The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a re... See more...

Aliases for KRT15 Gene

Aliases for KRT15 Gene

  • Keratin 15 2 3 5
  • Keratin, Type I Cytoskeletal 15 3 4
  • Type I Cytoskeletal 15 2 3
  • Keratin 15, Type I 2 3
  • Keratin-15, Basic 2 3
  • Keratin-15, Beta 2 3
  • Cytokeratin 15 2 3
  • CK-15 3 4
  • K15 3 4
  • Cytokeratin-15 4
  • Keratin-15 4
  • CK15 3
  • K1CO 3
  • KRTB 4

External Ids for KRT15 Gene

Previous GeneCards Identifiers for KRT15 Gene

  • GC17M039254
  • GC17P041715
  • GC17M039578
  • GC17M040043
  • GC17M036923
  • GC17M039674
  • GC17M035433
  • GC17M039675

Summaries for KRT15 Gene

Entrez Gene Summary for KRT15 Gene

  • The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRT15 Gene

KRT15 (Keratin 15) is a Protein Coding gene. Diseases associated with KRT15 include Castleman Disease and Eccrine Acrospiroma. Among its related pathways are Developmental Biology and Circadian entrainment. Gene Ontology (GO) annotations related to this gene include structural molecule activity and scaffold protein binding. An important paralog of this gene is KRT13.

Gene Wiki entry for KRT15 Gene

Additional gene information for KRT15 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRT15 Gene

Genomics for KRT15 Gene

GeneHancer (GH) Regulatory Elements for KRT15 Gene

Promoters and enhancers for KRT15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRT15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRT15 gene promoter:
  • HNF-4alpha1
  • p53
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for KRT15 Gene

Genomic Locations for KRT15 Gene
chr17:41,513,745-41,522,529
(GRCh38/hg38)
Size:
8,785 bases
Orientation:
Minus strand
chr17:39,669,995-39,678,781
(GRCh37/hg19)
Size:
8,787 bases
Orientation:
Minus strand

Genomic View for KRT15 Gene

Genes around KRT15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRT15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRT15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRT15 Gene

Proteins for KRT15 Gene

  • Protein details for KRT15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19012-K1C15_HUMAN
    Recommended name:
    Keratin, type I cytoskeletal 15
    Protein Accession:
    P19012
    Secondary Accessions:
    • B3KQY1
    • B3KRA2
    • E0CX14
    • Q53XV8
    • Q9BUG4

    Protein attributes for KRT15 Gene

    Size:
    456 amino acids
    Molecular mass:
    49212 Da
    Quaternary structure:
    • Heterotetramer of two type I and two type II keratins. Interacts with NOD2 (PubMed:27812135).
    Miscellaneous:
    • There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Alternative splice isoforms for KRT15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRT15 Gene

Post-translational modifications for KRT15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRT15 Gene

Domains & Families for KRT15 Gene

Gene Families for KRT15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KRT15 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ33920 fis, clone CTONG2016904, highly similar to KERATIN, TYPE I CYTOSKELETAL 15 (B3KRA2_HUMAN)
  • Keratin-15 (K1C15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P19012

UniProtKB/Swiss-Prot:

K1C15_HUMAN :
  • Belongs to the intermediate filament family.
Family:
  • Belongs to the intermediate filament family.
genes like me logo Genes that share domains with KRT15: view

Function for KRT15 Gene

Molecular function for KRT15 Gene

GENATLAS Biochemistry:
keratin 15,type I,basal layer

Phenotypes From GWAS Catalog for KRT15 Gene

Gene Ontology (GO) - Molecular Function for KRT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton TAS 2580298
GO:0005515 protein binding IPI 16189514
GO:0097110 scaffold protein binding IPI 10852826
genes like me logo Genes that share ontologies with KRT15: view
genes like me logo Genes that share phenotypes with KRT15: view

Animal Models for KRT15 Gene

MGI Knock Outs for KRT15:
  • Krt15 Krt15<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for KRT15 Gene

miRTarBase miRNAs that target KRT15

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KRT15 Gene

Localization for KRT15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRT15 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 2
plasma membrane 1
extracellular 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with KRT15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRT15 Gene

Pathways & Interactions for KRT15 Gene

genes like me logo Genes that share pathways with KRT15: view

Pathways by source for KRT15 Gene

2 Reactome pathways for KRT15 Gene

SIGNOR curated interactions for KRT15 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for KRT15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0008544 epidermis development TAS 2452170
GO:0031424 keratinization TAS --
GO:0070268 cornification TAS --
genes like me logo Genes that share ontologies with KRT15: view

Drugs & Compounds for KRT15 Gene

(3) Drugs for KRT15 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for KRT15 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRT15: view

Transcripts for KRT15 Gene

mRNA/cDNA for KRT15 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRT15

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRT15 Gene

No ASD Table

Relevant External Links for KRT15 Gene

GeneLoc Exon Structure for
KRT15
ECgene alternative splicing isoforms for
KRT15

Expression for KRT15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRT15 Gene

mRNA differential expression in normal tissues according to GTEx for KRT15 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.7), Skin - Not Sun Exposed (Suprapubic) (x7.9), Skin - Sun Exposed (Lower leg) (x6.6), and Vagina (x6.3).

