Aliases for KRT16 Gene
Aliases for KRT16 Gene
External Ids for KRT16 Gene
- HGNC: 6423
- Entrez Gene: 3868
- Ensembl: ENSG00000186832
- OMIM: 148067
- UniProtKB: P08779
Previous GeneCards Identifiers for KRT16 Gene
- GC17M020580
- GC17M041881
- GC17M039544
- GC17M040139
- GC17M037019
- GC17M039766
- GC17M035529
Summaries for KRT16 Gene
-
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT16 Gene
KRT16 (Keratin 16) is a Protein Coding gene. Diseases associated with KRT16 include Pachyonychia Congenita 1 and Palmoplantar Keratoderma, Nonepidermolytic, Focal 1. Among its related pathways are Keratinization and Cytoskeleton remodeling Neurofilaments. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of cytoskeleton. An important paralog of this gene is KRT14.
UniProtKB/Swiss-Prot for KRT16 Gene
-
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Additional gene information for KRT16 Gene
- Monarch Initiative
- Search for KRT16 at DataMed
- Search for KRT16 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRT16 Gene
Genomics for KRT16 Gene
GeneHancer (GH) Regulatory Elements for KRT16 Gene
Promoters and enhancers for KRT16 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KRT16 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KRT16 gene promoter:
-
- STAT3
- TBP
- STAT1
- RREB-1
- Pax-6
- Lmo2
- ATF-2
Regulatory Element Products
Genomic Locations for KRT16 Gene
Genomic Locations for KRT16 Gene
- chr17:41,609,778-41,615,899
- (GRCh38/hg38)
- Size:
- 6,122 bases
- Orientation:
- Minus strand
- chr17:39,766,030-39,772,151
- (GRCh37/hg19)
- Size:
- 6,122 bases
- Orientation:
- Minus strand
Genomic View for KRT16 Gene
Genes around KRT16 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.2 by Entrez Gene
- 17q21.2 by HGNC
- 17q21.2 by Ensembl
KRT16 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KRT16 Gene
Proteins for KRT16 Gene
-
Protein details for KRT16 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08779-K1C16_HUMAN
- Recommended name:
- Keratin, type I cytoskeletal 16
- Protein Accession:
- P08779
- A8K488
- P30654
- Q16402
- Q9UBG8
Protein attributes for KRT16 Gene
- Size:
- 473 amino acids
- Molecular mass:
- 51268 Da
- Quaternary structure:
-
- Heterodimer of a type I and a type II keratin. KRT16 associates with KRT6 isomers (KRT6A or KRT6B) (By similarity). Interacts with TCHP (PubMed:15731013). Interacts with TRADD (By similarity).
- Miscellaneous:
-
- There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).
Protein Expression for KRT16 Gene
Post-translational modifications for KRT16 Gene
Other Protein References for KRT16 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for KRT16
- Novus Biologicals Antibodies for KRT16
- Invitrogen Antibodies for KRT16 (AFLGC-KRT16)
- GeneTex KRT16 Antibody for KRT16
-
Santa Cruz Biotechnology (SCBT) Antibodies for KRT16
Protein Products
-
OriGene Purified Proteins for KRT16
- Search Origene for MassSpec and Protein Over-expression Lysates for KRT16
- Origene Custom Protein Services for KRT16
- ProSpec Recombinant Proteins for KRT16
- Search GeneTex for Proteins for KRT16
-
Abcam proteins for KRT16
Assay Products
- antibodies-online: Search results for 12 available KRT16 Elisa Kits ranked by validation data
- Compare Top KRT16 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for KRT16 Gene
Domains & Families for KRT16 Gene
Gene Families for KRT16 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for KRT16 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KRT16 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08779- Family:
-
- Belongs to the intermediate filament family.
