Aliases for KLRK1 Gene
Aliases for KLRK1 Gene
External Ids for KLRK1 Gene
- HGNC: 18788
- Entrez Gene: 22914
- Ensembl: ENSG00000213809
- OMIM: 611817
- UniProtKB: P26718
Previous HGNC Symbols for KLRK1 Gene
- D12S2489E
Previous GeneCards Identifiers for KLRK1 Gene
- GC12M010416
- GC12M010267
- GC12M010524
- GC12M010681
- GC12M010778
- GC12M011014
- GC12M011301
- GC12M011535
- GC12M011728
- GC12M011915
Summaries for KLRK1 Gene
-
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010]
GeneCards Summary for KLRK1 Gene
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. Diseases associated with KLRK1 include Congenital Cytomegalovirus and Htlv-1 Associated Myelopathy/Tropical Spastic Paraparesis. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is KLRD1.
UniProtKB/Swiss-Prot for KLRK1 Gene
-
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
Additional gene information for KLRK1 Gene
- Monarch Initiative
- Search for KLRK1 at DataMed
- Search for KLRK1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KLRK1 Gene
Genomics for KLRK1 Gene
GeneHancer (GH) Regulatory Elements for KLRK1 Gene
Promoters and enhancers for KLRK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around KLRK1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the KLRK1 gene promoter:
-
- POU2F1a
- POU2F1
- FOXJ2 (long isoform)
- FOXJ2
- SRF (504 AA)
- SRF
- POU2F1c
- POU2F1b
Regulatory Element Products
Genomic Locations for KLRK1 Gene
Genomic Locations for KLRK1 Gene
- chr12:10,372,353-10,391,874
- (GRCh38/hg38)
- Size:
- 19,522 bases
- Orientation:
- Minus strand
- chr12:10,524,952-10,544,473
- (GRCh37/hg19)
- Size:
- 19,522 bases
- Orientation:
- Minus strand
Genomic View for KLRK1 Gene
Genes around KLRK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.2 by Entrez Gene
- 12p13.2 by HGNC
- 12p13.2 by Ensembl
KLRK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for KLRK1 Gene
Proteins for KLRK1 Gene
-
Protein details for KLRK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26718-NKG2D_HUMAN
- Recommended name:
- NKG2-D type II integral membrane protein
- Protein Accession:
- P26718
- A8K7K5
- A8K7P4
- Q9NR41
Protein attributes for KLRK1 Gene
- Size:
- 216 amino acids
- Molecular mass:
- 25274 Da
- Quaternary structure:
-
- Homodimer; disulfide-linked. Heterohexamer composed of two subunits of KLRK1 and four subunits of HCST/DAP10. Interacts (via transmembrane domain) with HCST/DAP10 (via transmembrane domain); the interaction is required for KLRK1 NK cell surface and induces NK cell-mediated cytotoxicity. Does not interact with TYROBP. Interacts with CEACAM1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226).
- Miscellaneous:
-
- Is not capable of signal transduction by itself, but operates through the adapter protein HCST (PubMed:10426994 and PubMed:15894612). Some families of ligands for human and mouse KLRK1 receptors have been characterized being very similar in structure and highly likely to be orthologs. In humans, an additional distinct subfamily of ligands (MICA and MICB) differs structurally, having an extra MHC alpha 3-like domain (PubMed:23298206).
