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Aliases for KPNA5 Gene

Aliases for KPNA5 Gene

  • Karyopherin Subunit Alpha 5 2 3 5
  • Karyopherin Alpha 5 (Importin Alpha 6) 2 3
  • Importin Alpha 6 2 3
  • Karyopherin Subunit Alpha-5 4
  • Importin Subunit Alpha-6 3
  • Karyopherin Alpha 5 2
  • IPOA6 3
  • SRP6 3

External Ids for KPNA5 Gene

Previous GeneCards Identifiers for KPNA5 Gene

  • GC06P116845
  • GC06P117034
  • GC06P117056
  • GC06P117048
  • GC06P117109
  • GC06P114581

Summaries for KPNA5 Gene

Entrez Gene Summary for KPNA5 Gene

  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus. [provided by RefSeq, Jul 2008]

GeneCards Summary for KPNA5 Gene

KPNA5 (Karyopherin Subunit Alpha 5) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include binding and protein transporter activity. An important paralog of this gene is KPNA6.

UniProtKB/Swiss-Prot for KPNA5 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Gene Wiki entry for KPNA5 Gene

Additional gene information for KPNA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KPNA5 Gene

Genomics for KPNA5 Gene

GeneHancer (GH) Regulatory Elements for KPNA5 Gene

Promoters and enhancers for KPNA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I116679 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 552.5 +0.5 500 3.2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B KPNA5 GC06M116680 DSE ENSG00000240050 RWDD1 ENSG00000237021 CALHM6 ZUFSP TSPYL1 TSPYL4
GH06I116098 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 43.7 -580.4 -580436 4.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B NT5DC1 FRK KPNA5 COL10A1 TSPYL4 GC06M116078
GH06I116250 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21 -427.5 -427546 5.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B TSPYL4 DSE ENSG00000237021 KPNA5 ENSG00000234117 TSPYL1 ENSG00000240050 RSPH4A GC06M116250
GH06I116555 Enhancer 1 Ensembl ENCODE 20.6 -123.7 -123684 3.6 PKNOX1 NFIB ZNF529 SIN3A ZNF366 SCRT2 RCOR1 CEBPB ELF1 ZEB2 RSPH4A KPNA5 CALHM6 CALHM4 ENSG00000244158 KRT18P22 CBX3P9 ENSG00000234117 CALHM5 TRAPPC3L
GH06I116665 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 6.8 -13.6 -13584 3.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZUFSP CALHM5 KPNA5 RWDD1 DSE GC06P116597
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KPNA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KPNA5 gene promoter:

Genomic Locations for KPNA5 Gene

Genomic Locations for KPNA5 Gene
chr6:116,681,086-116,741,867
(GRCh38/hg38)
Size:
60,782 bases
Orientation:
Plus strand
chr6:117,002,350-117,063,030
(GRCh37/hg19)

Genomic View for KPNA5 Gene

Genes around KPNA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA5 Gene

Proteins for KPNA5 Gene

  • Protein details for KPNA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15131-IMA6_HUMAN
    Recommended name:
    Importin subunit alpha-6
    Protein Accession:
    O15131
    Secondary Accessions:
    • B2RAI5
    • Q86X23

    Protein attributes for KPNA5 Gene

    Size:
    536 amino acids
    Molecular mass:
    60349 Da
    Quaternary structure:
    • Forms a complex with importin subunit beta-1.
    SequenceCaution:
    • Sequence=AAH47409.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI20500.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for KPNA5 Gene

neXtProt entry for KPNA5 Gene

Post-translational modifications for KPNA5 Gene

  • Ubiquitination at isoforms=131
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KPNA5 Gene

Domains & Families for KPNA5 Gene

Gene Families for KPNA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Suggested Antigen Peptide Sequences for KPNA5 Gene

Graphical View of Domain Structure for InterPro Entry

O15131

UniProtKB/Swiss-Prot:

IMA6_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
Family:
  • Belongs to the importin alpha family.
genes like me logo Genes that share domains with KPNA5: view

Function for KPNA5 Gene

Molecular function for KPNA5 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Phenotypes From GWAS Catalog for KPNA5 Gene

Gene Ontology (GO) - Molecular Function for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15057270
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with KPNA5: view
genes like me logo Genes that share phenotypes with KPNA5: view

Clone Products

  • Addgene plasmids for KPNA5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA5 Gene

