The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids... See more...

Aliases for KPNA2 Gene

Aliases for KPNA2 Gene

  • Karyopherin Subunit Alpha 2 2 3 5
  • Karyopherin Alpha 2 (RAG Cohort 1, Importin Alpha 1) 2 3
  • Importin Subunit Alpha-1 3 4
  • RAG Cohort Protein 1 3 4
  • SRP1-Alpha 3 4
  • SRP1alpha 2 3
  • IPOA1 2 3
  • QIP2 2 3
  • RCH1 3 4
  • Karyopherin Subunit Alpha-2 4
  • Importin Subunit Alpha-2 3
  • Karyopherin Alpha 2 2
  • Importin-Alpha-P1 3
  • Importin Alpha 1 2
  • RAG Cohort 1 2
  • Pendulin 3
  • KPNA2 5
  • SRP1 4

External Ids for KPNA2 Gene

Previous HGNC Symbols for KPNA2 Gene

  • RCH1

Previous GeneCards Identifiers for KPNA2 Gene

  • GC17U990047
  • GC17P066449
  • GC17P066581
  • GC17M9N0103
  • GC17P063463
  • GC17P066031
  • GC17P061416

Summaries for KPNA2 Gene

Entrez Gene Summary for KPNA2 Gene

  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for KPNA2 Gene

KPNA2 (Karyopherin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with KPNA2 include Venezuelan Equine Encephalitis and Nijmegen Breakage Syndrome. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include histone deacetylase binding. An important paralog of this gene is KPNA7.

UniProtKB/Swiss-Prot Summary for KPNA2 Gene

  • Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Gene Wiki entry for KPNA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KPNA2 Gene

Genomics for KPNA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for KPNA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KPNA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KPNA2

Top Transcription factor binding sites by QIAGEN in the KPNA2 gene promoter:
  • AML1a
  • Evi-1
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • SRF
  • STAT3

Genomic Locations for KPNA2 Gene

Latest Assembly
chr17:68,035,636-68,047,364
(GRCh38/hg38)
Size:
11,729 bases
Orientation:
Plus strand

Previous Assembly
chr17:66,031,851-66,042,970
(GRCh37/hg19 by Entrez Gene)
Size:
11,120 bases
Orientation:
Plus strand

chr17:66,031,635-66,042,958
(GRCh37/hg19 by Ensembl)
Size:
11,324 bases
Orientation:
Plus strand

Genomic View for KPNA2 Gene

Genes around KPNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KPNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KPNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KPNA2 Gene

Proteins for KPNA2 Gene

  • Protein details for KPNA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52292-IMA1_HUMAN
    Recommended name:
    Importin subunit alpha-1
    Protein Accession:
    P52292
    Secondary Accessions:
    • B9EJD6
    • Q53YE3
    • Q6NVW7
    • Q9BRU5

    Protein attributes for KPNA2 Gene

    Size:
    529 amino acids
    Molecular mass:
    57862 Da
    Quaternary structure:
    • Heterodimer; with KPNB1 (PubMed:17596301). Interacts with ANP32E (By similarity). Component of a complex containing CSE1L, RAN and KPNA2. Interacts directly with CSE1L. Interacts with PLAG1. Interacts with APEX1 (via N-terminus). Interacts with FRG1 (via N-terminus). Interacts with ARL4A, CTNNBL1 and NBN. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with BAG6 (PubMed:29042515). Interacts with AIFM2; this interaction likely mediates the translocation of AIFM2 into the nucleus upon oxidative stress.
    • (Microbial infection) Interacts with HIV-1 Vpr.
    • (Microbial infection) Part of a tetrameric complex composed of CRM1, importin alpha/beta dimer and the Venezuelan equine encephalitis virus (VEEV) capsid; this complex blocks the receptor-mediated transport through the nuclear pore.
    • (Microbial infection) Interacts with SARS-COV virus ORF6 protein; this interaction blocks the receptor-mediated transport through the nuclear pore.
    • (Microbial infection) Interacts with Zika virus RNA-directed RNA polymerase NS5.
    • (Microbial infection) Interacts with SARS-CoV-2 ORF6 protein; this interaction may inhibit IFN-beta production by blocking IRF3 nuclear translocation.

