Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the... See more...

Aliases for KPNB1 Gene

Aliases for KPNB1 Gene

  • Karyopherin Subunit Beta 1 2 3 5
  • Pore Targeting Complex 97 KDa Subunit 3 4
  • Karyopherin (Importin) Beta 1 2 3
  • Importin Subunit Beta-1 3 4
  • Nuclear Factor P97 3 4
  • Importin 1 2 3
  • PTAC97 3 4
  • NTF97 3 4
  • Karyopherin Subunit Beta-1 4
  • Importin Beta-1 Subunit 3
  • Importin 90 3
  • Importin-90 4
  • Impnb 3
  • IMB1 3
  • IPO1 3
  • IPOB 3

External Ids for KPNB1 Gene

Previous GeneCards Identifiers for KPNB1 Gene

  • GC17P045432
  • GC17P048207
  • GC17P046069
  • GC17P046201
  • GC17P043082
  • GC17P045727
  • GC17P041096

Summaries for KPNB1 Gene

Entrez Gene Summary for KPNB1 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

GeneCards Summary for KPNB1 Gene

KPNB1 (Karyopherin Subunit Beta 1) is a Protein Coding gene. Diseases associated with KPNB1 include Venezuelan Equine Encephalitis and Influenza. Among its related pathways are Innate Immune System and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include enzyme binding. An important paralog of this gene is IPO5.

UniProtKB/Swiss-Prot Summary for KPNB1 Gene

  • Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Gene Wiki entry for KPNB1 Gene

Additional gene information for KPNB1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KPNB1 Gene

Genomics for KPNB1 Gene

GeneHancer (GH) Regulatory Elements for KPNB1 Gene

Promoters and enhancers for KPNB1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KPNB1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KPNB1

Top Transcription factor binding sites by QIAGEN in the KPNB1 gene promoter:
  • CBF(2)
  • CBF-B
  • CBF-C
  • CP1A
  • Evi-1
  • GATA-1
  • IRF-7A
  • SRF
  • SRF (504 AA)
  • STAT1

Genomic Locations for KPNB1 Gene

Genomic Locations for KPNB1 Gene
chr17:47,649,476-47,685,505
(GRCh38/hg38)
Size:
36,030 bases
Orientation:
Plus strand
chr17:45,726,842-45,762,871
(GRCh37/hg19)
Size:
36,030 bases
Orientation:
Plus strand

Genomic View for KPNB1 Gene

Genes around KPNB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNB1 Gene

Proteins for KPNB1 Gene

  • Protein details for KPNB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14974-IMB1_HUMAN
    Recommended name:
    Importin subunit beta-1
    Protein Accession:
    Q14974
    Secondary Accessions:
    • B7ZAV6
    • D3DTT3
    • Q14637
    • Q53XN2
    • Q96J27

    Protein attributes for KPNB1 Gene

    Size:
    876 amino acids
    Molecular mass:
    97170 Da
    Quaternary structure:
    • Forms a complex with an importin alpha subunit (PubMed:8617227, PubMed:8692944). Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with H2A, H2B, H3 and H4 histones (By similarity). Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN (By similarity). Interacts with NUMA1 (via C-terminus); this interaction is inhibited by RanGTP (PubMed:11229403).
    • (Microbial infection) Interacts with HIV-1 Rev and Tat.
    • (Microbial infection) Interacts with HTLV-1 Rex.
    • (Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein M.
    • (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.

    Three dimensional structures from OCA and Proteopedia for KPNB1 Gene

    Alternative splice isoforms for KPNB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KPNB1 Gene

Post-translational modifications for KPNB1 Gene

  • Mono-ADP-ribosylated by PARP16.
  • Ubiquitination at Lys23, Lys206, Lys62, Lys376, Lys537, Lys651, Lys730, Lys835, Lys859, and Lys867
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KPNB1 Gene

Domains & Families for KPNB1 Gene

Gene Families for KPNB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for KPNB1 Gene

Blocks:
  • Armadillo repeat
  • HEAT repeat
  • Importin-beta, N-terminal
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KPNB1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ79320, highly similar to Importin beta-1 subunit (B7ZAV6_HUMAN)
  • Pore targeting complex 97 kDa subunit (IMB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14974

UniProtKB/Swiss-Prot:

IMB1_HUMAN :
  • Belongs to the importin beta family. Importin beta-1 subfamily.
Family:
  • Belongs to the importin beta family. Importin beta-1 subfamily.
genes like me logo Genes that share domains with KPNB1: view

Function for KPNB1 Gene

Molecular function for KPNB1 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Phenotypes From GWAS Catalog for KPNB1 Gene

Gene Ontology (GO) - Molecular Function for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IEA,IPI 9405152
GO:0008139 nuclear localization sequence binding IBA,TAS 21873635
GO:0008270 zinc ion binding TAS 7615630
GO:0008536 Ran GTPase binding IEA --
genes like me logo Genes that share ontologies with KPNB1: view
genes like me logo Genes that share phenotypes with KPNB1: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for KPNB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNB1 Gene

