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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is loca... See more...
Aliases for KLRK1 Gene
Aliases for KLRK1 Gene
External Ids for KLRK1 Gene
- HGNC: 18788
- Entrez Gene: 22914
- Ensembl: ENSG00000213809
- OMIM: 611817
- UniProtKB: P26718
Previous HGNC Symbols for KLRK1 Gene
- D12S2489E
Previous GeneCards Identifiers for KLRK1 Gene
- GC12M010416
- GC12M010267
- GC12M010524
- GC12M010681
- GC12M012412
- GC12M012632
- GC12M012787
- GC12M013372
- GC12M010778
- GC12M011014
- GC12M011301
- GC12M011535
- GC12M011728
- GC12M011915
- GC12M012101
- GC12M012278
Summaries for KLRK1 Gene
-
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
GeneCards Summary for KLRK1 Gene
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. Diseases associated with KLRK1 include Cowpox and Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is CLEC12B.
UniProtKB/Swiss-Prot Summary for KLRK1 Gene
-
Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Additional gene information for KLRK1 Gene
- HGNC(18788)
- Entrez Gene(22914)
- Ensembl(ENSG00000213809)
- OMIM(611817)
- UniProtKB(P26718)
- Open Targets Platform(ENSG00000213809)
- Monarch Initiative
- Search for KLRK1 at DataMed
- Search for KLRK1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for KLRK1 Gene
Genomics for KLRK1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for KLRK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLRK1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for KLRK1
- Top Transcription factor binding sites by QIAGEN in the KLRK1 gene promoter:
-
- FOXJ2
- FOXJ2 (long isoform)
- POU2F1
- POU2F1a
- POU2F1b
- POU2F1c
- SRF
- SRF (504 AA)
Genomic Locations for KLRK1 Gene
Genomic Locations for KLRK1 Gene
- chr12:10,372,353-10,391,874
- (GRCh38/hg38)
- Size:
- 19,522 bases
- Orientation:
- Minus strand
- chr12:10,524,952-10,544,473
- (GRCh37/hg19)
- Size:
- 19,522 bases
- Orientation:
- Minus strand
Genomic View for KLRK1 Gene
Genes around KLRK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.2 by HGNC
- 12p13.2 by Entrez Gene
- 12p13.2 by Ensembl
KLRK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLRK1 Gene
Proteins for KLRK1 Gene
-
Protein details for KLRK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26718-NKG2D_HUMAN
- Recommended name:
- NKG2-D type II integral membrane protein
- Protein Accession:
- P26718
- A8K7K5
- A8K7P4
- Q9NR41
Protein attributes for KLRK1 Gene
- Size:
- 216 amino acids
- Molecular mass:
- 25274 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Does not interact with TYROBP. Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226).
- Miscellaneous:
-
- Is not capable of signal transduction by itself, but operates through the adapter protein HCST (PubMed:10426994 and PubMed:15894612). Some families of ligands for human and mouse KLRK1 receptors have been characterized being very similar in structure and highly likely to be orthologs. In humans, an additional distinct subfamily of ligands (MICA and MICB) differs structurally, having an extra MHC alpha 3-like domain (PubMed:23298206).
