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KRT20 Gene(Protein Coding)

Keratin 20

GCID:
GC17M040875
GIFtS:
48
Genes Participants
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Aliases for KRT20 Gene

Aliases for KRT20 Gene

  • Keratin 20 2 3 5
  • Keratin 20, Type I 2 3
  • Protein IT 3 4
  • CK-20 3 4
  • K20 3 4
  • Keratin, Type I Cytoskeletal 20 3
  • Cytokeratin 20 3
  • Cytokeratin-20 4
  • Keratin-20 4
  • KRT21 3
  • CD20 3
  • CK20 3

External Ids for KRT20 Gene

Previous GeneCards Identifiers for KRT20 Gene

  • GC17M038532
  • GC17M041208
  • GC17M038940
  • GC17M039405
  • GC17M036285
  • GC17M039030
  • GC17M034826

Summaries for KRT20 Gene

Entrez Gene Summary for KRT20 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT20 Gene

KRT20 (Keratin 20) is a Protein Coding gene. Diseases associated with KRT20 include Merkel Cell Carcinoma and Inverted Papilloma. Among its related pathways are Cytoskeletal Signaling and Keratinization. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT36.

UniProtKB/Swiss-Prot for KRT20 Gene

  • Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Gene Wiki entry for KRT20 Gene

Additional gene information for KRT20 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT20 Gene

Genomics for KRT20 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for KRT20 Gene

Promoters and enhancers for KRT20 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J040881 Promoter/Enhancer 1.1 EPDnew ENCODE 650.7 +1.4 1372 4.7 CTCF ZFP64 ZC3H11A ZNF384 ZNF781 ZNF518A ZNF697 ZNF335 SCRT2 PRDM10 KRT20 GC17P040954 TMEM99 NT5C3B MED24 ENSG00000234477 MSL1 SMARCE1 ENSG00000259623 LOC105371777
GH17J040886 Enhancer 0.5 ENCODE 650.7 -1.1 -1061 0.2 ZNF335 PRDM10 ZNF18 ZBTB20 KRT20 ENSG00000234477 GC17P040954 GC17P040968 LOC105371777
GH17J040908 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -27.7 -27732 8.7 FOXA2 MLX ARID4B SIN3A IRF4 ZNF213 ZNF143 FOS DEK SP5 KRT23 KRTAP3-2 MSL1 KRT20 TMEM99 KRT37 KRT28 KRT40 LOC100505782 KRT31
GH17J040948 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -69.5 -69470 11.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 DMAP1 SLC30A9 FOS SP5 KRTAP3-2 KRT23 KRTAP2-1 KRT39 KRT40 KRTAP2-2 ENSG00000234477 KRTAP3-3 KRTAP1-5 KRTAP3-1
GH17J040848 Enhancer 1.1 Ensembl ENCODE 10.9 +33.2 33189 6.9 ATF1 PKNOX1 FOXA2 ZNF133 FEZF1 NCOA2 TCF12 ATF7 FOS KLF13 GC17P040967 ENSG00000265359 TMEM99 KRT20 KRT28 ENSG00000234477 KRT37 KRT31 LOC100505782 MED24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT20 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • Nkx2-5
  • AREB6
  • POU6F1 (c2)

Genomic Locations for KRT20 Gene

Genomic Locations for KRT20 Gene
chr17:40,875,889-40,885,243
(GRCh38/hg38)
Size:
9,355 bases
Orientation:
Minus strand
chr17:39,032,141-39,041,495
(GRCh37/hg19)
Size:
9,355 bases
Orientation:
Minus strand

Genomic View for KRT20 Gene

Genes around KRT20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT20 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for KRT20 Gene

Proteins for KRT20 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for KRT20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35900-K1C20_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 20
    Protein Accession:
    P35900
    Secondary Accessions:
    • B2R6W7

    Protein attributes for KRT20 Gene

    Size:
    424 amino acids
    Molecular mass:
    48487 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Associates with KRT8.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT20 Gene

Protein Expression for KRT20 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for KRT20 Gene

  • Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
  • Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT20 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT20 Gene

Domains & Families for KRT20 Gene

Gene Families for KRT20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT20 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRT20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35900

UniProtKB/Swiss-Prot:

K1C20_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT20: view

Function for KRT20 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for KRT20 Gene

UniProtKB/Swiss-Prot Function:
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Phenotypes From GWAS Catalog for KRT20 Gene

Gene Ontology (GO) - Molecular Function for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 8359595
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with KRT20: view
genes like me logo Genes that share phenotypes with KRT20: view

Animal Model Products

CRISPR Products

miRNA for KRT20 Gene

miRTarBase miRNAs that target KRT20

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT20

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRT20 Gene

Localization for KRT20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRT20 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT20 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
mitochondrion 3
nucleus 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 10973561
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament NAS 8359595
genes like me logo Genes that share ontologies with KRT20: view

Pathways & Interactions for KRT20 Gene

genes like me logo Genes that share pathways with KRT20: view

Pathways by source for KRT20 Gene

2 Reactome pathways for KRT20 Gene
1 KEGG pathway for KRT20 Gene
1 Cell Signaling Technology pathway for KRT20 Gene

Gene Ontology (GO) - Biological Process for KRT20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0009267 cellular response to starvation IEA --
GO:0031424 keratinization TAS --
GO:0045109 intermediate filament organization IEA,IMP 12857878
GO:0050708 regulation of protein secretion IEA --
genes like me logo Genes that share ontologies with KRT20: view

No data available for SIGNOR curated interactions for KRT20 Gene

Drugs & Compounds for KRT20 Gene

Products:

  1. Drug

(10) Drugs for KRT20 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for KRT20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT20: view

Transcripts for KRT20 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for KRT20 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRT20 Gene

Keratin 20:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT20

Alternative Splicing Database (ASD) splice patterns (SP) for KRT20 Gene

No ASD Table

Relevant External Links for KRT20 Gene

GeneLoc Exon Structure for
KRT20
ECgene alternative splicing isoforms for
KRT20

Expression for KRT20 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT20 Gene

mRNA expression in normal human tissues for KRT20 Gene
mRNA expression by BioGPS for KRT20 GenemRNA expression by GTEx for KRT20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT20 Gene

This gene is overexpressed in Colon - Transverse (x36.8) and Small Intestine - Terminal Ileum (x13.0).

Protein differential expression in normal tissues from HIPED for KRT20 Gene

This gene is overexpressed in Colon (15.2), Saliva (15.2), Rectum (15.0), and Stomach (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT20 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT20 Gene:

KRT20

SOURCE GeneReport for Unigene cluster for KRT20 Gene:

Hs.84905

mRNA Expression by UniProt/SwissProt for KRT20 Gene:

P35900-K1C20_HUMAN
Tissue specificity: Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa.

Evidence on tissue expression from TISSUES for KRT20 Gene

  • Intestine(4.9)
  • Stomach(2.9)
  • Lung(2.6)
  • Pancreas(2.5)
  • Lymph node(2.3)
  • Skin(2.2)
  • Blood(2.1)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with KRT20: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT20 Gene

Orthologs for KRT20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia KRT20 34 33
  • 99.37 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia KRT20 34 33
  • 81.81 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Krt20 16 34 33
  • 80.82 (n)
rat
(Rattus norvegicus)
 Mammalia Krt20 33
  • 80.73 (n)
dog
(Canis familiaris)
 Mammalia KRT20 34 33
  • 80.33 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia KRT20 34
  • 61 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 59 (a)
 OneToMany
-- 34
  • 49 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves KRT20 34 33
  • 63.75 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 42 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii zgc:92061 34
  • 48 (a)
 ManyToMany
cyt1l 34
  • 47 (a)
 ManyToMany
wu:fb17f05 34
  • 47 (a)
 ManyToMany
cyt1 34
  • 47 (a)
 ManyToMany
zgc:109868 34
  • 47 (a)
 ManyToMany
krt17 34
  • 46 (a)
 ManyToMany
zgc:153629 34
  • 43 (a)
 ManyToMany
krt15 34
  • 42 (a)
 ManyToMany
zgc:92035 34
  • 42 (a)
 ManyToMany
krt1-19d 34
  • 41 (a)
 ManyToMany
zgc:136902 34
  • 40 (a)
 ManyToMany
si:dkeyp-113d7.4 34
  • 39 (a)
 ManyToMany
zgc:92533 34
  • 24 (a)
 ManyToMany
BX469912.1 34
  • 22 (a)
 ManyToMany
Species where no ortholog for KRT20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT20 Gene

ENSEMBL:
Gene Tree for KRT20 (if available)
TreeFam:
Gene Tree for KRT20 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT20: view image

Paralogs for KRT20 Gene

Paralogs for KRT20 Gene

(39) SIMAP similar genes for KRT20 Gene using alignment to 1 proteins:

  • K1C20_HUMAN
genes like me logo Genes that share paralogs with KRT20: view

Variants for KRT20 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for KRT20 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
VAR_036367 A colorectal cancer sample p.Ser4Arg
rs1000096802 -- 40,877,903(-) A/G intron_variant
rs1001038420 -- 40,875,824(-) G/A downstream_transcript_variant
rs1001089216 -- 40,882,438(-) C/G intron_variant
rs1001421610 -- 40,883,679(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT20 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159

Variation tolerance for KRT20 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT20 Gene

Human Gene Mutation Database (HGMD)
KRT20
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT20

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT20 Gene

Disorders for KRT20 Gene

MalaCards: The human disease database

(118) MalaCards diseases for KRT20 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
merkel cell carcinoma
  • trabecular adenocarcinoma
inverted papilloma
  • inverted papilloma, squamous cell
signet ring cell adenocarcinoma
  • signet ring carcinoma
paget disease, extramammary
  • cutaneous paget's disease
cystic basal cell carcinoma
  • skin cystic basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search KRT20 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with KRT20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT20 Gene

Publications for KRT20 Gene

  1. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. (PMID: 8359595) Moll R … Franke WW (Differentiation; research in biological diversity 1993) 2 3 4 22 58
  2. Keratin 20 helps maintain intermediate filament organization in intestinal epithelia. (PMID: 12857878) Zhou Q … Omary MB (Molecular biology of the cell 2003) 3 4 22 58
  3. An immunohistological study of cytokeratin 20 in human and mammalian oral epithelium. (PMID: 10973561) Barrett AW … Berkovitz BK (Archives of oral biology 2000) 3 4 22 58
  4. Identification of 15 loci influencing height in a Korean population. (PMID: 19893584) Kim JJ … Lee JK (Journal of human genetics 2010) 3 44 58
  5. The clinical implications of MMP-11 and CK-20 expression in human breast cancer. (PMID: 19914229) Cheng CW … Shen CY (Clinica chimica acta; international journal of clinical chemistry 2010) 3 22 58

Products for KRT20 Gene

  • Addgene plasmids for KRT20

Sources for KRT20 Gene

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