Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the... See more...

Aliases for KPNA6 Gene

Aliases for KPNA6 Gene

  • Karyopherin Subunit Alpha 6 2 3 5
  • Karyopherin Alpha 6 (Importin Alpha 7) 2 3
  • Importin Subunit Alpha-7 3 4
  • IPOA7 3 4
  • Karyopherin Subunit Alpha-6 4
  • Importin Alpha 7 Subunit 3
  • Karyopherin Alpha 6 2
  • Importin-Alpha-S2 3
  • Importin Alpha 7 2

External Ids for KPNA6 Gene

Previous GeneCards Identifiers for KPNA6 Gene

  • GC01P032388
  • GC01P031561
  • GC01P032000
  • GC01P032076
  • GC01P032242
  • GC01P032346
  • GC01P032573
  • GC01P030689

Summaries for KPNA6 Gene

Entrez Gene Summary for KPNA6 Gene

  • Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA6 Gene

KPNA6 (Karyopherin Subunit Alpha 6) is a Protein Coding gene. Diseases associated with KPNA6 include Intravenous Leiomyomatosis. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Measles. Gene Ontology (GO) annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA5.

UniProtKB/Swiss-Prot Summary for KPNA6 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for KPNA6 Gene

Additional gene information for KPNA6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KPNA6 Gene

Genomics for KPNA6 Gene

GeneHancer (GH) Regulatory Elements for KPNA6 Gene

Promoters and enhancers for KPNA6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KPNA6 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KPNA6

Top Transcription factor binding sites by QIAGEN in the KPNA6 gene promoter:
  • aMEF-2
  • Egr-2
  • HOXA5
  • MEF-2A
  • MIF-1
  • NF-1
  • Pax-4a
  • RFX1
  • SRF
  • SRF (504 AA)

Genomic Locations for KPNA6 Gene

Genomic Locations for KPNA6 Gene
chr1:32,108,043-32,176,568
(GRCh38/hg38)
Size:
68,526 bases
Orientation:
Plus strand
chr1:32,573,639-32,642,169
(GRCh37/hg19)
Size:
68,531 bases
Orientation:
Plus strand

Genomic View for KPNA6 Gene

Genes around KPNA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA6 Gene

Proteins for KPNA6 Gene

  • Protein details for KPNA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60684-IMA7_HUMAN
    Recommended name:
    Importin subunit alpha-7
    Protein Accession:
    O60684
    Secondary Accessions:
    • B2RDC7
    • D3DPP5
    • Q5VVU3

    Protein attributes for KPNA6 Gene

    Size:
    536 amino acids
    Molecular mass:
    60030 Da
    Quaternary structure:
    • Interacts with ZIC3 (By similarity). Forms a complex with importin subunit beta-1.
    • (Microbial infection) Interacts with ebolavirus protein VP24.

    Three dimensional structures from OCA and Proteopedia for KPNA6 Gene

neXtProt entry for KPNA6 Gene

Post-translational modifications for KPNA6 Gene

  • Ubiquitination at Lys18 and Lys49
  • Modification sites at PhosphoSitePlus

Other Protein References for KPNA6 Gene

No data available for DME Specific Peptides for KPNA6 Gene

Domains & Families for KPNA6 Gene

Gene Families for KPNA6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for KPNA6 Gene

Blocks:
  • Armadillo repeat
  • Importin alpha-like protein, beta-binding regon
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KPNA6 Gene

GenScript: Design optimal peptide antigens:
  • Karyopherin subunit alpha-6 (IMA7_HUMAN)
  • Karyopherin alpha 6 (Importin alpha 7) (Q5TFJ7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60684

UniProtKB/Swiss-Prot:

IMA7_HUMAN :
  • Belongs to the importin alpha family.
Family:
  • Belongs to the importin alpha family.
genes like me logo Genes that share domains with KPNA6: view

Function for KPNA6 Gene

Molecular function for KPNA6 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Phenotypes From GWAS Catalog for KPNA6 Gene

Gene Ontology (GO) - Molecular Function for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10523667
GO:0008139 nuclear localization sequence binding IBA 21873635
GO:0008565 protein transporter activity IEA --
GO:0061608 nuclear import signal receptor activity IEA --
genes like me logo Genes that share ontologies with KPNA6: view
genes like me logo Genes that share phenotypes with KPNA6: view

Animal Models for KPNA6 Gene

MGI Knock Outs for KPNA6:

miRNA for KPNA6 Gene

miRTarBase miRNAs that target KPNA6

Clone Products

  • Addgene plasmids for KPNA6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KPNA6 Gene

Localization for KPNA6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNA6 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA 21873635
GO:0005654 nucleoplasm IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA 21873635
genes like me logo Genes that share ontologies with KPNA6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KPNA6 Gene

