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Aliases for KNDC1 Gene

Aliases for KNDC1 Gene

  • Kinase Non-Catalytic C-Lobe Domain Containing 1 2 3 5
  • Kinase Non-Catalytic C-Lobe Domain-Containing Protein 1 3 4
  • Kinase Non-Catalytic C-Lobe Domain (KIND) Containing 1 2 3
  • Ras-GEF Domain-Containing Family Member 2 3 4
  • KIND Domain-Containing Protein 1 3 4
  • RasGEF Domain Family, Member 2 2 3
  • Cerebral Protein 9 3 4
  • C10orf23 3 4
  • RASGEF2 3 4
  • V-KIND 3 4
  • Protein Very KIND 3
  • BB439H18.3 3
  • Very-KIND 3
  • KIAA1768 4
  • VKIND 4

External Ids for KNDC1 Gene

Previous HGNC Symbols for KNDC1 Gene

  • C10orf23

Previous GeneCards Identifiers for KNDC1 Gene

  • GC10P134448
  • GC10P134862
  • GC10P134974
  • GC10P128521

Summaries for KNDC1 Gene

Entrez Gene Summary for KNDC1 Gene

  • The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]

GeneCards Summary for KNDC1 Gene

KNDC1 (Kinase Non-Catalytic C-Lobe Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and Ras guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for KNDC1 Gene

  • RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).

Additional gene information for KNDC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KNDC1 Gene

Genomics for KNDC1 Gene

GeneHancer (GH) Regulatory Elements for KNDC1 Gene

Promoters and enhancers for KNDC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I133160 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 569.6 0.0 -46 0.8 ZNF777 ZNF449 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 PATZ1 VEZF1 ZBTB20 KNDC1 RPL5P28
GH10I133158 Enhancer 0.7 ENCODE 568.2 -1.3 -1292 1.7 CTCF PKNOX1 ZNF777 ZNF792 ZIC2 ZKSCAN1 ZNF335 ZFHX2 GLIS2 ZBTB48 KNDC1 ENSG00000235245 TUBGCP2 CFAP46 SCART1 RPL5P28
GH10I133161 Enhancer 0.4 ENCODE 570.1 +1.3 1285 0.2 REST RFX5 KNDC1 PIR45195
GH10I133142 Enhancer 1.2 Ensembl ENCODE 28 -16.7 -16706 1.6 PKNOX1 ATF1 ZNF2 TCF12 GLIS2 ZNF213 GATA2 FOS ATF7 SP3 RPL5P28 GC10M133145 KNDC1 PIR56333
GH10I133163 Enhancer 0.5 ENCODE 26 +3.6 3625 0.2 RING1 ZFHX2 MAZ MNT EGR2 KNDC1 PIR45195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KNDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KNDC1 gene promoter:

Genomic Locations for KNDC1 Gene

Genomic Locations for KNDC1 Gene
65,966 bases
Plus strand

Genomic View for KNDC1 Gene

Genes around KNDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KNDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KNDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KNDC1 Gene

Proteins for KNDC1 Gene

  • Protein details for KNDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein very KIND
    Protein Accession:
    Secondary Accessions:
    • B0QZC5
    • Q5T233
    • Q6ZNH8
    • Q8TEE5
    • Q96LV7
    • Q9C095

    Protein attributes for KNDC1 Gene

    1749 amino acids
    Molecular mass:
    191397 Da
    Quaternary structure:
    • Interacts (via KIND2) with MAP2; the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites.
    • Sequence=BAB21859.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI17339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KNDC1 Gene

neXtProt entry for KNDC1 Gene

Post-translational modifications for KNDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KNDC1 Gene

No data available for DME Specific Peptides for KNDC1 Gene

Domains & Families for KNDC1 Gene

Gene Families for KNDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for KNDC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KNDC1: view

No data available for UniProtKB/Swiss-Prot for KNDC1 Gene

Function for KNDC1 Gene

Molecular function for KNDC1 Gene

UniProtKB/Swiss-Prot Function:
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352).

Gene Ontology (GO) - Molecular Function for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity IBA --
genes like me logo Genes that share ontologies with KNDC1: view
genes like me logo Genes that share phenotypes with KNDC1: view

Animal Models for KNDC1 Gene

MGI Knock Outs for KNDC1:

Animal Model Products

miRNA for KNDC1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KNDC1 Gene

Localization for KNDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KNDC1 Gene

Cell projection, dendrite. Perikaryon.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KNDC1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0030425 dendrite ISS --
GO:0032045 guanyl-nucleotide exchange factor complex ISS --
GO:0042995 cell projection IEA --
GO:0043025 neuronal cell body ISS --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KNDC1 Gene

Pathways & Interactions for KNDC1 Gene

SuperPathways for KNDC1 Gene

No Data Available

Interacting Proteins for KNDC1 Gene

Gene Ontology (GO) - Biological Process for KNDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008150 biological_process ND --
GO:0021707 cerebellar granule cell differentiation ISS --
GO:0048814 regulation of dendrite morphogenesis ISS --
genes like me logo Genes that share ontologies with KNDC1: view

No data available for Pathways by source and SIGNOR curated interactions for KNDC1 Gene

Drugs & Compounds for KNDC1 Gene

(3) Drugs for KNDC1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with KNDC1: view

Transcripts for KNDC1 Gene

Unigene Clusters for KNDC1 Gene

Kinase non-catalytic C-lobe domain (KIND) containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KNDC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - - - - -
SP2: - - - - - -
SP4: - - - -
SP5: - - -
SP6: - -
SP7: - -
SP8: - - - -

ExUns: 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34

Relevant External Links for KNDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KNDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KNDC1 Gene

mRNA differential expression in normal tissues according to GTEx for KNDC1 Gene

This gene is overexpressed in Brain - Cortex (x5.4), Brain - Cerebellum (x5.2), Brain - Cerebellar Hemisphere (x4.9), Brain - Frontal Cortex (BA9) (x4.2), and Pituitary (x4.1).

Protein differential expression in normal tissues from HIPED for KNDC1 Gene

This gene is overexpressed in Stomach (57.0) and Heart (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KNDC1 Gene

Protein tissue co-expression partners for KNDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KNDC1 Gene:


SOURCE GeneReport for Unigene cluster for KNDC1 Gene:


mRNA Expression by UniProt/SwissProt for KNDC1 Gene:

Tissue specificity: Expressed specifically in the cerebral cortex.

Evidence on tissue expression from TISSUES for KNDC1 Gene

  • Nervous system(4.7)
  • Spleen(4)
genes like me logo Genes that share expression patterns with KNDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KNDC1 Gene

Orthologs for KNDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KNDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KNDC1 34
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 88 (a)
-- 34
  • 47 (a)
(Mus musculus)
Mammalia Kndc1 33 16 34
  • 78.7 (n)
(Rattus norvegicus)
Mammalia Kndc1 33
  • 77.29 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 75 (a)
-- 34
  • 69 (a)
-- 34
  • 65 (a)
-- 34
  • 56 (a)
-- 34
  • 43 (a)
-- 34
  • 35 (a)
(Canis familiaris)
Mammalia KNDC1 34
  • 64 (a)
(Bos Taurus)
Mammalia KNDC1 34
  • 61 (a)
(Gallus gallus)
Aves KNDC1 33 34
  • 58.39 (n)
(Anolis carolinensis)
Reptilia KNDC1 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kndc1 33
  • 60.6 (n)
(Danio rerio)
Actinopterygii KNDC1 (1 of 2) 34
  • 43 (a)
KNDC1 (2 of 2) 34
  • 32 (a)
Species where no ortholog for KNDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KNDC1 Gene

Gene Tree for KNDC1 (if available)
Gene Tree for KNDC1 (if available)

Paralogs for KNDC1 Gene

(1) SIMAP similar genes for KNDC1 Gene using alignment to 3 proteins: Pseudogenes for KNDC1 Gene

genes like me logo Genes that share paralogs with KNDC1: view

No data available for Paralogs for KNDC1 Gene

Variants for KNDC1 Gene

Sequence variations from dbSNP and Humsavar for KNDC1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs869025238 uncertain-significance, Ductal breast carcinoma 133,200,385(+) G/T coding_sequence_variant, stop_gained
rs1000015295 -- 133,170,226(+) C/T intron_variant
rs1000089431 -- 133,178,596(+) G/A intron_variant
rs1000096301 -- 133,161,899(+) G/A intron_variant
rs1000126885 -- 133,200,868(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for KNDC1 Gene

Variant ID Type Subtype PubMed ID
dgv1465n54 CNV loss 21841781
dgv1471n54 CNV gain 21841781
dgv1472n54 CNV loss 21841781
dgv1473n54 CNV gain 21841781
dgv1474n54 CNV loss 21841781
dgv180e199 CNV deletion 23128226
dgv2e196 CNV duplication 17116639
dgv529e59 CNV duplication 20981092
dgv530e59 CNV duplication 20981092
dgv557n106 CNV deletion 24896259
dgv998n100 CNV gain 25217958
esv1050169 CNV deletion 17803354
esv1090620 CNV deletion 17803354
esv1106376 CNV deletion 17803354
esv1213053 CNV insertion 17803354
esv1549920 CNV deletion 17803354
esv1976405 CNV deletion 18987734
esv2151232 CNV deletion 18987734
esv22327 CNV loss 19812545
esv2583286 CNV deletion 19546169
esv2657046 CNV deletion 23128226
esv26610 CNV gain 19812545
esv2668433 CNV deletion 23128226
esv2674165 CNV deletion 23128226
esv2743835 CNV deletion 23290073
esv2743836 CNV deletion 23290073
esv2743837 CNV deletion 23290073
esv2743838 CNV deletion 23290073
esv2743839 CNV deletion 23290073
esv2743840 CNV deletion 23290073
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3360 CNV loss 18987735
esv3419215 CNV duplication 20981092
esv3547141 CNV deletion 23714750
esv3547148 CNV deletion 23714750
esv3625029 CNV gain 21293372
esv3625030 CNV gain 21293372
esv3625031 CNV gain 21293372
esv999631 CNV deletion 20482838
nsv1070912 CNV deletion 25765185
nsv1075824 CNV duplication 25765185
nsv1110682 CNV insertion 24896259
nsv1113352 CNV deletion 24896259
nsv1118194 CNV deletion 24896259
nsv1118485 CNV duplication 24896259
nsv1119417 CNV insertion 24896259
nsv1125518 CNV tandem duplication 24896259
nsv1141755 CNV insertion 24896259
nsv1148640 CNV insertion 26484159
nsv1151170 CNV duplication 26484159
nsv1151318 CNV deletion 26484159
nsv1159784 CNV deletion 26073780
nsv1159785 CNV deletion 26073780
nsv470980 CNV loss 18288195
nsv512194 CNV loss 21212237
nsv528260 CNV loss 19592680
nsv552574 CNV gain 21841781
nsv552577 CNV gain 21841781
nsv552583 CNV loss 21841781
nsv552586 CNV loss 21841781
nsv7630 CNV deletion 18451855
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832039 CNV loss 17160897
nsv8750 CNV gain+loss 18304495
nsv952704 CNV deletion 24416366
nsv952705 CNV deletion 24416366

Variation tolerance for KNDC1 Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KNDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KNDC1 Gene

Disorders for KNDC1 Gene

Additional Disease Information for KNDC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for KNDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KNDC1 Gene

Publications for KNDC1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. KNDC1 knockdown protects human umbilical vein endothelial cells from senescence. (PMID: 24788352) Zhang C … Hu G (Molecular medicine reports 2014) 3 4 58
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) Kırlı K … Görlich D (eLife 2015) 3 58
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58

Products for KNDC1 Gene

Sources for KNDC1 Gene

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