Three dimensional structures from OCA and Proteopedia for KLRK1 Gene
Alternative splice isoforms for KLRK1 Gene
- UniProtKB/Swiss-Prot:
Protein Expression for KLRK1 Gene
Post-translational modifications for KLRK1 Gene
Other Protein References for KLRK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for KLRK1 (NKG2D/CD314)
- Novus Biologicals Antibodies for KLRK1
-
Abcam antibodies for KLRK1
- Invitrogen Antibodies for KLRK1
- antibodies-online: Search results for 207 available KLRK1 Antibodies ranked by validation data
- Compare Top KLRK1 Antibodies
-
Recommended
- 46 FACS Antibodies (anti-human)
- 42 WB Antibodies (anti-human)
- 26 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 40 FACS Antibodies (anti-mouse)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 46 FACS Antibodies (anti-human)
- 42 WB Antibodies (anti-human)
- 26 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 40 FACS Antibodies (anti-mouse)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- GeneTex KLRK1 Antibody for KLRK1
-
Boster Bio Antibodies for KLRK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for KLRK1
- Sino Biological Antibodies for KLRK1
Protein Products
- R&D Systems Proteins and Enzymes for KLRK1 (NKG2D/CD314)
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KLRK1
- Origene Custom Protein Services for KLRK1
- Novus Biologicals proteins for KLRK1
- Sino Biological Recombinant Proteins for KLRK1
- Sino Biological Cell Lysates for KLRK1
- ProSpec Recombinant Proteins for KLRK1
- Search GeneTex for Proteins for KLRK1
-
Abcam proteins for KLRK1
Assay Products
No data available for DME Specific Peptides for KLRK1 Gene
Domains & Families for KLRK1 Gene
Gene Families for KLRK1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- CD markers
- Predicted membrane proteins
Protein Domains for KLRK1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for KLRK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for KLRK1 Gene
Function for KLRK1 Gene
Molecular function for KLRK1 Gene
- UniProtKB/Swiss-Prot Function:
- Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by interleukin IL15 in primary NK cells.
Phenotypes From GWAS Catalog for KLRK1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10426993 |
| GO:0030246 | carbohydrate binding | IEA | -- |
| GO:0032394 | MHC class Ib receptor activity | IEA | -- |
| GO:0038023 | signaling receptor activity | IDA | 17562706 |
| GO:0042288 | MHC class I protein binding | IEA | -- |
Phenotypes for KLRK1 Gene
- GenomeRNAi human phenotypes for KLRK1:
-
- Increased shRNA abundance (Z-score > 2)
- Multipolar spindles
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased IL-8 secretion
Animal Model Products
-
Taconic Biosciences Mouse Models for KLRK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLRK1
-
CRISPR Products
-
OriGene CRISPR knockouts for KLRK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
- genomics-online: gRNA clones - Search results for available KLRK1 gene related products
- Applied Biological Materials CRISPR for KLRK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
- GenScript: Design CRISPR guide RNA sequences for KLRK1
miRNA for KLRK1 Gene
- miRTarBase miRNAs that target KLRK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRK1
- genomics-online: shRNA clones - Search results for available KLRK1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KLRK1
- VectorBuilder custom plasmid, inducible vectors for KLRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
- genomics-online: cdna clones - Search results for available KLRK1 gene related products
- orf clones - Search results for available KLRK1 gene related products
- Applied Biological Materials Clones for KLRK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for KLRK1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KLRK1 Gene
Localization for KLRK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for KLRK1 Gene
- Cell membrane; Single-pass type II membrane protein. Note=Colocalized with HCST on the cell surface.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 2007850 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IDA | 10426994 |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for KLRK1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Innate Immune System |
.61
|
|
| 3 | Malaria |
-
|
|
| 4 | Immune response Role of DAP12 receptors in NK cells | ||
| 5 | Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers | ||
Pathways by source for KLRK1 Gene
6 Reactome pathways for KLRK1 Gene
2 KEGG pathways for KLRK1 Gene
2 R&D Systems pathways for KLRK1 Gene
Interacting Proteins for KLRK1 Gene
Selected Interacting proteins:
P26718-NKG2D_HUMAN