    Three dimensional structures from OCA and Proteopedia for KPNA2 Gene

neXtProt entry for KPNA2 Gene

Post-translational modifications for KPNA2 Gene

  • Ubiquitination at Lys83, Lys108, Lys123, Lys240, Lys291, Lys300, Lys353, and Lys486
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for KPNA2

No data available for DME Specific Peptides for KPNA2 Gene

Domains & Families for KPNA2 Gene

Gene Families for KPNA2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for KPNA2 Gene

InterPro:
Blocks:
  • Armadillo repeat
  • Importin alpha-like protein, beta-binding regon

Suggested Antigen Peptide Sequences for KPNA2 Gene

GenScript: Design optimal peptide antigens:
  • SRP1-alpha (IMA2_HUMAN)
  • Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (Q6NVW7_HUMAN)
  • Karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (Q7Z726_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P52292

UniProtKB/Swiss-Prot:

IMA1_HUMAN :
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • Belongs to the importin alpha family.
Domain:
  • Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.
  • The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).
  • The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).
Family:
  • Belongs to the importin alpha family.
genes like me logo Genes that share domains with KPNA2: view

Function for KPNA2 Gene

Molecular function for KPNA2 Gene

UniProtKB/Swiss-Prot Function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
GENATLAS Biochemistry:
karyopherin (importin) alpha 2,56kDa,component of the nuclear protein complex (NPC),yeast SRP1 and Xenopus importin homolog,involved in the nuclear transport system,recognizing the nuclear localization signal of nuclear proteins (NLS)

Phenotypes From GWAS Catalog for KPNA2 Gene

Gene Ontology (GO) - Molecular Function for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0005515 protein binding IEA,IPI 9168958
GO:0008139 nuclear localization sequence binding IDA 17324944
GO:0042826 histone deacetylase binding IPI 10869435
GO:0061608 nuclear import signal receptor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with KPNA2: view
genes like me logo Genes that share phenotypes with KPNA2: view

miRNA for KPNA2 Gene

miRTarBase miRNAs that target KPNA2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KPNA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KPNA2 Gene

Localization for KPNA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KPNA2 Gene

Cytoplasm. Nucleus.
Endoplasmic reticulum membrane. Golgi apparatus membrane. Note=(Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. {ECO:0000269 PubMed:17596301}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KPNA2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
golgi apparatus 4
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA,TAS 7754385
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with KPNA2: view

Pathways & Interactions for KPNA2 Gene

genes like me logo Genes that share pathways with KPNA2: view

Pathways by source for KPNA2 Gene

1 GeneGo (Thomson Reuters) pathway for KPNA2 Gene
  • Cell cycle_Spindle assembly and chromosome separation
2 Qiagen pathways for KPNA2 Gene
  • NFAT in Immune Response
  • Ran Pathway
1 Cell Signaling Technology pathway for KPNA2 Gene

SIGNOR curated interactions for KPNA2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for KPNA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000018 regulation of DNA recombination TAS 8016130
GO:0006259 DNA metabolic process TAS 9168958
GO:0006606 protein import into nucleus IEA --
GO:0006607 NLS-bearing protein import into nucleus IDA 17324944
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with KPNA2: view

Drugs & Compounds for KPNA2 Gene

(2) Drugs for KPNA2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KPNA2: view

Transcripts for KPNA2 Gene

mRNA/cDNA for KPNA2 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KPNA2

Alternative Splicing Database (ASD) splice patterns (SP) for KPNA2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - -
SP8: - -
SP9:

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for KPNA2 Gene

GeneLoc Exon Structure for
KPNA2

Expression for KPNA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KPNA2 Gene

mRNA differential expression in normal tissues according to GTEx for KPNA2 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for KPNA2 Gene

This gene is overexpressed in Bone (26.3), Lung (16.1), Testis (11.5), and Pancreas (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KPNA2 Gene



Protein tissue co-expression partners for KPNA2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KPNA2

SOURCE GeneReport for Unigene cluster for KPNA2 Gene:

Hs.594238

mRNA Expression by UniProt/SwissProt for KPNA2 Gene:

P52292-IMA1_HUMAN
Tissue specificity: Expressed ubiquitously.

