This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008] See more...

Aliases for KRI1 Gene

Aliases for KRI1 Gene

  • KRI1 Homolog 2 3 5
  • Protein KRI1 Homolog 3 4
  • KRI1 Homolog (S. Cerevisiae) 2
  • FLJ12949 2
  • KRI1 5

External Ids for KRI1 Gene

Previous GeneCards Identifiers for KRI1 Gene

  • GC19M010525
  • GC19M010663
  • GC19M010241

Summaries for KRI1 Gene

Entrez Gene Summary for KRI1 Gene

  • This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRI1 Gene

KRI1 (KRI1 Homolog) is a Protein Coding gene. Diseases associated with KRI1 include Cerebral Cavernous Malformations and Cerebrocostomandibular Syndrome.

Additional gene information for KRI1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRI1 Gene

Genomics for KRI1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KRI1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRI1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRI1

Top Transcription factor binding sites by QIAGEN in the KRI1 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • LCR-F1
  • NF-Y
  • NF-YA
  • NF-YB
  • p53

Genomic Locations for KRI1 Gene

Genomic Locations for KRI1 Gene
chr19:10,553,085-10,566,031
(GRCh38/hg38)
Size:
12,947 bases
Orientation:
Minus strand
chr19:10,663,761-10,676,713
(GRCh37/hg19)
Size:
12,953 bases
Orientation:
Minus strand

Genomic View for KRI1 Gene

Genes around KRI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRI1 Gene

Proteins for KRI1 Gene

  • Protein details for KRI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9T8-KRI1_HUMAN
    Recommended name:
    Protein KRI1 homolog
    Protein Accession:
    Q8N9T8
    Secondary Accessions:
    • Q2M1R5
    • Q2M1R7
    • Q7L5J7
    • Q96G92
    • Q9BU50
    • Q9H6I1
    • Q9H978

    Protein attributes for KRI1 Gene

    Size:
    703 amino acids
    Molecular mass:
    82598 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14357.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15278.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC04240.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for KRI1 Gene

Post-translational modifications for KRI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRI1 Gene

No data available for DME Specific Peptides for KRI1 Gene

Domains & Families for KRI1 Gene

Gene Families for KRI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRI1 Gene

GenScript: Design optimal peptide antigens:
  • KRI1 protein (B7ZLF4_HUMAN)
  • Protein KRI1 homolog (KRI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N9T8

UniProtKB/Swiss-Prot:

KRI1_HUMAN :
  • Belongs to the KRI1 family.
Family:
  • Belongs to the KRI1 family.
genes like me logo Genes that share domains with KRI1: view

Function for KRI1 Gene

Phenotypes From GWAS Catalog for KRI1 Gene

Gene Ontology (GO) - Molecular Function for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with KRI1: view
genes like me logo Genes that share phenotypes with KRI1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRI1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRI1 Gene

Localization for KRI1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRI1 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA,IDA --
GO:0030686 90S preribosome IBA 21873635
genes like me logo Genes that share ontologies with KRI1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRI1 Gene

Pathways & Interactions for KRI1 Gene

PathCards logo

SuperPathways for KRI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA 21873635
genes like me logo Genes that share ontologies with KRI1: view

No data available for Pathways by source and SIGNOR curated interactions for KRI1 Gene

Drugs & Compounds for KRI1 Gene

No Compound Related Data Available

Transcripts for KRI1 Gene

mRNA/cDNA for KRI1 Gene

2 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KRI1

Alternative Splicing Database (ASD) splice patterns (SP) for KRI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8:

Relevant External Links for KRI1 Gene

GeneLoc Exon Structure for
KRI1

Expression for KRI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for KRI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.3), CD8 Tcells (17.0), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KRI1 Gene



Protein tissue co-expression partners for KRI1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRI1

SOURCE GeneReport for Unigene cluster for KRI1 Gene:

Hs.709967

Evidence on tissue expression from TISSUES for KRI1 Gene

  • Lung(4.5)
  • Liver(4.2)
  • Nervous system(3.7)
  • Skin(3.5)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with KRI1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRI1 Gene

Orthologs for KRI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for KRI1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KRI1 30 31
  • 96.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia KRI1 30 31
  • 86.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia KRI1 30 31
  • 85.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC687183 30
  • 80.95 (n)
Mouse
(Mus musculus)
Mammalia Kri1 30 17 31
  • 80.41 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia KRI1 31
  • 64 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia KRI1 31
  • 62 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KRI1 31
  • 60 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kri1 30
  • 64.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii kri1 30 31
  • 62.04 (n)
OneToOne
Dr.20345 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5645 30 31
  • 55.87 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007295 30
  • 54.54 (n)
Worm
(Caenorhabditis elegans)
Secernentea F54C9.9 30 31
  • 46.57 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRI1 31 33
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3549 31
  • 43 (a)
OneToOne
Species where no ortholog for KRI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KRI1 Gene

ENSEMBL:
Gene Tree for KRI1 (if available)
TreeFam:
Gene Tree for KRI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRI1: view image

Paralogs for KRI1 Gene

No data available for Paralogs for KRI1 Gene

Variants for KRI1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRI1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11545166 - p.Glu179Ala
rs12984043 - p.Gly138Arg
rs1982074 - p.Leu445Pro
rs3087689 - p.Ser703Pro
rs33999611 - p.Arg336Trp

Additional dbSNP identifiers (rs#s) for KRI1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRI1 Gene

Variant ID Type Subtype PubMed ID
nsv833744 CNV loss 17160897
nsv833745 CNV loss 17160897

Variation tolerance for KRI1 Gene

Gene Damage Index Score: 17.21; 98.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRI1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRI1 Gene

Disorders for KRI1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for KRI1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search KRI1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KRI1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with KRI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRI1 Gene

Publications for KRI1 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PMID: 12878157) Imabayashi H … Umezawa A (Experimental cell research 2003) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3

Products for KRI1 Gene

Sources for KRI1 Gene