Three dimensional structures from OCA and Proteopedia for KLRK1 Gene
Alternative splice isoforms for KLRK1 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for KLRK1 Gene
Post-translational modifications for KLRK1 Gene
Other Protein References for KLRK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences KLRK1 / CD314 / NKG2D Antibody
-
Creative Biolabs
- Recombinant Anti-Human KLRK1 Antibody
- Anti-Human KLRK1 Therapeutic Antibody
- Anti-Human KLRK1 Therapeutic Antibody scFv Fragment
- Recombinant Mouse Anti-KLRK1 Antibody (CBL703)
- Mouse Anti-KLRK1 Recombinant Antibody (CBWJN-0915)
- Recombinant Llama Anti-KLRK1 Single Domain Antibody (ET2F9 )
- Recombinant Mouse Anti-KLRK1 Antibody (5C6)
- Mouse Anti-KLRK1 Recombinant Antibody (CBXC-1951)
- Mouse Anti-KLRK1 Recombinant Antibody (CBWJC-2267)
- Mouse Anti-KLRK1 Recombinant Antibody (A-7)
- Recombinant Human Anti-KLRK1 Antibody scFv Fragment (16F31)
- Anti-Human KLRK1 Therapeutic Antibody scFv Fragment (KYK-1.0)
-
BioLegend
- CD314 (NKG2D) Antibody (320802)
- CD314 (NKG2D) Antibody (320804)
- CD314 (NKG2D) Antibody (320807)
- CD314 (NKG2D) Antibody (320808)
- CD314 (NKG2D) Antibody (320806)
- CD314 (NKG2D) Antibody (320805)
- CD314 (NKG2D) Antibody (320811)
- CD314 (NKG2D) Antibody (320812)
- TCR Vgamma9 Antibody
- CD314 (NKG2D) Antibody (320814)
- CD314 (NKG2D) Antibody (320816)
- CD314 (NKG2D) Antibody (320819)
- PerCP/Cyanine5.5 CD314 (NKG2D) Antibody (320817)
- CD314 (NKG2D) Antibody (320815)
- CD314 (NKG2D) Antibody (320820)
- PerCP/Cyanine5.5 CD314 (NKG2D) Antibody (320818)
- CD314 (NKG2D) Antibody (320821)
- CD314 (NKG2D) Antibody (320822)
- APC/Cyanine7 CD314 (NKG2D) Antibody (320824)
- APC/Cyanine7 CD314 (NKG2D) Antibody (320823)
- CD314 (NKG2D) Antibody (320826)
- CD314 (NKG2D) Antibody (320825)
- CD314 (NKG2D) Antibody (320828)
- CD314 (NKG2D) Antibody (320827)
- CD314 (NKG2D) Antibody (320830)
- CD314 (NKG2D) Antibody (320829)
- APC/Fire(TM) 750 CD314 (NKG2D) Antibody (320833)
- CD314 (NKG2D) Antibody (320831)
- CD314 (NKG2D) Antibody (320832)
- APC/Fire(TM) 750 CD314 (NKG2D) Antibody (320834)
- TotalSeq(TM)-A0165 CD314 (NKG2D) Antibody
- TotalSeq(TM)-A0583 TCR Vgamma9 Antibody
- Novus Biologicals Antibodies for KLRK1
-
Abcam antibodies for KLRK1
- Invitrogen Antibodies for KLRK1 (AFLGC-Klrk1)
- antibodies-online: Show 42 available KLRK1 Antibodies ranked by validation data
- Compare Top KLRK1 Antibodies
-
Recommended
- 52 WB Antibodies (anti-human)
- 45 FACS Antibodies (anti-human)
- 28 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 35 FACS Antibodies (anti-mouse)
- 20 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLRK1
- Sino Biological Antibodies for KLRK1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KLRK1
- Origene Custom Protein Services for KLRK1
- Novus Biologicals proteins for KLRK1
- Sino Biological Recombinant Proteins for KLRK1
- Sino Biological Cell Lysates for KLRK1
- ProSpec Recombinant Proteins for KLRK1
-
Abcam proteins for KLRK1
Assay Products
- antibodies-online: Show 4 available KLRK1 Elisa Kits ranked by validation data
- Compare Top KLRK1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for KLRK1 Gene
Domains & Families for KLRK1 Gene
Gene Families for KLRK1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted membrane proteins
- Transporters
Protein Domains for KLRK1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLRK1 Gene
- GenScript: Design optimal peptide antigens:
-
- NKG2-D-activating NK receptor (NKG2D_HUMAN)
- NK cell receptor D (Q1HEA1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for KLRK1 Gene
Function for KLRK1 Gene
Molecular function for KLRK1 Gene
- UniProtKB/Swiss-Prot Function:
- Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by interleukin IL15 in primary NK cells.
