Aliases for KRR1 Gene

Aliases for KRR1 Gene

  • KRR1 Small Subunit Processome Component Homolog 2 3 4 5
  • KRR-R Motif-Containing Protein 1 3 4
  • HIV-1 Rev Binding Protein 2 2 3
  • HIV-1 Rev-Binding Protein 2 3 4
  • Rev-Interacting Protein 1 3 4
  • RIP-1 2 3
  • HRB2 3 4
  • KRR1, Small Subunit (SSU) Processome Component, Homolog (Yeast) 2
  • KRR1, Small Subunit (SSU) Processome Component, Homolog 3
  • KRR1, Small Subunit Processome Component Homolog 2
  • Rev Interacting Protein 3
  • Rip-1 4
  • KRR1 5

External Ids for KRR1 Gene

Previous HGNC Symbols for KRR1 Gene

  • HRB2

Previous GeneCards Identifiers for KRR1 Gene

  • GC12M074178
  • GC12M075891
  • GC12M072941

Summaries for KRR1 Gene

GeneCards Summary for KRR1 Gene

KRR1 (KRR1 Small Subunit Processome Component Homolog) is a Protein Coding gene. Diseases associated with KRR1 include Duodenum Adenoma and Duodenal Benign Neoplasm. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot Summary for KRR1 Gene

  • Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Gene Wiki entry for KRR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRR1 Gene

Genomics for KRR1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J075508 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 661.3 +0.9 914 4.9 SP1 CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 ZNF512 RFX1 SIX5 KRR1 ENSG00000257497 GLIPR1L2 GLIPR1L1 GLIPR1 CAPS2 PHLDA1 KCNC2
GH12J076017 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 25.7 -515.0 -514950 17.9 SP1 HNRNPL GATAD2A ATF7 PRDM10 ZNF629 REST TFE3 SOX13 IKZF1 PHLDA1 KRR1 ENSG00000257453 ENSG00000257839 lnc-GLIPR1-9
GH12J075477 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.3 +29.9 29874 7.5 CTCF ZNF629 POLR2A ZSCAN4 IKZF2 TRIM22 YY1 CEBPA CEBPB ARID3A GLIPR1 GLIPR1L2 KRR1 GLIPR1L1 CAPS2 ENSG00000257497 piR-38716-036
GH12J075329 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 35.7 +181.4 181410 1.4 CEBPG SP1 GATAD2A PRDM10 ZNF629 RFX1 NFKBIZ RFX5 ZNF692 TARDBP GLIPR1L1 lnc-KCNC2-5 KRR1 ENSG00000257941 CAPS2 GLIPR1L2 lnc-CAPS2-4 KCNC2
GH12J076346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 16.3 -836.3 -836324 2.9 SP1 HNRNPL CREB1 GATAD2A CTCF ZNF629 PRDM10 ZNF692 POLR2A TARDBP BBS10 KRR1 lnc-ZDHHC17-17 NAP1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRR1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRR1

Top Transcription factor binding sites by QIAGEN in the KRR1 gene promoter:
  • AREB6
  • CUTL1
  • FOXC1
  • FOXO4
  • HSF1 (long)
  • HSF1short
  • NF-AT3
  • NF-AT4
  • Nkx5-1

Genomic Locations for KRR1 Gene

Genomic Locations for KRR1 Gene
chr12:75,490,863-75,511,636
(GRCh38/hg38)
Size:
20,774 bases
Orientation:
Minus strand
chr12:75,890,684-75,905,418
(GRCh37/hg19)
Size:
14,735 bases
Orientation:
Minus strand

Genomic View for KRR1 Gene

Genes around KRR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRR1 Gene

Proteins for KRR1 Gene

  • Protein details for KRR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13601-KRR1_HUMAN
    Recommended name:
    KRR1 small subunit processome component homolog
    Protein Accession:
    Q13601
    Secondary Accessions:
    • A0FIK6
    • A0JLP0
    • B2R989
    • E7EUQ0
    • Q8NEA8
    • Q8TC37
    • Q96AT5

    Protein attributes for KRR1 Gene

    Size:
    381 amino acids
    Molecular mass:
    43665 Da
    Quaternary structure:
    • Component of the ribosomal small subunit (SSU) processome (By similarity). Directly interacts with HIV-1 protein VPR. Also identified in a complex with NR3C1 and HIV-1 protein VPR.
    SequenceCaution:
    • Sequence=AAB00557.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH05225.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for KRR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRR1 Gene

Post-translational modifications for KRR1 Gene

  • Ubiquitination at Lys106, Lys121, and Lys220
  • Modification sites at PhosphoSitePlus

Other Protein References for KRR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for KRR1
  • Boster Bio Antibodies for KRR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for KRR1

No data available for DME Specific Peptides for KRR1 Gene

Domains & Families for KRR1 Gene

Gene Families for KRR1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for KRR1 Gene

