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Aliases for KRT222 Gene

Aliases for KRT222 Gene

  • Keratin 222 2 3 5
  • Keratin-222 Pseudogene 3 4
  • Keratin 222, Type II 2 3
  • KRT222P 3 4
  • KA21 3 4
  • Keratin-Like Protein KRT222 3
  • Keratin 222 Pseudogene 2
  • Keratin-222 4

External Ids for KRT222 Gene

Previous HGNC Symbols for KRT222 Gene

  • KRT222P

Previous GeneCards Identifiers for KRT222 Gene

  • GC17M036065
  • GC17M038810
  • GC17M034606

Summaries for KRT222 Gene

GeneCards Summary for KRT222 Gene

KRT222 (Keratin 222) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is ENSG00000264058.

Additional gene information for KRT222 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT222 Gene

Genomics for KRT222 Gene

GeneHancer (GH) Regulatory Elements for KRT222 Gene

Promoters and enhancers for KRT222 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I040665 Promoter 0.9 EPDnew 550.8 0.0 -3 0.1 MAX RAD21 YY1 POLR2A MLLT1 ZNF600 HNF4A CUX1 ZBTB17 ENSG00000264058 KRT222 PIR54879
GH17I040664 Enhancer 0.6 Ensembl 550.8 +0.3 280 0.2 MAX RAD21 YY1 POLR2A PRDM10 MLLT1 ZNF600 HNF4A CUX1 ZBTB17 PIR54879 KRT222 ENSG00000264058 SMARCE1
GH17I040138 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 +524.8 524842 3.2 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 MCM3 CASC3 GC17M040140 MED1 SNORD124 SMARCE1 CDK12 MED24 MSL1 STARD3 IGFBP4
GH17I040217 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 8.6 +446.0 446022 2.9 HDGF FOXA2 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 WIPF2 MED1 CDK12 SMARCE1 RAPGEFL1 PGAP3 MSL1 STARD3 IGFBP4 ENSG00000266208
GH17I039753 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +908.6 908587 7.1 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YBX1 IRF4 ZNF766 GSDMB ORMDL3 THRA IKZF3 KRT222 SNORD124 MED24 STARD3 FBXL20 CDK12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRT222 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRT222 Gene

Genomic Locations for KRT222 Gene
10,517 bases
Minus strand

Genomic View for KRT222 Gene

Genes around KRT222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT222 Gene

Proteins for KRT222 Gene

  • Protein details for KRT222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-like protein KRT222
    Protein Accession:
    Secondary Accessions:
    • Q7Z368

    Protein attributes for KRT222 Gene

    295 amino acids
    Molecular mass:
    34158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRT222 Gene


neXtProt entry for KRT222 Gene

Post-translational modifications for KRT222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT222 Gene

No data available for DME Specific Peptides for KRT222 Gene

Domains & Families for KRT222 Gene

Gene Families for KRT222 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT222 Gene

Suggested Antigen Peptide Sequences for KRT222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT222: view

Function for KRT222 Gene

Phenotypes From GWAS Catalog for KRT222 Gene

Gene Ontology (GO) - Molecular Function for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT222: view

Phenotypes for KRT222 Gene

GenomeRNAi human phenotypes for KRT222:
genes like me logo Genes that share phenotypes with KRT222: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT222 Gene

Localization for KRT222 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT222 gene
Compartment Confidence
cytoskeleton 3
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT222 Gene

Pathways & Interactions for KRT222 Gene

SuperPathways for KRT222 Gene

No Data Available

Interacting Proteins for KRT222 Gene

Selected Interacting proteins: Q8N1A0-KT222_HUMAN for KRT222 Gene via IID MINT

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KRT222 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT222 Gene

Drugs & Compounds for KRT222 Gene

No Compound Related Data Available

Transcripts for KRT222 Gene

mRNA/cDNA for KRT222 Gene

Unigene Clusters for KRT222 Gene

Keratin 222:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT222 Gene

No ASD Table

Relevant External Links for KRT222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRT222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRT222 Gene

This gene is overexpressed in Skin (46.6) and Urine (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT222 Gene

Protein tissue co-expression partners for KRT222 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRT222 Gene:


SOURCE GeneReport for Unigene cluster for KRT222 Gene:


Evidence on tissue expression from TISSUES for KRT222 Gene

  • Nervous system(4.5)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with KRT222: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT222 Gene

Orthologs for KRT222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
KRT222 33
  • 99.66 (n)
(Canis familiaris)
Mammalia -- 34
  • 95 (a)
KRT222 33
  • 93.79 (n)
(Bos Taurus)
Mammalia KRT222 33 34
  • 93.56 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
(Mus musculus)
Mammalia Krt222 33 16 34
  • 85.94 (n)
(Rattus norvegicus)
Mammalia Krt222 33
  • 85.2 (n)
(Gallus gallus)
Aves KRT222 33 34
  • 70.73 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt222 33
  • 64.71 (n)
(Danio rerio)
Actinopterygii si:ch73-78i5.3 33
  • 59.1 (n)
KRT222 34
  • 27 (a)
Species where no ortholog for KRT222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT222 Gene

Gene Tree for KRT222 (if available)
Gene Tree for KRT222 (if available)

Paralogs for KRT222 Gene

Paralogs for KRT222 Gene

(1) SIMAP similar genes for KRT222 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRT222: view

Variants for KRT222 Gene

Sequence variations from dbSNP and Humsavar for KRT222 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000058895 -- 40,658,281(-) C/T intron_variant
rs1000127471 -- 40,656,433(-) G/A coding_sequence_variant, missense_variant
rs1000849529 -- 40,665,210(-) T/C upstream_transcript_variant
rs1001236584 -- 40,667,118(-) C/T upstream_transcript_variant
rs1001453020 -- 40,666,157(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT222 Gene

Variant ID Type Subtype PubMed ID
esv2758689 CNV gain 17122850
nsv1146669 OTHER inversion 26484159
nsv574994 CNV gain 21841781

Variation tolerance for KRT222 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT222 Gene

Disorders for KRT222 Gene

Additional Disease Information for KRT222

No disorders were found for KRT222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRT222 Gene

Publications for KRT222 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 4 58
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Comprehensive analysis of keratin gene clusters in humans and rodents. (PMID: 15085952) Hesse M … Magin TM (European journal of cell biology 2004) 3 58

Products for KRT222 Gene

Sources for KRT222 Gene

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