Function for KRT16 Gene
Molecular function for KRT16 Gene
- UniProtKB/Swiss-Prot Function:
- Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
- GENATLAS Biochemistry:
- keratin 16,type I,hair follicle,nail bed,palmoplantar skin,suprabasal orogenital mucosal keratinocytes,dimerizing with KRT6A,KRT6B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | NAS,IEA | 2451124 |
| GO:0005515 | protein binding | IPI | 15731013 |
Phenotypes for KRT16 Gene
- MGI mutant phenotypes for KRT16:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for KRT16:
Animal Models for KRT16 Gene
- MGI Knock Outs for KRT16:
-
- Krt16 Krt16<tm1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for KRT16
-
CRISPR Products
-
OriGene CRISPR knockouts for KRT16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT16
- genomics-online: gRNA clones - Search results for available KRT16 gene related products
- Applied Biological Materials CRISPR for KRT16
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT16
- GenScript: Design CRISPR guide RNA sequences for KRT16
miRNA for KRT16 Gene
- miRTarBase miRNAs that target KRT16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRT16
- Browse OriGene Inhibitory RNA Products For KRT16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT16
- genomics-online: shRNA clones - Search results for available KRT16 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRT16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRT16
- genomics-online: cdna clones - Search results for available KRT16 gene related products
- orf clones - Search results for available KRT16 gene related products
- Applied Biological Materials Clones for KRT16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KRT16
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for KRT16 Gene
Localization for KRT16 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Intermediate filaments (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IDA | 20403371 |
| GO:0005882 | intermediate filament | IEA,NAS | 2451124 |
| GO:0070062 | extracellular exosome | HDA | 19199708 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT16 Gene
Pathways & Interactions for KRT16 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Circadian entrainment | ||
| 2 | Developmental Biology | ||
| 3 | Keratinization |
.33
|
|
| 4 | Cytoskeleton remodeling Neurofilaments | ||
Pathways by source for KRT16 Gene
2 Reactome pathways for KRT16 Gene
1 KEGG pathway for KRT16 Gene
1 GeneGo (Thomson Reuters) pathway for KRT16 Gene
Interacting Proteins for KRT16 Gene
Selected Interacting proteins:
ENSP00000301653
P08779-K1C16_HUMAN
for KRT16 Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for KRT16
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002009 | morphogenesis of an epithelium | ISS | -- |
| GO:0006954 | inflammatory response | ISS,IEA | -- |
| GO:0007010 | cytoskeleton organization | NAS | 2451124 |
| GO:0007568 | aging | IDA | 21916889 |
| GO:0008283 | cell proliferation | TAS | 8595410 |
No data available for SIGNOR curated interactions for KRT16 Gene
Drugs & Compounds for KRT16 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Zinc | Approved, Investigational | Pharma | Target | 2430 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
Transcripts for KRT16 Gene
mRNA/cDNA for KRT16 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (659) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000301653 1644 bps (uc002hxg.5)
- ENST00000593067 910 bps (uc060fca.1)
- ENST00000588319 1000 bps (uc060fcb.1)
- ENST00000590990 499 bps (uc060fcc.1)
CRISPR Products
-
OriGene CRISPR knockouts for KRT16
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT16
- genomics-online: gRNA clones - Search results for available KRT16 gene related products
- Applied Biological Materials CRISPR for KRT16
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KRT16
- GenScript: Design CRISPR guide RNA sequences for KRT16
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KRT16
- Browse OriGene Inhibitory RNA Products For KRT16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT16
- genomics-online: shRNA clones - Search results for available KRT16 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KRT16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRT16
- genomics-online: cdna clones - Search results for available KRT16 gene related products
- orf clones - Search results for available KRT16 gene related products
- Applied Biological Materials Clones for KRT16
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KRT16 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
- Fetal Medulla Cells Hair Shaft
- Intermediate Keratinocytes Embryonic Epidermis
- Esophageal keratinocytes
- Epithelial cells (family)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Hair (Integumentary System)
- Fetal Companion Cells Companion Layer
- Fetal Medulla Cells Hair Shaft
- human epithelial stem cells(Yang R et. al. 2014)
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
- Mature airway epithelial cells(Wong AP et. al. 2012)
-
Epidermis (Integumentary System)
- Intermediate Keratinocytes Embryonic Epidermis
- human epithelial stem cells(Yang R et. al. 2014)
- Gut Tube (Gastrointestinal Tract)
- Thymus (Hematopoietic System)
- Eye (Sensory Organs)
- Esophagus
mRNA differential expression in normal tissues according to GTEx for KRT16 Gene
This gene is overexpressed in Esophagus - Mucosa (x17.8), Skin - Not Sun Exposed (Suprapubic) (x8.7), Minor Salivary Gland (x7.7), Vagina (x7.0), Cervix - Ectocervix (x6.2), and Skin - Sun Exposed (Lower leg) (x4.2).