InterPro:
Blocks:
  • KH domain
  • KH, type 1
ProtoNet:

Suggested Antigen Peptide Sequences for KRR1 Gene

GenScript: Design optimal peptide antigens:
  • KRR1 protein (A0JLP0_HUMAN)
  • Rev-interacting protein 1 (KRR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13601

UniProtKB/Swiss-Prot:

KRR1_HUMAN :
  • Belongs to the KRR1 family.
Family:
  • Belongs to the KRR1 family.
genes like me logo Genes that share domains with KRR1: view

Function for KRR1 Gene

Molecular function for KRR1 Gene

UniProtKB/Swiss-Prot Function:
Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity).

Phenotypes From GWAS Catalog for KRR1 Gene

Gene Ontology (GO) - Molecular Function for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 19590578
genes like me logo Genes that share ontologies with KRR1: view
genes like me logo Genes that share phenotypes with KRR1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRR1 Gene

Localization for KRR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRR1 Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV-1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR (Ref. 6).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRR1 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IBA,IDA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with KRR1: view

Pathways & Interactions for KRR1 Gene

genes like me logo Genes that share pathways with KRR1: view

Gene Ontology (GO) - Biological Process for KRR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with KRR1: view

No data available for SIGNOR curated interactions for KRR1 Gene

Drugs & Compounds for KRR1 Gene

No Compound Related Data Available

Transcripts for KRR1 Gene

mRNA/cDNA for KRR1 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRR1

Alternative Splicing Database (ASD) splice patterns (SP) for KRR1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for KRR1 Gene

GeneLoc Exon Structure for
KRR1

Expression for KRR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRR1 Gene

This gene is overexpressed in Pancreas (10.8), Lung (8.5), Peripheral blood mononuclear cells (6.9), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KRR1 Gene



Protein tissue co-expression partners for KRR1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRR1

SOURCE GeneReport for Unigene cluster for KRR1 Gene:

Hs.645517

Evidence on tissue expression from TISSUES for KRR1 Gene

  • Bone marrow(4.3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with KRR1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRR1 Gene

Orthologs for KRR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KRR1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRR1 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
KRR1 30
  • 90.11 (n)
-- 31
  • 82 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia KRR1 30 31
  • 90.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KRR1 31
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Krr1 30 17 31
  • 85.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Krr1 30
  • 85.52 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 80 (a)
OneToMany
-- 31
  • 75 (a)
OneToMany
-- 31
  • 72 (a)
OneToMany
Chicken
(Gallus gallus)
Aves KRR1 30 31
  • 79 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KRR1 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia krr1 30
  • 75.95 (n)
Str.2631 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6585 30
Zebrafish
(Danio rerio)
Actinopterygii krr1 30 31
  • 68.54 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta dbe 30 31
  • 59.22 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007912 30
  • 56.81 (n)
Worm
(Caenorhabditis elegans)
Secernentea C05C8.2 30 31
  • 58.65 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRR1 30 31 33
  • 60.78 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00506g 30
  • 58.44 (n)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR744W 30
  • 55.03 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G08420 30
  • 58.2 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0452800 30
  • 57.14 (n)
Os.13981 30
Barley
(Hordeum vulgare)
Liliopsida Hv.6360 30
Wheat
(Triticum aestivum)
Liliopsida Ta.1012 30
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mis3 30
  • 62.02 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3000 31
  • 61 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU07041 30
  • 54.18 (n)
Species where no ortholog for KRR1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KRR1 Gene

ENSEMBL:
Gene Tree for KRR1 (if available)
TreeFam:
Gene Tree for KRR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRR1: view image

Paralogs for KRR1 Gene

Pseudogenes.org Pseudogenes for KRR1 Gene

genes like me logo Genes that share paralogs with KRR1: view

No data available for Paralogs for KRR1 Gene

Variants for KRR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRR1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
784249 Benign: not provided 75,495,572(-) T/C THREE_PRIME_UTR_VARIANT,INTRON_VARIANT
rs11540407 - p.Arg134Gln

Additional dbSNP identifiers (rs#s) for KRR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRR1 Gene

Variant ID Type Subtype PubMed ID
nsv470305 CNV gain 18288195
nsv826439 CNV gain 20364138

Variation tolerance for KRR1 Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.92; 87.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRR1 Gene

Disorders for KRR1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KRR1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
duodenum adenoma
duodenal benign neoplasm
  • neoplasm of duodenum
colorectal cancer, hereditary nonpolyposis, type 7
  • hnpcc7
- elite association - COSMIC cancer census association via MalaCards
Search KRR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KRR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRR1 Gene

Publications for KRR1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4

Products for KRR1 Gene

  • Signalway Proteins for KRR1

Sources for KRR1 Gene