The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular ... See more...

Aliases for KRT20 Gene

Aliases for KRT20 Gene

  • Keratin 20 2 3 5
  • Keratin, Type I Cytoskeletal 20 3 4
  • Keratin 20, Type I 2 3
  • Protein IT 3 4
  • CK-20 3 4
  • K20 3 4
  • Cytokeratin 20 3
  • Cytokeratin-20 4
  • Keratin-20 4
  • KRT21 3
  • CD20 3
  • CK20 3

External Ids for KRT20 Gene

Previous GeneCards Identifiers for KRT20 Gene

  • GC17M038532
  • GC17M041208
  • GC17M038940
  • GC17M039405
  • GC17M036285
  • GC17M039030
  • GC17M034826

Summaries for KRT20 Gene

Entrez Gene Summary for KRT20 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT20 Gene

KRT20 (Keratin 20) is a Protein Coding gene. Diseases associated with KRT20 include Merkel Cell Carcinoma and Gastrointestinal Carcinoma. Among its related pathways are Keratinization and Relaxin signaling pathway. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT14.

UniProtKB/Swiss-Prot Summary for KRT20 Gene

  • Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Gene Wiki entry for KRT20 Gene

Additional gene information for KRT20 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT20 Gene

Genomics for KRT20 Gene

GeneHancer (GH) Regulatory Elements for KRT20 Gene

Promoters and enhancers for KRT20 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT20 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT20

Top Transcription factor binding sites by QIAGEN in the KRT20 gene promoter:
  • AREB6
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Nkx2-5
  • POU6F1 (c2)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KRT20 Gene

Genomic Locations for KRT20 Gene
chr17:40,875,889-40,885,243
(GRCh38/hg38)
Size:
9,355 bases
Orientation:
Minus strand
chr17:39,032,141-39,041,495
(GRCh37/hg19)
Size:
9,355 bases
Orientation:
Minus strand

Genomic View for KRT20 Gene

Genes around KRT20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT20 Gene

Proteins for KRT20 Gene

  • Protein details for KRT20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35900-K1C20_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 20
    Protein Accession:
    P35900
    Secondary Accessions:
    • B2R6W7

    Protein attributes for KRT20 Gene

    Size:
    424 amino acids
    Molecular mass:
    48487 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Associates with KRT8.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT20 Gene

Post-translational modifications for KRT20 Gene

  • Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT20 Gene

Domains & Families for KRT20 Gene

Gene Families for KRT20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT20 Gene

Blocks:
  • Intermediate filament protein
  • Type I keratin signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRT20 Gene

GenScript: Design optimal peptide antigens:
  • Protein IT (K1C20_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35900

UniProtKB/Swiss-Prot:

K1C20_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT20: view

Function for KRT20 Gene

Molecular function for KRT20 Gene

UniProtKB/Swiss-Prot Function:
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Phenotypes From GWAS Catalog for KRT20 Gene

Gene Ontology (GO) - Molecular Function for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 8359595
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT20: view
genes like me logo Genes that share phenotypes with KRT20: view

Animal Model Products

CRISPR Products

miRNA for KRT20 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT20 Gene

Localization for KRT20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT20 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10973561
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament NAS 8359595
genes like me logo Genes that share ontologies with KRT20: view

Pathways & Interactions for KRT20 Gene

genes like me logo Genes that share pathways with KRT20: view

Pathways by source for KRT20 Gene

2 Reactome pathways for KRT20 Gene
1 Cell Signaling Technology pathway for KRT20 Gene

Gene Ontology (GO) - Biological Process for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0009267 cellular response to starvation IEA --
GO:0031424 keratinization TAS --
GO:0045109 intermediate filament organization IEA,IMP 12857878
GO:0050708 regulation of protein secretion IEA --
genes like me logo Genes that share ontologies with KRT20: view

No data available for SIGNOR curated interactions for KRT20 Gene

Drugs & Compounds for KRT20 Gene

(10) Drugs for KRT20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for KRT20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT20: view

Transcripts for KRT20 Gene

mRNA/cDNA for KRT20 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT20

Alternative Splicing Database (ASD) splice patterns (SP) for KRT20 Gene

No ASD Table

Relevant External Links for KRT20 Gene

GeneLoc Exon Structure for
KRT20

Expression for KRT20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT20 Gene

This gene is overexpressed in Colon - Transverse (x36.8) and Small Intestine - Terminal Ileum (x13.0).

