Aliases for KPNA2 Gene
External Ids for KPNA2 Gene
Previous HGNC Symbols for KPNA2 Gene
Previous GeneCards Identifiers for KPNA2 Gene
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for KPNA2 Gene
KPNA2 (Karyopherin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with KPNA2 include Venezuelan Equine Encephalitis and Nijmegen Breakage Syndrome. Among its related pathways are Regulation of cytoplasmic and nuclear SMAD2/3 signaling and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include histone deacetylase binding. An important paralog of this gene is KPNA7.
UniProtKB/Swiss-Prot Summary for KPNA2 Gene
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.