Aliases for KRT19 Gene
External Ids for KRT19 Gene
Previous GeneCards Identifiers for KRT19 Gene
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT19 Gene
KRT19 (Keratin 19) is a Protein Coding gene. Diseases associated with KRT19 include Breast Cancer and Cholangiolocellular Carcinoma. Among its related pathways are Cytoskeleton remodeling Neurofilaments and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT15.
UniProtKB/Swiss-Prot Summary for KRT19 Gene
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.