The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear p... See more...

Aliases for KPNA5 Gene

Aliases for KPNA5 Gene

  • Karyopherin Subunit Alpha 5 2 3 5
  • Karyopherin Alpha 5 (Importin Alpha 6) 2 3
  • Importin Subunit Alpha-6 3 4
  • Importin Alpha 6 2 3
  • Karyopherin Subunit Alpha-5 4
  • Karyopherin Alpha 5 2
  • IPOA6 3
  • SRP6 3

External Ids for KPNA5 Gene

Previous GeneCards Identifiers for KPNA5 Gene

  • GC06P116845
  • GC06P117034
  • GC06P117056
  • GC06P117048
  • GC06P117109
  • GC06P114581

Summaries for KPNA5 Gene

Entrez Gene Summary for KPNA5 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA5 Gene

KPNA5 (Karyopherin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with KPNA5 include Influenza and Ebola Hemorrhagic Fever. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA6.

UniProtKB/Swiss-Prot Summary for KPNA5 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for KPNA5 Gene

Additional gene information for KPNA5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KPNA5 Gene

Genomics for KPNA5 Gene

GeneHancer (GH) Regulatory Elements for KPNA5 Gene

Promoters and enhancers for KPNA5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KPNA5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KPNA5

Top Transcription factor binding sites by QIAGEN in the KPNA5 gene promoter:
  • AML1a
  • FOXD3
  • ISGF-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • p53
  • TGIF

Genomic Locations for KPNA5 Gene

Genomic Locations for KPNA5 Gene
chr6:116,681,086-116,741,867
(GRCh38/hg38)
Size:
60,782 bases
Orientation:
Plus strand
chr6:117,002,350-117,063,030
(GRCh37/hg19)
Size:
60,681 bases
Orientation:
Plus strand

Genomic View for KPNA5 Gene

Genes around KPNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA5 Gene

Proteins for KPNA5 Gene

  • Protein details for KPNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15131-IMA6_HUMAN
    Recommended name:
    Importin subunit alpha-6
    Protein Accession:
    O15131
    Secondary Accessions:
    • B2RAI5
    • Q86X23

    Protein attributes for KPNA5 Gene

    Size:
    536 amino acids
    Molecular mass:
    60349 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1.
    • (Microbial infection) Interacts with ebolavirus protein VP24.
    SequenceCaution:
    • Sequence=AAH47409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KPNA5 Gene

neXtProt entry for KPNA5 Gene

Post-translational modifications for KPNA5 Gene

  • Ubiquitination at Lys131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KPNA5 Gene

Domains & Families for KPNA5 Gene

Gene Families for KPNA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for KPNA5 Gene

Blocks:
  • Armadillo repeat
  • Importin alpha-like protein, beta-binding regon
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KPNA5 Gene

GenScript: Design optimal peptide antigens:
  • Karyopherin subunit alpha-5 (IMA5_HUMAN)
  • Karyopherin alpha 5 (Importin alpha 6) (Q5TD89_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15131

UniProtKB/Swiss-Prot:

IMA6_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
Family:
  • Belongs to the importin alpha family.
genes like me logo Genes that share domains with KPNA5: view

Function for KPNA5 Gene

Molecular function for KPNA5 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Phenotypes From GWAS Catalog for KPNA5 Gene

Gene Ontology (GO) - Molecular Function for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15057270
GO:0008139 nuclear localization sequence binding IBA 21873635
GO:0008565 protein transporter activity IEA --
GO:0061608 nuclear import signal receptor activity IEA --
genes like me logo Genes that share ontologies with KPNA5: view
genes like me logo Genes that share phenotypes with KPNA5: view

Clone Products

  • Addgene plasmids for KPNA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA5 Gene

Localization for KPNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNA5 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA 21873635
GO:0005654 nucleoplasm IBA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KPNA5: view

