRT23 Gene using alignment to 5 proteins:

  • K1C23_HUMAN
  • I3L3Q6_HUMAN
  • J3QR55_HUMAN
  • Q8TC04_HUMAN
genes like me logo Genes that share paralogs with KRT23: view

Variants for KRT23 Gene

Sequence variations from dbSNP and Humsavar for KRT23 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000453958 -- 40,934,091(-) T/C intron_variant
rs1001074484 -- 40,937,813(-) G/T upstream_transcript_variant
rs1001147641 -- 40,923,306(-) G/C intron_variant
rs1001166156 -- 40,931,223(-) G/T intron_variant
rs1001452066 -- 40,924,811(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT23 Gene

Variant ID Type Subtype PubMed ID
esv2761957 CNV gain 21179565
esv3640559 CNV gain 21293372
esv3640560 CNV gain 21293372
nsv1146669 OTHER inversion 26484159
nsv574999 CNV loss 21841781
nsv9550 CNV loss 18304495

Variation tolerance for KRT23 Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.51; 64.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT23 Gene

Disorders for KRT23 Gene

Additional Disease Information for KRT23

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KRT23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT23 Gene

Publications for KRT23 Gene

  1. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. (PMID: 11135429) Zhang JS … Smith DI (Genes, chromosomes & cancer 2001) 2 3 4 22 58
  2. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  3. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 44 58
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 44 58
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 44 58

Products for KRT23 Gene

Sources for KRT23 Gene

Loading form....