Aliases for KRBA2 Gene

Aliases for KRBA2 Gene

  • KRAB-A Domain Containing 2 2 3 5
  • KRAB-A Domain-Containing Protein 2 3 4
  • KRAB A Domain Containing 2 2

External Ids for KRBA2 Gene

Previous GeneCards Identifiers for KRBA2 Gene

  • GC17M008213
  • GC17M008271
  • GC17M008166
  • GC17M008368
  • GC17M008614
  • GC17M008659
  • GC17M008688
  • GC17M008571

Summaries for KRBA2 Gene

GeneCards Summary for KRBA2 Gene

KRBA2 (KRAB-A Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

Additional gene information for KRBA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KRBA2 Gene

Genomics for KRBA2 Gene

GeneHancer (GH) Regulatory Elements for KRBA2 Gene

Promoters and enhancers for KRBA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KRBA2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KRBA2

Top Transcription factor binding sites by QIAGEN in the KRBA2 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • COMP1
  • GATA-1
  • GCNF
  • GCNF-1
  • HOXA3
  • IRF-7A
  • Nkx6-1

Genomic Locations for KRBA2 Gene

Genomic Locations for KRBA2 Gene
chr17:8,356,902-8,376,711
(GRCh38/hg38)
Size:
19,810 bases
Orientation:
Minus strand
chr17:8,271,955-8,280,029
(GRCh37/hg19)
Size:
8,075 bases
Orientation:
Minus strand

Genomic View for KRBA2 Gene

Genes around KRBA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA2 Gene

Proteins for KRBA2 Gene

  • Protein details for KRBA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG9-KRBA2_HUMAN
    Recommended name:
    KRAB-A domain-containing protein 2
    Protein Accession:
    Q6ZNG9
    Secondary Accessions:
    • Q8IYY0

    Protein attributes for KRBA2 Gene

    Size:
    492 amino acids
    Molecular mass:
    56205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRBA2 Gene

Post-translational modifications for KRBA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBA2 Gene

Domains & Families for KRBA2 Gene

Gene Families for KRBA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRBA2 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRBA2 Gene

GenScript: Design optimal peptide antigens:
  • KRAB-A domain-containing protein 2 (KRBA2_HUMAN)
genes like me logo Genes that share domains with KRBA2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KRBA2 Gene

Function for KRBA2 Gene

Phenotypes From GWAS Catalog for KRBA2 Gene

Gene Ontology (GO) - Molecular Function for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBA2: view
genes like me logo Genes that share phenotypes with KRBA2: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBA2 Gene

Localization for KRBA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRBA2 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
cytoskeleton 0
mitochondrion 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA2 Gene

Pathways & Interactions for KRBA2 Gene

PathCards logo

SuperPathways for KRBA2 Gene

No Data Available

Interacting Proteins for KRBA2 Gene

;

Gene Ontology (GO) - Biological Process for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Pathways by source and SIGNOR curated interactions for KRBA2 Gene

Drugs & Compounds for KRBA2 Gene

No Compound Related Data Available

Transcripts for KRBA2 Gene

mRNA/cDNA for KRBA2 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA2 Gene

No ASD Table

Relevant External Links for KRBA2 Gene

GeneLoc Exon Structure for
KRBA2

Expression for KRBA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRBA2 Gene

Protein differential expression in normal tissues from HIPED for KRBA2 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRBA2 Gene



Protein tissue co-expression partners for KRBA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KRBA2

SOURCE GeneReport for Unigene cluster for KRBA2 Gene:

Hs.304604

Evidence on tissue expression from TISSUES for KRBA2 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with KRBA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRBA2 Gene

Orthologs for KRBA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRBA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRBA2 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRBA2 31 30
  • 87.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KRBA2 30
  • 86.11 (n)
mouse
(Mus musculus)
Mammalia 2410018M08Rik 31
  • 4 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 1 (a)
ManyToMany
-- 31
  • 1 (a)
ManyToMany
-- 31
  • 1 (a)
ManyToMany
-- 31
  • 1 (a)
ManyToMany
-- 31
  • 1 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii KRBA2 31
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 2 (a)
OneToOne
Species where no ortholog for KRBA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRBA2 Gene

ENSEMBL:
Gene Tree for KRBA2 (if available)
TreeFam:
Gene Tree for KRBA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KRBA2: view image

Paralogs for KRBA2 Gene

(2) SIMAP similar genes for KRBA2 Gene using alignment to 3 proteins:

  • KRBA2_HUMAN
  • A8MX02_HUMAN
  • J3QQQ9_HUMAN
genes like me logo Genes that share paralogs with KRBA2: view

No data available for Paralogs for KRBA2 Gene

Variants for KRBA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KRBA2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs370752 - p.Thr435Met

Additional dbSNP identifiers (rs#s) for KRBA2 Gene

Variation tolerance for KRBA2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRBA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRBA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRBA2 Gene

Disorders for KRBA2 Gene

Additional Disease Information for KRBA2

No disorders were found for KRBA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBA2 Gene

Publications for KRBA2 Gene

  1. On the transposon origins of mammalian SCAND3 and KRBA2, two zinc-finger genes carrying an integrase/transposase domain. (PMID: 23550032) Llorens C … Moya A (Mobile genetic elements 2012) 2 3 54
  2. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling. (PMID: 27591049) Elliott PR … Gyrd-Hansen M (Molecular cell 2016) 3 54
  3. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. (PMID: 26990986) Nguyen TV … Deshaies RJ (Molecular cell 2016) 3 54
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 54

Products for KRBA2 Gene

Sources for KRBA2 Gene