The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017] See more...

Aliases for KNOP1 Gene

Aliases for KNOP1 Gene

  • Lysine Rich Nucleolar Protein 1 2 3 5
  • Family With Sequence Similarity 191, Member A 2 3
  • Testis-Specific Gene 118 Protein 3 4
  • Lysine-Rich Nucleolar Protein 1 3 4
  • C16orf88 3 4
  • FAM191A 3 4
  • TSG118 3 4
  • Chromosome 16 Open Reading Frame 88 2
  • Testis-Specific Gene 118 2
  • Protein C16orf88 3
  • Protein FAM191A 4
  • 101F10.1 3

External Ids for KNOP1 Gene

Previous HGNC Symbols for KNOP1 Gene

  • C16orf88

Summaries for KNOP1 Gene

Entrez Gene Summary for KNOP1 Gene

  • The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017]

GeneCards Summary for KNOP1 Gene

KNOP1 (Lysine Rich Nucleolar Protein 1) is a Protein Coding gene. Diseases associated with KNOP1 include Obsessive-Compulsive Disorder.

Additional gene information for KNOP1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KNOP1 Gene

Genomics for KNOP1 Gene

GeneHancer (GH) Regulatory Elements for KNOP1 Gene

Promoters and enhancers for KNOP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J019715 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 543.9 +0.6 611 4.1 EP300 ZBTB40 ZNF217 SIN3A MYC POLR2G USF1 NCOR1 PHF8 SIX5 KNOP1 IQCK NONHSAG018797.2 RPS15A
GH16J019695 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 61 +20.8 20761 8 ZNF217 TCF12 POLR2G NCOR1 JUND FOS CLOCK KLF4 MYC ZBTB7A piR-42491-080 KNOP1 VPS35L ENSG00000276571 ENSG00000261312
GH16J019742 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 53.8 -26.9 -26918 5 FOXK2 NCOR1 ZIC2 TCF7 FOXA1 SKI TEAD1 TBX3 ZKSCAN8 ZSCAN9 KNOP1 IQCK VPS35L ENSG00000261195 NONHSAG018797.2
GH16J019756 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 44.9 -39.6 -39640 2 JUND TGIF2 TEAD1 KLF9 SAP130 MBD1 SPI1 NR2F2 CREM SMAD4 KNOP1 GPRC5B CCP110 IQCK ENSG00000261195 NONHSAG018797.2
GH16J019857 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 29 -142.1 -142086 4.9 POLR2A HDAC2 FOXA2 ZBTB17 YY1 ZFHX2 EBF1 SIN3A GLIS1 JUND lnc-KNOP1-3 KNOP1 GPRC5B VPS35L ACSM5 lnc-KNOP1-2 IQCK NONHSAG018797.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around KNOP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KNOP1

Genomic Locations for KNOP1 Gene

Genomic Locations for KNOP1 Gene
chr16:19,701,937-19,718,361
(GRCh38/hg38)
Size:
16,425 bases
Orientation:
Minus strand
chr16:19,714,902-19,729,557
(GRCh37/hg19)
Size:
14,656 bases
Orientation:
Minus strand

Genomic View for KNOP1 Gene

Genes around KNOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KNOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KNOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNOP1 Gene

Proteins for KNOP1 Gene

  • Protein details for KNOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ED39-KNOP1_HUMAN
    Recommended name:
    Lysine-rich nucleolar protein 1
    Protein Accession:
    Q1ED39
    Secondary Accessions:
    • O43328
    • Q5FWF3

    Protein attributes for KNOP1 Gene

    Size:
    458 amino acids
    Molecular mass:
    51589 Da
    Quaternary structure:
    • Interacts with ZNF106.
    SequenceCaution:
    • Sequence=AAC05805.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH89430.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for KNOP1 Gene

Post-translational modifications for KNOP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KNOP1 Gene

Domains & Families for KNOP1 Gene

Gene Families for KNOP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KNOP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KNOP1 Gene

GenScript: Design optimal peptide antigens:
  • Testis-specific gene 118 protein (CP088_HUMAN)
genes like me logo Genes that share domains with KNOP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KNOP1 Gene

Function for KNOP1 Gene

Phenotypes From GWAS Catalog for KNOP1 Gene

Gene Ontology (GO) - Molecular Function for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with KNOP1: view
genes like me logo Genes that share phenotypes with KNOP1: view

Animal Models for KNOP1 Gene

MGI Knock Outs for KNOP1:
  • Knop1 Knop1<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KNOP1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KNOP1 Gene

Localization for KNOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNOP1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KNOP1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with KNOP1: view

Pathways & Interactions for KNOP1 Gene

PathCards logo

SuperPathways for KNOP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KNOP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KNOP1 Gene

Drugs & Compounds for KNOP1 Gene

No Compound Related Data Available

Transcripts for KNOP1 Gene

mRNA/cDNA for KNOP1 Gene

12 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KNOP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KNOP1 Gene

No ASD Table

Relevant External Links for KNOP1 Gene

GeneLoc Exon Structure for
KNOP1

Expression for KNOP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KNOP1 Gene

Protein differential expression in normal tissues from HIPED for KNOP1 Gene

This gene is overexpressed in Lung (54.3) and Fetal ovary (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KNOP1 Gene



Protein tissue co-expression partners for KNOP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KNOP1

SOURCE GeneReport for Unigene cluster for KNOP1 Gene:

Hs.585209

Evidence on tissue expression from TISSUES for KNOP1 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with KNOP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KNOP1 Gene

Orthologs for KNOP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KNOP1 31
  • 96 (a)
OneToOne
C16H16orf88 30
  • 95.61 (n)
dog
(Canis familiaris)
Mammalia KNOP1 31 30
  • 81.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia KNOP1 31 30
  • 80.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Knop1 17 31 30
  • 72.8 (n)
rat
(Rattus norvegicus)
Mammalia LOC680982 30
  • 66.99 (n)
oppossum
(Monodelphis domestica)
Mammalia KNOP1 31
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves KNOP1 31
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KNOP1 31
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii knop1 31
  • 25 (a)
OneToOne
Species where no ortholog for KNOP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNOP1 Gene

ENSEMBL:
Gene Tree for KNOP1 (if available)
TreeFam:
Gene Tree for KNOP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for KNOP1: view image

Paralogs for KNOP1 Gene

genes like me logo Genes that share paralogs with KNOP1: view

No data available for Paralogs for KNOP1 Gene

Variants for KNOP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for KNOP1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs11640454 - p.Arg28Gln
rs2074036 - p.Ala266Val
rs28424569 - p.Val276Ala

Additional dbSNP identifiers (rs#s) for KNOP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KNOP1 Gene

Variant ID Type Subtype PubMed ID
esv2714055 CNV deletion 23290073
esv991936 CNV loss 20482838
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781
nsv952946 CNV deletion 24416366

Variation tolerance for KNOP1 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KNOP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KNOP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KNOP1 Gene

Disorders for KNOP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KNOP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards
Search KNOP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KNOP1

genes like me logo Genes that share disorders with KNOP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KNOP1 Gene

Publications for KNOP1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4 54
  2. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. (PMID: 30463901) Yu L … Engel JD (Genes & development 2018) 3 54
  3. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. (PMID: 29128334) Malty RH … Babu M (Cell systems 2017) 3 54

Products for KNOP1 Gene

Sources for KNOP1 Gene