Localization for KPNA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA5 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNA5 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IBA --
GO:0005654 nucleoplasm IBA,TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
genes like me logo Genes that share ontologies with KPNA5: view

Pathways & Interactions for KPNA5 Gene

genes like me logo Genes that share pathways with KPNA5: view

Gene Ontology (GO) - Biological Process for KPNA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus TAS 9395085
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0019054 modulation by virus of host process TAS --
genes like me logo Genes that share ontologies with KPNA5: view

No data available for SIGNOR curated interactions for KPNA5 Gene

Drugs & Compounds for KPNA5 Gene

(1) Drugs for KPNA5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA5: view

Transcripts for KPNA5 Gene

Unigene Clusters for KPNA5 Gene

Karyopherin alpha 5 (importin alpha 6):
Representative Sequences:

Clone Products

  • Addgene plasmids for KPNA5

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA5 Gene

No ASD Table

Relevant External Links for KPNA5 Gene

GeneLoc Exon Structure for
KPNA5
ECgene alternative splicing isoforms for
KPNA5

Expression for KPNA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KPNA5 Gene

Protein differential expression in normal tissues from HIPED for KPNA5 Gene

This gene is overexpressed in Liver (27.7), Testis (15.2), Cervix (12.3), and Heart (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KPNA5 Gene



Protein tissue co-expression partners for KPNA5 Gene

NURSA nuclear receptor signaling pathways regulating expression of KPNA5 Gene:

KPNA5

SOURCE GeneReport for Unigene cluster for KPNA5 Gene:

Hs.182971

mRNA Expression by UniProt/SwissProt for KPNA5 Gene:

O15131-IMA6_HUMAN
Tissue specificity: Testis.

Evidence on tissue expression from TISSUES for KPNA5 Gene

  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with KPNA5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNA5 Gene

Orthologs for KPNA5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KPNA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KPNA5 33 34
  • 99.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KPNA5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KPNA5 33 34
  • 95.3 (n)
cow
(Bos Taurus)
Mammalia KPNA5 33 34
  • 95.05 (n)
oppossum
(Monodelphis domestica)
Mammalia KPNA5 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kpna5 33
  • 89.61 (n)
chicken
(Gallus gallus)
Aves KPNA5 33 34
  • 82.81 (n)
lizard
(Anolis carolinensis)
Reptilia KPNA5 34
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii kpna5 33 34
  • 73.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta Kap-alpha1 35 34
  • 61 (a)
Pen 35
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea ima-2 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SRP1 33 34
  • 58.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D08580g 33
  • 57.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL150W 33
  • 54.49 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MOS6 33
  • 57.42 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10515 33
barley
(Hordeum vulgare)
Liliopsida Hv.1976 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cut15 33
  • 58.01 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01249 33
  • 54.32 (n)
Species where no ortholog for KPNA5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KPNA5 Gene

ENSEMBL:
Gene Tree for KPNA5 (if available)
TreeFam:
Gene Tree for KPNA5 (if available)

Paralogs for KPNA5 Gene

Paralogs for KPNA5 Gene

(6) SIMAP similar genes for KPNA5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KPNA5: view

Variants for KPNA5 Gene

Sequence variations from dbSNP and Humsavar for KPNA5 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_036245 A breast cancer sample p.Phe45Leu
VAR_036246 A breast cancer sample p.Arg316Ser
rs1000015104 -- 116,730,286(+) C/T intron_variant
rs1000032614 -- 116,718,759(+) A/G intron_variant
rs1000075617 -- 116,716,392(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KPNA5 Gene

Variant ID Type Subtype PubMed ID
esv2732608 CNV deletion 23290073
nsv523972 CNV gain 19592680

Variation tolerance for KPNA5 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KPNA5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA5 Gene

Disorders for KPNA5 Gene

Additional Disease Information for KPNA5

No disorders were found for KPNA5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KPNA5 Gene

Publications for KPNA5 Gene

  1. Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family. (PMID: 9395085) Köhler M … Hartmann E (FEBS letters 1997) 2 3 4 58
  2. A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway. (PMID: 12610148) Lischka P … Stamminger T (Journal of virology 2003) 3 4 58
  3. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. (PMID: 12740372) Melen K … Julkunen I (The Journal of biological chemistry 2003) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58

Products for KPNA5 Gene

  • Addgene plasmids for KPNA5

Sources for KPNA5 Gene

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