Protein differential expression in normal tissues from HIPED for KRT15 Gene

This gene is overexpressed in Skin (17.0), Esophagus (10.7), Cervix (10.7), and Saliva (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRT15 Gene



NURSA nuclear receptor signaling pathways regulating expression of KRT15 Gene:

KRT15

SOURCE GeneReport for Unigene cluster for KRT15 Gene:

Hs.654570

mRNA Expression by UniProt/SwissProt for KRT15 Gene:

P19012-K1C15_HUMAN
Tissue specificity: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

Evidence on tissue expression from TISSUES for KRT15 Gene

  • Pancreas(4.2)
  • Skin(4.2)
  • Lung(3.2)
  • Eye(2.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with KRT15: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRT15 Gene

Orthologs for KRT15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRT15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRT15 33 32
  • 98.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KRT15 33 32
  • 89.65 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Krt15 17 33 32
  • 87.25 (n)
rat
(Rattus norvegicus)
Mammalia Krt15 32
  • 86.65 (n)
cow
(Bos Taurus)
Mammalia KRT15 33 32
  • 84.47 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 63 (a)
ManyToMany
chicken
(Gallus gallus)
Aves KRT15 33 32
  • 76.5 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76282 32
zebrafish
(Danio rerio)
Actinopterygii zgc:153629 32
  • 67.09 (n)
cki 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12002 32
Species where no ortholog for KRT15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRT15 Gene

ENSEMBL:
Gene Tree for KRT15 (if available)
TreeFam:
Gene Tree for KRT15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRT15: view image

Paralogs for KRT15 Gene

(57) SIMAP similar genes for KRT15 Gene using alignment to 6 proteins:

  • K1C15_HUMAN
  • A8MT21_HUMAN
  • B3KRA2_HUMAN
  • C9JTG5_HUMAN
  • K7EMX0_HUMAN
  • K7EQK9_HUMAN
genes like me logo Genes that share paralogs with KRT15: view

Variants for KRT15 Gene

Sequence variations from dbSNP and Humsavar for KRT15 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000884343 -- 41,520,413(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000936445 -- 41,520,292(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001482736 -- 41,518,767(-) C/T coding_sequence_variant, missense_variant
rs1001601913 -- 41,522,712(-) C/T upstream_transcript_variant
rs1001639220 -- 41,521,764(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRT15 Gene

Variant ID Type Subtype PubMed ID
esv2758690 CNV gain+loss 17122850
esv2760463 CNV gain 21179565
esv34903 CNV gain 17911159
esv3640588 CNV gain 21293372
esv3640589 CNV gain 21293372
nsv1062354 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv442419 CNV gain 18776908
nsv483014 CNV loss 15286789
nsv510711 CNV deletion 20534489
nsv526466 CNV gain 19592680
nsv827992 CNV gain 20364138
nsv9555 CNV gain 18304495

Variation tolerance for KRT15 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.65; 78.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRT15 Gene

Human Gene Mutation Database (HGMD)
KRT15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRT15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRT15 Gene

Disorders for KRT15 Gene

MalaCards: The human disease database

(26) MalaCards diseases for KRT15 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
castleman disease
  • angiofollicular lymph hyperplasia
eccrine acrospiroma
  • eccrine hidradenoma
eccrine sweat gland neoplasm
  • eccrine skin neoplasm
central centrifugal cicatricial alopecia
  • ccca
eccrine sweat gland cancer
  • malignant eccrine skin neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search KRT15 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRT15

genes like me logo Genes that share disorders with KRT15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRT15 Gene

Publications for KRT15 Gene

  1. Genomic organization and amplification of the human keratin 15 and keratin 19 genes. (PMID: 10623642) Whittock NV … McGrath JA (Biochemical and biophysical research communications 2000) 3 4 23 56
  2. Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes. (PMID: 10084315) Waseem A … Leigh IM (The Journal of investigative dermatology 1999) 3 4 23 56
  3. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. (PMID: 27812135) Thiébaut R … Ollendorff V (PloS one 2016) 3 4 56
  4. Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus. (PMID: 19162247) Al-Refu K … Goodfield M (Autoimmunity reviews 2009) 3 23 56
  5. Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma. (PMID: 18789069) Choi CW … Cho KH (The Journal of dermatology 2008) 3 23 56

Products for KRT15 Gene

Sources for KRT15 Gene