Pathways & Interactions for KPNA6 Gene

PathCards logo

SuperPathways for KPNA6 Gene

SuperPathway Contained pathways
1 Measles
2 Cell cycle_Spindle assembly and chromosome separation
-
genes like me logo Genes that share pathways with KPNA6: view

Pathways by source for KPNA6 Gene

1 KEGG pathway for KPNA6 Gene
1 GeneGo (Thomson Reuters) pathway for KPNA6 Gene
  • Cell cycle_Spindle assembly and chromosome separation

SIGNOR curated interactions for KPNA6 Gene

Activates:

Gene Ontology (GO) - Biological Process for KPNA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus IBA,TAS 21873635
GO:0015031 protein transport IEA --
GO:0030683 evasion or tolerance by virus of host immune response IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with KPNA6: view

Drugs & Compounds for KPNA6 Gene

(1) Drugs for KPNA6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA6: view

Transcripts for KPNA6 Gene

mRNA/cDNA for KPNA6 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for KPNA6

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for KPNA6 Gene

GeneLoc Exon Structure for
KPNA6

Expression for KPNA6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KPNA6 Gene

Protein differential expression in normal tissues from HIPED for KPNA6 Gene

This gene is overexpressed in Fetal ovary (9.7) and Peripheral blood mononuclear cells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KPNA6 Gene



Protein tissue co-expression partners for KPNA6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KPNA6

SOURCE GeneReport for Unigene cluster for KPNA6 Gene:

Hs.470588

mRNA Expression by UniProt/SwissProt for KPNA6 Gene:

O60684-IMA7_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for KPNA6 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with KPNA6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNA6 Gene

Orthologs for KPNA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA6 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 100 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KPNA6 31 30
  • 99.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA6 31 30
  • 94.9 (n)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA6 31 30
  • 94.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA6 31
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna6 30
  • 92.52 (n)
mouse
(Mus musculus)
Mammalia Kpna6 17 31 30
  • 91.79 (n)
chicken
(Gallus gallus)
Aves KPNA6 31 30
  • 80.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA6 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kpna6 30
  • 76.49 (n)
zebrafish
(Danio rerio)
Actinopterygii KPNA6 31
  • 89 (a)
OneToOne
LOC100149852 30
  • 75.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005401 30
  • 61.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 31 32 30
  • 60.65 (n)
OneToMany
Pen 32
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 32
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 33 31
  • 51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons IMPA-2 30
  • 57.54 (n)
rice
(Oryza sativa)
Liliopsida Os01g0253300 30
  • 58.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes imp1 30
  • 55.67 (n)
Species where no ortholog for KPNA6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KPNA6 Gene

ENSEMBL:
Gene Tree for KPNA6 (if available)
TreeFam:
Gene Tree for KPNA6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KPNA6: view image

Paralogs for KPNA6 Gene

Paralogs for KPNA6 Gene

(6) SIMAP similar genes for KPNA6 Gene using alignment to 7 proteins:

  • IMA7_HUMAN
  • F5GYL8_HUMAN
  • F5H4G7_HUMAN
  • G1UI19_HUMAN
  • L8E7Z7_HUMAN
  • Q5TFJ7_HUMAN
  • S4R3E5_HUMAN
genes like me logo Genes that share paralogs with KPNA6: view

Variants for KPNA6 Gene

Additional dbSNP identifiers (rs#s) for KPNA6 Gene

Structural Variations from Database of Genomic Variants (DGV) for KPNA6 Gene

Variant ID Type Subtype PubMed ID
esv3585667 CNV loss 21293372
esv3585668 CNV gain 21293372
nsv1122325 CNV deletion 24896259

Variation tolerance for KPNA6 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KPNA6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KPNA6 Gene

Disorders for KPNA6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KPNA6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intravenous leiomyomatosis
  • leiomyomatosis
- elite association - COSMIC cancer census association via MalaCards
Search KPNA6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KPNA6

genes like me logo Genes that share disorders with KPNA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA6 Gene

Publications for KPNA6 Gene

  1. Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. (PMID: 10523667) Köhler M … Hartmann E (Molecular and cellular biology 1999) 2 3 4 23 54
  2. Regulation of Stat3 nuclear import by importin alpha5 and importin alpha7 via two different functional sequence elements. (PMID: 16298512) Ma J … Cao X (Cellular signalling 2006) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Acetylation of importin-alpha nuclear import factors by CBP/p300. (PMID: 10801418) Bannister AJ … Kouzarides T (Current biology : CB 2000) 3 23 54

Products for KPNA6 Gene

Sources for KPNA6 Gene