Protein differential expression in normal tissues from HIPED for KRT20 Gene

This gene is overexpressed in Colon (15.2), Saliva (15.2), Rectum (15.0), and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT20 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT20

SOURCE GeneReport for Unigene cluster for KRT20 Gene:

Hs.84905

mRNA Expression by UniProt/SwissProt for KRT20 Gene:

P35900-K1C20_HUMAN
Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.

Evidence on tissue expression from TISSUES for KRT20 Gene

  • Intestine(4.9)
  • Stomach(2.9)
  • Lung(2.6)
  • Pancreas(2.5)
  • Lymph node(2.3)
  • Skin(2.2)
  • Blood(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with KRT20: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT20 Gene

Orthologs for KRT20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT20 31 30
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KRT20 31 30
  • 81.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Krt20 17 31 30
  • 80.82 (n)
rat
(Rattus norvegicus)
Mammalia Krt20 30
  • 80.73 (n)
dog
(Canis familiaris)
Mammalia KRT20 31 30
  • 80.33 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KRT20 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 59 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves KRT20 31 30
  • 63.75 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:92061 31
  • 48 (a)
ManyToMany
cyt1l 31
  • 47 (a)
ManyToMany
wu:fb17f05 31
  • 47 (a)
ManyToMany
cyt1 31
  • 47 (a)
ManyToMany
zgc:109868 31
  • 47 (a)
ManyToMany
krt17 31
  • 46 (a)
ManyToMany
zgc:153629 31
  • 43 (a)
ManyToMany
krt15 31
  • 42 (a)
ManyToMany
zgc:92035 31
  • 42 (a)
ManyToMany
krt1-19d 31
  • 41 (a)
ManyToMany
zgc:136902 31
  • 40 (a)
ManyToMany
si:dkeyp-113d7.4 31
  • 39 (a)
ManyToMany
zgc:92533 31
  • 24 (a)
ManyToMany
BX469912.1 31
  • 22 (a)
ManyToMany
Species where no ortholog for KRT20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT20 Gene

ENSEMBL:
Gene Tree for KRT20 (if available)
TreeFam:
Gene Tree for KRT20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT20: view image

Paralogs for KRT20 Gene

genes like me logo Genes that share paralogs with KRT20: view

Variants for KRT20 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT20 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
711187 Benign: not provided 40,878,150(-) G/A SYNONYMOUS_VARIANT
713644 Likely Benign: not provided 40,880,765(-) T/C MISSENSE_VARIANT
755295 Likely Benign: not provided 40,880,211(-) A/C SYNONYMOUS_VARIANT
764910 Likely Benign: not provided 40,878,321(-) G/A SYNONYMOUS_VARIANT
777163 Benign: not provided 40,878,290(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for KRT20 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT20 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT20 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT20 Gene

Human Gene Mutation Database (HGMD)
KRT20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT20 Gene

Disorders for KRT20 Gene

MalaCards: The human disease database

(172) MalaCards diseases for KRT20 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
merkel cell carcinoma
  • trabecular adenocarcinoma
gastrointestinal carcinoma
  • gastrointestinal neoplasms
signet ring cell adenocarcinoma
  • signet ring carcinoma
neuroendocrine carcinoma
  • neuroendocrine cancer
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KRT20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT20 Gene

Publications for KRT20 Gene

  1. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PMID: 8359595) Moll R … Franke WW (Differentiation; research in biological diversity 1993) 2 3 4 23 54
  2. Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PMID: 12857878) Zhou Q … Omary MB (Molecular biology of the cell 2003) 3 4 23 54
  3. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PMID: 10973561) Barrett AW … Berkovitz BK (Archives of oral biology 2000) 3 4 23 54
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 41 54
  5. The clinical implications of MMP-11 and CK-20 expression in human breast cancer. (PMID: 19914229) Cheng CW … Shen CY (Clinica chimica acta; international journal of clinical chemistry 2010) 3 23 54

Products for KRT20 Gene

Sources for KRT20 Gene