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Aliases for KNOP1 Gene

Aliases for KNOP1 Gene

  • Lysine Rich Nucleolar Protein 1 2 3 5
  • Family With Sequence Similarity 191, Member A 2 3
  • Testis-Specific Gene 118 Protein 3 4
  • C16orf88 3 4
  • FAM191A 3 4
  • TSG118 3 4
  • Chromosome 16 Open Reading Frame 88 2
  • Lysine-Rich Nucleolar Protein 1 3
  • Testis-Specific Gene 118 2
  • Protein C16orf88 3
  • Protein FAM191A 4
  • 101F10.1 3

External Ids for KNOP1 Gene

Previous HGNC Symbols for KNOP1 Gene

  • C16orf88

Summaries for KNOP1 Gene

Entrez Gene Summary for KNOP1 Gene

  • The protein encoded by this gene is a nucleolar protein that interacts with zinc finger 106 protein. The encoded protein has several of the same characteristics as nucleostemin and may be involved in testis development. [provided by RefSeq, Feb 2017]

GeneCards Summary for KNOP1 Gene

KNOP1 (Lysine Rich Nucleolar Protein 1) is a Protein Coding gene. Diseases associated with KNOP1 include Obsessive-Compulsive Disorder.

Additional gene information for KNOP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNOP1 Gene

Genomics for KNOP1 Gene

GeneHancer (GH) Regulatory Elements for KNOP1 Gene

Promoters and enhancers for KNOP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I019715 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 594 +0.7 682 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 E2F8 KNOP1 IQCK RPS15A
GH16I019719 Enhancer 0.2 dbSUPER 550.8 -2.0 -1956 1.2 KNOP1 IQCK LOC105371115
GH16I019695 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 60.7 +20.0 20041 6.4 FOXA2 ARID4B FEZF1 ZNF2 ZNF48 FOS RUNX3 SSRP1 STAT3 HNF4A KNOP1 C16orf62 ENSG00000276571 GC16M019702
GH16I019709 Enhancer 0.9 ENCODE dbSUPER 50.1 +7.9 7863 1.4 MEIS2 MXI1 TEAD4 TAL1 ZFP64 TCF12 NCOR1 CBFA2T2 NFIA CBFA2T3 KNOP1 C16orf62 ENSG00000261312 IQCK
GH16I019783 Enhancer 0.8 ENCODE dbSUPER 55.5 -66.3 -66278 3.3 SOX5 SOX13 TFAP4 FOXA2 FOXA3 HLF NFYC NR2F2 FOXA1 ZKSCAN1 KNOP1 IQCK LOC105371115 LARP7P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KNOP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for KNOP1 Gene

Genomic Locations for KNOP1 Gene
chr16:19,701,934-19,718,361
(GRCh38/hg38)
Size:
16,428 bases
Orientation:
Minus strand
chr16:19,714,902-19,729,557
(GRCh37/hg19)

Genomic View for KNOP1 Gene

Genes around KNOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KNOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KNOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNOP1 Gene

Proteins for KNOP1 Gene

  • Protein details for KNOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q1ED39-KNOP1_HUMAN
    Recommended name:
    Lysine-rich nucleolar protein 1
    Protein Accession:
    Q1ED39
    Secondary Accessions:
    • O43328
    • Q5FWF3

    Protein attributes for KNOP1 Gene

    Size:
    458 amino acids
    Molecular mass:
    51589 Da
    Quaternary structure:
    • Interacts with ZNF106.
    SequenceCaution:
    • Sequence=AAC05805.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH89430.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for KNOP1 Gene

Post-translational modifications for KNOP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KNOP1 Gene

Domains & Families for KNOP1 Gene

Gene Families for KNOP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KNOP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KNOP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KNOP1: view

No data available for UniProtKB/Swiss-Prot for KNOP1 Gene

Function for KNOP1 Gene

Phenotypes From GWAS Catalog for KNOP1 Gene

Gene Ontology (GO) - Molecular Function for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
genes like me logo Genes that share ontologies with KNOP1: view
genes like me logo Genes that share phenotypes with KNOP1: view

Animal Models for KNOP1 Gene

MGI Knock Outs for KNOP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KNOP1 Gene

Localization for KNOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNOP1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KNOP1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for KNOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with KNOP1: view

Pathways & Interactions for KNOP1 Gene

SuperPathways for KNOP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KNOP1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KNOP1 Gene

Drugs & Compounds for KNOP1 Gene

No Compound Related Data Available

Transcripts for KNOP1 Gene

Unigene Clusters for KNOP1 Gene

Lysine-rich nucleolar protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for KNOP1 Gene

No ASD Table

Relevant External Links for KNOP1 Gene

GeneLoc Exon Structure for
KNOP1
ECgene alternative splicing isoforms for
KNOP1

Expression for KNOP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KNOP1 Gene

Protein differential expression in normal tissues from HIPED for KNOP1 Gene

This gene is overexpressed in Lung (54.3) and Fetal ovary (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KNOP1 Gene



Protein tissue co-expression partners for KNOP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KNOP1 Gene:

KNOP1

SOURCE GeneReport for Unigene cluster for KNOP1 Gene:

Hs.585209

Evidence on tissue expression from TISSUES for KNOP1 Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with KNOP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KNOP1 Gene

Orthologs for KNOP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KNOP1 34
  • 96 (a)
OneToOne
C16H16orf88 33
  • 95.61 (n)
dog
(Canis familiaris)
Mammalia KNOP1 33 34
  • 81.37 (n)
cow
(Bos Taurus)
Mammalia KNOP1 33 34
  • 80.61 (n)
mouse
(Mus musculus)
Mammalia Knop1 33 16 34
  • 72.8 (n)
rat
(Rattus norvegicus)
Mammalia LOC680982 33
  • 66.99 (n)
oppossum
(Monodelphis domestica)
Mammalia KNOP1 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves KNOP1 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KNOP1 34
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii knop1 34
  • 25 (a)
OneToOne
Species where no ortholog for KNOP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNOP1 Gene

ENSEMBL:
Gene Tree for KNOP1 (if available)
TreeFam:
Gene Tree for KNOP1 (if available)

Paralogs for KNOP1 Gene

genes like me logo Genes that share paralogs with KNOP1: view

No data available for Paralogs for KNOP1 Gene

Variants for KNOP1 Gene

Sequence variations from dbSNP and Humsavar for KNOP1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000101254 -- 19,717,218(-) T/A intron_variant
rs1000438223 -- 19,715,517(-) T/G intron_variant
rs1000472411 -- 19,719,912(-) A/C/G upstream_transcript_variant
rs1000521338 -- 19,719,713(-) C/T upstream_transcript_variant
rs1000764947 -- 19,710,148(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KNOP1 Gene

Variant ID Type Subtype PubMed ID
esv2714055 CNV deletion 23290073
esv991936 CNV loss 20482838
nsv436835 CNV insertion 17901297
nsv571582 CNV gain 21841781
nsv952946 CNV deletion 24416366

Variation tolerance for KNOP1 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.13; 61.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KNOP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KNOP1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KNOP1 Gene

Disorders for KNOP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for KNOP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
obsessive-compulsive disorder
  • ocd
- elite association - COSMIC cancer census association via MalaCards
Search KNOP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KNOP1

genes like me logo Genes that share disorders with KNOP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KNOP1 Gene

Publications for KNOP1 Gene

  1. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus BJ … Adams MD (Genomics 1999) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. (PMID: 24821223) Mattheisen M … Nestadt G (Molecular psychiatry 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for KNOP1 Gene

Sources for KNOP1 Gene

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