Aliases for KREMEN2 Gene
External Ids for KREMEN2 Gene
Previous GeneCards Identifiers for KREMEN2 Gene
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for KREMEN2 Gene
KREMEN2 (Kringle Containing Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with KREMEN2 include Cone-Rod Dystrophy 2. Among its related pathways are Signaling by GPCR and S45 mutants of beta-catenin arent phosphorylated. An important paralog of this gene is KREMEN1.
UniProtKB/Swiss-Prot Summary for KREMEN2 Gene
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.