Aliases for KRT10 Gene
External Ids for KRT10 Gene
Previous HGNC Symbols for KRT10 Gene
Previous GeneCards Identifiers for KRT10 Gene
This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
GeneCards Summary for KRT10 Gene
KRT10 (Keratin 10) is a Protein Coding gene. Diseases associated with KRT10 include Epidermolytic Hyperkeratosis and Erythroderma, Ichthyosiform, Congenital Reticular. Among its related pathways are Developmental Biology and Staphylococcus aureus infection. Gene Ontology (GO) annotations related to this gene include structural molecule activity and structural constituent of epidermis. An important paralog of this gene is KRT14.
UniProtKB/Swiss-Prot Summary for KRT10 Gene
Plays a role in the establishment of the epidermal barrier on plantar skin.
(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.
(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.