Aliases for KRT222 Gene

Aliases for KRT222 Gene

  • Keratin 222 2 3 5
  • Keratin-Like Protein KRT222 3 4
  • Keratin-222 Pseudogene 3 4
  • Keratin 222, Type II 2 3
  • KRT222P 3 4
  • KA21 3 4
  • Keratin 222 Pseudogene 2
  • Keratin-222 4

External Ids for KRT222 Gene

Previous HGNC Symbols for KRT222 Gene

  • KRT222P

Previous GeneCards Identifiers for KRT222 Gene

  • GC17M036065
  • GC17M038810
  • GC17M034606

Summaries for KRT222 Gene

GeneCards Summary for KRT222 Gene

KRT222 (Keratin 222) is a Protein Coding gene. Diseases associated with KRT222 include Epulis. Gene Ontology (GO) annotations related to this gene include structural molecule activity. An important paralog of this gene is ENSG00000264058.

Additional gene information for KRT222 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT222 Gene

Genomics for KRT222 Gene

GeneHancer (GH) Regulatory Elements for KRT222 Gene

Promoters and enhancers for KRT222 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J040664 Promoter 1.1 EPDnew Ensembl 500.7 +0.1 80 1 ZBTB17 ZNF335 ZFP91 RAD21 ATF4 MAX HNF4A POLR2A CUX1 PRDM10 ENSG00000264058 KRT222 KRT24 SMARCE1
GH17J040470 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 +178.7 178731 32.1 ZNF217 CTCF TCF12 ZNF300 POLR2G JUND FOS TEAD4 ZNF639 EP300 TNS4 SNORD124 SMARCE1 IGFBP4 MED24 THRA KRT10 STARD3 RPL23AP75 KRT222
GH17J040138 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.3 +524.8 524842 3.2 HNRNPK EP300 ZSCAN5C SIN3A NRF1 TCF12 ZNF300 POLR2G BCLAF1 RBAK CASC3 lnc-NR1D1-2 MED1 SMARCE1 CDK12 SNORD124 MED24 MSL1 RPL19 IGFBP4
GH17J040217 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 8.6 +445.7 445722 3.5 HNRNPK ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 TCF12 USF1 WIPF2 SMARCE1 MED1 CDK12 RAPGEFL1 IGFBP4 ENSG00000266208 PGAP3 MSL1 RARA
GH17J039753 Promoter/Enhancer 2 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.3 +908.6 908587 7.1 RXRA HNRNPK CTCF NRF1 POLR2G SP1 PHF8 ZFX EP300 ZIC2 GSDMB ORMDL3 THRA IKZF3 KRT222 SNORD124 MED24 STARD3 FBXL20 CDK12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT222 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT222

Genomic Locations for KRT222 Gene

Genomic Locations for KRT222 Gene
10,517 bases
Minus strand
10,517 bases
Minus strand

Genomic View for KRT222 Gene

Genes around KRT222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT222 Gene

Proteins for KRT222 Gene

  • Protein details for KRT222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratin-like protein KRT222
    Protein Accession:
    Secondary Accessions:
    • Q7Z368

    Protein attributes for KRT222 Gene

    295 amino acids
    Molecular mass:
    34158 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRT222 Gene


neXtProt entry for KRT222 Gene

Post-translational modifications for KRT222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT222 Gene

No data available for DME Specific Peptides for KRT222 Gene

Domains & Families for KRT222 Gene

Gene Families for KRT222 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRT222 Gene


Suggested Antigen Peptide Sequences for KRT222 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-222 pseudogene (KT222_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the intermediate filament family.
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT222: view

Function for KRT222 Gene

Phenotypes From GWAS Catalog for KRT222 Gene

Gene Ontology (GO) - Molecular Function for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRT222: view
genes like me logo Genes that share phenotypes with KRT222: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT222 Gene

Localization for KRT222 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT222 gene
Compartment Confidence
cytoskeleton 3
peroxisome 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRT222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT222 Gene

Pathways & Interactions for KRT222 Gene

PathCards logo

SuperPathways for KRT222 Gene

No Data Available

Interacting Proteins for KRT222 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8N1A0-KT222_HUMAN ENSP00000377616 for KRT222 Gene via MINT STRING IID


Gene Ontology (GO) - Biological Process for KRT222 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRT222 Gene

Drugs & Compounds for KRT222 Gene

No Compound Related Data Available

Transcripts for KRT222 Gene

mRNA/cDNA for KRT222 Gene

6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT222 Gene

No ASD Table

Relevant External Links for KRT222 Gene

GeneLoc Exon Structure for

Expression for KRT222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT222 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRT222 Gene

This gene is overexpressed in Skin (46.6) and Urine (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT222 Gene

Protein tissue co-expression partners for KRT222 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT222

SOURCE GeneReport for Unigene cluster for KRT222 Gene:


Evidence on tissue expression from TISSUES for KRT222 Gene

  • Nervous system(4.5)
  • Adrenal gland(4.2)
genes like me logo Genes that share expression patterns with KRT222: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT222 Gene

Orthologs for KRT222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
KRT222 30
  • 99.66 (n)
(Canis familiaris)
Mammalia -- 31
  • 95 (a)
KRT222 30
  • 93.79 (n)
(Bos Taurus)
Mammalia KRT222 31 30
  • 93.56 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 87 (a)
(Mus musculus)
Mammalia Krt222 17 31 30
  • 85.94 (n)
(Rattus norvegicus)
Mammalia Krt222 30
  • 85.2 (n)
(Gallus gallus)
Aves KRT222 31 30
  • 70.73 (n)
(Anolis carolinensis)
Reptilia -- 31
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia krt222 30
  • 64.71 (n)
(Danio rerio)
Actinopterygii si:ch73-78i5.3 30
  • 59.1 (n)
KRT222 31
  • 27 (a)
Species where no ortholog for KRT222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT222 Gene

Gene Tree for KRT222 (if available)
Gene Tree for KRT222 (if available)
Evolutionary constrained regions (ECRs) for KRT222: view image

Paralogs for KRT222 Gene

(1) SIMAP similar genes for KRT222 Gene using alignment to 2 proteins:

  • KT222_HUMAN
genes like me logo Genes that share paralogs with KRT222: view

Variants for KRT222 Gene

Additional dbSNP identifiers (rs#s) for KRT222 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT222 Gene

Variant ID Type Subtype PubMed ID
esv2758689 CNV gain 17122850
nsv1146669 OTHER inversion 26484159
nsv574994 CNV gain 21841781

Variation tolerance for KRT222 Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT222 Gene

Disorders for KRT222 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KRT222 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • epulides
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KRT222

genes like me logo Genes that share disorders with KRT222: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT222 Gene

Publications for KRT222 Gene

  1. New consensus nomenclature for mammalian keratins. (PMID: 16831889) Schweizer J … Wright MW (The Journal of cell biology 2006) 2 3 4 54
  2. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54
  3. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 54
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for KRT222 Gene

Sources for KRT222 Gene