ENSP00000240618
for KLRK1 Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for KLRK1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | IEA | -- |
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0007165 | signal transduction | TAS | 2007850 |
| GO:0030101 | natural killer cell activation | TAS | 18676862 |
Transcripts for KLRK1 Gene
mRNA/cDNA for KLRK1 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (84) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000240618 1553 bps (uc009zhj.4)
- ENST00000540267 1787 bps (uc058ldn.1)
- ENST00000544449 2064 bps (uc058ldo.1)
- ENST00000540818 951 bps (uc058ldq.1)
- ENST00000396451 734 bps (uc058ldw.1)
Unigene Clusters for KLRK1 Gene
- Killer cell lectin-like receptor subfamily K, member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for KLRK1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
- genomics-online: gRNA clones - Search results for available KLRK1 gene related products
- Applied Biological Materials CRISPR for KLRK1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
- GenScript: Design CRISPR guide RNA sequences for KLRK1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRK1
- genomics-online: shRNA clones - Search results for available KLRK1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for KLRK1
- VectorBuilder custom plasmid, inducible vectors for KLRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRK1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
- genomics-online: cdna clones - Search results for available KLRK1 gene related products
- orf clones - Search results for available KLRK1 gene related products
- Applied Biological Materials Clones for KLRK1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for KLRK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- T-Cytotoxic Cells Peripheral Blood
- T-Cytotoxic Cells Thymus
- Natural killer-like cells(Woll PS et. al. 2009)
-
Thymus (Hematopoietic System)
- T-Cytotoxic Cells Thymus
This gene is overexpressed in CD8 Tcells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KLRK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of KLRK1 Gene:
KLRK1SOURCE GeneReport for Unigene cluster for KLRK1 Gene:
Hs.387787mRNA Expression by UniProt/SwissProt for KLRK1 Gene:
P26718-NKG2D_HUMAN
Tissue specificity:
Expressed in natural killer (NK) cells, CD8(+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs).
Evidence on tissue expression from TISSUES for KLRK1 Gene
- Spleen(4.4)
- Stomach(4.2)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for KLRK1
-
OriGene qPCR primer pairs for KLRK1
- genomics-online: primer clones - Search results for available KLRK1 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KLRK1 Gene
Orthologs for KLRK1 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | KLRK1 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | KLRK1 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | KLRK1 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Klrk1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | KLRK1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany |
- Species where no ortholog for KLRK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for KLRK1 Gene
- ENSEMBL:
- Gene Tree for KLRK1 (if available)
- TreeFam:
- Gene Tree for KLRK1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for KLRK1: view image
Paralogs for KLRK1 Gene
Paralogs for KLRK1 Gene
(10) SIMAP similar genes for KLRK1 Gene using alignment to 4 proteins:
- NKG2D_HUMAN
- J7GQY5_HUMAN
- Q1HEA1_HUMAN
- Q8WZ67_HUMAN
Variants for KLRK1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000147161 | -- | 10,381,503(-) | G/C | intron_variant | |
| rs1000194817 | -- | 10,375,794(-) | T/C | intron_variant | |
| rs1000446964 | -- | 10,389,733(-) | A/G | intron_variant | |
| rs1000455309 | -- | 10,379,061(-) | G/T | intron_variant | |
| rs1000657951 | -- | 10,385,579(-) | T/C | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2358n54 | CNV | loss | 21841781 |
| esv3892136 | CNV | loss | 25118596 |
| nsv1036390 | CNV | loss | 25217958 |
| nsv557455 | CNV | loss | 21841781 |
| nsv832328 | CNV | gain | 17160897 |
| nsv8914 | CNV | loss | 18304495 |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for KLRK1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KLRK1 Gene
Disorders for KLRK1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital cytomegalovirus |
|
|
| htlv-1 associated myelopathy/tropical spastic paraparesis |
|
|
| large granular lymphocyte leukemia |
|
|
| cowpox |
|
|
| celiac disease 1 |
|
Search KLRK1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for KLRK1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for KLRK1 Gene
Publications for KLRK1 Gene