This gene is overexpressed in Urinary Bladder (35.3), Hair follicle (14.6), and Saliva (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT16 Gene
NURSA nuclear receptor signaling pathways regulating expression of KRT16 Gene:
KRT16SOURCE GeneReport for Unigene cluster for KRT16 Gene:
Hs.655160mRNA Expression by UniProt/SwissProt for KRT16 Gene:
P08779-K1C16_HUMAN
Tissue specificity:
Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts.
Evidence on tissue expression from TISSUES for KRT16 Gene
- Skin(5)
- Liver(4.2)
- Blood(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT16 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- scalp
- skull
- tongue
- tooth
- vocal cord
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- hair
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for KRT16
-
OriGene qPCR primer pairs and template standards for KRT16
- genomics-online: primer clones - Search results for available KRT16 gene related products
Gene Expression Assay Products
Orthologs for KRT16 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KRT16 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KRT16 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Krt16 33 |
|
||
| cow (Bos Taurus) |
Mammalia | KRT16 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Krt16 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | KRT14 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | Dr.25556 33 |
|
- Species where no ortholog for KRT16 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for KRT16 Gene
- ENSEMBL:
- Gene Tree for KRT16 (if available)
- TreeFam:
- Gene Tree for KRT16 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KRT16: view image
Paralogs for KRT16 Gene
Paralogs for KRT16 Gene
(52) SIMAP similar genes for KRT16 Gene using alignment to 3 proteins:
- K1C16_HUMAN
- K7ENV3_HUMAN
- K7ENW6_HUMAN
- keratin
- KRT14
- K14
- GUCA1B
- JUP
- KRT17
- KRT15
- KRT13
- KRT19
- KRT34
- KRT33A
- KRT33B
- KRT31
- KRT12
- KRT10
- KRT35
- KRT20
- KRT9
- KRT32
- KRT27
- KRT18
- KRT24
- KRT23
- KRT36
- KRTHA7
- KRT38
- KRT37
- KRT28
- KRT26
- KRT25
- KRT39
- KRT7
- KRT40
- VIM
- KRT5
- PRPH
- NEFL
- NEFM
- GFAP
- KRT8
- DES
- KRT75
- KRT3
- KRT1
- INA
- KRT76
- KRT2
- tmp_locus_29
- KRT4
- KRT6C
- KRT6B
- KRT77
Pseudogenes.org Pseudogenes for KRT16 Gene
Variants for KRT16 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs145649029 | uncertain-significance, Inborn genetic diseases | 41,611,115(-) | A/G | coding_sequence_variant, missense_variant | |
| rs28928894 | pathogenic, not-provided, not provided, Pachyonychia congenita 1, Pachyonychia congenita 1 (PC1) [MIM:167200] | 41,612,327(-) | A/C/G/T | coding_sequence_variant, missense_variant | |
| rs28928895 | pathogenic, not-provided, not provided, Pachyonychia congenita 1, Pachyonychia congenita 1 (PC1) [MIM:167200] | 41,612,306(-) | A/G/T | coding_sequence_variant, missense_variant | |
| rs57424749 | pathogenic, not-provided, Pachyonychia congenita 1, not provided, Pachyonychia congenita 1 (PC1) [MIM:167200] | 41,612,309(-) | C/G/T | coding_sequence_variant, missense_variant | |
| rs58181827 | pathogenic, Pachyonychia congenita 1, not provided | 41,612,298(-) | AGGAGG/AGG | coding_sequence_variant, inframe_deletion |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2758690 | CNV | gain+loss | 17122850 |
| esv34903 | CNV | gain | 17911159 |
| esv3640591 | CNV | gain | 21293372 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv575040 | CNV | gain | 21841781 |
| nsv827992 | CNV | gain | 20364138 |
| nsv962326 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
96.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.10;
61.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KRT16 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT16 Gene
Disorders for KRT16 Gene
(33) MalaCards diseases for KRT16 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| pachyonychia congenita 1 |
|
|
| palmoplantar keratoderma, nonepidermolytic, focal 1 |
|
|
| isolated focal non-epidermolytic palmoplantar keratoderma |
|
|
| palmoplantar keratoderma, nonepidermolytic |
