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Aliases for KRBOX4 Gene

Aliases for KRBOX4 Gene

  • KRAB Box Domain Containing 4 2 3 5
  • KRAB Box Domain-Containing Protein 4 3 4
  • Zinc Finger Family Member 673 2 3
  • Zinc Finger Protein 673 2 3
  • ZNF673 3 4
  • Putative Zinc Finger Transcription Factor 3
  • KRAB Domain-Containing Protein 4 3
  • Hypothetical Protein FLJ20344 2

External Ids for KRBOX4 Gene

Previous HGNC Symbols for KRBOX4 Gene

  • ZNF673

Previous GeneCards Identifiers for KRBOX4 Gene

  • GC0XP046307

Summaries for KRBOX4 Gene

Entrez Gene Summary for KRBOX4 Gene

  • This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for KRBOX4 Gene

KRBOX4 (KRAB Box Domain Containing 4) is a Protein Coding gene. Diseases associated with KRBOX4 include Diffuse Mesangial Sclerosis and Wilms Tumor 1. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ENSG00000283930.

Additional gene information for KRBOX4 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBOX4 Gene

Genomics for KRBOX4 Gene

GeneHancer (GH) Regulatory Elements for KRBOX4 Gene

Promoters and enhancers for KRBOX4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI046446 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.7 688 2.5 ARID4B SIN3A YY1 ETS1 GLIS2 ELK1 ZNF143 RUNX3 SP3 RXRA KRBOX4 SLC9A7 LOC100113397
GH0XI047216 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 +771.7 771662 5 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZNF2 IRF4 YY1 POLR2B LOC105373194 CDK16 ZNF81 LOC100113397 INE1 ZNF182 ZNF674-AS1 LINC01560 USP11 ZNF674
GH0XI046544 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6 +99.6 99619 4.6 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF674-AS1 ZNF674 LOC100113397 LINC01560 INE1 SLC9A7 NUS1P1 ZNF41 KRBOX4 ENSG00000277721
GH0XI046586 Enhancer 0.8 Ensembl ENCODE 6.6 +141.9 141937 3.6 JUNB EBF1 BATF RELA CTBP1 JUND IKZF1 ATF7 WT1 RUNX3 SLC9A7 KRBOX4 CHST7 PIR58897
GH0XI046551 Enhancer 0.8 Ensembl ENCODE 6 +105.4 105425 2 PKNOX1 CBFA2T3 DPF2 HIC1 ZNF335 SP1 NCOR1 SMARCA4 GLIS1 ZNF600 ENSG00000277721 SLC9A7 KRBOX4 ZNF674-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRBOX4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KRBOX4 Gene

Genomic Locations for KRBOX4 Gene
50,566 bases
Plus strand

Genomic View for KRBOX4 Gene

Genes around KRBOX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBOX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBOX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBOX4 Gene

Proteins for KRBOX4 Gene

  • Protein details for KRBOX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    KRAB domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K0Y8
    • B3KU22
    • Q96EA3
    • Q9NXB1

    Protein attributes for KRBOX4 Gene

    171 amino acids
    Molecular mass:
    20100 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRBOX4 Gene


neXtProt entry for KRBOX4 Gene

Post-translational modifications for KRBOX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBOX4 Gene

Domains & Families for KRBOX4 Gene

Gene Families for KRBOX4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRBOX4 Gene


Suggested Antigen Peptide Sequences for KRBOX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRBOX4: view

No data available for UniProtKB/Swiss-Prot for KRBOX4 Gene

Function for KRBOX4 Gene

Gene Ontology (GO) - Molecular Function for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBOX4: view
genes like me logo Genes that share phenotypes with KRBOX4: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBOX4 Gene

Localization for KRBOX4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRBOX4 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBOX4 Gene

Pathways & Interactions for KRBOX4 Gene

SuperPathways for KRBOX4 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with KRBOX4: view

Pathways by source for KRBOX4 Gene

2 Reactome pathways for KRBOX4 Gene

Gene Ontology (GO) - Biological Process for KRBOX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with KRBOX4: view

No data available for SIGNOR curated interactions for KRBOX4 Gene

Drugs & Compounds for KRBOX4 Gene

(2) Drugs for KRBOX4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for KRBOX4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KRBOX4: view

Transcripts for KRBOX4 Gene

Unigene Clusters for KRBOX4 Gene

KRAB box domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBOX4 Gene

No ASD Table

Relevant External Links for KRBOX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRBOX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRBOX4 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRBOX4 Gene:


SOURCE GeneReport for Unigene cluster for KRBOX4 Gene:


mRNA Expression by UniProt/SwissProt for KRBOX4 Gene:

Tissue specificity: Expressed in brain, ovary, testis, prostate, tonsil, heart, bone marrow, colon, breast and kidney.

Evidence on tissue expression from TISSUES for KRBOX4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with KRBOX4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRBOX4 Gene

Orthologs for KRBOX4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRBOX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF673 33
  • 98.8 (n)
  • 94 (a)
(Canis familiaris)
Mammalia -- 34
  • 67 (a)
-- 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia KRBOX4 34
  • 17 (a)
Species where no ortholog for KRBOX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRBOX4 Gene

Gene Tree for KRBOX4 (if available)
Gene Tree for KRBOX4 (if available)

Paralogs for KRBOX4 Gene

Paralogs for KRBOX4 Gene

(250) SIMAP similar genes for KRBOX4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBOX4: view

Variants for KRBOX4 Gene

Sequence variations from dbSNP and Humsavar for KRBOX4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000290993 -- 46,469,167(+) G/A intron_variant
rs1000700967 -- 46,456,325(+) A/G intron_variant
rs1000897773 -- 46,471,885(+) C/A intron_variant
rs1000913500 -- 46,462,934(+) C/T intron_variant
rs1001025559 -- 46,449,644(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KRBOX4 Gene

Variant ID Type Subtype PubMed ID
esv3576853 CNV gain 25503493
esv3576854 CNV gain 25503493
nsv480496 CNV novel sequence insertion 20440878
nsv526411 CNV gain 19592680

Variation tolerance for KRBOX4 Gene

Residual Variation Intolerance Score: 59.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRBOX4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRBOX4 Gene

Disorders for KRBOX4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KRBOX4 Gene - From: GeneCards

Disorder Aliases PubMed IDs
diffuse mesangial sclerosis
  • diffuse isolated mesangial sclerosis
wilms tumor 1
  • wt1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for KRBOX4

genes like me logo Genes that share disorders with KRBOX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KRBOX4 Gene

Publications for KRBOX4 Gene

  1. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton DL … Meindl A (Genomics 2002) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for KRBOX4 Gene

Sources for KRBOX4 Gene

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