- Association of an NKG2D gene variant with systemic lupus erythematosus in two populations. (PMID: 19735685) Kabalak G … Witte T (Human immunology 2010) 3 22 44 58
- Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms. (PMID: 18023027) Melum E … Lie BA (Hepatology (Baltimore, Md.) 2008) 3 22 44 58
- Decreased risk of colorectal cancer with the high natural killer cell activity NKG2D genotype in Japanese. (PMID: 18174257) Furue H … Tajima K (Carcinogenesis 2008) 3 22 44 58
- A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. (PMID: 15294961) Rosen DB … Lanier LL (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 22 58
- Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands. (PMID: 12679019) McFarland BJ … Strong RK (Structure (London, England : 1993) 2003) 3 4 22 58
Products for KLRK1 Gene
- R&D Systems Antibodies for KLRK1 (NKG2D/CD314)
- R&D Systems Proteins and Enzymes for KLRK1 (NKG2D/CD314)
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for KLRK1
- Origene Custom Protein Services for KLRK1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for KLRK1
- Browse OriGene Inhibitory RNA Products For KLRK1
- OriGene qPCR primer pairs and template standards for KLRK1
- OriGene qPCR primer pairs for KLRK1
- OriGene CRISPR knockouts for KLRK1
- OriGene ORF clones in human for KLRK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For KLRK1
- GenScript: Next-day shipping of latest version cDNA ORF clones for KLRK1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for KLRK1
- GenScript Custom Assay Services for KLRK1
- GenScript Custom overexpressing Cell Line Services for KLRK1
- GenScript: Design CRISPR guide RNA sequences for KLRK1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for KLRK1
- Sino Biological Human cDNA Clone for KLRK1
- Sino Biological Recombinant Proteins for KLRK1
- Sino Biological Cell Lysates for KLRK1
- Sino Biological Antibodies for KLRK1
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for KLRK1
- Novus Biologicals proteins for KLRK1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for KLRK1
- Abcam proteins for KLRK1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for KLRK1
- Taconic Biosciences Mouse Models for KLRK1
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for KLRK1
- Cyagen custom Knockout/knockin (KOKI) mouse models for KLRK1
- VectorBuilder custom plasmid, inducible vectors for KLRK1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for KLRK1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 207 available KLRK1 Antibodies ranked by validation data
- Compare Top KLRK1 Antibodies
- Recommended
- 46 FACS Antibodies (anti-human)
- 42 WB Antibodies (anti-human)
- 26 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 40 FACS Antibodies (anti-mouse)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- 46 FACS Antibodies (anti-human)
- 42 WB Antibodies (anti-human)
- 26 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 10 IHC (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 2 BCA Antibodies (anti-human)
- 2 Neut Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 40 FACS Antibodies (anti-mouse)
- 17 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 2 Func Antibodies (anti-mouse)
- 2 ICFC Antibodies (anti-mouse)
- 1 IF Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 9 WB Antibodies (anti-rat)
- antibodies-online: Search results for 3 available KLRK1 Elisa Kits ranked by validation data
- Compare Top KLRK1 Elisa Kits
- Recommended
- antibodies-online: Search results for 21 available KLRK1 Proteins ranked by validation data
- Compare Top KLRK1 Proteins
- GeneTex KLRK1 Antibody for KLRK1
- Search GeneTex for Proteins for KLRK1
- Santa Cruz Biotechnology (SCBT) Antibodies for KLRK1
- Search Santa Cruz Biotechnology (SCBT) for KLRK1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for KLRK1
- Horizon Cell Lines for KLRK1
- genomics-online: cdna clones - Search results for available KLRK1 gene related products
- orf clones - Search results for available KLRK1 gene related products
- genomics-online: gRNA clones - Search results for available KLRK1 gene related products
- genomics-online: primer clones - Search results for available KLRK1 gene related products
- genomics-online: shRNA clones - Search results for available KLRK1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for KLRK1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for KLRK1
- GeneCopoeia miRNA 3'UTR Target clone products for KLRK1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for KLRK1
- Boster Bio Antibodies for KLRK1
- Browse Boster Bio ELISA Kits
Sources for KLRK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt