The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, th... See more...

Aliases for KRT19 Gene

Aliases for KRT19 Gene

  • Keratin 19 2 3 5
  • Keratin, Type I Cytoskeletal 19 2 3 4
  • K19 2 3 4
  • 40-KDa Keratin Intermediate Filament 2 3
  • Keratin, Type I, 40-Kd 2 3
  • Keratin 19, Type I 2 3
  • Cytokeratin 19 2 3
  • CK-19 3 4
  • CK19 2 3
  • K1CS 2 3
  • Cytokeratin-19 4
  • Keratin-19 4
  • MGC15366 2
  • KRT19 5

External Ids for KRT19 Gene

Previous GeneCards Identifiers for KRT19 Gene

  • GC17M039264
  • GC17P041708
  • GC17M039588
  • GC17M040053
  • GC17M036933
  • GC17M039679
  • GC17M035443

Summaries for KRT19 Gene

Entrez Gene Summary for KRT19 Gene

  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT19 Gene

KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Breast Cancer and Cholangiolocellular Carcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT15.

UniProtKB/Swiss-Prot Summary for KRT19 Gene

  • Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene Wiki entry for KRT19 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT19 Gene

Genomics for KRT19 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRT19 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT19 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRT19

Top Transcription factor binding sites by QIAGEN in the KRT19 gene promoter:
  • AP-2alpha isoform 2
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KRT19 Gene

Genomic Locations for KRT19 Gene
chr17:41,523,617-41,528,308
(GRCh38/hg38)
Size:
4,692 bases
Orientation:
Minus strand
chr17:39,679,869-39,684,641
(GRCh37/hg19)
Size:
4,773 bases
Orientation:
Minus strand

Genomic View for KRT19 Gene

Genes around KRT19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT19 Gene

Proteins for KRT19 Gene

  • Protein details for KRT19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08727-K1C19_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 19
    Protein Accession:
    P08727
    Secondary Accessions:
    • B2R874
    • Q5XG83
    • Q6NW33
    • Q7L5M9
    • Q96A53
    • Q96FV1
    • Q9BYF9
    • Q9P1Y4

    Protein attributes for KRT19 Gene

    Size:
    400 amino acids
    Molecular mass:
    44106 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.
    • (Microbial infection) Interacts with hepatitis C virus/HCV core protein.
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

neXtProt entry for KRT19 Gene

Post-translational modifications for KRT19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRT19 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for KRT19 Gene

Domains & Families for KRT19 Gene

Gene Families for KRT19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRT19 Gene

InterPro:
Blocks:
  • Intermediate filament protein
  • Type I keratin signature
ProtoNet:

Suggested Antigen Peptide Sequences for KRT19 Gene

GenScript: Design optimal peptide antigens:
  • Keratin-19 (K1C19_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08727

UniProtKB/Swiss-Prot:

K1C19_HUMAN :
  • This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
  • Belongs to the intermediate filament family.
Domain:
  • This keratin differs from all other IF proteins in lacking the C-terminal tail domain.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT19: view

Function for KRT19 Gene

Molecular function for KRT19 Gene

UniProtKB/Swiss-Prot Function:
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
GENATLAS Biochemistry:
keratin 19,type I (maybe included in KRTI@1),simple epithelia,hair follicle,nail bed

Phenotypes From GWAS Catalog for KRT19 Gene

Gene Ontology (GO) - Molecular Function for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 2448790
GO:0005515 protein binding IPI 15846844
GO:0008307 structural constituent of muscle IDA 16000376
GO:0044877 protein-containing complex binding IEA --
genes like me logo Genes that share ontologies with KRT19: view
genes like me logo Genes that share phenotypes with KRT19: view

Animal Models for KRT19 Gene

MGI Knock Outs for KRT19:

Animal Model Products

CRISPR Products

miRNA for KRT19 Gene

miRTarBase miRNAs that target KRT19

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT19

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KRT19 Gene

Localization for KRT19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT19 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 4
mitochondrion 3
nucleus 3
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0005886 plasma membrane IDA 23377137
GO:0016010 dystrophin-associated glycoprotein complex IEA --
GO:0016327 apicolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with KRT19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT19 Gene

Pathways & Interactions for KRT19 Gene

genes like me logo Genes that share pathways with KRT19: view

Pathways by source for KRT19 Gene

1 BioSystems pathway for KRT19 Gene
2 Reactome pathways for KRT19 Gene
1 GeneGo (Thomson Reuters) pathway for KRT19 Gene
  • Cytoskeleton remodeling Keratin filaments
1 Cell Signaling Technology pathway for KRT19 Gene

SIGNOR curated interactions for KRT19 Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for KRT19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0016032 viral process IEA --
GO:0031424 keratinization TAS --
GO:0043627 response to estrogen IEP 10037815
GO:0045214 sarcomere organization IDA 16000376
genes like me logo Genes that share ontologies with KRT19: view