|
|
| type i |
|
|
Search KRT16 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
K1C16_HUMAN- Pachyonychia congenita 1 (PC1) [MIM:167200]: An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present. {ECO:0000269 PubMed:10521820, ECO:0000269 PubMed:10606845, ECO:0000269 PubMed:10839714, ECO:0000269 PubMed:11359398, ECO:0000269 PubMed:11886499, ECO:0000269 PubMed:16250206, ECO:0000269 PubMed:17719747, ECO:0000269 PubMed:21160496, ECO:0000269 PubMed:21326300, ECO:0000269 PubMed:22668561, ECO:0000269 PubMed:24118415, ECO:0000269 PubMed:7539673}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1) [MIM:613000]: A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present. {ECO:0000269 PubMed:8595410}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Note=KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
Additional Disease Information for KRT16
No data available for Genatlas for KRT16 Gene
Publications for KRT16 Gene
- A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita. (PMID: 17719747) Liao H … Smith FJ (Journal of dermatological science 2007) 3 4 22 58
- Delayed-onset pachyonychia congenita associated with a novel mutation in the central 2B domain of keratin 16. (PMID: 11359398) Connors JB … Milstone LM (The British journal of dermatology 2001) 3 4 22 58
- Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita. (PMID: 11886499) Terrinoni A … McLean WH (The Journal of investigative dermatology 2001) 3 4 22 58
- Novel keratin 16 mutations and protein expression studies in pachyonychia congenita type 1 and focal palmoplantar keratoderma. (PMID: 10839714) Smith FJ … McLean WH (Experimental dermatology 2000) 3 4 22 58
- A mutation in the V1 domain of K16 is responsible for unilateral palmoplantar verrucous nevus. (PMID: 10844556) Terrinoni A … Melino G (The Journal of investigative dermatology 2000) 3 4 22 58
Products for KRT16 Gene
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- GenScript Custom overexpressing Cell Line Services for KRT16
- GenScript: Design CRISPR guide RNA sequences for KRT16
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for KRT16
- Sino Biological Human cDNA Clone for KRT16
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KRT16
- Novus Biologicals lysates and proteins for KRT16
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
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- Abcam proteins for KRT16
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- Search Knockout (KO) Validated Antibodies
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- ProSpec Recombinant Proteins for KRT16
- Invitrogen Antibodies for KRT16 (AFLGC-KRT16)
- Cyagen custom Knockout/knockin (KOKI) mouse models for KRT16
- antibodies-online: Search results for 111 available KRT16 Antibodies ranked by validation data
- Compare Top KRT16 Antibodies
- antibodies-online: Search results for 12 available KRT16 Elisa Kits ranked by validation data
- Compare Top KRT16 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 8 available KRT16 Proteins ranked by validation data
- Compare Top KRT16 Proteins
- GeneTex KRT16 Antibody for KRT16
- Search GeneTex for Proteins for KRT16
- Santa Cruz Biotechnology (SCBT) Antibodies for KRT16
- Search Santa Cruz Biotechnology (SCBT) for KRT16 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KRT16
- Horizon Cell Lines for KRT16
- genomics-online: cdna clones - Search results for available KRT16 gene related products
- orf clones - Search results for available KRT16 gene related products
- genomics-online: gRNA clones - Search results for available KRT16 gene related products
- genomics-online: primer clones - Search results for available KRT16 gene related products
- genomics-online: shRNA clones - Search results for available KRT16 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KRT16
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KRT16
- GeneCopoeia miRNA 3'UTR Target clone products for KRT16
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT16
Sources for KRT16 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt