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Aliases for KRBA2 Gene

Aliases for KRBA2 Gene

  • KRAB-A Domain Containing 2 2 3 5
  • KRAB A Domain Containing 2 2

External Ids for KRBA2 Gene

Previous GeneCards Identifiers for KRBA2 Gene

  • GC17M008213
  • GC17M008271
  • GC17M008166

Summaries for KRBA2 Gene

GeneCards Summary for KRBA2 Gene

KRBA2 (KRAB-A Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZBED9.

Additional gene information for KRBA2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRBA2 Gene

Genomics for KRBA2 Gene

GeneHancer (GH) Regulatory Elements for KRBA2 Gene

Promoters and enhancers for KRBA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I008375 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569.1 +0.2 210 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 POLR2B E2F8 KRBA2 PIR59981 ODF4 ENSG00000265749 RNF222 ENSG00000212206 ENSG00000263809 RPL26
GH17I008379 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.1 -6.0 -6039 6.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF143 MCM3 SP3 NFYC ZNF610 ENSG00000263809 RPL26 ENSG00000265749 PFAS SNORD10 EIF4A1 CTC1 POLR2A SNORA48 TP53
GH17I008435 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -59.8 -59796 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDEL1 RPL26 KRBA2 RNF222 RNU7-43P ENSG00000212206 MYH10 GC17P008467
GH17I008412 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.3 -36.3 -36271 1.6 HDAC1 KLF1 ATF1 ZNF473 ZBTB21 JUN CEBPG RAD21 HIC1 FOSL1 NDEL1 WRAP53 RPL26 KRBA2 ZBTB4 SLC25A35 RANGRF PFAS PIK3R6 CNTROB
GH17I008409 Enhancer 1.1 Ensembl ENCODE 11.3 -33.8 -33796 1.2 ARID4B IRF4 ZNF48 ZNF143 FOS RUNX3 RXRA NCOA1 MXD4 REST RPL26 KRBA2 SLC25A35 RANGRF PFAS NDEL1 RNF222
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRBA2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRBA2 gene promoter:

Genomic Locations for KRBA2 Gene

Genomic Locations for KRBA2 Gene
chr17:8,368,637-8,376,711
(GRCh38/hg38)
Size:
8,075 bases
Orientation:
Minus strand
chr17:8,271,955-8,280,029
(GRCh37/hg19)

Genomic View for KRBA2 Gene

Genes around KRBA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRBA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRBA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRBA2 Gene

Proteins for KRBA2 Gene

  • Protein details for KRBA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG9-KRBA2_HUMAN
    Recommended name:
    KRAB-A domain-containing protein 2
    Protein Accession:
    Q6ZNG9
    Secondary Accessions:
    • Q8IYY0

    Protein attributes for KRBA2 Gene

    Size:
    492 amino acids
    Molecular mass:
    56205 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRBA2 Gene

Post-translational modifications for KRBA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KRBA2 Gene

Domains & Families for KRBA2 Gene

Gene Families for KRBA2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for KRBA2 Gene

Suggested Antigen Peptide Sequences for KRBA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRBA2: view

No data available for UniProtKB/Swiss-Prot for KRBA2 Gene

Function for KRBA2 Gene

Gene Ontology (GO) - Molecular Function for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with KRBA2: view
genes like me logo Genes that share phenotypes with KRBA2: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRBA2 Gene

Localization for KRBA2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRBA2 gene
Compartment Confidence
nucleus 2
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRBA2 Gene

Pathways & Interactions for KRBA2 Gene

SuperPathways for KRBA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRBA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0015074 DNA integration IEA --
genes like me logo Genes that share ontologies with KRBA2: view

No data available for Pathways by source and SIGNOR curated interactions for KRBA2 Gene

Drugs & Compounds for KRBA2 Gene

No Compound Related Data Available

Transcripts for KRBA2 Gene

mRNA/cDNA for KRBA2 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRBA2 Gene

KRAB-A domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRBA2 Gene

No ASD Table

Relevant External Links for KRBA2 Gene

GeneLoc Exon Structure for
KRBA2
ECgene alternative splicing isoforms for
KRBA2

Expression for KRBA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRBA2 Gene

Protein differential expression in normal tissues from HIPED for KRBA2 Gene

This gene is overexpressed in Spleen (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRBA2 Gene



Protein tissue co-expression partners for KRBA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRBA2 Gene:

KRBA2

SOURCE GeneReport for Unigene cluster for KRBA2 Gene:

Hs.304604

Evidence on tissue expression from TISSUES for KRBA2 Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with KRBA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRBA2 Gene

Orthologs for KRBA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRBA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRBA2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRBA2 33 34
  • 87.62 (n)
cow
(Bos Taurus)
Mammalia KRBA2 33
  • 86.11 (n)
mouse
(Mus musculus)
Mammalia 2410018M08Rik 34
  • 4 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 1 (a)
ManyToMany
-- 34
  • 1 (a)
ManyToMany
-- 34
  • 1 (a)
ManyToMany
-- 34
  • 1 (a)
ManyToMany
-- 34
  • 1 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii KRBA2 34
  • 1 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 2 (a)
OneToOne
Species where no ortholog for KRBA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRBA2 Gene

ENSEMBL:
Gene Tree for KRBA2 (if available)
TreeFam:
Gene Tree for KRBA2 (if available)

Paralogs for KRBA2 Gene

(2) SIMAP similar genes for KRBA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRBA2: view

Variants for KRBA2 Gene

Sequence variations from dbSNP and Humsavar for KRBA2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000014266 -- 8,373,534(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000139054 -- 8,373,081(-) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000225855 -- 8,369,694(-) T/C/G coding_sequence_variant, missense_variant
rs1000341371 -- 8,377,729(-) A/T upstream_transcript_variant
rs1000560092 -- 8,368,409(-) T/C 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Variation tolerance for KRBA2 Gene

Residual Variation Intolerance Score: 88% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRBA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRBA2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for KRBA2 Gene

Disorders for KRBA2 Gene

Additional Disease Information for KRBA2

No disorders were found for KRBA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRBA2 Gene

Publications for KRBA2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. (PMID: 26990986) Nguyen TV … Deshaies RJ (Molecular cell 2016) 3 58
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58

Products for KRBA2 Gene

Sources for KRBA2 Gene

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