Drugs & Compounds for KRT19 Gene

(23) Drugs for KRT19 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for KRT19 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT19: view

Transcripts for KRT19 Gene

mRNA/cDNA for KRT19 Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT19

Alternative Splicing Database (ASD) splice patterns (SP) for KRT19 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - -
SP2: -
SP3: - - - -
SP4:
SP5: - - - - - - - - - - -
SP6: - - -
SP7:

Relevant External Links for KRT19 Gene

GeneLoc Exon Structure for
KRT19

Expression for KRT19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRT19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRT19 Gene

This gene is overexpressed in Esophagus - Mucosa (x7.4), Minor Salivary Gland (x6.6), Colon - Transverse (x6.3), Small Intestine - Terminal Ileum (x4.8), and Bladder (x4.7).

Protein differential expression in normal tissues from HIPED for KRT19 Gene

This gene is overexpressed in Salivary gland (10.7), Saliva (9.6), and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT19 Gene



Protein tissue co-expression partners for KRT19 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRT19

SOURCE GeneReport for Unigene cluster for KRT19 Gene:

Hs.654568

mRNA Expression by UniProt/SwissProt for KRT19 Gene:

P08727-K1C19_HUMAN
Tissue specificity: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

Evidence on tissue expression from TISSUES for KRT19 Gene

  • Pancreas(5)
  • Intestine(4.8)
  • Lung(4.8)
  • Blood(4.6)
  • Liver(4.6)
  • Skin(4.6)
  • Eye(4.6)
  • Lymph node(4.5)
  • Kidney(4.1)
  • Nervous system(4)
  • Stomach(4)
  • Thyroid gland(3.8)
  • Gall bladder(3.7)
  • Heart(2.9)
  • Muscle(2.8)
  • Adrenal gland(2.4)
  • Bone marrow(2.3)
  • Bone(2)
genes like me logo Genes that share expression patterns with KRT19: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT19 Gene

Orthologs for KRT19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT19 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRT19 30 31
  • 99.08 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRT19 30 31
  • 88.97 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRT19 30 31
  • 88.35 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Krt19 30 17 31
  • 83.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krt19 30
  • 83 (n)
Oppossum
(Monodelphis domestica)
Mammalia KRT19 31
  • 79 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KRT19 30 31
  • 72.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KRT19 31
  • 68 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia krt19 30
  • 71.21 (n)
Species where no ortholog for KRT19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for KRT19 Gene

ENSEMBL:
Gene Tree for KRT19 (if available)
TreeFam:
Gene Tree for KRT19 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT19: view image

Paralogs for KRT19 Gene

genes like me logo Genes that share paralogs with KRT19: view

Variants for KRT19 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRT19 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
734201 Benign: not provided 41,525,229(-) G/A SYNONYMOUS_VARIANT
734202 Benign: not provided 41,528,017(-) C/A SYNONYMOUS_VARIANT
rs11550883 Benign: not specified; not provided 41,528,158(-) G/A SYNONYMOUS_VARIANT
rs200777034 Not Provided: not provided 41,528,199(-) C/T MISSENSE_VARIANT
rs267607654 Not Provided: not provided 41,524,516(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for KRT19 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRT19 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv2760463 CNV gain 21179565
esv34903 CNV gain 17911159
esv3640588 CNV gain 21293372
esv3640589 CNV gain 21293372
nsv1062354 CNV gain 25217958
nsv1063389 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv442419 CNV gain 18776908
nsv510711 CNV deletion 20534489
nsv526466 CNV gain 19592680
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495
nsv978425 CNV duplication 23825009

Variation tolerance for KRT19 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT19 Gene

Disorders for KRT19 Gene

MalaCards: The human disease database

(141) MalaCards diseases for KRT19 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
cholangiolocellular carcinoma
syringocystadenoma papilliferum
  • papillary hidradenoma
papillary carcinoma
  • carcinoma papillary
follicular adenoma
  • follicular adenoma of the thyroid gland
- elite association - COSMIC cancer census association via MalaCards
Search KRT19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KRT19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT19 Gene

Publications for KRT19 Gene

  1. Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19. (PMID: 16000376) Stone MR … Bloch RJ (Molecular biology of the cell 2005) 3 4 23
  2. Genomic organization and amplification of the human keratin 15 and keratin 19 genes. (PMID: 10623642) Whittock NV … McGrath JA (Biochemical and biophysical research communications 2000) 3 4 23
  3. Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization. (PMID: 10212274) Zhou X … Omary MB (The Journal of biological chemistry 1999) 3 4 23
  4. Universal markers of thyroid malignancies: galectin-3, HBME-1, and cytokeratin-19. (PMID: 20198455) Barut F … Ozdamar SO (Endocrine pathology 2010) 3 23
  5. Clinical meaning of age-related expression of fecal cytokeratin 19 in colorectal malignancy. (PMID: 19849844) Chang CC … Huang CJ (BMC cancer 2009) 3 23

Products for KRT19 Gene