Aliases for KREMEN1 Gene
External Ids for KREMEN1 Gene
Previous HGNC Symbols for KREMEN1 Gene
Previous GeneCards Identifiers for KREMEN1 Gene
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for KREMEN1 Gene
KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. Diseases associated with KREMEN1 include Ectodermal Dysplasia 13, Hair/Tooth Type and Hand, Foot And Mouth Disease. Among its related pathways are Signaling by GPCR and S45 mutants of beta-catenin arent phosphorylated. An important paralog of this gene is KREMEN2.
UniProtKB/Swiss-Prot Summary for KREMEN1 Gene
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.