Pathways & Interactions for KPNA5 Gene

genes like me logo Genes that share pathways with KPNA5: view

Pathways by source for KPNA5 Gene

1 GeneGo (Thomson Reuters) pathway for KPNA5 Gene
  • Cell cycle_Spindle assembly and chromosome separation

Gene Ontology (GO) - Biological Process for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus IBA,TAS 21873635
GO:0015031 protein transport IEA --
GO:0016032 viral process IEA --
GO:0019054 modulation by virus of host process TAS --
genes like me logo Genes that share ontologies with KPNA5: view

No data available for SIGNOR curated interactions for KPNA5 Gene

Drugs & Compounds for KPNA5 Gene

(1) Drugs for KPNA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA5: view

Transcripts for KPNA5 Gene

mRNA/cDNA for KPNA5 Gene

8 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for KPNA5

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA5 Gene

No ASD Table

Relevant External Links for KPNA5 Gene

GeneLoc Exon Structure for
KPNA5

Expression for KPNA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KPNA5 Gene

Protein differential expression in normal tissues from HIPED for KPNA5 Gene

This gene is overexpressed in Liver (27.7), Testis (15.2), Cervix (12.3), and Heart (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KPNA5 Gene



Protein tissue co-expression partners for KPNA5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KPNA5

SOURCE GeneReport for Unigene cluster for KPNA5 Gene:

Hs.182971

mRNA Expression by UniProt/SwissProt for KPNA5 Gene:

O15131-IMA6_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for KPNA5 Gene

  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with KPNA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNA5 Gene

Orthologs for KPNA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA5 31 30
  • 99.81 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA5 31
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA5 31 30
  • 95.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KPNA5 31 30
  • 95.05 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KPNA5 31
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna5 30
  • 89.61 (n)
chicken
(Gallus gallus)
Aves KPNA5 31 30
  • 82.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KPNA5 31
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kpna5 31 30
  • 73.78 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 31 32
  • 61 (a)
OneToMany
Pen 32
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 32
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 31 30
  • 58.65 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08580g 30
  • 57.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL150W 30
  • 54.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MOS6 30
  • 57.42 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10515 30
barley
(Hordeum vulgare)
Liliopsida Hv.1976 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 66 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut15 30
  • 58.01 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01249 30
  • 54.32 (n)
Species where no ortholog for KPNA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KPNA5 Gene

ENSEMBL:
Gene Tree for KPNA5 (if available)
TreeFam:
Gene Tree for KPNA5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KPNA5: view image

Paralogs for KPNA5 Gene

Paralogs for KPNA5 Gene

(6) SIMAP similar genes for KPNA5 Gene using alignment to 3 proteins:

  • IMA6_HUMAN
  • H0Y3K0_HUMAN
  • Q5TD90_HUMAN
genes like me logo Genes that share paralogs with KPNA5: view

Variants for KPNA5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KPNA5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
VAR_036245 A breast cancer sample p.Phe45Leu
VAR_036246 A breast cancer sample p.Arg316Ser

Additional dbSNP identifiers (rs#s) for KPNA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for KPNA5 Gene

Variant ID Type Subtype PubMed ID
esv2732608 CNV deletion 23290073
nsv523972 CNV gain 19592680

Variation tolerance for KPNA5 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KPNA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA5 Gene

Disorders for KPNA5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KPNA5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
ebola hemorrhagic fever
  • ebola virus disease
- elite association - COSMIC cancer census association via MalaCards
Search KPNA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KPNA5

genes like me logo Genes that share disorders with KPNA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA5 Gene

Publications for KPNA5 Gene

  1. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Köhler M … Hartmann E (FEBS letters 1997) 2 3 4 54
  2. Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1. (PMID: 17928350) Reid SP … Basler CF (Journal of virology 2007) 4 23 54
  3. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P … Stamminger T (Journal of virology 2003) 3 4 54
  4. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PMID: 12740372) Melen K … Julkunen I (The Journal of biological chemistry 2003) 3 4 54
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54

Products for KPNA5 Gene

Sources for KPNA5 Gene