Localization for KPNB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNB1 Gene

Cytoplasm. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNB1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 5
extracellular 4
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nuclear membrane (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA 21873635
GO:0005635 nuclear envelope IEA,IDA 22701565
GO:0005643 nuclear pore TAS 7627554
genes like me logo Genes that share ontologies with KPNB1: view

Pathways & Interactions for KPNB1 Gene

genes like me logo Genes that share pathways with KPNB1: view

Pathways by source for KPNB1 Gene

2 GeneGo (Thomson Reuters) pathways for KPNB1 Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Development_TGF-beta receptor signaling
4 Qiagen pathways for KPNB1 Gene
  • NFAT in Immune Response
  • Ran Pathway
  • SMAD Signaling Network
  • SREBP Proteolysis
1 Cell Signaling Technology pathway for KPNB1 Gene

SIGNOR curated interactions for KPNB1 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006606 protein import into nucleus IEA,IDA 7615630
GO:0006607 NLS-bearing protein import into nucleus TAS 7627554
GO:0006610 ribosomal protein import into nucleus IDA 9687515
GO:0006886 intracellular protein transport IEA --
genes like me logo Genes that share ontologies with KPNB1: view

Drugs & Compounds for KPNB1 Gene

(1) Drugs for KPNB1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for KPNB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with KPNB1: view

Transcripts for KPNB1 Gene

mRNA/cDNA for KPNB1 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for KPNB1

Alternative Splicing Database (ASD) splice patterns (SP) for KPNB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - -
SP6: - - - - - - -
SP7: -
SP8:
SP9: -
SP10: - - - - - - - - - - - - - - - - - -
SP11:
SP12: - - - - - - - -
SP13: - -
SP14:

ExUns: 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29a · 29b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10: - - - - - - - - - -
SP11:
SP12:
SP13:
SP14:

Relevant External Links for KPNB1 Gene

GeneLoc Exon Structure for
KPNB1

Expression for KPNB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KPNB1 Gene

Protein differential expression in normal tissues from HIPED for KPNB1 Gene

This gene is overexpressed in Bone (26.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KPNB1 Gene



Protein tissue co-expression partners for KPNB1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KPNB1

SOURCE GeneReport for Unigene cluster for KPNB1 Gene:

Hs.532793

Evidence on tissue expression from TISSUES for KPNB1 Gene

  • Lung(3.4)
  • Kidney(3.1)
  • Spleen(2.1)
  • Heart(2)
  • Lymph node(2)
  • Nervous system(4.9)
  • Eye(4.7)
  • Liver(4.5)
  • Skin(4.5)
  • Muscle(4.3)
  • Intestine(3.9)
genes like me logo Genes that share expression patterns with KPNB1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNB1 Gene

Orthologs for KPNB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNB1 31 30
  • 99.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNB1 31
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNB1 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KPNB1 31 30
  • 95.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KPNB1 31 30
  • 94.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Kpnb1 17 31 30
  • 91.97 (n)
rat
(Rattus norvegicus)
Mammalia Kpnb1 30
  • 91.73 (n)
chicken
(Gallus gallus)
Aves KPNB1 31 30
  • 82.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNB1 31
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpnb1 30
  • 79.87 (n)
Str.2859 30
zebrafish
(Danio rerio)
Actinopterygii kpnb1 31 30
  • 77.47 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009921 30
  • 60.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fs(2)Ket 31 32 30
  • 59.3 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea imb-1 31 32 30
  • 52.91 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05665g 30
  • 48.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAP95 33 31 30
  • 47.2 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL187W 30
  • 46.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G53480 30
  • 50.1 (n)
rice
(Oryza sativa)
Liliopsida Os12g0568800 30
  • 50.94 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.20906 30
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6563 31
  • 61 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes kap95 30
  • 50.06 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU02011 30
  • 49.46 (n)
Species where no ortholog for KPNB1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for KPNB1 Gene

ENSEMBL:
Gene Tree for KPNB1 (if available)
TreeFam:
Gene Tree for KPNB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KPNB1: view image

Paralogs for KPNB1 Gene

Paralogs for KPNB1 Gene

Pseudogenes.org Pseudogenes for KPNB1 Gene

genes like me logo Genes that share paralogs with KPNB1: view

Variants for KPNB1 Gene

Additional dbSNP identifiers (rs#s) for KPNB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KPNB1 Gene

Variant ID Type Subtype PubMed ID
esv2758693 CNV gain+loss 17122850
nsv428344 CNV gain 18775914
nsv525267 CNV gain 19592680
nsv978435 CNV duplication 23825009

Variation tolerance for KPNB1 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KPNB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KPNB1 Gene

Disorders for KPNB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for KPNB1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
venezuelan equine encephalitis