Evidence on tissue expression from TISSUES for KPNA2 Gene

  • Nervous system(4.9)
  • Skin(4.5)
  • Bone marrow(4.4)
  • Stomach(4.3)
  • Liver(4)
  • Eye(3.8)
  • Kidney(3.6)
  • Intestine(3.6)
  • Blood(3.4)
  • Lung(3.2)
  • Lymph node(2.5)
  • Muscle(2.4)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with KPNA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KPNA2 Gene

Orthologs for KPNA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KPNA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia KPNA2 29 30
  • 98.44 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 97 (a)
OneToMany
-- 30
  • 96 (a)
OneToMany
KPNA2 29 30
  • 93.51 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Gm10184 30
  • 95 (a)
OneToMany
Kpna2 29 16
  • 87.59 (n)
Cow
(Bos Taurus)
Mammalia KPNA2 29 30
  • 90.99 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 88 (a)
OneToMany
-- 30
  • 85 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Kpna2 29
  • 87.27 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia KPNA2 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves KPNA2 29 30
  • 77.27 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia KPNA2 30
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia kpna2 29
  • 70.41 (n)
Str.6468 29
African clawed frog
(Xenopus laevis)
Amphibia kpna2-prov 29
Zebrafish
(Danio rerio)
Actinopterygii kpna2 29 30
  • 68.2 (n)
OneToOne
hmzeh0389 29
Fruit Fly
(Drosophila melanogaster)
Insecta Pen 29 31
  • 54.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009792 29
  • 54.16 (n)
Worm
(Caenorhabditis elegans)
Secernentea ima-2 30 31
  • 37 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 48 (a)
OneToMany
Species where no ortholog for KPNA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for KPNA2 Gene

ENSEMBL:
Gene Tree for KPNA2 (if available)
TreeFam:
Gene Tree for KPNA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KPNA2: view image
Alliance of Genome Resources:
Additional Orthologs for KPNA2

Paralogs for KPNA2 Gene

Paralogs for KPNA2 Gene

(6) SIMAP similar genes for KPNA2 Gene using alignment to 6 proteins:

  • IMA1_HUMAN
  • J3KS65_HUMAN
  • J3QL07_HUMAN
  • J3QLL0_HUMAN
  • Q6NVW7_HUMAN
  • Q7Z726_HUMAN
genes like me logo Genes that share paralogs with KPNA2: view

Variants for KPNA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KPNA2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs1136739 Benign: not provided 68,044,059(+) T/C
NM_002266.4(KPNA2):c.1152T>C (p.Ser384=)
SYNONYMOUS
rs1802813 Benign: not provided 68,042,280(+) A/T
NM_002266.4(KPNA2):c.498A>T (p.Ala166=)
SYNONYMOUS
rs1059558 -- p.Gly365Ser
rs11545989 -- p.Pro165Arg
rs17850031 -- p.Lys453Asn

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for KPNA2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for KPNA2 Gene

Variant ID Type Subtype PubMed ID
esv2716136 CNV deletion 23290073
esv2716138 CNV deletion 23290073
nsv1120054 OTHER inversion 24896259
nsv436233 CNV deletion 17901297
nsv978458 CNV duplication 23825009

Variation tolerance for KPNA2 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KPNA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KPNA2
Leiden Open Variation Database (LOVD)
KPNA2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KPNA2 Gene

Disorders for KPNA2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for KPNA2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
venezuelan equine encephalitis
  • venezuelan equine fever
nijmegen breakage syndrome
  • nbs
retinitis pigmentosa 40
  • rp40
- elite association - COSMIC cancer census association via MalaCards
Search KPNA2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KPNA2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with KPNA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KPNA2 Gene

Publications for KPNA2 Gene

  1. Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane. (PMID: 17596301) Frieman M … Baric RS (Journal of virology 2007) 3 4 22
  2. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. (PMID: 16188882) Tseng SF … Teng SC (The Journal of biological chemistry 2005) 3 4 22
  3. Genomic structure of karyopherin alpha2 ( KPNA2) within a low-copy repeat on chromosome 17q23-q24 and mutation analysis in patients with Russell-Silver syndrome. (PMID: 11735022) Dörr SN … Hansmann IN (Human genetics 2001) 3 4 22
  4. Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins. (PMID: 7604027) Moroianu J … Radu A (Proceedings of the National Academy of Sciences of the United States of America 1995) 3 4 22
  5. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. (PMID: 7754385) Weis K … Lamond AI (Science (New York, N.Y.) 1995) 2 3 4

Products for KPNA2 Gene

Sources for KPNA2 Gene