Phenotypes From GWAS Catalog for KLRK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10426993 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0032394 | MHC class Ib receptor activity | IEA | -- |
| GO:0038023 | signaling receptor activity | TAS,IDA | 17562706 |
| GO:0042288 | MHC class I protein binding | IEA | -- |
Phenotypes for KLRK1 Gene
- GenomeRNAi human phenotypes for KLRK1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Increased IL-8 secretion
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Multipolar spindles
Animal Model Products
-
Taconic Biosciences Mouse Models for KLRK1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KLRK1 - Select products 50% OFF >
- * KLRK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KLRK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
miRNA for KLRK1 Gene
- miRTarBase miRNAs that target KLRK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
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Clone Products
- Applied Biological Materials (abm): Clones for KLRK1 - Select products 50% OFF >
- * KLRK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202802
- MG222529
- MR202802
- MR202802L1
- MR202802L2
- MR202802L3
- MR202802L4
- MR222529
- MR222529L3
- MR222529L4
- MR228611
- RC208050
- RC208050L1
- RC208050L2
- RC208050L3
- RC208050L4
- RG208050
- RR209367
- RR209367L3
- RR209367L4
- MR202802L1V
- MR202802L2V
- MR202802L3V
- MR202802L4V
- MR222529L3V
- MR222529L4V
- RC208050L1V
- RC208050L2V
- RC208050L3V
- RC208050L4V
- RR209367L3V
- RR209367L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLRK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
Cell Line Products
-
Horizon Cell Lines for KLRK1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRK1 Gene
Localization for KLRK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLRK1 Gene
- Cell membrane. Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2007850 |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0009986 | cell surface | IBA,IDA | 10426994 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for KLRK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Malaria |
-
|
|
| 4 | Immune response Role of DAP12 receptors in NK cells | ||
| 5 | Hematopoietic Stem Cells and Lineage-specific Markers | ||
Pathways by source for KLRK1 Gene
6 Reactome pathways for KLRK1 Gene
2 KEGG pathways for KLRK1 Gene
2 R&D Systems pathways for KLRK1 Gene
Interacting Proteins for KLRK1 Gene
Selected Interacting proteins:
P26718-NKG2D_HUMAN
ENSP00000240618
for KLRK1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for KLRK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | IEA | -- |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0007165 | signal transduction | TAS | 2007850 |
| GO:0030101 | natural killer cell activation | TAS | 18676862 |
Transcripts for KLRK1 Gene
mRNA/cDNA for KLRK1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000240618 1576 nts (view in UCSC)
- ENST00000396451 734 nts (view in UCSC)
- ENST00000540267 1787 nts (view in UCSC)
- ENST00000540818 951 nts (view in UCSC)
- ENST00000544449 2064 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for KLRK1 - Select products 50% OFF >
- * KLRK1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for KLRK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRK1
Clone Products
- Applied Biological Materials (abm): Clones for KLRK1 - Select products 50% OFF >
- * KLRK1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG202802
- MG222529
- MR202802
- MR202802L1
- MR202802L2
- MR202802L3
- MR202802L4
- MR222529
- MR222529L3
- MR222529L4
- MR228611
- RC208050
- RC208050L1
- RC208050L2
- RC208050L3
- RC208050L4
- RG208050
- RR209367
- RR209367L3
- RR209367L4
- MR202802L1V
- MR202802L2V
- MR202802L3V
- MR202802L4V
- MR222529L3V
- MR222529L4V
- RC208050L1V
- RC208050L2V
- RC208050L3V
- RC208050L4V
- RR209367L3V
- RR209367L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for KLRK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
Relevant External Links for KLRK1 Gene
- GeneLoc Exon Structure for
- KLRK1
Expression for KLRK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- T-Cytotoxic Cells Peripheral Blood
- T-Cytotoxic Cells Thymus
- Natural killer-like cells(Woll PS et. al. 2009)
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRK1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for KLRK1
SOURCE GeneReport for Unigene cluster for KLRK1 Gene:
Hs.387787mRNA Expression by UniProt/SwissProt for KLRK1 Gene:
P26718-NKG2D_HUMAN
Tissue specificity:
Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Evidence on tissue expression from TISSUES for KLRK1 Gene
- Spleen(4.7)
- Stomach(4.4)
- Blood(3.7)
- Lymph node(3.5)
- Bone marrow(3.1)
- Intestine(3)
- Lung(2.9)
- Liver(2.7)
- Heart(2.3)
- Skin(2.3)
- Nervous system(2.2)
- Kidney(2.1)
Primer Products
-
OriGene qPCR primer pairs for KLRK1
-
OriGene qPCR primer pairs and template standards for KLRK1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRK1 Gene
Orthologs for KLRK1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | KLRK1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | KLRK1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | KLRK1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Klrk1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | KLRK1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany |
- Species where no ortholog for KLRK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for KLRK1 Gene
- ENSEMBL:
- Gene Tree for KLRK1 (if available)
- TreeFam:
- Gene Tree for KLRK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLRK1: view image
Paralogs for KLRK1 Gene
Paralogs for KLRK1 Gene
(10) SIMAP similar genes for KLRK1 Gene using alignment to 4 proteins:
- NKG2D_HUMAN
- J7GQY5_HUMAN
- Q1HEA1_HUMAN
- Q8WZ67_HUMAN
Variants for KLRK1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2358n54 | CNV | loss | 21841781 |
| esv3892136 | CNV | loss | 25118596 |
| nsv1036390 | CNV | loss | 25217958 |
| nsv557455 | CNV | loss | 21841781 |
| nsv832328 | CNV | gain | 17160897 |
| nsv8914 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLRK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRK1 Gene
Disorders for KLRK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cowpox |
|
|
| immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia |
|
|
| alveolar echinococcosis |
|
|
| alopecia areata |
|
|
| t-cell large granular lymphocyte leukemia |
|
|
Search KLRK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLRK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for KLRK1 Gene
Publications for KLRK1 Gene
- Association of an NKG2D gene variant with systemic lupus erythematosus in two populations. (PMID: 19735685) Kabalak G … Witte T (Human immunology 2010) 3 23 41
- Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. (PMID: 18174257) Furue H … Tajima K (Carcinogenesis 2008) 3 23 41
- Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms. (PMID: 18023027) Melum E … Lie BA (Hepatology (Baltimore, Md.) 2008) 3 23 41
- Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis. (PMID: 18361934) Garrido P … Ruiz-Cabello F (Human immunology 2008) 3 23 41
- A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. (PMID: 15294961) Rosen DB … Lanier LL (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 23
ExternalLinks
Products for KLRK1 Gene
- View all 22 R&D Systems KLRK1 (NKG2D/CD314) Products
- View all R&D Systems KLRK1 (NKG2D/CD314) Proteins and Enzymes
- View all 20 R&D Systems KLRK1 (NKG2D/CD314) Primary Antibodies
- View all R&D Systems KLRK1 (NKG2D/CD314) cDNA Clones
- Learn more about R&D Systems custom KLRK1 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KLRK1
- Origene Custom Protein Services for KLRK1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
- OriGene qPCR primer pairs for KLRK1
- OriGene qPCR primer pairs and template standards for KLRK1
- OriGene CRISPR knockouts for KLRK1
- MG202802
- MG222529
- MR202802
- MR202802L1
- MR202802L2
- MR202802L3
- MR202802L4
- MR222529
- MR222529L3
- MR222529L4
- MR228611
- RC208050
- RC208050L1
- RC208050L2
- RC208050L3
- RC208050L4
- RG208050
- RR209367
- RR209367L3
- RR209367L4
- MR202802L1V
- MR202802L2V
- MR202802L3V
- MR202802L4V
- MR222529L3V
- MR222529L4V
- RC208050L1V
- RC208050L2V
- RC208050L3V
- RC208050L4V
- RR209367L3V
- RR209367L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KLRK1
- Sino Biological Human cDNA Clone for KLRK1
- Sino Biological Recombinant Proteins for KLRK1
- Sino Biological Cell Lysates for KLRK1
- Sino Biological Antibodies for KLRK1
- Browse Sino Biological Assays
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals proteins for KLRK1
- Browse Antibodies
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- Abcam proteins for KLRK1
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- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for KLRK1
- Taconic Biosciences Mouse Models for KLRK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KLRK1 (AFLGC-Klrk1)
- VectorBuilder Custom and pre-made DNA vectors for KLRK1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for KLRK1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for KLRK1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for KLRK1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for KLRK1
- antibodies-online: Show 42 available KLRK1 Antibodies ranked by validation data
- Compare Top KLRK1 Antibodies
- Recommended
- 52 WB Antibodies (anti-human)
- 45 FACS Antibodies (anti-human)
- 28 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 35 FACS Antibodies (anti-mouse)
- 20 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 12 WB Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- antibodies-online: Show 4 available KLRK1 Elisa Kits ranked by validation data
- Compare Top KLRK1 Elisa Kits
- Quality Products:
- antibodies-online: Show 28 available KLRK1 Proteins ranked by validation data
- Compare Top KLRK1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for KLRK1
- Search Santa Cruz Biotechnology (SCBT) for KLRK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
- Horizon Cell Lines for KLRK1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for KLRK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRK1
Sources for KLRK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB